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DK1585510T3 - Alpha-aminoamidderivater, der er nyttige som antimigrænemidler - Google Patents

Alpha-aminoamidderivater, der er nyttige som antimigrænemidler

Info

Publication number
DK1585510T3
DK1585510T3 DK03772344T DK03772344T DK1585510T3 DK 1585510 T3 DK1585510 T3 DK 1585510T3 DK 03772344 T DK03772344 T DK 03772344T DK 03772344 T DK03772344 T DK 03772344T DK 1585510 T3 DK1585510 T3 DK 1585510T3
Authority
DK
Denmark
Prior art keywords
alpha
derivatives useful
aminoamide derivatives
migraine agents
migraine
Prior art date
Application number
DK03772344T
Other languages
English (en)
Inventor
Patricia Salvati
Marcello Calabresi
Luciano Dho
Orietta Veneroni
Piero Melloni
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Application granted granted Critical
Publication of DK1585510T3 publication Critical patent/DK1585510T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DK03772344T 2003-01-16 2003-11-18 Alpha-aminoamidderivater, der er nyttige som antimigrænemidler DK1585510T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03000921A EP1438956A1 (en) 2003-01-16 2003-01-16 Alpha-aminoamide derivatives useful as antimigraine agents
PCT/EP2003/012889 WO2004062655A1 (en) 2003-01-16 2003-11-18 Alpha-aminoamide derivatives useful as antimigraine agents

Publications (1)

Publication Number Publication Date
DK1585510T3 true DK1585510T3 (da) 2008-02-25

Family

ID=32524140

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03772344T DK1585510T3 (da) 2003-01-16 2003-11-18 Alpha-aminoamidderivater, der er nyttige som antimigrænemidler

Country Status (21)

Country Link
US (2) US7709523B2 (da)
EP (2) EP1438956A1 (da)
JP (1) JP4885455B2 (da)
KR (1) KR101049694B1 (da)
CN (1) CN100418517C (da)
AT (1) ATE380026T1 (da)
AU (1) AU2003279399B8 (da)
BR (1) BRPI0317795B8 (da)
CA (1) CA2510514C (da)
CY (1) CY1107274T1 (da)
DE (1) DE60317935T2 (da)
DK (1) DK1585510T3 (da)
ES (1) ES2295658T3 (da)
HK (1) HK1086487A1 (da)
MX (1) MXPA05007339A (da)
NO (1) NO333610B1 (da)
NZ (1) NZ541117A (da)
PT (1) PT1585510E (da)
RU (1) RU2336077C2 (da)
SI (1) SI1585510T1 (da)
WO (1) WO2004062655A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
ATE317280T1 (de) * 2001-09-03 2006-02-15 Newron Pharm Spa Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
ES2339021T3 (es) * 2003-08-25 2010-05-14 Newron Pharmaceuticals S.P.A. Derivados de alfa-aminoamida utiles como agentes antiinflamatorios.
RS51411B (en) * 2004-09-10 2011-02-28 Newron Pharmaceuticals S.P.A. USE (R) - (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDE AS SELECTIVE MODULATORS OF SODIUM AND / OR CALCIUM CHANNELS
HUE028329T2 (en) 2005-12-22 2016-12-28 Newron Pharm Spa 2-Phenylethylamino derivatives acting as calcium and / or sodium channel modulators
EA017123B1 (ru) 2006-06-19 2012-10-30 Ньюрон Фармасьютикалс С.П.А. Способ получения 2-[4-(3- и 2-фторбензилокси)бензиламино]пропанамидов
FR2903985B1 (fr) 2006-07-24 2008-09-05 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
CA2689561C (en) 2007-06-15 2015-11-17 Newron Pharmaceuticals S.P.A. Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
CA2936209C (en) * 2007-12-11 2020-02-11 Newron Pharmaceuticals S.P.A. Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
DK2563355T3 (da) * 2010-04-27 2016-09-12 Newron Pharm Spa Fremgangsmåde til fremstilling af ralfinamid-methansulfonatsalte eller R-enantiomerer deraf.
KR101705718B1 (ko) * 2013-12-30 2017-02-14 이화여자대학교 산학협력단 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
CN107522654B (zh) * 2016-06-21 2020-09-01 中国人民解放军军事医学科学院毒物药物研究所 新的α-氨基酰胺衍生物及其医药用途
WO2019205147A1 (zh) * 2018-04-28 2019-10-31 上海璃道医药科技有限公司 包含苯并含氧脂肪环结构的氨基乙酰胺类化合物及其用途
CN112716927B (zh) * 2020-10-12 2022-10-14 复旦大学 α-氨基酰胺类化合物及其制备方法与应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140748A (en) 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US3658967A (en) * 1966-06-23 1972-04-25 Ici Ltd Carboxylic acid derivatives for lowering the concentration of triglycerides in the blood
CH480308A (de) * 1966-08-11 1969-10-31 Ciba Geigy Verfahren zur Herstellung von Thiosemicarbazid-Verbindungen
US4049663A (en) * 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
US4311853A (en) * 1979-02-06 1982-01-19 The Radiochemical Centre Limited Selenium derivatives of thyroxine and tri-iodothyronine
DE3050800C2 (da) * 1979-03-22 1989-06-22 Continental Pharma Inc., Bruessel/Bruxelles, Be
US4267354A (en) * 1979-04-25 1981-05-12 E. R. Squibb & Sons, Inc. Substituted amides having antiinflammatory activity and intermediates
ZA805476B (en) 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
EP0144853B1 (en) * 1983-11-21 1990-09-26 Fujisawa Pharmaceutical Co., Ltd. Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4839369A (en) 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
GB8714901D0 (en) * 1986-07-23 1987-07-29 Ici Plc Amide derivatives
GB2216515A (en) * 1988-03-04 1989-10-11 Nippon Shinyaku Co Ltd Acylphenol derivatives
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
DE3928488A1 (de) 1989-08-29 1991-03-07 Standard Elektrik Lorenz Ag Interferometrisches messsystem
DE69224861T2 (de) 1991-07-30 1998-08-06 Korea Res Inst Chem Tech Neue Phenylacetamidderivate und Verfahren zu ihrer Herstellung
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
GB9306899D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
GB9306886D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
US5475007A (en) * 1993-05-28 1995-12-12 The Regents Of The University Of California 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof
US5482964A (en) * 1994-10-11 1996-01-09 Warner-Lambert Company Substituted phenoxyhydroxypropyl amines as central nervous system agents
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US5741818A (en) * 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
GB9515411D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa N-(4-substituted-benzyl)-2-aminolactam derivatives
GB9515412D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
US5688830A (en) * 1996-01-25 1997-11-18 Syntex (U.S.A.) Inc. Treatment of neuropathic pain
JP4160136B2 (ja) * 1996-08-29 2008-10-01 武田薬品工業株式会社 縮合環状エーテル類、その製造法および剤
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
GB9625795D0 (en) 1996-12-12 1997-01-29 Smithkline Beecham Plc Novel treatment
GB9706730D0 (en) 1997-04-03 1997-05-21 Pharmacia & Upjohn Spa 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives
DE69829048T2 (de) 1997-04-22 2006-02-09 Euro-Celtique S.A. Die verwendung von durch carbozyklische und heterozyklische reste substituierte semicarbazonen und thiosemicarbazonen als natriumkanalblocker
EP2201945B1 (en) * 1997-11-21 2013-03-06 Purdue Neuroscience Company Use of substituted 2-aminoacetamides for treating or ameliorating anxiety
GB9727521D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
AU754681B2 (en) * 1998-02-04 2002-11-21 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
JP2000191533A (ja) * 1998-10-19 2000-07-11 Eisai Co Ltd 鎮痛剤
CN1148188C (zh) * 1998-10-19 2004-05-05 卫材株式会社 镇痛剂
US6281211B1 (en) * 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
KR20020015308A (ko) * 1999-03-26 2002-02-27 추후보정 아릴 치환된 피라졸, 이미다졸, 옥사졸, 티아졸 및 피롤,및 이의 용도
EP1169060B1 (en) 1999-04-09 2005-08-31 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
ATE317280T1 (de) * 2001-09-03 2006-02-15 Newron Pharm Spa Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (en) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
RS51411B (en) * 2004-09-10 2011-02-28 Newron Pharmaceuticals S.P.A. USE (R) - (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDE AS SELECTIVE MODULATORS OF SODIUM AND / OR CALCIUM CHANNELS

Also Published As

Publication number Publication date
US20100267835A1 (en) 2010-10-21
HK1086487A1 (en) 2006-09-22
AU2003279399B2 (en) 2008-11-27
CY1107274T1 (el) 2012-11-21
NO20053780D0 (no) 2005-08-09
CA2510514C (en) 2011-07-26
NZ541117A (en) 2008-02-29
ES2295658T3 (es) 2008-04-16
ATE380026T1 (de) 2007-12-15
NO20053780L (no) 2005-10-13
EP1585510A1 (en) 2005-10-19
CN1738611A (zh) 2006-02-22
DE60317935D1 (de) 2008-01-17
AU2003279399B8 (en) 2009-01-29
JP4885455B2 (ja) 2012-02-29
NO333610B1 (no) 2013-07-22
JP2006514060A (ja) 2006-04-27
RU2005125919A (ru) 2006-01-10
KR101049694B1 (ko) 2011-07-19
AU2003279399A1 (en) 2004-08-10
SI1585510T1 (sl) 2008-04-30
MXPA05007339A (es) 2005-09-30
EP1438956A1 (en) 2004-07-21
PT1585510E (pt) 2008-02-28
EP1585510B1 (en) 2007-12-05
KR20050094852A (ko) 2005-09-28
CA2510514A1 (en) 2004-07-29
BR0317795A (pt) 2005-11-22
RU2336077C2 (ru) 2008-10-20
DE60317935T2 (de) 2008-11-27
WO2004062655A1 (en) 2004-07-29
BRPI0317795B1 (pt) 2019-04-02
BRPI0317795B8 (pt) 2021-05-25
CN100418517C (zh) 2008-09-17
US7709523B2 (en) 2010-05-04
US20060079570A1 (en) 2006-04-13

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