[go: up one dir, main page]

DK1050588T3 - Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning - Google Patents

Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning

Info

Publication number
DK1050588T3
DK1050588T3 DK00202824T DK00202824T DK1050588T3 DK 1050588 T3 DK1050588 T3 DK 1050588T3 DK 00202824 T DK00202824 T DK 00202824T DK 00202824 T DK00202824 T DK 00202824T DK 1050588 T3 DK1050588 T3 DK 1050588T3
Authority
DK
Denmark
Prior art keywords
substrate
sample application
present
analyte
channels
Prior art date
Application number
DK00202824T
Other languages
Danish (da)
English (en)
Inventor
Hermanus Johannes Mari Kreuwel
Damme Hendrik Sibolt Van
Original Assignee
Pamgene Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pamgene Bv filed Critical Pamgene Bv
Application granted granted Critical
Publication of DK1050588T3 publication Critical patent/DK1050588T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Clinical Laboratory Science (AREA)
  • Inorganic Chemistry (AREA)
  • Cell Biology (AREA)
  • AIDS & HIV (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK00202824T 1997-07-11 1998-07-07 Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning DK1050588T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97202140 1997-07-11
EP98940253A EP0975427B1 (de) 1997-07-11 1998-07-07 Vorrichtung zur durchführung eines tests, verwendung einer membran zur herstellung dieser vorrichtung, kit mit dieser vorrichtung und analyseverfahren unter verwendung dieses gerätes.
EP00202824A EP1050588B1 (de) 1997-07-11 1998-07-07 Verfahren zur Herstellung einer Vorrichtung zur Durchführung eines Tests, Verwendung einer Membran zur Herstellung dieser Vorrichtung, Kit mit dieser Vorrichtung und Analyseverfahren unter Verwendung dieses Gerätes

Publications (1)

Publication Number Publication Date
DK1050588T3 true DK1050588T3 (da) 2005-04-25

Family

ID=8228537

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00202824T DK1050588T3 (da) 1997-07-11 1998-07-07 Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning
DK98940253T DK0975427T3 (da) 1997-07-11 1998-07-07 Indretning til udførelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98940253T DK0975427T3 (da) 1997-07-11 1998-07-07 Indretning til udførelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning

Country Status (13)

Country Link
US (3) US6225131B1 (de)
EP (2) EP1050588B1 (de)
JP (1) JP3208390B2 (de)
KR (1) KR100421262B1 (de)
AT (2) ATE199663T1 (de)
AU (1) AU724382B2 (de)
CA (1) CA2290945C (de)
DE (2) DE69828083T2 (de)
DK (2) DK1050588T3 (de)
ES (2) ES2157669T3 (de)
GR (1) GR3036010T3 (de)
PT (2) PT975427E (de)
WO (1) WO1999002266A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6521187B1 (en) 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
EP1050588B1 (de) 1997-07-11 2004-12-08 PamGene B.V. Verfahren zur Herstellung einer Vorrichtung zur Durchführung eines Tests, Verwendung einer Membran zur Herstellung dieser Vorrichtung, Kit mit dieser Vorrichtung und Analyseverfahren unter Verwendung dieses Gerätes
US6855539B2 (en) 1997-07-11 2005-02-15 Pamgene International B.V. Device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device
GB9820163D0 (en) * 1998-09-17 1998-11-11 Sentec Ltd Micro-fabricated coded labels, reading systems and their applications
CA2378717A1 (en) * 1999-08-16 2001-02-22 Pamgene B.V. Preparation of metal oxide supports loaded with biomolecules
US6383748B1 (en) 1999-09-14 2002-05-07 Pamgene B.V. Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
US6656432B1 (en) * 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
JP2001186880A (ja) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Ｄｎａチップの製造方法
US6503736B1 (en) 1999-11-12 2003-01-07 BIOMéRIEUX, INC. Antibodies to crosslinkers and methods for using the same
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
WO2001073125A2 (en) * 2000-03-24 2001-10-04 Lyles Mark B High throughput screening array containing porous material
US6676904B1 (en) * 2000-07-12 2004-01-13 Us Gov Sec Navy Nanoporous membrane immunosensor
US7105134B2 (en) * 2001-03-13 2006-09-12 Pamgene B.V. Device for holding a substrate
US6886409B2 (en) 2001-03-13 2005-05-03 Pamgene International B.V. System for controlling the flow of a fluid through a substrate
US6869532B2 (en) 2001-06-04 2005-03-22 Cuno Incorporated Nucleic acid binding matrix
JP2005520484A (ja) * 2001-07-06 2005-07-14 ４５４ コーポレイション 多孔性フィルターを使用し、独立した並行する化学的微量反応を隔離するための方法
CA2482887A1 (en) * 2002-04-19 2003-10-30 Pamgene B.V. System, substrate plate and incubation device for conducting bioassays
US20030207099A1 (en) * 2002-05-01 2003-11-06 Gillmor Susan D. Low-contact-angle polymer membranes and method for fabricating micro-bioarrays
EP1513953A1 (de) 2002-06-03 2005-03-16 PamGene B.V. Verfahren für integrierte chemische und biochemische reaktionen mit hohem durchsatz
DE60307645T2 (de) * 2002-06-03 2007-09-13 Pamgene B.V. Hoch-durchsatz assay zur messung von zellulären antworten mit hilfe von mikroarrays
EP1512012B1 (de) * 2002-06-03 2006-10-25 PamGene B.V. Biomolekulares kinetik-messverfahren mit hilfe von einem durchfluss-mikroarray
US7153687B2 (en) * 2002-08-13 2006-12-26 Hong Kong Dna Chips Limited Apparatus and methods for detecting DNA in biological samples
AU2007224397B2 (en) * 2002-08-13 2011-06-02 Hai Kang Life Corporation Limited Apparatus and Methods for Detecting DNA in Biological Samples
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
CA2497288A1 (en) * 2002-09-02 2004-03-11 Pamgene B.V. Novel integrated microarray analysis
WO2004025563A1 (en) 2002-09-12 2004-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
EP1575707A1 (de) 2002-09-12 2005-09-21 Cyvera Corporation Verfahren und vorrichtung zur ausrichtung von länglichen mikroperlen zu deren untersuchung
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
WO2004048936A2 (en) * 2002-11-26 2004-06-10 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
EP1622714A1 (de) * 2003-04-10 2006-02-08 PamGene B.V. Verfahren zur immobilisierung von biomolekülen auf metalloxidträger
WO2004104584A1 (ja) * 2003-05-26 2004-12-02 Olympus Corporation 生体関連物質の検査方法と、そのための流体移送装置と流体移送方法
US20040259142A1 (en) * 2003-06-04 2004-12-23 Imperial College Innovations Limited Products and methods
GB0312747D0 (en) * 2003-06-04 2003-07-09 Imp College Innovations Ltd Products and methods
EP1660228A1 (de) * 2003-08-21 2006-05-31 PamGene B.V. Mikromatrizenträger für die synthese von bioproben
WO2005052582A2 (en) * 2003-11-28 2005-06-09 Pamgene B.V. Methods and apparatus for cell based microarray assays
JP2005204609A (ja) 2004-01-26 2005-08-04 Canon Inc 有機物固定化用キット、有機物固定化構造体及びその製造方法
EP1718411B1 (de) * 2004-02-11 2010-04-07 PamGene B.V. Vorrichtung zur analyse einer wechselwirkung zwischen target- und sondenmolekülen
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
CA2587674A1 (en) 2004-11-16 2006-05-26 Illumina, Inc. Method and apparatus for reading coded microbeads
WO2006055735A2 (en) 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
US20060141486A1 (en) * 2004-12-29 2006-06-29 Coonan Everett W Porous substrates and arrays comprising the same
CN101278186A (zh) * 2005-10-03 2008-10-01 皇家飞利浦电子股份有限公司 提高灵敏度的生物传感器
JP2009510427A (ja) * 2005-10-03 2009-03-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学的に整合された基板を有するバイオセンサ
WO2007041692A2 (en) * 2005-10-04 2007-04-12 Magic Technologies, Inc. Microfluidic detection of analytes
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
EP1960105A1 (de) * 2005-11-25 2008-08-27 Koninklijke Philips Electronics N.V. Mikrofluidische vorrichtung mit poröser membran und unverzweigtem kanal
CN101375166B (zh) 2006-01-25 2013-07-10 皇家飞利浦电子股份有限公司 用于分析流体的装置
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
JP2008249534A (ja) * 2007-03-30 2008-10-16 Sanyo Chem Ind Ltd 免疫測定用担体
EP2260943A1 (de) * 2009-06-11 2010-12-15 Innosieve Diagnostics B.V. Mikrofilter-Zentrifugenrohr
EP2756308A1 (de) 2011-09-16 2014-07-23 PamGene B.V. Verfahren zur vorhersage der reaktion auf eine endokrine therapie
CA2981990A1 (en) 2015-04-09 2016-10-13 Axela Inc. Disposable bioassay cartridge and method of performing multiple assay steps and fluid transfer within the cartridge
CA3091695A1 (en) 2018-02-20 2019-08-29 Prominent Medical Inc. Aluminum oxide surfaces and interface molecules

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
US3671410A (en) * 1970-02-16 1972-06-20 Philip Morris Inc Method for making metal oxide membranes
DE2429196A1 (de) 1973-07-09 1975-02-06 Corning Glass Works Poroese anorganische traeger mit iminogruppen
US4427415A (en) 1979-01-05 1984-01-24 Cleveland Patrick H Manifold vacuum biochemical test method and device
US4693985A (en) * 1984-08-21 1987-09-15 Pall Corporation Methods of concentrating ligands and active membranes used therefor
GB8426264D0 (en) 1984-10-17 1984-11-21 Alcan Int Ltd Porous films
US4777021A (en) 1986-04-25 1988-10-11 Richard K. Wertz Manifold vacuum device for biochemical and immunological uses
AU700315B2 (en) 1993-10-28 1998-12-24 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5772735A (en) * 1995-11-02 1998-06-30 University Of New Mexico Supported inorganic membranes
EP1050588B1 (de) 1997-07-11 2004-12-08 PamGene B.V. Verfahren zur Herstellung einer Vorrichtung zur Durchführung eines Tests, Verwendung einer Membran zur Herstellung dieser Vorrichtung, Kit mit dieser Vorrichtung und Analyseverfahren unter Verwendung dieses Gerätes

Also Published As

Publication number Publication date
US6864102B2 (en) 2005-03-08
PT975427E (pt) 2001-08-30
DE69800595D1 (de) 2001-04-19
PT1050588E (pt) 2005-04-29
ES2157669T3 (es) 2001-08-16
US6225131B1 (en) 2001-05-01
AU8863298A (en) 1999-02-08
EP0975427A1 (de) 2000-02-02
DK0975427T3 (da) 2001-07-09
WO1999002266A1 (en) 1999-01-21
EP1050588A1 (de) 2000-11-08
EP0975427B1 (de) 2001-03-14
JP3208390B2 (ja) 2001-09-10
KR20010020283A (ko) 2001-03-15
US20020127738A1 (en) 2002-09-12
US6635493B2 (en) 2003-10-21
GR3036010T3 (en) 2001-09-28
US20020102565A1 (en) 2002-08-01
JP2000515251A (ja) 2000-11-14
DE69828083D1 (de) 2005-01-13
ATE284451T1 (de) 2004-12-15
DE69800595T2 (de) 2001-10-18
CA2290945A1 (en) 1999-01-21
ATE199663T1 (de) 2001-03-15
ES2234513T3 (es) 2005-07-01
EP1050588B1 (de) 2004-12-08
DE69828083T2 (de) 2005-09-08
KR100421262B1 (ko) 2004-03-10
CA2290945C (en) 2002-05-28
AU724382B2 (en) 2000-09-21

Similar Documents

Publication Publication Date Title
DK1050588T3 (da) Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning
ATE327507T1 (de) Verdrängungstest auf einer porösen membran
AU579137B2 (en) Test device and a method for the detection of a component of a liquid sample
DK265688D0 (da) Fastfaseanalyse under anvendelse af kapillarstroemning
DK1157743T3 (da) Mikrofremstillet poröst gennemströmningsapparat til diskret påvisning af bindingsreaktioner
CA2383262A1 (en) Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
EP0806666A3 (de) Verfahren und Vorrichtung zur Einschrittbestimmung von Vollblut
ES2185709T3 (es) Aparato y metodo para realizar manipulaciones microfluidicas para analisis y sintesis quimicos.
WO2002097398A3 (en) Closed substrate platforms suitable for analysis of biomolecules
DK0910794T3 (da) Flerlagsenzymelektrodemembraner og fremgangsmåder til fremstilling deraf
DK1151300T3 (da) Assay til påvisning af en bindingspartner
MX9705535A (es) Portador de prueba diagnostica independiente del volumen y metodos en los cuales se usan para determinar un analito o substancia que se va a analizar.
AU6834700A (en) Device and method for determining multiple analytes
WO1999016781A3 (de) Automatisierbare universell anwendbare probenvorbereitungsmethode
DE59804930D1 (de) Kapillaraktives testelement mit träger und abdeckung
ATE268904T1 (de) Zellbasiertes festphasentest
CA2311165A1 (en) Improvements in or relating to electrochemical assays
DK1044376T3 (da) Analytisk metode, der gør brug af partikler, og testkit til udøvelse af metoden
CA2418520A1 (fr) Masque pour le depot et l'etalement de reactifs sur un support d'analyse
DE59907982D1 (de) Verfahren zum Nachweis einer bei Apoptose aktivierten Protease
WO2002057493A3 (en) Methods for determining organisms
WO2000029619A3 (en) Multielement analytical device for assay of nucleic acid sequences and uses therefore
DK0998974T3 (da) Fremgangsmåde til målrettet anbringelse af reagenser på immobiliseret biologisk materiale