DK1208086T3 - Benzamidformulering med histondeacetylaseinhibitoraktivitet - Google Patents

Benzamidformulering med histondeacetylaseinhibitoraktivitet

Info

Publication number: DK1208086T3
Authority: DK; Denmark
Prior art keywords: histone deacetylase; deacetylase inhibitor; inhibitor activity; benzamide; formulation
Prior art date: 1999-08-30

Application number

DK00956496T

Other languages

Danish (da)

English (en)

Inventor

Masahiko Ishibashi

Masahiro Sakabe

Ikuo Sakai

Tsuneji Suzuki

Tomoyuki Ando

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-30

Filing date

2000-08-29

Publication date

2006-06-19

2000-08-29 Application filed by Schering Ag filed Critical Schering Ag

2006-06-19 Application granted granted Critical

2006-06-19 Publication of DK1208086T3 publication Critical patent/DK1208086T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK00956496T 1999-08-30 2000-08-29 Benzamidformulering med histondeacetylaseinhibitoraktivitet DK1208086T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP24244499A JP2001081031A (ja)	1999-08-30	1999-08-30	溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤

Publications (1)

Publication Number	Publication Date
DK1208086T3 true DK1208086T3 (da)	2006-06-19

Family

ID=17089193

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00956496T DK1208086T3 (da)	1999-08-30	2000-08-29	Benzamidformulering med histondeacetylaseinhibitoraktivitet

Country Status (32)

Country	Link
US (1)	US6638530B1 (zh)
EP (1)	EP1208086B1 (zh)
JP (2)	JP2001081031A (zh)
KR (1)	KR100712640B1 (zh)
CN (1)	CN1147472C (zh)
AR (1)	AR025434A1 (zh)
AT (1)	ATE318258T1 (zh)
AU (1)	AU773617B2 (zh)
BG (1)	BG65544B1 (zh)
BR (1)	BR0013648A (zh)
CA (1)	CA2382886C (zh)
CZ (1)	CZ301737B6 (zh)
DE (1)	DE60026144T2 (zh)
DK (1)	DK1208086T3 (zh)
EE (1)	EE05063B1 (zh)
ES (1)	ES2259289T3 (zh)
HK (1)	HK1046277B (zh)
HR (1)	HRP20020182B1 (zh)
HU (1)	HUP0203330A3 (zh)
IL (2)	IL148357A0 (zh)
MX (1)	MXPA02002090A (zh)
NO (1)	NO322532B1 (zh)
NZ (1)	NZ517520A (zh)
PL (1)	PL201274B1 (zh)
PT (1)	PT1208086E (zh)
RU (1)	RU2260428C2 (zh)
SI (1)	SI1208086T1 (zh)
SK (1)	SK287252B6 (zh)
TW (1)	TWI268778B (zh)
UA (1)	UA72541C2 (zh)
WO (1)	WO2001016106A1 (zh)
ZA (1)	ZA200201424B (zh)

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US20040116522A1 (en) *	2001-03-30	2004-06-17	Yutaka Yamagata	Medicinal solutions
US6897220B2 (en)	2001-09-14	2005-05-24	Methylgene, Inc.	Inhibitors of histone deacetylase
KR20040048411A (ko)	2001-09-14	2004-06-09	메틸진, 인크.	히스톤 데아세틸라아제의 억제제
US7868204B2 (en)	2001-09-14	2011-01-11	Methylgene Inc.	Inhibitors of histone deacetylase
AU2006252047B2 (en) *	2001-09-14	2010-02-11	Methylgene Inc.	Inhibitors of histone deacetylase
US6706686B2 (en)	2001-09-27	2004-03-16	The Regents Of The University Of Colorado	Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
JP4638148B2 (ja)	2001-10-16	2011-02-23	スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ	神経変性疾患および脳の癌の処置
JPWO2003070691A1 (ja) *	2002-02-21	2005-06-09	財団法人大阪産業振興機構	Ｎ−ヒドロキシカルボキサミド誘導体
US7148257B2 (en)	2002-03-04	2006-12-12	Merck Hdac Research, Llc	Methods of treating mesothelioma with suberoylanilide hydroxamic acid
EP2082737B1 (en)	2002-03-04	2014-12-31	Merck HDAC Research, LLC	Methods of inducing terminal differentiation
US7456219B2 (en)	2002-03-04	2008-11-25	Merck Hdac Research, Llc	Polymorphs of suberoylanilide hydroxamic acid
EP1490013B1 (en)	2002-03-07	2010-02-17	University Of Delaware	Methods for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising hydroxyurea
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DE10233412A1 (de) *	2002-07-23	2004-02-12	4Sc Ag	Neue Verbindungen als Histondeacetylase-Inhibitoren
US7154002B1 (en)	2002-10-08	2006-12-26	Takeda San Diego, Inc.	Histone deacetylase inhibitors
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GB0226855D0 (en) *	2002-11-18	2002-12-24	Queen Mary & Westfield College	Histone deacetylase inhibitors
US7244751B2 (en) *	2003-02-14	2007-07-17	Shenzhen Chipscreen Biosciences Ltd.	Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
US7169801B2 (en)	2003-03-17	2007-01-30	Takeda San Diego, Inc.	Histone deacetylase inhibitors
CN100455564C (zh) *	2003-09-12	2009-01-28	深圳微芯生物科技有限责任公司	组蛋白去乙酰化酶抑制剂及其药用制剂的制备和应用
JP4809228B2 (ja) *	2003-09-24	2011-11-09	メチルジーンインコーポレイテッド	ヒストンデアセチラーゼの阻害剤
CN1882529A (zh) *	2003-09-24	2006-12-20	梅特希尔基因公司	组蛋白脱乙酰基酶抑制剂
CA2552279C (en) *	2003-12-02	2014-07-15	The Ohio State University Research Foundation	Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors
US20080057529A1 (en) *	2003-12-18	2008-03-06	Michele Pallaoro	Method for Identifying Histone Deacetylase Inhibitors
US7253204B2 (en)	2004-03-26	2007-08-07	Methylgene Inc.	Inhibitors of histone deacetylase
US7642275B2 (en)	2004-12-16	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US20100087328A1 (en) *	2005-03-01	2010-04-08	The Regents Of The University Of Michigan	Brm expression and related diagnostics
US7604939B2 (en) *	2005-03-01	2009-10-20	The Regents Of The University Of Michigan	Methods of identifying active BRM expression-promoting HDAC inhibitors
EP1896436A2 (en)	2005-05-11	2008-03-12	Takeda San Diego, Inc.	Histone deacetylase inhibitors
TWI365068B (en)	2005-05-20	2012-06-01	Merck Sharp & Dohme	Formulations of suberoylanilide hydroxamic acid and methods for producing same
EA200800321A1 (ru)	2005-07-14	2008-06-30	Такеда Сан Диего, Инк.	Ингибиторы гистондеацетилазы
US20100152188A1 (en) *	2005-08-05	2010-06-17	Akella Satya Surya Visweswara Srinivas	Novel Heterocyclic Compounds
RU2437662C2 (ru) *	2006-04-07	2011-12-27	Меррион Рисерч Iii Лимитед	Твердая пероральная лекарственная форма, содержащая усилитель
US8598168B2 (en)	2006-04-07	2013-12-03	Methylgene Inc.	Inhibitors of histone deacetylase
US20070292512A1 (en) *	2006-06-09	2007-12-20	Merrion Research Ii Limited	Solid Oral Dosage Form Containing an Enhancer
KR20090125209A (ko)	2007-03-28	2009-12-03	산텐 세이야꾸 가부시키가이샤	히스톤 탈아세틸화 효소 저해 작용을 갖는 화합물을 유효 성분으로서 함유하는 안압 하강제
US20110044952A1 (en) *	2007-11-27	2011-02-24	Ottawa Health Research Institute	Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors
CA2725390C (en) *	2008-04-08	2014-09-23	Syndax Pharmaceuticals, Inc.	Use of a hdac inhibitor and a her-2 inhibitor in the treatment of breast cancer
CN102056615A (zh) *	2008-05-07	2011-05-11	默里昂研究Ⅲ有限公司	肽的组合物及其制备方法
JP2011520891A (ja) *	2008-05-16	2011-07-21	チップスクリーンバイオサイエンシーズエルティーディー．	強力かつ選択的なヒストン脱アセチル化酵素阻害剤としての６−アミノニコチンアミド誘導体
US8623853B2 (en)	2008-07-23	2014-01-07	The Brigham And Women's Hospital, Inc.	Treatment of cancers characterized by chromosomal rearrangement of the NUT gene
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EP2661273A4 (en)	2011-01-07	2014-06-04	Merrion Res Iii Ltd	IRON PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION
CN103172540B (zh) *	2013-03-18	2015-07-01	潍坊博创国际生物医药研究院	苯甘氨酸类组蛋白去乙酰酶抑制剂及其制备方法和应用
US10184933B2 (en)	2013-10-01	2019-01-22	The J. David Gladstone Industries	Compositions, systems and methods for gene expression noise drug screening and uses thereof
ES2975708T3 (es)	2015-01-29	2024-07-12	Novo Nordisk As	Comprimidos que comprenden agonista del GLP-1 y recubrimiento entérico
PL3954690T3 (pl)	2015-07-02	2023-08-14	Acerta Pharma B.V.	Postacie stałe i formulacje (s)-4-(8-amino-3-(1-(but-2-ynoilo)pirolidyn-2-ylo)imidazo[1,5-a]-pirazyn-1-ylo)-n-(pirydyn-2-ylo)benzamidu
TWI808055B (zh)	2016-05-11	2023-07-11	美商滬亞生物國際有限公司	Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh)	2016-05-11	2023-03-01	美商滬亞生物國際有限公司	Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
CA3030142A1 (en) *	2016-07-08	2018-01-11	Ranedis Pharmaceuticals, Llc	Compositions and methods of treating and/or preventing lysosomal storage diseases and other monogenetic metabolic diseases
WO2018222572A1 (en) *	2017-06-01	2018-12-06	Warner Babcock Institute For Green Chemistry, Llc	Non-covalent derivatives and methods of treatment
WO2018226939A1 (en) *	2017-06-07	2018-12-13	Ranedis Pharmaceuticals, Llc	Compositions and methods of treating and/or preventing cancer
WO2020218518A1 (ja)	2019-04-25	2020-10-29	富士製薬工業株式会社	医薬製剤およびその製造方法
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1999
- 1999-08-30 JP JP24244499A patent/JP2001081031A/ja active Pending
2000
- 2000-08-29 ES ES00956496T patent/ES2259289T3/es not_active Expired - Lifetime
- 2000-08-29 IL IL14835700A patent/IL148357A0/xx active IP Right Grant
- 2000-08-29 CZ CZ20020724A patent/CZ301737B6/cs not_active IP Right Cessation
- 2000-08-29 EE EEP200200097A patent/EE05063B1/xx not_active IP Right Cessation
- 2000-08-29 EP EP00956496A patent/EP1208086B1/en not_active Expired - Lifetime
- 2000-08-29 RU RU2002107992/15A patent/RU2260428C2/ru active IP Right Revival
- 2000-08-29 CN CNB008122849A patent/CN1147472C/zh not_active Expired - Fee Related
- 2000-08-29 HU HU0203330A patent/HUP0203330A3/hu unknown
- 2000-08-29 WO PCT/EP2000/008421 patent/WO2001016106A1/en active IP Right Grant
- 2000-08-29 PL PL353063A patent/PL201274B1/pl not_active IP Right Cessation
- 2000-08-29 JP JP2001519675A patent/JP2003508386A/ja not_active Withdrawn
- 2000-08-29 NZ NZ517520A patent/NZ517520A/en not_active IP Right Cessation
- 2000-08-29 CA CA002382886A patent/CA2382886C/en not_active Expired - Fee Related
- 2000-08-29 US US10/069,582 patent/US6638530B1/en not_active Expired - Fee Related
- 2000-08-29 MX MXPA02002090A patent/MXPA02002090A/es active IP Right Grant
- 2000-08-29 AU AU68416/00A patent/AU773617B2/en not_active Ceased
- 2000-08-29 KR KR1020027002163A patent/KR100712640B1/ko not_active Expired - Fee Related
- 2000-08-29 SK SK261-2002A patent/SK287252B6/sk not_active IP Right Cessation
- 2000-08-29 AR ARP000104493A patent/AR025434A1/es unknown
- 2000-08-29 DE DE60026144T patent/DE60026144T2/de not_active Expired - Lifetime
- 2000-08-29 UA UA2002032271A patent/UA72541C2/uk unknown
- 2000-08-29 BR BR0013648-4A patent/BR0013648A/pt not_active Application Discontinuation
- 2000-08-29 PT PT00956496T patent/PT1208086E/pt unknown
- 2000-08-29 SI SI200030851T patent/SI1208086T1/sl unknown
- 2000-08-29 AT AT00956496T patent/ATE318258T1/de active
- 2000-08-29 TW TW089117485A patent/TWI268778B/zh not_active IP Right Cessation
- 2000-08-29 DK DK00956496T patent/DK1208086T3/da active
2002
- 2002-02-20 ZA ZA200201424A patent/ZA200201424B/en unknown
- 2002-02-25 IL IL148357A patent/IL148357A/en not_active IP Right Cessation
- 2002-02-26 BG BG106439A patent/BG65544B1/bg unknown
- 2002-02-27 NO NO20020952A patent/NO322532B1/no not_active IP Right Cessation
- 2002-02-27 HR HR20020182A patent/HRP20020182B1/xx not_active IP Right Cessation
- 2002-10-22 HK HK02107642.5A patent/HK1046277B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK1046277B (zh)	2004-11-26
IL148357A (en)	2006-12-10
IL148357A0 (en)	2002-09-12
HK1046277A1 (en)	2003-01-03
US6638530B1 (en)	2003-10-28
CZ2002724A3 (cs)	2002-07-17
KR20020023424A (ko)	2002-03-28
EP1208086A1 (en)	2002-05-29
EE200200097A (et)	2003-04-15
JP2003508386A (ja)	2003-03-04
BG106439A (en)	2002-11-29
MXPA02002090A (es)	2003-08-20
ZA200201424B (en)	2002-11-27
CZ301737B6 (cs)	2010-06-09
DE60026144T2 (de)	2006-11-16
CA2382886C (en)	2009-06-09
AU6841600A (en)	2001-03-26
NO20020952L (no)	2002-03-20
HRP20020182B1 (en)	2007-08-31
ATE318258T1 (de)	2006-03-15
UA72541C2 (en)	2005-03-15
NZ517520A (en)	2003-05-30
NO322532B1 (no)	2006-10-23
SK287252B6 (sk)	2010-04-07
JP2001081031A (ja)	2001-03-27
EE05063B1 (et)	2008-08-15
BR0013648A (pt)	2002-05-07
KR100712640B1 (ko)	2007-05-02
DE60026144D1 (de)	2006-04-27
HUP0203330A2 (hu)	2003-02-28
SI1208086T1 (sl)	2006-08-31
PT1208086E (pt)	2006-07-31
CN1147472C (zh)	2004-04-28
AU773617B2 (en)	2004-05-27
NO20020952D0 (no)	2002-02-27
SK2612002A3 (en)	2002-09-10
AR025434A1 (es)	2002-11-27
HRP20020182A2 (en)	2004-02-29
TWI268778B (en)	2006-12-21
RU2260428C2 (ru)	2005-09-20
EP1208086B1 (en)	2006-02-22
PL201274B1 (pl)	2009-03-31
HUP0203330A3 (en)	2004-03-01
CN1371366A (zh)	2002-09-25
BG65544B1 (bg)	2008-11-28
PL353063A1 (en)	2003-10-06
CA2382886A1 (en)	2001-03-08
WO2001016106A1 (en)	2001-03-08
ES2259289T3 (es)	2006-10-01

Publication	Publication Date	Title
DK1208086T3 (da)	2006-06-19	Benzamidformulering med histondeacetylaseinhibitoraktivitet
DK1495002T3 (da)	2012-12-03	Benzamide derivatives useful as histone deacetylase inhibitors
HK1257248A1 (zh)	2019-10-18	作為具有强的分化和抗增殖活性的組蛋白脫乙酰基酶抑制劑的苯甲酰胺衍生物
CY2015053I1 (el)	2016-06-22	Υδροξαμικα παραγωγα χρησιμα ως αναστολεις δεακετυλασης
ATE473005T1 (de)	2010-07-15	Histone-deacetylase-inhibitoren
ATE354366T1 (de)	2007-03-15	Histondeacetylase-hemmer
EE200100373A (et)	2002-10-15	Bensoheterotsüklid ja nende kasutamine MEK inhibiitoritena
NO20012688D0 (no)	2001-05-31	Benzamidderivater og anvendelse derav som APOB-100 sekresjonsinhibitorer
AU2003219595A8 (en)	2003-10-27	Alpha,beta-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors
NO20012245L (no)	2001-07-10	Anthranilsyreamider og anvendelse derav som medikamenter
NO20020383L (no)	2002-01-24	Mutilinderivater og deres anvendelse som anti-bakterielle midler
DE60031633D1 (de)	2006-12-14	Wirkstofffreisetzendes elastisches band
ATE455754T1 (de)	2010-02-15	Arylsulfonamid-substituierte hydroxamsäure- derivate
NO20032183L (no)	2003-11-17	Histon-deacetylase-inhibitor og anvendelse derav
EP1408946A4 (en)	2004-06-09	HISTONE DEACETYLASE INHIBITORS
EE200100611A (et)	2003-02-17	NOS inhibiitorite uued farmatseutilised kombinatsioonid
NO20020326L (no)	2002-03-20	Sammensetning og anvendelse av en inhibitor av PPAR-delta-aktivitet
EE200100084A (xx)	2002-08-15	NOS inhibiitorite uued farmatseutilised kasutusv�imalused
DK1301184T3 (da)	2005-07-18	Valproinsyre og derivater deraf som histondeacetylaseinhibitorer