DK169890B1 - 3-Substitueret 2-carboxy-indolderivater, farmaceutisk præparat indeholdende forbindelserne, fremgangsmåde til fremstilling af forbindelserne samt anvendelse af forbindelserne til fremstilling af et lægemiddel - Google Patents

3-Substitueret 2-carboxy-indolderivater, farmaceutisk præparat indeholdende forbindelserne, fremgangsmåde til fremstilling af forbindelserne samt anvendelse af forbindelserne til fremstilling af et lægemiddel Download PDF

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Publication number: DK169890B1
Authority: DK; Denmark
Prior art keywords: compounds; compound; carboxy; preparation; compound according
Prior art date: 1992-04-16

Application number

DK043193A

Other languages

Danish (da)

English (en)

Other versions

DK43193D0 (da

DK43193A (da

Inventor

Alfredo Cugola

Giovanni Gaviraghi

Original Assignee

Glaxo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-16

Filing date

1993-04-15

Publication date

1995-03-27

1993-04-15 Application filed by Glaxo Spa filed Critical Glaxo Spa

1993-04-15 Publication of DK43193D0 publication Critical patent/DK43193D0/da

1993-10-17 Publication of DK43193A publication Critical patent/DK43193A/da

1995-03-27 Application granted granted Critical

1995-03-27 Publication of DK169890B1 publication Critical patent/DK169890B1/da

Links

150000001875 compounds Chemical class 0.000 title claims description 65
-1 3-Substituted 2-carboxy-indole Chemical class 0.000 title claims description 43
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QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical class CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
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QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
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229910052623 talc Inorganic materials 0.000 description 1
238000010998 test method Methods 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

DK043193A 1992-04-16 1993-04-15 3-Substitueret 2-carboxy-indolderivater, farmaceutisk præparat indeholdende forbindelserne, fremgangsmåde til fremstilling af forbindelserne samt anvendelse af forbindelserne til fremstilling af et lægemiddel DK169890B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929208492A GB9208492D0 (en)	1992-04-16	1992-04-16	Heterocyclic compounds
GB9208492		1992-04-16

Publications (3)

Publication Number	Publication Date
DK43193D0 DK43193D0 (da)	1993-04-15
DK43193A DK43193A (da)	1993-10-17
DK169890B1 true DK169890B1 (da)	1995-03-27

Family

ID=10714220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK043193A DK169890B1 (da)	1992-04-16	1993-04-15	3-Substitueret 2-carboxy-indolderivater, farmaceutisk præparat indeholdende forbindelserne, fremgangsmåde til fremstilling af forbindelserne samt anvendelse af forbindelserne til fremstilling af et lægemiddel

Country Status (41)

Country	Link
US (4)	US5373018A (el)
EP (1)	EP0568136A1 (el)
JP (2)	JPH07505407A (el)
KR (1)	KR100264114B1 (el)
CN (1)	CN1042331C (el)
AP (1)	AP480A (el)
AT (1)	AT403917B (el)
AU (1)	AU666927B2 (el)
BE (1)	BE1006343A5 (el)
BG (1)	BG62136B1 (el)
BR (1)	BR1100323A (el)
CA (3)	CA2094075A1 (el)
CH (1)	CH685630A5 (el)
CY (1)	CY2038B1 (el)
CZ (1)	CZ285799B6 (el)
DK (1)	DK169890B1 (el)
ES (1)	ES2105924B1 (el)
FI (1)	FI106198B (el)
FR (1)	FR2690919B1 (el)
GB (2)	GB9208492D0 (el)
GE (1)	GEP19991704B (el)
GR (1)	GR1001619B (el)
HK (1)	HK95797A (el)
HU (2)	HU217964B (el)
IL (1)	IL105412A (el)
IS (1)	IS3994A (el)
IT (1)	IT1265325B1 (el)
LU (1)	LU88248A1 (el)
MX (1)	MX9302195A (el)
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NO (1)	NO301879B1 (el)
NZ (1)	NZ247413A (el)
OA (1)	OA10103A (el)
PL (1)	PL176451B1 (el)
RO (1)	RO113242B1 (el)
RU (1)	RU2129544C1 (el)
SE (1)	SE504336C2 (el)
SK (1)	SK281941B6 (el)
TW (1)	TW224457B (el)
WO (1)	WO1993021153A1 (el)
ZA (1)	ZA932642B (el)

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1992
- 1992-04-16 GB GB929208492A patent/GB9208492D0/en active Pending
1993
- 1993-04-14 ZA ZA932642A patent/ZA932642B/xx unknown
- 1993-04-15 BE BE9300371A patent/BE1006343A5/fr active
- 1993-04-15 US US08/046,947 patent/US5373018A/en not_active Expired - Fee Related
- 1993-04-15 NZ NZ247413A patent/NZ247413A/en unknown
- 1993-04-15 RO RO94-01658A patent/RO113242B1/ro unknown
- 1993-04-15 AU AU36923/93A patent/AU666927B2/en not_active Ceased
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- 1993-04-15 CZ CZ942543A patent/CZ285799B6/cs not_active IP Right Cessation
- 1993-04-15 JP JP5517997A patent/JPH07505407A/ja active Pending
- 1993-04-15 DK DK043193A patent/DK169890B1/da active
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- 1993-04-15 EP EP93201103A patent/EP0568136A1/en not_active Withdrawn
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- 1993-04-16 AP APAP/P/1993/000524A patent/AP480A/en active
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1994
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- 1994-10-14 NO NO943913A patent/NO301879B1/no not_active IP Right Cessation
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1995
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1997
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1998
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Also Published As

Publication number	Publication date
NO943913L (no)	1994-12-14
EP0568136A1 (en)	1993-11-03
AU666927B2 (en)	1996-02-29
CZ285799B6 (cs)	1999-11-17
HU217964B (hu)	2000-05-28
JPH07505407A (ja)	1995-06-15
CY2038B1 (en)	1998-04-30
SE504336C2 (sv)	1997-01-13
CA2094073A1 (en)	1993-10-17
PL176451B1 (pl)	1999-05-31
IS3994A (is)	1993-10-17
AP480A (en)	1996-03-22
US5510367A (en)	1996-04-23
GB2266091A (en)	1993-10-20
FI106198B (fi)	2000-12-15
ZA932642B (en)	1994-01-10
RU94045915A (ru)	1996-09-10
MX9302195A (es)	1994-03-31
ITRM930236A0 (it)	1993-04-15
HUT70526A (en)	1995-10-30
IL105412A0 (en)	1993-08-18
CN1042331C (zh)	1999-03-03
ITRM930236A1 (it)	1994-10-15
WO1993021153A1 (en)	1993-10-28
RO113242B1 (ro)	1998-05-29
RU2129544C1 (ru)	1999-04-27
CA2094075A1 (en)	1993-10-17
BG62136B1 (bg)	1999-03-31
ES2105924A1 (es)	1997-10-16
IT1265325B1 (it)	1996-10-31
CZ254394A3 (en)	1995-07-12
CA2094076A1 (en)	1993-10-17
BE1006343A5 (fr)	1994-07-26
ES2105924B1 (es)	1998-07-01
FI944800L (fi)	1994-10-12
CH685630A5 (fr)	1995-08-31
IL105412A (en)	1998-02-22
GR1001619B (el)	1994-07-29
SE9301241L (sv)	1993-10-17
BG99111A (bg)	1995-05-31
NO301879B1 (no)	1997-12-22
JPH0649027A (ja)	1994-02-22
FR2690919A1 (fr)	1993-11-12
OA10103A (en)	1996-12-18
AT403917B (de)	1998-06-25
AU3692393A (en)	1993-10-21
ATA75293A (de)	1997-11-15
US5373018A (en)	1994-12-13
BR1100323A (pt)	2000-06-27
GB9307808D0 (en)	1993-06-02
SE9301241D0 (sv)	1993-04-15
KR100264114B1 (ko)	2000-11-01
MY112232A (en)	2001-05-31
US5374648A (en)	1994-12-20
CN1085212A (zh)	1994-04-13
AP9300524A0 (en)	1993-04-30
HU9402975D0 (en)	1995-02-28
SK281941B6 (sk)	2001-09-11
SK124194A3 (en)	1995-05-10
US5374649A (en)	1994-12-20
FI944800A0 (fi)	1994-10-12
FR2690919B1 (fr)	1995-05-05
DK43193D0 (da)	1993-04-15
TW224457B (el)	1994-06-01
GB9208492D0 (en)	1992-06-03
DK43193A (da)	1993-10-17
GEP19991704B (en)	1999-08-05
HK95797A (en)	1997-08-08
GB2266091B (en)	1995-08-09
NZ247413A (en)	1995-12-21
LU88248A1 (fr)	1994-03-01
NO943913D0 (no)	1994-10-14
HU211826A9 (en)	1995-12-28

Publication	Publication Date	Title
DK169890B1 (da)	1995-03-27	3-Substitueret 2-carboxy-indolderivater, farmaceutisk præparat indeholdende forbindelserne, fremgangsmåde til fremstilling af forbindelserne samt anvendelse af forbindelserne til fremstilling af et lægemiddel
US5686461A (en)	1997-11-11	Indole derivatives
AP877A (en)	2000-09-27	Tetrahydroquinoline derivatives as EAA antagonists.
JP4108123B2 (ja)	2008-06-25	Ｎｍｄａアンタゴニストとしてのテトラヒドロキノリン
EP1042317B1 (en)	2003-05-14	Indole derivatives as PKC-inhiboitors
NZ337793A (en)	2001-02-23	Quinoline-2-carboxylic acid derivatives and the use of these derivatives in the preparation of medicaments for antagonising the effect of excitatory amino acids upon the NMDA receptor complex
WO1995007887A1 (en)	1995-03-23	Indole derivatives as antagonists of excitatory amino acids
MXPA99008720A (en)	2000-01-01	Quinoline-2-carboxylic acid derivative and its use as excitatory amino acids antagonist
CZ340599A3 (cs)	2000-03-15	Derivát kyseliny chinolin-2-karboxylové

Legal Events

Date	Code	Title	Description
1993-04-15	A0	Application filed