[go: up one dir, main page]

DK2875043T3 - Glucagonanaloger - Google Patents

Glucagonanaloger Download PDF

Info

Publication number
DK2875043T3
DK2875043T3 DK13756832.5T DK13756832T DK2875043T3 DK 2875043 T3 DK2875043 T3 DK 2875043T3 DK 13756832 T DK13756832 T DK 13756832T DK 2875043 T3 DK2875043 T3 DK 2875043T3
Authority
DK
Denmark
Prior art keywords
aib
glu
ser
seq
compound
Prior art date
Application number
DK13756832.5T
Other languages
English (en)
Inventor
Lise Giehm
Ditte Riber
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Application granted granted Critical
Publication of DK2875043T3 publication Critical patent/DK2875043T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Claims (15)

1. Forbindelse med formel I:
(I) eller et farmaceutisk acceptabelt salt eller solvat deraf; hvor R1 er hydrogen, C-m alkyl, acetyl, formyl, benzoyl eller trifluoracetyl; R2 er OH eller NH2; og Z er en aminosyresekvens afledt af sekvensen med formel la: His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu- Asp-Ser-Arg-Arg-Ala-Glri-Asp-Phe-Val-Gln-Trp-Leu-Glu-Asn-Thr (la) og yderligere omfattende mindst fire aminosyresubstitutioner eller -deletioner, der kun er på sekvenspositioner udvalgt blandt 2, 3, 4, 9, 10, 15, 16, 17, 20, 21,24, 28 og 29, som følger: X2 er udvalgt blandt Aib og Ala; X3 er udvalgt blandt His, Pro, Dab(Ac), Dap(Ac) og Gln(Me); X4 er DAIa; X9 er Glu; X10 er udvalgt blandt Val, Leu, N-Me-Tyr og N-Me-DTyr; X15 er Glu; X16 er udvalgt blandt Aib, Lys, Glu, Leu, Val, DVal, Phe, His, Arg, Pro, DPro, N-Me-Ser og N-Me-DSer; X17 er udvalgt blandt Ala og Ser; X20 er udvalgt blandt Glu og Lys; X21 er udvalgt blandt Glu, Lys og Ser; X24 er udvalgt blandt Lys, Ser, Glu og Ala; X28 er udvalgt blandt Ser og Lys og Glu eller er fraværende; X29 er udvalgt blandt Ser og Ala eller er fraværende; forudsat, at Z ikke er udvalgt blandt: HSQGTFTSDYSKYLDSARAEDFVKWLEST; og HSQGTFTSDYSKYLESRRAKEFVEWLEST; hvor forbindelsen har glucagonagonistaktivitet og forbedret opløselighed og/eller stabilitet sammenlignet med nativt humant glucagon.
2. Forbindelse ifølge krav 1 med formel I:
(I) eller et farmaceutisk acceptabelt salt eller solvat deraf; hvor R1 er hydrogen, C1-4 alkyl, acetyl, formyl, benzoyl eller trifluoracetyl; R2 er OH eller NH2; og Z er en aminosyresekvens afledt af sekvensen med formel la: His-Scr-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Scr-Lys-Tyr-Leu- Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Glu-Asn-Thr (la) og yderligere omfattende mindst fire aminosyresubstitutioner eller -deletioner, der kun er på sekvenspositioner (angivet som X) udvalgt blandt 2, 3, 9, 10, 15,16,17, 20, 21,24, 28 og 29, som følger: X2 er udvalgt blandt Aib og Ala; X3 er udvalgt blandt His og Pro; X9 er Glu; X10 er udvalgt blandt N-Me-Tyr og N-Me-DTyr; X15 er Glu; X16 er udvalgt blandt Aib, Lys, Glu, Leu, Val, DVal, Phe, His, Arg, Pro, DPro, N-Me-Ser og N-Me-DSer; X17 er udvalgt blandt Ala og Ser; X20 er udvalgt blandt Glu og Lys; X21 er udvalgt blandt Glu, Lys og Ser; X24 er udvalgt blandt Lys, Ser, Glu og Ala; X28 er udvalgt blandt Ser og Lys eller er fraværende; X29 er udvalgt blandt Ser og Ala eller er fraværende; forudsat, at Z ikke er udvalgt blandt: HSQGTFTSDYSKYLDSARAEDFVKWLEST; og HSQGTFTSDYSKYLESRRAKEFVEWLEST; hvor forbindelsen har glucagonagonistaktivitet og forbedret opløselighed og/eller stabilitet sammenlignet med nativt humant glucagon.
3. Forbindelse eller farmaceutisk acceptabelt salt eller solvat deraf ifølge krav 1, hvor mindst fire aminosyresubstitutioner eller -deletioner på aminosyrese- kvenspositioner (angivet som X) udvalgt blandt 2, 3, 4, 9, 10, 15, 16, 17, 20, 21,24, 28 og 29 af forbindelsen med formel I er som følger: X2 er udvalgt blandt Aib og Ala; X3 er udvalgt blandt His og Pro; X4 er DAIa; X9 er Glu; X10 er udvalgt blandt N-Me-Tyr og N-Me-DTyr; X15 er Glu; X16 er udvalgt blandt Aib, Lys, Glu, Leu, Val, Phe, His og Arg; X17 er udvalgt blandt Ala og Ser; X20 er udvalgt blandt Glu og Lys; X21 er udvalgt blandt Glu, Lys og Ser; X24 er udvalgt blandt Lys, Ser, Glu og Ala; X28 er udvalgt blandt Ser, Glu og Lyseller er fraværende; X29 er udvalgt blandt Ser og Ala eller er fraværende.
4. Forbindelse eller farmaceutisk acceptabelt salt eller solvat deraf ifølge krav 1, hvor de mindst fire aminosyresubstitutioner eller -deletioner er på aminosy-resekvenspositioner (angivet ved et X) udvalgt blandt 2, 3, 4, 10, 15, 16, 17, 20, 21,24, 28 og 29 af forbindelsen med formel I og er som følger: X2 er Ala; X3 er Dab(Ac), Dap(Ac) og Gln(Me); X4 er DAIa; X10 er udvalgt blandt Leu og Val; X15 er Glu; X16 er udvalgt blandt Aib, Lys, Glu, Leu og Val; X17 er Ala; X20 er udvalgt blandt Glu og Lys; X21 er udvalgt blandt Glu og Ser; X24 er udvalgt blandt Lys, Ser og Glu; X28 er udvalgt blandt Ser, Glu og Lys; X29 er Ala eller er fraværende.
5. Forbindelse eller farmaceutisk acceptabelt salt eller solvat deraf ifølge krav 1, hvor de mindst fire aminosyresubstitutioner eller -deletioner er på aminosy- resekvenspositioner (angivet ved et X) udvalgt blandt 2, 3, 4, 16, 17, 20, 21, 24, 28 og 29 af forbindelsen med formel I og er som følger: X2 er Ala; X3 er Dab(Ac), Dap(Ac), Gln(Me) eller His; X4 er DAIa; X16 er udvalgt blandt Aib, Lys, Glu; X17 er Ala; X20 er udvalgt blandt Glu og Lys; X21 er udvalgt blandt Glu og Ser; X24 er udvalgt blandt Lys, Ser og Glu; X28 er udvalgt blandt Ser, Glu og Lys; X29 er Ala eller er fraværende.
6. Forbindelse ifølge et hvilket som helst af kravene 1 til 5, hvor X17 er Ala.
7. Forbindelse eller farmaceutisk acceptabelt salt eller solvat deraf ifølge et hvilket som helst af kravene 1 til 5, hvor Z er udvalgt fra gruppen bestående af: HSQGTFTSDYSKYLDSARAESFVKWLEST (SEQ ID NO: 2) HSQGTFTSDYSKYLDSARAEDFVKWLEET (SEQ ID NO: 3) HSQGTFTSDYSKYLDKARAEDFVKWLEST (SEQ ID NO: 4) HSQGTFTSDYSKYLDSARAEDFVAWLEST (SEQ ID NO: 5) HSQGTFTSDYSKYLDEARAKDFVEWLEKT (SEQ ID NO: 6) HSQGTFTSDYSKYLDSARAEDFVEWLEST (SEQ ID NO: 7) HSQGTFTSDYSKYLESARAEDFVKWLEST (SEQ ID NO: 9) HSQGTFTSDYSKYLDSARAEEFVKWLEST (SEQ ID NO: 10) HSQGTFTSDYSKYLDSARAEDFVSWLEST (SEQ ID NO: 11) HSQGTFTSDLSKYLDSARAEDFVKWLEST (SEQ ID NO: 12) HSQGTFTSDYSKYLD-Aib-ARAEDFVKWLEST (SEQ ID NO: 13) HSQGTFTSDYSKYLDSARAEDFVKWLES (SEQ ID NO: 14) HSQGTFTSDYSKYLDEARAEDFVKWLEST (SEQ ID NO: 15) HSQGTFTSDYSKYLD-Aib-ARAESFVKWLEST (SEQ ID NO: 16) HSQGTFTSDYSKYLESARAESFVKWLEST (SEQ ID NO: 17) HSQGTFTSDYSKYLDLARAEDFVKWLEST (SEQ ID NO: 18) HSQGTFTSDYSKYLDKRRAEDFVSWLEST (SEQ ID NO: 19) HSQGTFTSDYSKYLDVARAESFVKWLEST (SEQ ID NO: 20) HAQGTFTSDYSKYLD-Aib-ARAESFVKWLEST (SEQ ID NO: 21) HSQGTFTSDYSKYLD-Aib-ARAEEFVKWLEST (SEQ ID NO: 22) HSQ-DAIa-TFTSDYSKYLD-Aib-ARAESFVKWLEST (SEQ ID NO: 23) HSQGTFTSDVSKYLD-Aib-ARAESFVKWLEST (SEQ ID NO: 24) HS-[Dab(Ac)]-GTFTSDYSKYLD-Aib-ARAESFVKWLEST (SEQ ID NO: 25) HSQGTFTSDYSKYLD-Aib-RRAESFVKWLEST (SEQ ID NO: 26) HS-[Gln(Me)]-GTFTSDYSKYLD-Aib-ARAESFVKWLEST (SEQ ID NO: 27) HSQGTFTSDYSKYLDEARAKSFVEWLEKT (SEQ ID NO: 28) HSQGTFTSDYSKYLDEARAKSFVEWLEST (SEQ ID NO: 29) HSQGTFTSDYSKYLD-Aib-ARAKSFVEWLEKT (SEQ ID NO: 30) HSQGTFTSDYSKYLD-Aib-ARAESFVKWLESA (SEQ ID NO: 31) HSQGTFTSDYSKYLD-Aib-ARAESFVKWLEST (SEQ ID NO: 32) HS-[Dab(Ac)]-GTFTSDYSKYLD-Aib-ARAESFVKWLEST (SEQ ID NO: 33) HSQGTFTSDYSKYLD-Aib-ARAEEFVSWLEKT (SEQ ID NO: 34) HSQGTFTSDYSKYLD-Aib-ARAEKFVEWLEST (SEQ ID NO: 35) HSQGTFTSDYSKYLD-Aib-ARAEEFVAWLEST (SEQ ID NO: 36) HSQGTFTSDYSKYLD-Aib-ARAEEFVKWLEET (SEQ ID NO: 37) HSQGTFTSDYSKYLE-Aib-ARAEEFVKWLEST (SEQ ID NO: 38) HSHGTFTSDYSKYLD-Aib-ARAEEFVKWLEST (SEQ ID NO: 39) HS-[Dab(Ac)]-GTFTSDYSKYLD-Aib-ARAEEFVKWLEST (SEQ ID NO: 40) °9 HS-[Dap(Ac)]-GTFTSDYSKYLD-Aib-ARAEEFVKWLEST (SEQ ID NO: 41).
8. Forbindelse ifølge et hvilket som helst af kravene 1 til 5, udvalgt fra gruppen bestående af: Hy-HSQGTFTSDYSKYLDSARAESFVKWLEST-OH Hy-HSQGTFTSDYSKYLDSARAEDFVKWLEET-OH Hy-HSQGTFTSDYSKYLDKARAEDFVKWLEST-OH Hy-HSQGTFTSDYSKYLDSARAEDFVAWLEST-OH Hy-HSQGTFTSDYSKYLDEARAKDFVEWLEKT-OH Hy-HSQGTFTSDYSKYLDSARAEDFVEWLEST-OH Hy-HSQGTFTSDYSKYLESARAEDFVKWLEST-OH Hy-HSQGTFTSDYSKYLDSARAEEFVKWLEST-OH Hy-HSQGTFTSDYSKYLDSARAEDFVSWLEST-OH Hy-HSQGTFTSDLSKYLDSARAEDFVKWLEST-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAEDFVKWLEST-OH Hy-HSQGTFTSDYSKYLDSARAEDFVKWLES-OH Hy-HSQGTFTSDYSKYLDEARAEDFVKWLEST-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAESFVKWLEST-OH Hy-HSQGTFTSDYSKYLESARAESFVKWLEST-OH Hy-HSQGTFTSDYSKYLDLARAEDFVKWLEST-OH Hy-HSQGTFTSDYSKYLDKRRAEDFVSWLEST-OH Hy-HSQGTFTSDYSKYLDVARAESFVKWLEST-OH Hy-HAQGTFTSDYSKYLD-Aib-ARAESFVKWLEST-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAEEFVKWLEST-OH Hy-HSQ-DAIa-TFTSDYSKYLD-Aib-ARAESFVKWLEST-OH Hy-HSQGTFTSDVSKYLD-Aib-ARAESFVKWLEST-OH Hy-HS-[Dab(Ac)]-GTFTSDYSKYLD-Aib-ARAESFVKWLEST-NH2 Hy-HSQGTFTSDYSKYLD-Aib-RRAESFVKWLEST-OH Hy-HS-[Gln(Me)]-GTFTSDYSKYLD-Aib-ARAESFVKWLEST-OH Hy-HSQGTFTSDYSKYLDEARAKSFVEWLEKT-OH Hy-HSQGTFTSDYSKYLDEARAKSFVEWLEST-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAKSFVEWLEKT-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAESFVKWLESA-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAESFVKWLEST-NH2 Hy-HS-[Dab(Ac)]-GTFTSDYSKYLD-Aib-ARAESFVKWLEST-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAEEFVSWLEKT-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAEKFVEWLEST-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAEEFVAWLEST-OH Hy-HSQGTFTSDYSKYLD-Aib-ARAEEFVKWLEET-OH Hy-HSQGTFTSDYSKYLE-Aib-ARAEEFVKWLEST-OH Hy-HSHGTFTSDYSKYLD-Aib-ARAEEFVKWLEST-NH2 Hy-HS-[Dab(Ac)]-GTFTSDYSKYLD-Aib-ARAEEFVKWLEST-OH Hy-HS-[Dab(Ac)]-GTFTSDYSKYLD-Aib-ARAEEFVKWLEST-NH2 Hy-HS-[Dap(Ac)]-GTFTSDYSKYLD-Aib-ARAEEFVKWLEST-NH2 eller et farmaceutisk acceptabelt salt eller solvat deraf.
9. Nukleinsyrekonstrukt, der koder for et peptid Z ifølge et hvilket som helst af kravene 1 til 7, hvor peptidet udelukkende består af naturligt forekommende aminosyrer.
10. Ekspressionsvektor omfattende et nukleinsyrekonstrukt ifølge krav 9.
11. Værtscelle omfattende et nukleinsyrekonstrukt ifølge krav 9 eller en ekspressionsvektor ifølge krav 10.
12. Farmaceutisk sammensætning omfattende en forbindelse eller et farmaceutisk acceptabelt salt eller solvat deraf ifølge et hvilket som helst af kravene 1 -8 og en farmaceutisk acceptabel bærer.
13. Forbindelse eller farmaceutisk acceptabelt salt eller solvat deraf ifølge et hvilket som helst af kravene 1-8 til anvendelse i en fremgangsmåde til medicinsk behandling.
14. Forbindelse eller farmaceutisk acceptabelt salt eller solvat deraf ifølge et hvilket som helst af kravene 1-8 til anvendelse i en fremgangsmåde til behandling af hypoglykæmi, akut hypoglykæmi, kronisk hypoglykæmi, type 2-diabetes, nedsat glukosetolerance, type 1-diabetes, adipositas, koronar hjertesygdom, aterosklerose, hypertension, dyslipidæmi, hepatisk steatose, β-blokker-forgiftning, insulinom og Von Gierkes sygdom.
15. Forbindelse eller farmaceutisk acceptabelt salt eller solvat deraf til anvendelse ifølge krav 14, hvor hypoglykæmien er udvalgt fra gruppen bestående af: diabetisk hypoglykæmi, akut insulininduceret hypoglykæmi, non-diabetisk hypoglykæmi, reaktiv hypoglykæmi, fastende hypoglykæmi, lægemiddelinduceret hypoglykæmi, alkoholinduceret hypoglykæmi, gastrisk by-pass-induceret hypoglykæmi og hypoglykæmi, der forekommer under graviditet.
DK13756832.5T 2012-07-23 2013-07-23 Glucagonanaloger DK2875043T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261674706P 2012-07-23 2012-07-23
US201361785611P 2013-03-14 2013-03-14
DKPA201300360 2013-06-14
PCT/EP2013/065519 WO2014016300A1 (en) 2012-07-23 2013-07-23 Glucagon analogues

Publications (1)

Publication Number Publication Date
DK2875043T3 true DK2875043T3 (da) 2017-03-27

Family

ID=49996630

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13756832.5T DK2875043T3 (da) 2012-07-23 2013-07-23 Glucagonanaloger

Country Status (28)

Country Link
US (3) US10442847B2 (da)
EP (1) EP2875043B1 (da)
JP (3) JP6534927B2 (da)
KR (1) KR102129235B1 (da)
CN (2) CN104662038B (da)
AR (1) AR091866A1 (da)
AU (1) AU2013295035B2 (da)
BR (1) BR112015001451B1 (da)
CA (1) CA2878991C (da)
DK (1) DK2875043T3 (da)
EA (1) EA033399B1 (da)
ES (1) ES2620111T3 (da)
FI (1) FIC20240034I1 (da)
FR (1) FR24C1043I1 (da)
HK (1) HK1210787A1 (da)
IL (1) IL236554B (da)
IN (1) IN2015DN00544A (da)
MX (1) MX356957B (da)
MY (1) MY170671A (da)
NL (1) NL301294I2 (da)
NZ (1) NZ704043A (da)
PH (1) PH12015500115B1 (da)
PL (1) PL2875043T3 (da)
SG (1) SG11201500375PA (da)
TW (1) TWI642682B (da)
UA (1) UA117103C2 (da)
WO (1) WO2014016300A1 (da)
ZA (1) ZA201702364B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA022816B1 (ru) 2009-07-13 2016-03-31 Зилэнд Фарма А/С Ацилированные аналоги глюкагона
TWI689515B (zh) 2012-05-03 2020-04-01 丹麥商西蘭製藥公司 Ｇｉｐ-ｇｌｐ-１雙重促效劑化合物及方法
AU2013295035B2 (en) * 2012-07-23 2017-08-03 Zealand Pharma A/S Glucagon analogues
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
EP2934566B1 (en) 2012-12-21 2017-06-21 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
KR102394515B1 (ko) 2013-10-17 2022-05-09 질랜드 파마 에이/에스 아실화된 글루카곤 유사체
CA2929459C (en) 2013-11-06 2022-05-03 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
KR102310392B1 (ko) 2013-11-06 2021-10-13 질랜드 파마 에이/에스 글루카곤-ｇｌｐ-1-ｇｉｐ 삼원 효능제 화합물
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086729A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/gip receptor agonists
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
EP3151852A1 (en) 2014-06-04 2017-04-12 Novo Nordisk A/S Glp-1/glucagon receptor co-agonists for medical use
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
DK3212218T3 (da) 2014-10-29 2021-08-30 Zealand Pharma As GIP-agonistforbindelser og fremgangsmåder
PL3283507T3 (pl) 2015-04-16 2020-05-18 Zealand Pharma A/S Acylowany analog glukagonu
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
TWI622596B (zh) * 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
GB201710822D0 (en) * 2017-07-05 2017-08-16 Zealand Pharma As Methods and medical uses relating to the treatment of hypoglycaemia
CN110913888A (zh) 2017-07-14 2020-03-24 Xeris药物公司 治疗先天性高胰岛素血症的方法
CN111936159A (zh) * 2018-01-23 2020-11-13 Xeris药物公司 使用微剂量的稳定胰高血糖素治疗减肥术后低血糖症
WO2021185821A1 (en) * 2020-03-16 2021-09-23 Zealand Pharma A/S Liquid formulations of glucagon analogues
MX2023015068A (es) * 2021-06-18 2024-01-17 Beijing Tuo Jie Biopharmaceutical Co Ltd Analogo de glucagon y uso medico del mismo.
CN113501871B (zh) * 2021-07-21 2022-10-28 汉肽生物医药集团有限公司 一种固液相结合制备达西高血糖素的方法
WO2025056677A1 (en) 2023-09-15 2025-03-20 Zealand Pharma A/S Dasiglucagon for use in the treatment of congenital hyperinsulinism

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4288627A (en) 1980-02-12 1981-09-08 Phillips Petroleum Company Oxidation of thiols employing cobalt molybdate/triethylamine catalyst
NZ202757A (en) 1981-12-23 1985-11-08 Novo Industri As Peptides and medicaments
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
DK0512042T3 (da) 1990-01-24 1998-05-11 Douglas I Buckley GLP-1-analoger anvendelige ved diabetesbehandling
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
WO1991017243A1 (en) 1990-05-09 1991-11-14 Novo Nordisk A/S A cellulase preparation comprising an endoglucanase enzyme
DK36392D0 (da) 1992-03-19 1992-03-19 Novo Nordisk As Anvendelse af kemisk forbindelse
DK39892D0 (da) 1992-03-25 1992-03-25 Bernard Thorens Peptid
US5846747A (en) 1992-03-25 1998-12-08 Novo Nordisk A/S Method for detecting glucagon-like peptide-1 antagonists and agonists
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
WO1995005848A1 (en) 1993-08-24 1995-03-02 Novo Nordisk A/S Protracted glp-1
HUT73490A (en) 1993-09-07 1996-08-28 Amylin Pharmaceuticals Inc Methods for regulating gastrointestinal mobility
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5523449A (en) 1995-05-17 1996-06-04 Bayer Corporation Process for preparing phosphorodichlorido-dithioates by reacting alkylmercaptans with phosphorus trichloride in the presence of sulfur
US6767887B1 (en) 1996-06-05 2004-07-27 Roche Diagnostics Gmbh Exendin analogues, processes for their preparation and medicaments containing them
US6110703A (en) 1996-07-05 2000-08-29 Novo Nordisk A/S Method for the production of polypeptides
EP0966297B2 (en) 1996-08-08 2013-02-27 Amylin Pharmaceuticals, Inc. Regulation of gastrointestinal motility
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US7235627B2 (en) 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
DE69737479D1 (de) 1996-08-30 2007-04-26 Novo Nordisk As Glp-1 derivate
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
JP4405594B2 (ja) 1996-09-09 2010-01-27 ジーランド ファーマ アクティーゼルスカブ 改良型固相ペプチド合成及びかかる合成において利用するための試薬
KR20000036015A (ko) 1996-09-09 2000-06-26 스타이니스 에바 알파-히드록시산 링커를 함유하는 펩티드 프로드럭
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
WO1998022577A1 (en) 1996-11-15 1998-05-28 Maria Grazia Masucci Fusion proteins having increased half-lives
ES2247676T3 (es) 1997-01-07 2006-03-01 Amylin Pharmaceuticals, Inc. Uso de las exendinas y de los agonistas de las mismas para la reduccion de la ingesta alimenticia.
US6410511B2 (en) 1997-01-08 2002-06-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
US6136784A (en) 1997-01-08 2000-10-24 Amylin Pharmaceuticals, Inc. Amylin agonist pharmaceutical compositions containing insulin
EP0981611A1 (en) 1997-02-05 2000-03-01 1149336 Ontario Inc. Polynucleotides encoding proexendin, and methods and uses thereof
US5846937A (en) 1997-03-03 1998-12-08 1149336 Ontario Inc. Method of using exendin and GLP-1 to affect the central nervous system
CN1261878A (zh) 1997-05-07 2000-08-02 柏林马克斯普朗克科学促进协会 新的半胱氨酸衍生物,它们的制备方法和含有它们的药物
NZ502592A (en) 1997-08-08 2002-03-28 Amylin Pharmaceuticals Inc Exendin agonist peptides and their use in the treatment of type I and II diabetes
US7157555B1 (en) 1997-08-08 2007-01-02 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
US7223725B1 (en) 1997-11-14 2007-05-29 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
BR9814189A (pt) 1997-11-14 2000-10-03 Amylin Pharmaceuticals Inc "compostos agonistas da exendina"
US7220721B1 (en) 1997-11-14 2007-05-22 Amylin Pharmaceuticals, Inc. Exendin agonist peptides
AU757748B2 (en) 1997-11-14 2003-03-06 Amylin Pharmaceuticals, Inc. Novel exendin agonist compounds
JP2001525371A (ja) 1997-12-05 2001-12-11 イーライ・リリー・アンド・カンパニー Ｇｌｐ−１製剤
US6703359B1 (en) 1998-02-13 2004-03-09 Amylin Pharmaceuticals, Inc. Inotropic and diuretic effects of exendin and GLP-1
ATE366115T1 (de) 1998-02-13 2007-07-15 Amylin Pharmaceuticals Inc Inotropische und diuretische effekte von exendin und glp-1
AU3247799A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
AU2610899A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S N-terminally modified glp-1 derivatives
CA2321026A1 (en) 1998-03-09 1999-09-16 Zealand Pharmaceuticals A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
ATE269103T1 (de) 1998-03-13 2004-07-15 Novo Nordisk As Stabilisierte wässerige glukagonlösungen enthaltend detergenzien
WO1999049788A1 (en) 1998-03-30 1999-10-07 Focus Surgery, Inc. Ablation system
SE9802080D0 (sv) 1998-06-11 1998-06-11 Hellstroem Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein
DE69941510D1 (de) 1998-08-10 2009-11-19 Us Gov Nat Inst Health Differenzierung von nicht-insulin in insulin-produzierende zellen durch glp-1 und exendin-4 und dessen verwendung
EP1119625B1 (en) 1998-10-07 2005-06-29 Medical College Of Georgia Research Institute, Inc. Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
US6284725B1 (en) 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
JP3702181B2 (ja) 1998-12-07 2005-10-05 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Ｇｌｐ−１の類似体
JP2002538084A (ja) 1999-01-14 2002-11-12 アミリン・ファーマシューティカルズ，インコーポレイテッド グルカゴンを抑制する方法
US7399489B2 (en) 1999-01-14 2008-07-15 Amylin Pharmaceuticals, Inc. Exendin analog formulations
DE122007000042I2 (de) 1999-01-14 2011-05-05 Amylin Pharmaceuticals Inc Neue exendin agonist formulierungen und deren verabreichung
US6451987B1 (en) 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
HUP0200297A3 (en) 1999-03-17 2002-09-30 Novo Nordisk As Method for acylating peptides and the glutaminic acid derivatives as acylating agents
US6271241B1 (en) 1999-04-02 2001-08-07 Neurogen Corporation Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
US6924264B1 (en) 1999-04-30 2005-08-02 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
AU775063C (en) 1999-04-30 2005-05-12 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
ES2209885T3 (es) 1999-05-17 2004-07-01 Conjuchem, Inc. Peptidos insulinotropicos de larga duracion.
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US6506724B1 (en) 1999-06-01 2003-01-14 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus
US6344180B1 (en) 1999-06-15 2002-02-05 Bionebraska, Inc. GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
EP1076066A1 (en) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
MXPA02006118A (es) 2000-10-20 2004-08-23 Amylin Pharmaceuticals Inc Tratamiento de la invernacion del miocardio y cardiopatia diabetica con un peptido glp-1.
GB0121709D0 (en) 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
WO2003053460A1 (en) 2001-12-19 2003-07-03 Eli Lilly And Company Crystalline compositions for controlling blood glucose
HUP0700126A2 (en) 2001-12-20 2007-06-28 Lilly Co Eli Insulin molecule having protracted time action
CA2490564A1 (en) 2002-07-04 2004-01-15 Zealand Pharma A/S Glp-1 and methods for treating diabetes
RU2376314C2 (ru) 2002-10-02 2009-12-20 Зилэнд Фарма А/С Стабилизированные соединения эксендина-4
US7192922B2 (en) 2002-11-19 2007-03-20 Allegheny-Singer Research Institute Method of treating left ventricular dysfunction
GB0300571D0 (en) 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
WO2004096854A2 (en) 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
MXPA05013048A (es) * 2003-06-03 2006-03-02 Novo Nordisk As Composiciones peptodicas farmaceuticas estabilizadas.
US7623530B2 (en) 2003-11-20 2009-11-24 Nokia Corporation Indication of service flow termination by network control to policy decision function
US20090202494A1 (en) 2004-01-30 2009-08-13 Antonio Cruz Combined use of glp-1 agonists and gastrin for regulating blood glucose levels
US8076288B2 (en) 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
KR101340354B1 (ko) 2004-11-12 2013-12-11 노보 노르디스크 에이/에스 안정한 펩티드 제제
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
WO2006121860A2 (en) 2005-05-06 2006-11-16 Bayer Pharmaceuticals Corporation Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use
PT1891105E (pt) 2005-06-13 2012-06-27 Imp Innovations Ltd Análogos de oxintomodulina e seus efeitos sobre o comportamento da alimentação
WO2007024899A2 (en) 2005-08-23 2007-03-01 The General Hospital Corporation Use of glp-1, glp-1 derivatives or glp-1 fragments for skin regeneration, stimulation of hair growth, or treatment of diabetes
EP1959986B1 (en) * 2005-11-07 2014-07-23 Indiana University Research and Technology Corporation Glucagon analogs exhibiting physiological solubility and stability
WO2007081824A2 (en) 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
WO2007095737A1 (en) 2006-02-21 2007-08-30 Waratah Pharmaceuticals Inc. Combination therapy for the treatment of diabetes comprising an exendin agonist and a gastrin compound
EP2471811B1 (en) 2006-02-22 2015-09-16 Merck Sharp & Dohme Corp. Oxyntomodulin derivatives
ES2673822T3 (es) 2006-07-18 2018-06-25 Sanofi Anticuerpo antagonista contra EphA2 para el tratamiento de cáncer
ITMI20061607A1 (it) 2006-08-09 2008-02-10 Maria Vincenza Carriero Peptidi con attivita farmacologica
EP2074140B8 (en) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
NZ597554A (en) 2006-11-08 2014-04-30 Zealand Pharma As Selective glucagon-like-peptide-2 (glp-2) analogues
WO2008071010A1 (en) 2006-12-12 2008-06-19 Waratah Pharmaceuticals Inc. Combination treatments with selected growth/hormone regulatory factors for diabetes and related diseases
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
MX2009006564A (es) * 2007-01-05 2009-06-26 Univ Indiana Res & Tech Corp Analogos de glucagon que muestran solubilidad potenciada en amortiguadores a ph fisiologico.
JP6017754B2 (ja) 2007-02-15 2016-11-02 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ グルカゴン／ｇｌｐ−１受容体コアゴニスト
FR2917552B1 (fr) 2007-06-15 2009-08-28 Sagem Defense Securite Procede de regulation de la gigue de transmission au sein d'un terminal de reception
EP2158214B1 (en) 2007-06-15 2011-08-17 Zealand Pharma A/S Glucagon analogues
EP2025684A1 (en) 2007-08-15 2009-02-18 Zealand Pharma A/S Glucagon analogues
NZ603812A (en) 2007-11-20 2014-06-27 Ambrx Inc Modified insulin polypeptides and their uses
GB2455553B (en) 2007-12-14 2012-10-24 Nuaire Ltd Motor mounting assembly for an axial fan
NZ586589A (en) 2008-01-09 2012-04-27 Sanofi Aventis Deutschland Novel insulin analogues having an extremely delayed time-action profile
DE102008003566A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
KR20100111682A (ko) 2008-01-09 2010-10-15 사노피-아벤티스 도이칠란트 게엠베하 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
CN102065885A (zh) 2008-04-22 2011-05-18 卡斯西部储备大学 同种型特异性的胰岛素类似物
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
KR20110039230A (ko) * 2008-06-17 2011-04-15 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 생리학적 ｐＨ 완충액에서 강화된 용해도 및 안정성을 나타내는 글루카곤 유사체
CN103641907A (zh) 2008-06-17 2014-03-19 印第安纳大学研究及科技有限公司 胰高血糖素/glp-1受体共激动剂
CN104945500B (zh) 2008-06-17 2019-07-09 印第安纳大学研究及科技有限公司 基于gip的混合激动剂用于治疗代谢紊乱和肥胖症
PL219335B1 (pl) 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
KR20110061552A (ko) 2008-07-31 2011-06-09 케이스 웨스턴 리저브 유니버시티 할로겐 안정화된 인슐린
AU2009280017B2 (en) 2008-08-07 2013-01-10 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide
ES2561208T3 (es) 2008-09-12 2016-02-25 Novo Nordisk A/S Método de acilación de un péptido o una proteína
DK2370461T3 (da) 2008-12-15 2013-12-16 Zealand Pharma As Glucagonanaloger
WO2010070255A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
KR20150116912A (ko) 2008-12-15 2015-10-16 질랜드 파마 에이/에스 글루카곤 유사체
EA020520B1 (ru) 2008-12-15 2014-11-28 Зилэнд Фарма А/С Аналоги глюкагона
WO2010080609A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
EP2376520B1 (en) 2008-12-19 2014-02-12 Indiana University Research&Technology Corporation Insulin analogs
WO2010096052A1 (en) 2009-02-19 2010-08-26 Merck Sharp & Dohme Corp. Oxyntomodulin analogs
US20100240883A1 (en) 2009-03-18 2010-09-23 Nian Wu Lipid-drug conjugates for drug delivery
CN101519446A (zh) 2009-03-31 2009-09-02 上海一就生物医药有限公司 一种重组人胰岛素及其类似物的制备方法
CN102459338A (zh) 2009-05-08 2012-05-16 霍夫曼-拉罗奇有限公司 人源化抗egfl7抗体及其使用方法
CA2765026A1 (en) 2009-06-16 2010-12-23 Indiana University Research And Technology Corporation Gip receptor-active glucagon compounds
EA022816B1 (ru) 2009-07-13 2016-03-31 Зилэнд Фарма А/С Ацилированные аналоги глюкагона
RU2559540C2 (ru) 2009-12-16 2015-08-10 Ново Нордиск А/С Дважды ацилированные производные glp-1
WO2011084808A2 (en) 2009-12-21 2011-07-14 Amunix Operating Inc. Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases
CN102892425A (zh) 2010-01-20 2013-01-23 西兰制药公司 心脏病症的治疗
EP2528618A4 (en) 2010-01-27 2015-05-27 Univ Indiana Res & Tech Corp GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS
AR080592A1 (es) 2010-03-26 2012-04-18 Lilly Co Eli Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso
EP2552950A1 (en) * 2010-03-26 2013-02-06 Novo Nordisk A/S Novel glucagon analogues
US20130053310A1 (en) * 2010-03-26 2013-02-28 Novo Nordisk A/S Novel glucagon analogues
EP2565205B1 (en) 2010-04-27 2015-07-01 Betta Pharmaceuticals Co., Ltd. Glucagon-like peptide-1 analogue and use thereof
CA2797133C (en) 2010-04-27 2019-08-06 Zealand Pharma A/S Peptide conjugates of glp-1 receptor agonists and gastrin and their use
UY33462A (es) 2010-06-23 2012-01-31 Zealand Pharma As Analogos de glucagon
EP2585482B1 (en) 2010-06-24 2019-03-27 Zealand Pharma A/S Glucagon analogues
WO2011163473A1 (en) * 2010-06-25 2011-12-29 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility and stability in physiological ph buffers
CN103209711B (zh) 2010-11-09 2016-04-13 诺沃—诺迪斯克有限公司 双-酰化的glp-1衍生物
PH12013501495A1 (en) 2011-01-20 2013-09-16 Zealand Pharma As Combination of acylated glucagon analogues with insulin analogues
AU2012234276A1 (en) 2011-03-28 2013-08-29 Novo Nordisk A/S Novel glucagon analogues
JP6022538B2 (ja) 2011-04-12 2016-11-09 ノヴォ ノルディスク アー／エス 二重アシル化されたｇｌｐ−１誘導体
WO2012150503A2 (en) 2011-05-03 2012-11-08 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
EP2707713A2 (en) 2011-05-10 2014-03-19 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
EP2718317B1 (en) 2011-06-10 2018-11-14 Beijing Hanmi Pharmaceutical Co., Ltd. Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
TWI596110B (zh) * 2011-09-23 2017-08-21 諾佛 儂迪克股份有限公司 新穎升糖素類似物
JP2015502380A (ja) 2011-12-23 2015-01-22 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
WO2013098408A1 (en) * 2011-12-30 2013-07-04 Zealand Pharma A/S Glucagon and cck receptor agonist peptide conjugates
TWI689515B (zh) 2012-05-03 2020-04-01 丹麥商西蘭製藥公司 Ｇｉｐ-ｇｌｐ-１雙重促效劑化合物及方法
KR20150006052A (ko) 2012-05-03 2015-01-15 질랜드 파마 에이/에스 글루카곤-유사 펩타이드-2 (ｇｌｐ-2) 유사체
AU2013295035B2 (en) * 2012-07-23 2017-08-03 Zealand Pharma A/S Glucagon analogues
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
KR102394515B1 (ko) 2013-10-17 2022-05-09 질랜드 파마 에이/에스 아실화된 글루카곤 유사체
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
CA2929459C (en) 2013-11-06 2022-05-03 Zealand Pharma A/S Gip-glp-1 dual agonist compounds and methods
US9963496B2 (en) 2014-02-18 2018-05-08 Novo Nordisk A/S Stable glucagon analogues and use for treatment of hypoglycaemia
PL3283507T3 (pl) 2015-04-16 2020-05-18 Zealand Pharma A/S Acylowany analog glukagonu

Also Published As

Publication number Publication date
CA2878991C (en) 2021-12-07
SG11201500375PA (en) 2015-02-27
JP6534927B2 (ja) 2019-06-26
JP2015524419A (ja) 2015-08-24
UA117103C2 (uk) 2018-06-25
AU2013295035A1 (en) 2015-02-12
EP2875043B1 (en) 2016-12-21
MY170671A (en) 2019-08-26
TW201404785A (zh) 2014-02-01
MX356957B (es) 2018-06-20
TWI642682B (zh) 2018-12-01
JP2019187419A (ja) 2019-10-31
US11795204B2 (en) 2023-10-24
CN109456400A (zh) 2019-03-12
JP2022023029A (ja) 2022-02-07
US20200207825A1 (en) 2020-07-02
EA201590058A1 (ru) 2015-09-30
US10442847B2 (en) 2019-10-15
FIC20240034I1 (fi) 2024-10-23
AR091866A1 (es) 2015-03-04
EP2875043A1 (en) 2015-05-27
BR112015001451B1 (pt) 2022-03-29
CA2878991A1 (en) 2014-01-30
FR24C1043I1 (fr) 2024-12-06
AU2013295035B2 (en) 2017-08-03
PL2875043T3 (pl) 2017-06-30
US20240067696A1 (en) 2024-02-29
MX2015000990A (es) 2015-03-20
IN2015DN00544A (da) 2015-06-26
EA033399B1 (ru) 2019-10-31
PH12015500115A1 (en) 2015-03-30
ES2620111T3 (es) 2017-06-27
KR102129235B1 (ko) 2020-07-06
CN104662038B (zh) 2018-11-06
NL301294I2 (nl) 2024-11-18
NZ704043A (en) 2017-07-28
HK1210787A1 (en) 2016-05-06
KR20150032912A (ko) 2015-03-30
PH12015500115B1 (en) 2015-03-30
ZA201702364B (en) 2019-05-29
WO2014016300A1 (en) 2014-01-30
IL236554B (en) 2020-04-30
BR112015001451A2 (pt) 2017-07-04
US20150210744A1 (en) 2015-07-30
CN104662038A (zh) 2015-05-27
IL236554A0 (en) 2015-02-26

Similar Documents

Publication Publication Date Title
US20240067696A1 (en) Glucagon analogues
US11008375B2 (en) GIP-GLP-1 dual agonist compounds and methods
AU2011206979B2 (en) Treatment of cardiac conditions
EP2718316B1 (en) Polypeptides
TWI694082B (zh) 選擇性ｐｙｙ化合物及其用途
RU2559320C2 (ru) Новые аналоги глюкагона
US8486890B2 (en) Amylin derivatives
US20130053310A1 (en) Novel glucagon analogues
EP3423481B1 (en) Glp-1 derivatives and uses thereof
TW201733613A (zh) 用於治療肥胖之升糖素及glp-1共促效劑
CN104395338A (zh) 人胰岛淀粉样多肽类似物
US20210094999A1 (en) Novel Acylated Insulin Analogues and Uses Thereof
CN102076353A (zh) 胰岛淀粉样多肽和鲑鱼降钙素的衍生杂合肽
KR20200080331A (ko) 글루카곤 유사체
WO2024245233A1 (zh) 一种口服递送的多肽衍生物