DK1208086T3 - Benzamidformulering med histondeacetylaseinhibitoraktivitet - Google Patents

Benzamidformulering med histondeacetylaseinhibitoraktivitet

Info

Publication number: DK1208086T3
Authority: DK; Denmark
Prior art keywords: histone deacetylase; deacetylase inhibitor; inhibitor activity; benzamide; formulation
Prior art date: 1999-08-30

Application number

DK00956496T

Other languages

English (en)

Inventor

Masahiko Ishibashi

Masahiro Sakabe

Ikuo Sakai

Tsuneji Suzuki

Tomoyuki Ando

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-30

Filing date

2000-08-29

Publication date

2006-06-19

2000-08-29 Application filed by Schering Ag filed Critical Schering Ag

2006-06-19 Application granted granted Critical

2006-06-19 Publication of DK1208086T3 publication Critical patent/DK1208086T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK00956496T 1999-08-30 2000-08-29 Benzamidformulering med histondeacetylaseinhibitoraktivitet DK1208086T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP24244499A JP2001081031A (ja)	1999-08-30	1999-08-30	溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤

Publications (1)

Publication Number	Publication Date
DK1208086T3 true DK1208086T3 (da)	2006-06-19

Family

ID=17089193

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00956496T DK1208086T3 (da)	1999-08-30	2000-08-29	Benzamidformulering med histondeacetylaseinhibitoraktivitet

Country Status (32)

Country	Link
US (1)	US6638530B1 (da)
EP (1)	EP1208086B1 (da)
JP (2)	JP2001081031A (da)
KR (1)	KR100712640B1 (da)
CN (1)	CN1147472C (da)
AR (1)	AR025434A1 (da)
AT (1)	ATE318258T1 (da)
AU (1)	AU773617B2 (da)
BG (1)	BG65544B1 (da)
BR (1)	BR0013648A (da)
CA (1)	CA2382886C (da)
CZ (1)	CZ301737B6 (da)
DE (1)	DE60026144T2 (da)
DK (1)	DK1208086T3 (da)
EE (1)	EE05063B1 (da)
ES (1)	ES2259289T3 (da)
HK (1)	HK1046277B (da)
HR (1)	HRP20020182B1 (da)
HU (1)	HUP0203330A3 (da)
IL (2)	IL148357A0 (da)
MX (1)	MXPA02002090A (da)
NO (1)	NO322532B1 (da)
NZ (1)	NZ517520A (da)
PL (1)	PL201274B1 (da)
PT (1)	PT1208086E (da)
RU (1)	RU2260428C2 (da)
SI (1)	SI1208086T1 (da)
SK (1)	SK287252B6 (da)
TW (1)	TWI268778B (da)
UA (1)	UA72541C2 (da)
WO (1)	WO2001016106A1 (da)
ZA (1)	ZA200201424B (da)

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WO2002078669A1 (fr) *	2001-03-30	2002-10-10	Takeda Chemical Industries, Ltd.	Solutions medicinales
AU2006252047B2 (en) *	2001-09-14	2010-02-11	Methylgene Inc.	Inhibitors of histone deacetylase
KR20100107509A (ko)	2001-09-14	2010-10-05	9222-9129 퀘벡 인코포레이티드	히스톤 데아세틸라아제의 억제제
US6897220B2 (en)	2001-09-14	2005-05-24	Methylgene, Inc.	Inhibitors of histone deacetylase
US7868204B2 (en)	2001-09-14	2011-01-11	Methylgene Inc.	Inhibitors of histone deacetylase
US6706686B2 (en)	2001-09-27	2004-03-16	The Regents Of The University Of Colorado	Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
EP1443928B1 (en)	2001-10-16	2011-07-27	Sloan-Kettering Institute For Cancer Research	Treatment of neurodegenerative diseases and cancer of the brain
AU2003211362A1 (en) *	2002-02-21	2003-09-09	Osaka Industrial Promotion Organization	N-hydroxycarboxamide derivative
WO2003075839A2 (en)	2002-03-04	2003-09-18	Aton Pharma, Inc.	Methods of inducing terminal differentiation
US7456219B2 (en)	2002-03-04	2008-11-25	Merck Hdac Research, Llc	Polymorphs of suberoylanilide hydroxamic acid
US7148257B2 (en)	2002-03-04	2006-12-12	Merck Hdac Research, Llc	Methods of treating mesothelioma with suberoylanilide hydroxamic acid
CA2478479A1 (en)	2002-03-07	2003-09-18	University Of Delaware	Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phagebeta protein, or hydroxyurea
GB0209715D0 (en) *	2002-04-27	2002-06-05	Astrazeneca Ab	Chemical compounds
DE10233412A1 (de) *	2002-07-23	2004-02-12	4Sc Ag	Neue Verbindungen als Histondeacetylase-Inhibitoren
US7154002B1 (en)	2002-10-08	2006-12-26	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7250514B1 (en)	2002-10-21	2007-07-31	Takeda San Diego, Inc.	Histone deacetylase inhibitors
GB0226855D0 (en) *	2002-11-18	2002-12-24	Queen Mary & Westfield College	Histone deacetylase inhibitors
US7244751B2 (en) *	2003-02-14	2007-07-17	Shenzhen Chipscreen Biosciences Ltd.	Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
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CN100455564C (zh) *	2003-09-12	2009-01-28	深圳微芯生物科技有限责任公司	组蛋白去乙酰化酶抑制剂及其药用制剂的制备和应用
CN1882529A (zh) *	2003-09-24	2006-12-20	梅特希尔基因公司	组蛋白脱乙酰基酶抑制剂
CA2539117A1 (en) *	2003-09-24	2005-04-07	Methylgene Inc.	Inhibitors of histone deacetylase
JP5107579B2 (ja) *	2003-12-02	2012-12-26	ザオハイオステートユニバーシティーリサーチファウンデーション	新規の種類のヒストン脱アセチル化酵素阻害剤としてのＺｎ２＋キレートモチーフ係留短鎖脂肪酸
EP1697538A1 (en) *	2003-12-18	2006-09-06	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A.	Method for identifying histone deacetylase inhibitors
US7253204B2 (en)	2004-03-26	2007-08-07	Methylgene Inc.	Inhibitors of histone deacetylase
WO2006066133A2 (en)	2004-12-16	2006-06-22	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US20100087328A1 (en) *	2005-03-01	2010-04-08	The Regents Of The University Of Michigan	Brm expression and related diagnostics
WO2006094068A2 (en) *	2005-03-01	2006-09-08	The Regents Of The University Of Michigan	Hdac inhibitors that promote brm expression and brm related diagnostics
EP1896436A2 (en)	2005-05-11	2008-03-12	Takeda San Diego, Inc.	Histone deacetylase inhibitors
TWI365068B (en)	2005-05-20	2012-06-01	Merck Sharp & Dohme	Formulations of suberoylanilide hydroxamic acid and methods for producing same
BRPI0613429A2 (pt)	2005-07-14	2009-02-10	Takeda San Diego Inc	inibidores de histona desacetilase
WO2007017728A2 (en) *	2005-08-05	2007-02-15	Orchid Research Laboratories Limited	Novel heterocyclic compounds
WO2007118137A1 (en)	2006-04-07	2007-10-18	Methylgene Inc.	Benzamide derivatives as inhibitors of histone deacetylase
BRPI0710503A2 (pt) *	2006-04-07	2011-08-16	Merrion Res Iii Ltd	uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral
WO2007146234A2 (en) *	2006-06-09	2007-12-21	Merrion Research Ii Limited	Solid oral dosage form containing an enhancer
US20100056522A1 (en)	2007-03-28	2010-03-04	Santen Pharmaceutical Co., Ltd.	Intraocular pressure-lowering agent comprising compound having histone deacetylase inhibitor effect as active ingredient
CA2706750A1 (en) *	2007-11-27	2009-06-04	Ottawa Health Research Institute	Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors
US20110182888A1 (en) *	2008-04-08	2011-07-28	Peter Ordentlich	Administration of an Inhibitor of HDAC, an Inhibitor of HER-2, and a Selective Estrogen Receptor Modulator
EP2288368A1 (en) *	2008-05-07	2011-03-02	Merrion Research III Limited	Compositions of peptides and processes of preparation thereof
EP2285376A4 (en) *	2008-05-16	2011-07-20	Chipscreen Biosciences Ltd	6-AMINONICOTINAMIDE DERIVATIVES FORMING POWERFUL AND SELECTIVE HISTONE DEACETYLASE INHIBITORS
WO2010011700A2 (en)	2008-07-23	2010-01-28	The Brigham And Women's Hospital, Inc.	Treatment of cancers characterized by chromosomal rearrangement of the nut gene
JP2012518686A (ja) *	2009-02-25	2012-08-16	メリオン・リサーチ・Ｉｉｉ・リミテッド	ビスホスホネート類の組成物および薬物送達
US9089484B2 (en)	2010-03-26	2015-07-28	Merrion Research Iii Limited	Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
CA2819234A1 (en)	2011-01-07	2012-07-12	Merrion Research Iii Limited	Pharmaceutical compositions of iron for oral administration
CN103172540B (zh) *	2013-03-18	2015-07-01	潍坊博创国际生物医药研究院	苯甘氨酸类组蛋白去乙酰酶抑制剂及其制备方法和应用
EP3470536A1 (en)	2013-10-01	2019-04-17	The J. David Gladstone Institutes	Compositions, systems and methods for gene expression noise drug screening and uses thereof
WO2016120378A1 (en)	2015-01-29	2016-08-04	Novo Nordisk A/S	Tablets comprising glp-1 agonist and enteric coating
ES2895802T3 (es)	2015-07-02	2022-02-22	Acerta Pharma Bv	Formas sólidas y formulaciones de (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-N-(piridin-2-il)benzamida
TWI808055B (zh)	2016-05-11	2023-07-11	美商滬亞生物國際有限公司	Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh)	2016-05-11	2023-03-01	美商滬亞生物國際有限公司	Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
AU2017292776A1 (en) *	2016-07-08	2019-02-21	Ranedis Pharmaceuticals, Llc	Compositions and methods of treating and/or preventing lysosomal storage diseases and other monogenetic metabolic diseases
WO2018222572A1 (en) *	2017-06-01	2018-12-06	Warner Babcock Institute For Green Chemistry, Llc	Non-covalent derivatives and methods of treatment
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JP3354090B2 (ja) *	1996-09-30	2002-12-09	シエーリングアクチエンゲゼルシャフト	分化誘導剤
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1999
- 1999-08-30 JP JP24244499A patent/JP2001081031A/ja active Pending
2000
- 2000-08-29 BR BR0013648-4A patent/BR0013648A/pt not_active Application Discontinuation
- 2000-08-29 SI SI200030851T patent/SI1208086T1/sl unknown
- 2000-08-29 NZ NZ517520A patent/NZ517520A/en not_active IP Right Cessation
- 2000-08-29 CA CA002382886A patent/CA2382886C/en not_active Expired - Fee Related
- 2000-08-29 AU AU68416/00A patent/AU773617B2/en not_active Ceased
- 2000-08-29 DE DE60026144T patent/DE60026144T2/de not_active Expired - Lifetime
- 2000-08-29 EE EEP200200097A patent/EE05063B1/xx not_active IP Right Cessation
- 2000-08-29 CZ CZ20020724A patent/CZ301737B6/cs not_active IP Right Cessation
- 2000-08-29 WO PCT/EP2000/008421 patent/WO2001016106A1/en active IP Right Grant
- 2000-08-29 AR ARP000104493A patent/AR025434A1/es unknown
- 2000-08-29 EP EP00956496A patent/EP1208086B1/en not_active Expired - Lifetime
- 2000-08-29 DK DK00956496T patent/DK1208086T3/da active
- 2000-08-29 UA UA2002032271A patent/UA72541C2/uk unknown
- 2000-08-29 RU RU2002107992/15A patent/RU2260428C2/ru active IP Right Revival
- 2000-08-29 IL IL14835700A patent/IL148357A0/xx active IP Right Grant
- 2000-08-29 KR KR1020027002163A patent/KR100712640B1/ko not_active IP Right Cessation
- 2000-08-29 JP JP2001519675A patent/JP2003508386A/ja not_active Withdrawn
- 2000-08-29 HU HU0203330A patent/HUP0203330A3/hu unknown
- 2000-08-29 PL PL353063A patent/PL201274B1/pl not_active IP Right Cessation
- 2000-08-29 MX MXPA02002090A patent/MXPA02002090A/es active IP Right Grant
- 2000-08-29 ES ES00956496T patent/ES2259289T3/es not_active Expired - Lifetime
- 2000-08-29 SK SK261-2002A patent/SK287252B6/sk not_active IP Right Cessation
- 2000-08-29 US US10/069,582 patent/US6638530B1/en not_active Expired - Fee Related
- 2000-08-29 TW TW089117485A patent/TWI268778B/zh not_active IP Right Cessation
- 2000-08-29 CN CNB008122849A patent/CN1147472C/zh not_active Expired - Fee Related
- 2000-08-29 AT AT00956496T patent/ATE318258T1/de active
- 2000-08-29 PT PT00956496T patent/PT1208086E/pt unknown
2002
- 2002-02-20 ZA ZA200201424A patent/ZA200201424B/en unknown
- 2002-02-25 IL IL148357A patent/IL148357A/en not_active IP Right Cessation
- 2002-02-26 BG BG106439A patent/BG65544B1/bg unknown
- 2002-02-27 HR HR20020182A patent/HRP20020182B1/xx not_active IP Right Cessation
- 2002-02-27 NO NO20020952A patent/NO322532B1/no not_active IP Right Cessation
- 2002-10-22 HK HK02107642.5A patent/HK1046277B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ2002724A3 (cs)	2002-07-17
HRP20020182B1 (en)	2007-08-31
CA2382886C (en)	2009-06-09
HUP0203330A3 (en)	2004-03-01
ATE318258T1 (de)	2006-03-15
TWI268778B (en)	2006-12-21
SI1208086T1 (sl)	2006-08-31
MXPA02002090A (es)	2003-08-20
KR100712640B1 (ko)	2007-05-02
NO20020952D0 (no)	2002-02-27
HRP20020182A2 (en)	2004-02-29
KR20020023424A (ko)	2002-03-28
CN1371366A (zh)	2002-09-25
EE200200097A (et)	2003-04-15
EP1208086B1 (en)	2006-02-22
AU773617B2 (en)	2004-05-27
UA72541C2 (en)	2005-03-15
JP2001081031A (ja)	2001-03-27
EP1208086A1 (en)	2002-05-29
AR025434A1 (es)	2002-11-27
SK2612002A3 (en)	2002-09-10
DE60026144D1 (de)	2006-04-27
SK287252B6 (sk)	2010-04-07
HUP0203330A2 (hu)	2003-02-28
HK1046277A1 (en)	2003-01-03
RU2260428C2 (ru)	2005-09-20
ES2259289T3 (es)	2006-10-01
CN1147472C (zh)	2004-04-28
CZ301737B6 (cs)	2010-06-09
NO322532B1 (no)	2006-10-23
WO2001016106A1 (en)	2001-03-08
AU6841600A (en)	2001-03-26
PL353063A1 (en)	2003-10-06
CA2382886A1 (en)	2001-03-08
US6638530B1 (en)	2003-10-28
IL148357A0 (en)	2002-09-12
NZ517520A (en)	2003-05-30
ZA200201424B (en)	2002-11-27
PT1208086E (pt)	2006-07-31
BG106439A (en)	2002-11-29
PL201274B1 (pl)	2009-03-31
NO20020952L (no)	2002-03-20
BG65544B1 (bg)	2008-11-28
EE05063B1 (et)	2008-08-15
BR0013648A (pt)	2002-05-07
IL148357A (en)	2006-12-10
DE60026144T2 (de)	2006-11-16
HK1046277B (zh)	2004-11-26
JP2003508386A (ja)	2003-03-04

Publication	Publication Date	Title
DK1208086T3 (da)	2006-06-19	Benzamidformulering med histondeacetylaseinhibitoraktivitet
DK1495002T3 (da)	2012-12-03	Benzamide derivatives useful as histone deacetylase inhibitors
HK1257248A1 (zh)	2019-10-18	作為具有强的分化和抗增殖活性的組蛋白脫乙酰基酶抑制劑的苯甲酰胺衍生物
CY2015053I1 (el)	2016-06-22	Υδροξαμικα παραγωγα χρησιμα ως αναστολεις δεακετυλασης
ATE521592T1 (de)	2011-09-15	Histone-deacetylase-inhibitoren
ATE354366T1 (de)	2007-03-15	Histondeacetylase-hemmer
EE200100373A (et)	2002-10-15	Bensoheterotsüklid ja nende kasutamine MEK inhibiitoritena
NO20012688D0 (no)	2001-05-31	Benzamidderivater og anvendelse derav som APOB-100 sekresjonsinhibitorer
NO20012245D0 (no)	2001-05-07	Anthranilsyreamider og anvendelse derav som medikamenter
NO20020383L (no)	2002-01-24	Mutilinderivater og deres anvendelse som anti-bakterielle midler
AU2003219595A8 (en)	2003-10-27	Alpha,beta-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors
DE60031633D1 (de)	2006-12-14	Wirkstofffreisetzendes elastisches band
ATE455754T1 (de)	2010-02-15	Arylsulfonamid-substituierte hydroxamsäure- derivate
EE200100611A (et)	2003-02-17	NOS inhibiitorite uued farmatseutilised kombinatsioonid
NO20032183L (no)	2003-11-17	Histon-deacetylase-inhibitor og anvendelse derav
EP1408946A4 (en)	2004-06-09	HISTONE DEACETYLASE INHIBITORS
NO20020326L (no)	2002-03-20	Sammensetning og anvendelse av en inhibitor av PPAR-delta-aktivitet
EE200100084A (xx)	2002-08-15	NOS inhibiitorite uued farmatseutilised kasutusv�imalused
NO20011654D0 (no)	2001-04-02	Benzamidderivater som trombininhibitorer