DK1095040T3 - Hidtil ukendte benzoxazoler med PDE-inhiberende aktivitet - Google Patents
Hidtil ukendte benzoxazoler med PDE-inhiberende aktivitetInfo
- Publication number
- DK1095040T3 DK1095040T3 DK99931198T DK99931198T DK1095040T3 DK 1095040 T3 DK1095040 T3 DK 1095040T3 DK 99931198 T DK99931198 T DK 99931198T DK 99931198 T DK99931198 T DK 99931198T DK 1095040 T3 DK1095040 T3 DK 1095040T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitory activity
- pde inhibitory
- pde
- benzoxazoles
- novel
- Prior art date
Links
- 150000000183 1,3-benzoxazoles Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 101000909851 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) cAMP/cGMP dual specificity phosphodiesterase Rv0805 Proteins 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98112469 | 1998-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1095040T3 true DK1095040T3 (da) | 2004-07-26 |
Family
ID=8232222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99931198T DK1095040T3 (da) | 1998-07-06 | 1999-06-26 | Hidtil ukendte benzoxazoler med PDE-inhiberende aktivitet |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6376485B1 (pt) |
| EP (1) | EP1095040B1 (pt) |
| JP (1) | JP2002519423A (pt) |
| AT (1) | ATE263166T1 (pt) |
| AU (1) | AU761647B2 (pt) |
| CA (1) | CA2336894A1 (pt) |
| DE (1) | DE69916066T2 (pt) |
| DK (1) | DK1095040T3 (pt) |
| ES (1) | ES2219031T3 (pt) |
| IL (1) | IL140468A0 (pt) |
| PT (1) | PT1095040E (pt) |
| SI (1) | SI1095040T1 (pt) |
| WO (1) | WO2000001695A1 (pt) |
| ZA (1) | ZA200100088B (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| AU2008326385B2 (en) * | 2007-11-21 | 2013-12-05 | Decode Genetics Ehf | Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405633A (en) * | 1982-03-01 | 1983-09-20 | Usv Pharmaceutical Corporation | Method of treatment of asthma |
| US4490373A (en) * | 1983-05-20 | 1984-12-25 | Usv Pharmaceutical Corporation | Method of treating asthma |
| DE69531623T2 (de) * | 1994-10-12 | 2004-06-17 | Euroceltique S.A. | Neue benzoxazole |
| DE59610031D1 (de) * | 1995-05-18 | 2003-02-06 | Altana Pharma Ag | Cyclohexyldihydrobenzofurane |
| ATE325110T1 (de) * | 1995-05-19 | 2006-06-15 | Kyowa Hakko Kogyo Kk | Sauerstoff enthaltende heterocyclische verbindungen |
-
1999
- 1999-06-26 AU AU47786/99A patent/AU761647B2/en not_active Ceased
- 1999-06-26 DK DK99931198T patent/DK1095040T3/da active
- 1999-06-26 DE DE69916066T patent/DE69916066T2/de not_active Expired - Fee Related
- 1999-06-26 ES ES99931198T patent/ES2219031T3/es not_active Expired - Lifetime
- 1999-06-26 SI SI9930588T patent/SI1095040T1/xx unknown
- 1999-06-26 IL IL14046899A patent/IL140468A0/xx not_active IP Right Cessation
- 1999-06-26 ZA ZA200100088A patent/ZA200100088B/en unknown
- 1999-06-26 PT PT99931198T patent/PT1095040E/pt unknown
- 1999-06-26 EP EP99931198A patent/EP1095040B1/en not_active Expired - Lifetime
- 1999-06-26 US US09/720,812 patent/US6376485B1/en not_active Expired - Fee Related
- 1999-06-26 AT AT99931198T patent/ATE263166T1/de not_active IP Right Cessation
- 1999-06-26 WO PCT/EP1999/004451 patent/WO2000001695A1/en active Search and Examination
- 1999-06-26 JP JP2000558098A patent/JP2002519423A/ja not_active Withdrawn
- 1999-06-26 CA CA002336894A patent/CA2336894A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT1095040E (pt) | 2004-08-31 |
| SI1095040T1 (en) | 2004-10-31 |
| AU761647B2 (en) | 2003-06-05 |
| ZA200100088B (en) | 2002-05-06 |
| EP1095040A1 (en) | 2001-05-02 |
| ATE263166T1 (de) | 2004-04-15 |
| JP2002519423A (ja) | 2002-07-02 |
| DE69916066T2 (de) | 2005-02-24 |
| WO2000001695A1 (en) | 2000-01-13 |
| EP1095040B1 (en) | 2004-03-31 |
| IL140468A0 (en) | 2002-02-10 |
| ES2219031T3 (es) | 2004-11-16 |
| US6376485B1 (en) | 2002-04-23 |
| CA2336894A1 (en) | 2000-01-13 |
| AU4778699A (en) | 2000-01-24 |
| DE69916066D1 (de) | 2004-05-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE402174T1 (de) | Imidazopyridinderivate als kinaseinhibitoren | |
| YU37903A (sh) | POSTUPCI LEČENJA STANJA POVEZANIH SA p38 KINAZOM I JEDINJENJA PIROLOTRIAZINA KOJA SE KORISTE KAO INHIBITORI KINAZE | |
| WO2003013484A3 (en) | N-monoacylated derivatives of o-phenylenediamines, their six membered heterocyclic analogues and their use as pharmaceutical agents | |
| HUP0202795A2 (hu) | Pirimidin- és pirazinszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| EA200501009A1 (ru) | Замещённые пирролопиразольные производные в качестве ингибиторов киназы | |
| MY132106A (en) | New pyridazin-3(2h)-one derivatives | |
| PT828728E (pt) | Di-hidrobenzofuranos de fenilo | |
| MY139302A (en) | Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof | |
| NO20055421L (no) | Kinolinderivater som fosfodiestrase-inhibitorer | |
| MX2007000028A (es) | Derivados de nicotinamida y su uso como agentes terapeuticos. | |
| SE0202463D0 (sv) | Novel compounds | |
| ECSP066314A (es) | Derivados piridilo y su uso como agentes terapéuticos | |
| DE602004017194D1 (de) | Pyridylpyrrol-derivate als wirksame kinase-hemmer | |
| RS101304A (sr) | Indolni, azaindolni i srodni heterociklični 4-alkenil piperidinski amidi | |
| DK1095040T3 (da) | Hidtil ukendte benzoxazoler med PDE-inhiberende aktivitet | |
| NO20061839L (no) | Benzimidazolderivater, sammensetninger inneholdende dem, fremstilling derav, og anvendelse derav | |
| PT1412354E (pt) | Derivados de triazolil-imidazopiridina e de triazolilpurinas uteis como ligandos do receptor a2a da adenosina e sua utilizacao como medicamentos | |
| ATE230404T1 (de) | Cyclohexyldihydrobenzofurane | |
| GB0308201D0 (en) | Novel compounds | |
| ATE233754T1 (de) | Diphenyl-piperidin derivate | |
| SE0301701D0 (sv) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | |
| SE0301699D0 (sv) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | |
| MXPA02004441A (es) | Derivados de isoxazol como inhibidores de la fosfodiesterasa. | |
| PL359409A1 (en) | Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity | |
| MXPA05012772A (es) | Derivados de benzotiazol y uso de los mismos en el tratamiento de enfermedades relacionadas con el receptor a2a de adenosina. |