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DK2443089T3 - Deutereret isoindolin-1,3-dion-derivater som pde4- og tnf-alfa-inhibitorer - Google Patents

Deutereret isoindolin-1,3-dion-derivater som pde4- og tnf-alfa-inhibitorer

Info

Publication number
DK2443089T3
DK2443089T3 DK10727607.3T DK10727607T DK2443089T3 DK 2443089 T3 DK2443089 T3 DK 2443089T3 DK 10727607 T DK10727607 T DK 10727607T DK 2443089 T3 DK2443089 T3 DK 2443089T3
Authority
DK
Denmark
Prior art keywords
isoindolin
pde4
deuterated
tnf
dion derivatives
Prior art date
Application number
DK10727607.3T
Other languages
English (en)
Inventor
Julie F Liu
Original Assignee
Concert Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2443089T3 publication Critical patent/DK2443089T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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DK10727607.3T 2009-06-18 2010-06-15 Deutereret isoindolin-1,3-dion-derivater som pde4- og tnf-alfa-inhibitorer DK2443089T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26895309P 2009-06-18 2009-06-18
PCT/US2010/038577 WO2010147922A1 (en) 2009-06-18 2010-06-15 Deuterated i soindoline- i, 3-dione derivatives as pde4 and tnf-alpha inhibitors

Publications (1)

Publication Number Publication Date
DK2443089T3 true DK2443089T3 (da) 2014-06-16

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DK10727607.3T DK2443089T3 (da) 2009-06-18 2010-06-15 Deutereret isoindolin-1,3-dion-derivater som pde4- og tnf-alfa-inhibitorer

Country Status (18)

Country Link
US (5) US8124646B2 (da)
EP (3) EP3090999A1 (da)
JP (2) JP5852565B2 (da)
AU (1) AU2010260249B2 (da)
BR (1) BRPI1012313B1 (da)
CA (1) CA2765015C (da)
DK (1) DK2443089T3 (da)
EA (1) EA021019B1 (da)
ES (2) ES2469849T3 (da)
HR (1) HRP20140520T1 (da)
ME (1) ME01883B (da)
MX (1) MX2011013880A (da)
PL (1) PL2443089T3 (da)
PT (1) PT2443089E (da)
RS (1) RS53357B (da)
SI (1) SI2443089T1 (da)
SM (1) SMT201400101B (da)
WO (1) WO2010147922A1 (da)

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AU2015341301B2 (en) * 2014-10-30 2019-05-16 Kangpu Biopharmaceuticals, Ltd. Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof
CN104447445B (zh) * 2014-12-05 2016-07-06 新发药业有限公司 一种合成阿普斯特中间体的制备方法
CN104458961A (zh) * 2014-12-11 2015-03-25 南京艾德凯腾生物医药有限责任公司 阿普斯特有关物质检测方法
WO2016174685A1 (en) * 2015-04-27 2016-11-03 Mylan Laboratories Limited Process for the enantiomeric resolution of apremilast intermediates
CN105175283A (zh) * 2015-09-23 2015-12-23 蚌埠中实化学技术有限公司 一种3-乙氧基-4-甲氧基苯腈的制备方法
WO2017059040A1 (en) * 2015-09-29 2017-04-06 Pliva Hrvatska D.O.O. Processes for the preparation of apremilast and intermediates thereof
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CN105218428A (zh) * 2015-10-20 2016-01-06 南京美嘉宁逸医药研究开发有限公司 一种高手性纯度的阿普斯特的制备方法
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
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CN111808098B (zh) * 2020-06-29 2021-08-24 Vtv治疗有限责任公司 喹啉衍生物，其药学上可接受的盐及其使用方法

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US20150105438A1 (en) 2015-04-16
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