DK2094278T3 - Anvendelse af lipidindholdende partikler, omfattende quillaja saponins til behandling af cancer - Google Patents
Anvendelse af lipidindholdende partikler, omfattende quillaja saponins til behandling af cancer Download PDFInfo
- Publication number
- DK2094278T3 DK2094278T3 DK07835461.0T DK07835461T DK2094278T3 DK 2094278 T3 DK2094278 T3 DK 2094278T3 DK 07835461 T DK07835461 T DK 07835461T DK 2094278 T3 DK2094278 T3 DK 2094278T3
- Authority
- DK
- Denmark
- Prior art keywords
- kgi
- cells
- saponin
- cell
- cancer
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Oncology (AREA)
Claims (10)
1. Anvendelse af iscom matrixpartikler omfattende mindst et lipid valgt blandt cholesterol og phospholipid og mindst en saponin, hvor saponinen er en rå saponinfraktion fra Quillaja Saponaria Molina eller en delfraktion deraf, hvilke partikler ikke indeholder cancer antigener til fremstilling af et lægemiddel til behandling af cancer.
2. Anvendelse ifølge krav 1, hvor saponinen er valgt fra fraktion A, fraktion B, fraktion C, fraktioner QA 1-22 af Quillaja Saponaria Molina, Spicoside og Q VAC.
3. Anvendelse ifølge et hvilket som helst af kravene 1 og 2, hvor saponinfraktionen er hydrofektisk, såsom fraktioner, der ikke indeholder fedtsyrer, f.eks. Fraktion A, Quil 4-15, og det stimulerer og modulerer immunresponset, såsom cellemedieret immunitet.
4. Anvendelse ifølge et hvilket som helst af kravene 1 -3, hvor saponinfraktionen er hydrofob, såsom fraktioner, der indeholder fedtsyrer, f.eks. i saponins 4-position, såsom fraktion C og B i Quil A eller fraktioner fra regionen mellem fraktionerne A og B, fraktioner QA 15-21 af Quillaja Saponaria Molina og har en drabende virkning på cancerceller.
5. Anvendelse ifølge krav 4, hvor iscom matrixpartiklerne endvidere også omfatter hydrofile saponiner.
6. Anvendelse ifølge et hvilket som helst af kravene 1-5, hvor iscom matrixpartikler indeholder mindst to forskellige saponinfraktioner i en og samme lipidholdige partikel.
7. Anvendelse ifølge et hvilket som helst af kravene 1-6, hvor iscom matrixpartiklerne indeholder mindst to forskellige saponinfraktioner, hvorved en af de mindst to forskellige saponinfraktioner er kompleksbundet i en lipidholdig partikel, og den anden (de andre ) af de mindst to forskellige saponinfraktioner er komplekse bundet i en anden (anden) fysisk forskellig lipid indeholdende partikel (er).
8. Anvendelse ifølge et hvilket som helst af kravene 6 og 7, hvor de forskellige saponiner er hydrofile og hydrofobe saponiner.
9. Anvendelse ifølge et hvilket som helst af kravene 1 -8, hvor yderligere cancerbehandlingsforbindelser anvendes sammen med iscom matrixpartiklerne, f.eks. valgt blandt platin koordinationsforbindelser, taxanforbindelser, camptothecinforbindelser, antitumor-vinca-alkaloider, antitumor-nukleosidderivater, nitrogen-sennep- eller nitrosoureaalkyleringsmidler, antitumor-anthracyclinderivater, trastzumab og antitumor podophyllotoxinderivater, Quila A og subfragmenter deraf.
10. Kit af dele til anvendelse i en fremgangsmåde til behandling af cancer, omfattende mindst to dele, hvor en del omfatter iscom matrixpartikler omfattende mindst en saponinfraktion, hvor saponinen er en rå saponinfraktion fra Quillaja Saponaria Molina eller en delfraktion deraf som er hydrofob med en dræbende virkning på cancerceller; og den anden del omfatter lipidholdige partikler med mindst en saponinfraktion, der er hydrofil, stimulerer og modulerer immunresponsen, såsom celleformidlet immunitet, hvor kittet ikke indeholder cancer antigener.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86644506P | 2006-11-20 | 2006-11-20 | |
| PCT/SE2007/050878 WO2008063129A1 (en) | 2006-11-20 | 2007-11-20 | Use of lipid containing particles comprising quillaja saponins for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2094278T3 true DK2094278T3 (da) | 2017-07-24 |
Family
ID=39429971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07835461.0T DK2094278T3 (da) | 2006-11-20 | 2007-11-20 | Anvendelse af lipidindholdende partikler, omfattende quillaja saponins til behandling af cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9040081B2 (da) |
| EP (1) | EP2094278B1 (da) |
| JP (1) | JP5301455B2 (da) |
| CN (1) | CN101563090B (da) |
| AU (1) | AU2007322424B2 (da) |
| CA (1) | CA2669209C (da) |
| DK (1) | DK2094278T3 (da) |
| ES (1) | ES2630205T3 (da) |
| WO (1) | WO2008063129A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110256167A1 (en) | 2008-12-23 | 2011-10-20 | Carla Christina Schrier | Immunostimulating saponins for use in situ tumor-destruction therapy |
| JP2013035820A (ja) * | 2011-05-10 | 2013-02-21 | Maruzen Pharmaceut Co Ltd | Ｔｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物 |
| CN102210862B (zh) * | 2011-06-01 | 2013-06-12 | 中国人民解放军南京军区福州总医院 | 基于Livin的免疫刺激复合物及其制备方法和应用 |
| EP4176871A1 (en) * | 2011-10-03 | 2023-05-10 | Canqura Oncology Ab | Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds |
| US9907846B2 (en) | 2013-04-01 | 2018-03-06 | Mx Adjuvac Ab | Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions |
| JP6869177B2 (ja) * | 2014-05-23 | 2021-05-12 | フィブロ アニマル ヘルス コーポレーションＰｈｉｂｒｏ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｃｏｒｐｏｒａｔｉｏｎ | 組み合わせ、組成物及び動物に組み合わせ又は組成物を投与する方法 |
| US10422555B2 (en) * | 2017-07-19 | 2019-09-24 | Haier Us Appliance Solutions, Inc. | Refrigerator appliance with a caloric heat pump |
| FR3072880A1 (fr) * | 2017-10-30 | 2019-05-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Formulation liposomale et son utilisation en therapie anti-tumorale |
| WO2019105408A1 (en) * | 2017-11-29 | 2019-06-06 | Xiamen Ginposome Pharmaceutical Co., Ltd. | Novel liposomes with ginsenoside derivative as membrane material and preparations thereof |
| EP3669890A1 (en) * | 2018-12-18 | 2020-06-24 | Croda International PLC | Filamentous nanoparticles having vaccine adjuvant effect |
| CN113498350A (zh) * | 2018-12-21 | 2021-10-12 | 萨普雷米科技有限公司 | 皂苷缀合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| SE502569C2 (sv) * | 1991-05-31 | 1995-11-13 | British Tech Group | Användning av en immunologiskt inert matris av en sterol och saponiner som kan bilda sfäriska nanopartiklar med snäv storleksfördelning som läkemedelsbärare, partiklar, komposition samt kit |
| AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| GB9620795D0 (en) | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
| US6846489B1 (en) | 1995-04-25 | 2005-01-25 | Smithkline Beecham Biologicals S.A. | Vaccines containing a saponin and a sterol |
| AUPO732997A0 (en) | 1997-06-12 | 1997-07-03 | Csl Limited | Ganglioside immunostimulating complexes and uses thereof |
| GB9712347D0 (en) * | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| IL145982A0 (en) | 1999-04-19 | 2002-07-25 | Smithkline Beecham Biolog | Vaccines |
| SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| US20050175623A1 (en) * | 2004-02-10 | 2005-08-11 | Zheng-Pin Wang | Saponins as anticancer agent |
| NZ553244A (en) | 2004-07-18 | 2009-10-30 | Csl Ltd | Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses |
-
2007
- 2007-11-20 US US12/515,684 patent/US9040081B2/en active Active
- 2007-11-20 DK DK07835461.0T patent/DK2094278T3/da active
- 2007-11-20 CA CA2669209A patent/CA2669209C/en active Active
- 2007-11-20 EP EP07835461.0A patent/EP2094278B1/en not_active Not-in-force
- 2007-11-20 JP JP2009538372A patent/JP5301455B2/ja not_active Expired - Fee Related
- 2007-11-20 ES ES07835461.0T patent/ES2630205T3/es active Active
- 2007-11-20 AU AU2007322424A patent/AU2007322424B2/en not_active Ceased
- 2007-11-20 WO PCT/SE2007/050878 patent/WO2008063129A1/en active Application Filing
- 2007-11-20 CN CN2007800431072A patent/CN101563090B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5301455B2 (ja) | 2013-09-25 |
| CA2669209A1 (en) | 2008-05-29 |
| CN101563090B (zh) | 2013-01-02 |
| ES2630205T3 (es) | 2017-08-18 |
| AU2007322424A1 (en) | 2008-05-29 |
| AU2007322424B2 (en) | 2013-05-16 |
| US20100119591A1 (en) | 2010-05-13 |
| EP2094278B1 (en) | 2017-04-05 |
| US9040081B2 (en) | 2015-05-26 |
| CN101563090A (zh) | 2009-10-21 |
| EP2094278A1 (en) | 2009-09-02 |
| WO2008063129A1 (en) | 2008-05-29 |
| CA2669209C (en) | 2016-01-26 |
| JP2010510308A (ja) | 2010-04-02 |
| EP2094278A4 (en) | 2011-08-10 |
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