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DK2267150T3 - Oxiderbar forbindelse som en indre reference i kontrolopløsninger til biosensorer - Google Patents

Oxiderbar forbindelse som en indre reference i kontrolopløsninger til biosensorer Download PDF

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Publication number
DK2267150T3
DK2267150T3 DK10181914.2T DK10181914T DK2267150T3 DK 2267150 T3 DK2267150 T3 DK 2267150T3 DK 10181914 T DK10181914 T DK 10181914T DK 2267150 T3 DK2267150 T3 DK 2267150T3
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Denmark
Prior art keywords
internal reference
glucose
potential
compound
analyte
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DK10181914.2T
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English (en)
Inventor
Huan-Ping Wu
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Bayer Healthcare Llc
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Publication of DK2267150T3 publication Critical patent/DK2267150T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104998—Glucose, ketone, nitrate standard or control

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Ecology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (11)

1. Fremgangsmåde til at skelne en kontrolopløsning fra en biologisk prøve under anvendelse af en elektrokemisk sensor, hvor den elektrokemiske sensor måler mængden af en analyt, hvilken fremgangsmåde omfatter følgende trin: tilvejebringelse af en kontrolopløsning, der inkluderer en indre referenceforbindelse, en buffer og en forudbestemt mængde analyt, hvilken indre referenceforbindelse har et højere potentiale end det potentiale, der er nødvendigt for at måle oxidationen af analytten, og hvilken indre referenceforbindelse er forskellig fra bufferen; tilvejebringelse af en elektrokemisk sensor (10), der har en arbejdselektrode (16), en modelektrode (18) og mindst ét reagens (22); indførelse af kontrolopløsningen i den elektrokemiske sensor; påføring af et første potentiale på den elektrokemiske sensor, der er tilstrækkeligt til at oxidere analytten og utilstrækkeligt til at oxidere den indre referenceforbindelse, og måling af den resulterende første elektriske strøm; efter påføring af det første potentiale påføring af et andet potentiale på den elektrokemiske sensor, hvilket andet potentiale er tilstrækkeligt til at oxidere analytten og den indre referenceforbindelse, og måling af den resulterende anden elektriske strøm; som reaktion på, at forholdet mellem den anden elektriske strøm og den første elektriske strøm er tilstrækkeligt større end 1, bestemmelse af, at en kontrolopløsning er til stede, og som reaktion på, at forholdet mellem den anden elektriske strøm og den første elektriske strøm er ca. 1, bestemmelse af, at en biologisk prøve er til stede.
2. Fremgangsmåde ifølge krav 1, hvor analytten er glucose.
3. Fremgangsmåde ifølge krav 1, hvor prøven er en biologisk prøve.
4. Fremgangsmåde ifølge krav 3, hvor den biologiske prøve er fuldblod.
5. Fremgangsmåde ifølge krav 1, hvor den indre referenceforbindelse er en oxiderbar organometallisk forbindelse, en koordinationsforbindelse eller en organisk aminforbindelse.
6. Fremgangsmåde ifølge krav 5, hvor den indre referenceforbindelse er en organisk aminforbindelse.
7. Fremgangsmåde ifølge krav 6, hvor den organiske aminforbindelse er 3-(N-morpholino)-propansulfonsyre, N-(2-hydroxyethyl)-piperazin-N1-(2-ethansulfonsyre), 2-[(2-hydroxy- 1,1-bis(hydroxymethyl)-ethylamino]-ethansulfonsyre, 2- morphholinoethansulfonsyre, bis(2-hydroxyethyl)-amino- tris(hydroxymethyl)-methan-[bis-tris], 4-aminobenzonitril, 4-aminobenzoesyre eller 4-iodanilin.
8. Fremgangsmåde ifølge krav 5, hvor den indre referenceforbindelse er en oxiderbar organometallisk forbindelse.
9. Fremgangsmåde ifølge krav 8, hvor den oxiderbare organometalliske forbindelse er ferrocen eller et ferrocenderivat.
10. Fremgangsmåde ifølge krav 5, hvor den indre referenceforbindelse er en koordinationsforbindelse.
11. Fremgangsmåde ifølge krav 10, hvor koordinationsforbindelsen er kaliumferrocyanid.
DK10181914.2T 2005-04-08 2006-04-07 Oxiderbar forbindelse som en indre reference i kontrolopløsninger til biosensorer DK2267150T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66972905P 2005-04-08 2005-04-08
PCT/US2006/012940 WO2006110504A1 (en) 2005-04-08 2006-04-07 Oxidizable species as an internal reference in control solutions for biosensors
EP06749468.2A EP1869203B1 (en) 2005-04-08 2006-04-07 Series of control solutions for biosensors comprising an oxidizable species as an internal reference
EP10181914.2A EP2267150B1 (en) 2005-04-08 2006-04-07 Oxidizable species as an internal reference in control solutions for biosensors

Publications (1)

Publication Number Publication Date
DK2267150T3 true DK2267150T3 (da) 2015-12-21

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US (4) US8002965B2 (da)
EP (2) EP1869203B1 (da)
JP (1) JP5009897B2 (da)
CN (3) CN101180403B (da)
BR (1) BRPI0609633B1 (da)
CA (1) CA2603542C (da)
DK (1) DK2267150T3 (da)
ES (1) ES2552083T3 (da)
HK (1) HK1205258A1 (da)
MX (1) MX2007012373A (da)
NO (1) NO20075709L (da)
PL (1) PL2267150T3 (da)
RU (1) RU2453843C2 (da)
TW (1) TW200641352A (da)
WO (1) WO2006110504A1 (da)

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BRPI0609633A2 (pt) 2010-04-20
US20160091454A1 (en) 2016-03-31
US9766198B2 (en) 2017-09-19
NO20075709L (no) 2007-11-08
RU2007141387A (ru) 2009-05-20
CN102778487A (zh) 2012-11-14
ES2552083T3 (es) 2015-11-25
CN104407124A (zh) 2015-03-11
MX2007012373A (es) 2007-12-10
JP2008536125A (ja) 2008-09-04
JP5009897B2 (ja) 2012-08-22
HK1173214A1 (en) 2013-05-10
CA2603542C (en) 2014-01-14
BRPI0609633B1 (pt) 2016-01-26
US20140147872A1 (en) 2014-05-29
EP1869203B1 (en) 2020-08-12
US8702926B2 (en) 2014-04-22
TW200641352A (en) 2006-12-01
RU2453843C2 (ru) 2012-06-20
EP2267150A1 (en) 2010-12-29
EP2267150B1 (en) 2015-09-30
US8002965B2 (en) 2011-08-23
CN102778487B (zh) 2015-02-18
HK1205258A1 (en) 2015-12-11
US20090014339A1 (en) 2009-01-15
WO2006110504A1 (en) 2006-10-19
CA2603542A1 (en) 2006-10-19
PL2267150T3 (pl) 2016-03-31
US9244078B2 (en) 2016-01-26
CN101180403B (zh) 2014-11-12
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CN101180403A (zh) 2008-05-14

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