[go: up one dir, main page]

DK2180787T3 - Nitrooliesyremodulering af type ii-diabetes - Google Patents

Nitrooliesyremodulering af type ii-diabetes

Info

Publication number
DK2180787T3
DK2180787T3 DK08780348.2T DK08780348T DK2180787T3 DK 2180787 T3 DK2180787 T3 DK 2180787T3 DK 08780348 T DK08780348 T DK 08780348T DK 2180787 T3 DK2180787 T3 DK 2180787T3
Authority
DK
Denmark
Prior art keywords
nitroolic
diabetes
type
acid modulation
modulation
Prior art date
Application number
DK08780348.2T
Other languages
English (en)
Inventor
Bruce A Freeman
Original Assignee
Univ Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh
Application granted granted Critical
Publication of DK2180787T3 publication Critical patent/DK2180787T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK08780348.2T 2007-08-01 2008-08-01 Nitrooliesyremodulering af type ii-diabetes DK2180787T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95336007P 2007-08-01 2007-08-01
PCT/US2008/009274 WO2009017802A1 (en) 2007-08-01 2008-08-01 Nitro-fattyacid modulation of type ii diabetes

Publications (1)

Publication Number Publication Date
DK2180787T3 true DK2180787T3 (da) 2014-02-03

Family

ID=40304683

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08780348.2T DK2180787T3 (da) 2007-08-01 2008-08-01 Nitrooliesyremodulering af type ii-diabetes

Country Status (4)

Country Link
US (8) US8324277B2 (da)
EP (2) EP2679224A1 (da)
DK (1) DK2180787T3 (da)
WO (1) WO2009017802A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3410371B2 (ja) * 1998-08-18 2003-05-26 リンテック株式会社 ウエハ裏面研削時の表面保護シートおよびその利用方法
WO2005110396A2 (en) 2004-04-28 2005-11-24 Uab Research Foundation Nitrated lipids and methods of making and using thereof
WO2009017802A1 (en) * 2007-08-01 2009-02-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Nitro-fattyacid modulation of type ii diabetes
WO2009134383A2 (en) * 2008-05-01 2009-11-05 Complexa Inc. Vinyl substituted fatty acids
US8686038B2 (en) 2008-06-19 2014-04-01 The Univsersity of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
US20140024713A1 (en) 2008-06-19 2014-01-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
CN102307464A (zh) * 2008-12-31 2012-01-04 尼特罗米加公司 含有硝基脂肪酸的营养制品
WO2011014261A1 (en) 2009-07-31 2011-02-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fatty acids as anti-inflammatory agents
US8686167B2 (en) 2009-10-02 2014-04-01 Complexa, Inc. Heteroatom containing substituted fatty acids
WO2011089265A1 (en) 2010-01-25 2011-07-28 Bridge Bioresearch Plc Use of fatty acid compounds for lowering blood glucose levels
JP2013526865A (ja) 2010-05-13 2013-06-27 ニトロメガ コーポレーション ニトロ脂肪酸、神経保護および/または認識減退の抑制
JP2013534930A (ja) * 2010-06-28 2013-09-09 コンプレクサ,インコーポレイテッド 糖尿病を治療するための多成分調剤
WO2013028501A1 (en) 2011-08-19 2013-02-28 The University Of Utah Research Foundation Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
EP3303339B1 (en) 2015-07-07 2021-01-13 H. Lundbeck A/S Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
CN113440506A (zh) 2015-10-02 2021-09-28 康普莱克夏公司 使用治疗有效量的活化脂肪酸预防、治疗和逆转疾病
CN109071405A (zh) 2016-03-04 2018-12-21 高等教育联邦系统-匹兹堡大学 使用治疗有效量的二羧酸化合物预防、治疗和逆转疾病
JP2019529501A (ja) 2016-10-05 2019-10-17 ユニバーシティ オブ ピッツバーグ−オブ ザ コモンウェルス システム オブ ハイヤー エデュケーションUniversity Of Pittsburgh Of The Commonwealth System Of Higher Education 可逆的に保護された、チオレート化求電子性脂肪酸としてのプロドラッグ
JP2019529517A (ja) * 2016-10-05 2019-10-17 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション ニトロソ化およびアルキル化反応を媒介するニトロアルケンの新規可逆的窒素酸化物誘導体
KR20210014662A (ko) 2018-05-25 2021-02-09 이마라 인크. 6-[(3S,4S)-4-메틸-1-(피리미딘-2-일메틸)피롤리딘-3-일]-3-테트라히드로피란-4-일-7H-이미다조[1,5-a]피라진-8-온의 일수화물 및 결정형
EP3843737A4 (en) 2018-08-31 2022-06-01 Imara Inc. PDE9 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB587992A (en) 1944-12-11 1947-05-12 Charles William Scaife Improvements in and relating to the production of organic nitrogen compounds
US3578687A (en) 1968-01-30 1971-05-11 Texaco Inc Process for producing 4-nitroalkanoic acids
US3819561A (en) 1970-10-23 1974-06-25 Aerojet General Co Wetting agents for non-aqueous dispersions
JPS5313608B2 (da) 1972-06-16 1978-05-11
JPS5318013B2 (da) 1973-03-19 1978-06-13
US4599430A (en) 1981-12-21 1986-07-08 The Standard Oil Company Nitrogenation of hydrocarbons, including the production of maleimide
JPS62132804A (ja) 1985-12-05 1987-06-16 Aguro Kanesho Kk 植物生長調節剤
US5412137A (en) 1993-06-07 1995-05-02 Sandoz Ltd. Process for preparing phosphinyloxy propanaminium inner salt derivatives
CA2202503C (en) 1994-10-13 2008-07-15 Antonio Ferrante Modified polyunsaturated fatty acids
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
GB9618420D0 (en) 1996-09-04 1996-10-16 Scotia Holdings Plc Fatty acid treatment
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
WO1999022719A1 (fr) 1997-10-30 1999-05-14 Morishita Jintan Co., Ltd. Preparation de capsule contenant un acide gras insature ou un derive de celui-ci, et procede de fabrication
WO2000009075A2 (en) 1998-08-14 2000-02-24 Galenica Pharmaceuticals, Inc. Chemically modified saponins and the use thereof as adjuvants
MXPA01009893A (es) 1999-04-01 2003-07-28 Esperion Therapeutics Inc Compuestos con eter, composiciones y usos de estos.
WO2001006983A2 (en) 1999-07-22 2001-02-01 Incell Corporation, Llc Fatty acids to minimize cancer therapy side effects
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
AUPQ291499A0 (en) 1999-09-17 1999-10-07 Women's And Children's Hospital Adelaide Novel nitro and sulphur containing compounds
US6346231B1 (en) 1999-10-06 2002-02-12 Joar Opheim Flavored gelatin capsule and method of manufacture
US20010037598A1 (en) 1999-12-14 2001-11-08 Suppes Galen J. Process for producing cetane improvers from triglycerides
DE60144401D1 (de) 2000-02-16 2011-05-19 Brigham & Womens Hospital Aspirin-ausgelöste Lipidmediatoren
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
AR034120A1 (es) 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
AR032318A1 (es) 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
CN1232480C (zh) 2000-06-28 2005-12-21 萨宝集团公司 制备硝基烯烃的方法
AR031129A1 (es) 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
EE200300510A (et) 2001-04-18 2004-02-16 Prometic Biosciences Inc. Keskmise pikkusega ahelaga rasvhapped, glütseriidid ja nende analoogid kui neutrofiilide ellujäämis- ja aktiveerimisfaktorid
US7105556B2 (en) 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
EP1407767A4 (en) 2001-06-18 2007-01-24 Yamada Sachiko AGONIST MEDICINAL PREPARATIONS PPAR $ G (G)
JP2005501096A (ja) 2001-08-17 2005-01-13 ユニヴァーシティ オブ ピッツバーグ 肥満、代謝症候群、糖尿病、血管障害及び腎臓疾患を治療又は予防するエストラジオールメタボライトの投与
GB0123961D0 (en) 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates
WO2003039533A1 (en) 2001-11-06 2003-05-15 The Brigham And Women's Hospital, Inc. Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
MXPA05002883A (es) * 2002-08-20 2005-10-05 Protemix Corp Ltd Formas de dosis y terapias relacionadas.
WO2004028469A2 (en) 2002-09-27 2004-04-08 Martek Biosciences Corporation Docohexaenoic acid for improved glycemic control
US7166575B2 (en) 2002-12-17 2007-01-23 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
WO2005016864A1 (en) 2003-07-29 2005-02-24 The Arizona Disease Control Research Commission Conjugated nitro alkene anticancer agents based on isoprenoid metabolism
US20050136103A1 (en) 2003-09-17 2005-06-23 Ben-Sasson Shmuel A. Compositions capable of facilitating penetration across a biological barrier
BRPI0507236A (pt) 2004-01-30 2007-06-26 Peplin Biolipids Pty Ltd método para o tratamento ou profilaxia de uma condição, e, composto
MXPA06011871A (es) 2004-04-15 2007-10-08 Chiasma Inc Composiciones capaces de facilitar la penetracion a traves de una barrera biologica.
WO2005110396A2 (en) 2004-04-28 2005-11-24 Uab Research Foundation Nitrated lipids and methods of making and using thereof
CN101027318B (zh) 2004-07-19 2016-05-25 比奥孔有限公司 胰岛素-低聚物共轭物,制剂及其用途
WO2006011397A1 (ja) 2004-07-27 2006-02-02 Kowa Company., Ltd. 糖尿病の予防または治療のための薬剤
EA010802B1 (ru) 2004-11-19 2008-12-30 Мартек Байосайенсиз Корпорейшн Оксилипины из полиненасыщенных жирных кислот с длинной цепью и способы их получения и применения
US20070032420A1 (en) * 2005-02-09 2007-02-08 Entelos, Inc. Treating diabetes with glucagon-like peptide-1 secretagogues
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
WO2008008767A2 (en) 2006-07-14 2008-01-17 Cedars-Sinai Medical Center Methods of using ppar-gamma agonists and caspase-dependent chemotherapeutic agents for the treatment of cancer
RU2009101324A (ru) 2006-07-19 2010-07-27 Ризолвикс Фармасьютикалз, Инк. (Us) Композиции и способы лечения воспаления слизистой оболочки
CN101663031A (zh) 2007-02-20 2010-03-03 马泰克生物科学公司 来自长链多不饱和脂肪酸的氧脂素及其制备方法和使用方法
WO2009017802A1 (en) 2007-08-01 2009-02-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Nitro-fattyacid modulation of type ii diabetes
US20090137527A1 (en) 2007-09-14 2009-05-28 Resolvyx Pharmaceuticals, Inc. Compositions and methods for modulating immune function
US20110092594A1 (en) 2008-04-18 2011-04-21 Tianxin Yang Use of nitrated lipids for treatment of lipid disorders and obesity, and lipid- and obesity-related conditions
WO2009134383A2 (en) 2008-05-01 2009-11-05 Complexa Inc. Vinyl substituted fatty acids
WO2009149496A1 (en) 2008-06-10 2009-12-17 Central Northern Adelaide Health Service Treatment of diabetes and complications thereof and related disorders
US20140024713A1 (en) 2008-06-19 2014-01-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
US8686038B2 (en) 2008-06-19 2014-04-01 The Univsersity of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
CA2984026C (en) 2008-10-09 2020-02-11 Arbutus Biopharma Corporation Improved amino lipids and methods for the delivery of nucleic acids
US8937194B2 (en) 2008-12-31 2015-01-20 Nitromega Corp. Topical compositions containing nitro fatty acids
CN102307464A (zh) 2008-12-31 2012-01-04 尼特罗米加公司 含有硝基脂肪酸的营养制品
US20100286257A1 (en) 2009-05-08 2010-11-11 Perricone Nicholas V Methods Of Use Of Nitroalkane Compositions In Dermatologic Applications To Prevent or Treat Skin Aging
US20100286271A1 (en) 2009-05-08 2010-11-11 Perricone Nicholas V Nitro-alkyl Compound Compositions
US20100286272A1 (en) 2009-05-08 2010-11-11 Perricone Nicholas V Methods Of Use Of Nitroalkene Compositions In Dermatologic Applications
KR20120046754A (ko) 2009-07-29 2012-05-10 페노미넘 디스커버리스 인코포레이티드 히드록시 지방산 화합물 및 질병 치료 및 진단을 위한 그의 용도
WO2011014261A1 (en) 2009-07-31 2011-02-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fatty acids as anti-inflammatory agents
US8686167B2 (en) 2009-10-02 2014-04-01 Complexa, Inc. Heteroatom containing substituted fatty acids
WO2011098746A1 (en) 2010-02-09 2011-08-18 Pulmagen Therapeutics (Inflammation) Limited Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone
JP2013526865A (ja) 2010-05-13 2013-06-27 ニトロメガ コーポレーション ニトロ脂肪酸、神経保護および/または認識減退の抑制
JP2013534930A (ja) 2010-06-28 2013-09-09 コンプレクサ,インコーポレイテッド 糖尿病を治療するための多成分調剤
WO2013028501A1 (en) 2011-08-19 2013-02-28 The University Of Utah Research Foundation Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
US9271952B2 (en) 2011-10-11 2016-03-01 Complexa, Inc. Compositions and methods for treating nephropathy
JP2015508065A (ja) 2012-02-03 2015-03-16 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 抗炎症薬としての脂肪酸
US8956541B2 (en) 2012-06-18 2015-02-17 Eco Verde Technologies, Inc. Composition and method for retention of solvated compounds and ions
WO2014204872A2 (en) 2013-06-14 2014-12-24 Complexa, Inc. Composition and method for inhibition of pkng from mycobacterium tuberculosis

Also Published As

Publication number Publication date
US20130059912A1 (en) 2013-03-07
EP2180787A4 (en) 2010-09-01
US20210220315A1 (en) 2021-07-22
US20140309303A1 (en) 2014-10-16
US20160045467A1 (en) 2016-02-18
US9700534B2 (en) 2017-07-11
US20180250257A9 (en) 2018-09-06
US20190274987A1 (en) 2019-09-12
US20100216884A1 (en) 2010-08-26
EP2180787B1 (en) 2013-10-30
US9186408B2 (en) 2015-11-17
US10869850B2 (en) 2020-12-22
WO2009017802A1 (en) 2009-02-05
WO2009017802A9 (en) 2014-12-04
US10258589B2 (en) 2019-04-16
EP2679224A1 (en) 2014-01-01
US8324277B2 (en) 2012-12-04
US10576051B2 (en) 2020-03-03
US8735449B2 (en) 2014-05-27
US20180125806A1 (en) 2018-05-10
US20200230095A1 (en) 2020-07-23
EP2180787A1 (en) 2010-05-05

Similar Documents

Publication Publication Date Title
DK2180787T3 (da) Nitrooliesyremodulering af type ii-diabetes
DK3225251T3 (da) Modulering af pro-neurotrofinaktivitet
DK2274417T3 (da) Cellulær produktion af glucarsyre
DK2219469T3 (da) Modificering af enzymatisk disponerede proteiner
DK2111555T3 (da) Diagnosticering af præeklampsi
DK2304911T3 (da) Optisk signalmodulation
FI20085855L (fi) Aaltojohtoelementti
DK2317851T3 (da) Anvendelse af 5-fluorcytosin som fungicid
DE112007000789A5 (de) Verwendung von Bora-tetraazepentalenen
DK2358714T3 (da) Alkylcyclohexylethere af dihydrotetraazabenzoazulener
BRPI0810660A2 (pt) Derivados do ácido lipóico
DE602007011741D1 (de) Optisches modulationselement
EP2267093A4 (en) ADHESIVE COMPOSITION
DK3005986T3 (da) Infusion af lægemidler
DK2114147T3 (da) Reduktion af bivirkninger af tramadol
BRPI0912547A2 (pt) aba de fixação
DK2307441T3 (da) Fremgangsmåde til fremstilling af insulinforbindelser
DK2231640T3 (da) Beta-aminosyrederivater til behandling af diabetes
DK2245079T3 (da) Klæbestof
DK2181065T3 (da) Partialoxidation af carbonhydrider
DK2308860T3 (da) Immunosuppressor baseret på afbrydelse af tcr-nck-interaktion
BRPI0918146A2 (pt) corantes ácidos
DK2145547T3 (da) Forbedret stabilitet af aromatiske forbindelser
DK2097079T3 (da) Modulering af prostaglandin/cyclooxygenase-metabolske veje
DK2171083T3 (da) Biosensing af molekylær konformation