DK1002108T3 - Anvendelse af MHC klasse II-ligander som adjuvans til vaccination af LAG-3 ved cancerbehandling - Google Patents

Anvendelse af MHC klasse II-ligander som adjuvans til vaccination af LAG-3 ved cancerbehandling

Info

Publication number: DK1002108T3
Authority: DK; Denmark
Prior art keywords: mhc class; lag; adjuvant; vaccination; ligands
Prior art date: 1997-07-25

Application number

DK98945090T

Other languages

English (en)

Inventor

Frederique Triebel

Original Assignee

Roussy Inst Gustave

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-25

Filing date

1998-07-23

Publication date

2006-08-21

1998-07-23 Application filed by Roussy Inst Gustave, Applied Research Systems filed Critical Roussy Inst Gustave

2006-08-21 Application granted granted Critical

2006-08-21 Publication of DK1002108T3 publication Critical patent/DK1002108T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Cell Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Virology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK98945090T 1997-07-25 1998-07-23 Anvendelse af MHC klasse II-ligander som adjuvans til vaccination af LAG-3 ved cancerbehandling DK1002108T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97401800A EP0893507A1 (en)	1997-07-25	1997-07-25	Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment

Publications (1)

Publication Number	Publication Date
DK1002108T3 true DK1002108T3 (da)	2006-08-21

Family

ID=8229825

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98945090T DK1002108T3 (da)	1997-07-25	1998-07-23	Anvendelse af MHC klasse II-ligander som adjuvans til vaccination af LAG-3 ved cancerbehandling

Country Status (20)

Country	Link
US (2)	US6410509B1 (da)
EP (3)	EP0893507A1 (da)
JP (1)	JP4723722B2 (da)
KR (1)	KR100603075B1 (da)
CN (1)	CN1184320C (da)
AT (2)	ATE324455T1 (da)
AU (1)	AU753738B2 (da)
BR (1)	BR9811037A (da)
CA (2)	CA2732570C (da)
DE (2)	DE69834330T2 (da)
DK (1)	DK1002108T3 (da)
EA (3)	EA005405B1 (da)
EE (1)	EE200000039A (da)
ES (1)	ES2262242T3 (da)
HK (1)	HK1030014A1 (da)
IL (2)	IL134212A0 (da)
NO (1)	NO20000378D0 (da)
PT (1)	PT1002108E (da)
UA (1)	UA75322C2 (da)
WO (1)	WO1999004810A2 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE519779T1 (de) *	2001-09-19	2011-08-15	Roussy Inst Gustave	An das glu-pro motiv-bindende proteine und peptide, diese enthaltende therapeutische zusammensetzungen und deren anwendungen
EP1596871A4 (en)	2003-02-28	2006-08-23	Drew M Pardoll	T-CELL REGULATION
KR20050082389A (ko) *	2004-02-18	2005-08-23	메덱스젠 주식회사	직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물
FR2868781B1 (fr) *	2004-04-13	2008-02-22	Immutep	Composition de vaccin comprenant un ligand cmh de classe ii couple a un antigene, procede de preparation et utilisations
EP1777523A1 (en) *	2005-10-19	2007-04-25	INSERM (Institut National de la Santé et de la Recherche Médicale)	An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
EP2044949A1 (en) *	2007-10-05	2009-04-08	Immutep	Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
WO2011031139A1 (en)	2009-09-09	2011-03-17	Universiteit Utrecht Holding B.V.	An ataq protein or a part thereof as a vaccine
SA110310855B1 (ar)	2009-11-13	2014-09-16	Laboratories Leti S L Unipersonal	استخدام مصدر l3 و/ أو l5 كلقاح أو كوسيلة تشخيصية لمرض طفيلي
PL2638062T3 (pl)	2010-11-10	2018-11-30	Laboratorios Leti, S.L.	Nowy adiuwant
GB201322626D0 (en)	2013-12-19	2014-02-05	Immutep S A	Combined preparations for the treatment of cancer
JOP20200094A1 (ar)	2014-01-24	2017-06-16	Dana Farber Cancer Inst Inc	جزيئات جسم مضاد لـ pd-1 واستخداماتها
CN103751778B (zh) *	2014-01-28	2016-09-28	复旦大学	3′-脱氧腺苷在制备广谱疫苗增效的免疫佐剂中的应用
ME03558B (me)	2014-03-14	2020-07-20	Novartis Ag	Molekuli anti-lag-3 antiтela i njihove upotrebe
AU2015329070B2 (en)	2014-10-07	2018-11-22	Nec Corporation	Hsp70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen-presenting cell
US9827308B2 (en)	2014-12-10	2017-11-28	Wisconsin Alumni Research Foundation	Mini-intronic plasmid DNA vaccines in combination with LAG3 blockade
GB201500374D0 (en)	2015-01-09	2015-02-25	Immutep S A	Combined preparations for the treatment of cancer
TW202115102A (zh)	2015-03-09	2021-04-16	日商賽多利克公司	來自gpc3之胜肽、使用此胜肽之用於治療或預防癌症之醫藥組成物、免疫誘導劑、及抗原呈現細胞之製造方法
TWI738646B (zh)	2015-04-07	2021-09-11	日商賽多利克公司	醫藥組成物
JP6925980B2 (ja)	2015-05-13	2021-08-25	アジェナスインコーポレイテッド	がんの処置および予防のためのワクチン
IL274572B2 (en)	2015-07-16	2024-01-01	Biolinerx Ltd	Compositions and methods for treating cancer
US10265379B2 (en)	2015-09-16	2019-04-23	Annabelle Rodriguez Oquendo	Use of recombinant lymphocyte activation gene-3 as a companion therapeutic for patients at risk for cardiovascular disease and other chronic inflammatory diseases
WO2017046409A1 (en)	2015-09-18	2017-03-23	Rijksuniversiteit Groningen	Long chain inulin for stimulating an immune response
BR112019006075A2 (pt)	2016-10-11	2019-06-18	Cytlimic Inc	medicamento
CN108204958A (zh) *	2016-12-19	2018-06-26	伊缪泰普有限公司	结合测定
JP2021522239A (ja)	2018-04-26	2021-08-30	アジェナスインコーポレイテッド	熱ショックタンパク質結合ペプチド組成物およびその使用方法
CA3114585A1 (en) *	2018-09-27	2020-04-02	Genocea Biosciences, Inc.	Treatment methods
JP2020138940A (ja)	2019-02-28	2020-09-03	テルモ株式会社	治療方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ226414A (en) *	1987-10-02	1992-07-28	Genentech Inc	Cd4 peptide adhesion variants and their preparation and use
JPH03505039A (ja) *	1988-08-22	1991-11-07	アメリカ合衆国	可溶性ｃｄ４を発現するレトロウイルスベクター、エイズの遺伝子治療法
JPH02231083A (ja) *	1988-08-31	1990-09-13	Eisai Co Ltd	組換ナチュラルキラー細胞活性化因子
IL93599A0 (en) *	1989-03-03	1990-12-23	Microgenesys Inc	Kit and/or composition for the prevention or treatment of aids
EP0394827A1 (en) *	1989-04-26	1990-10-31	F. Hoffmann-La Roche Ag	Chimaeric CD4-immunoglobulin polypeptides
FR2656800B1 (fr) *	1990-01-08	1992-05-15	Roussy Inst Gustave	Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US5851828A (en) *	1991-03-07	1998-12-22	The General Hospital Corporation	Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
EP0681483B1 (en) *	1993-01-26	2005-08-24	The Trustees of the University of Pennsylvania (a corporation of Pennsylvania)	Compositions and methods for delivery of genetic material
SE510135C2 (sv) *	1994-05-05	1999-04-19	Berol Nobel Ab	Vattenhaltig suspension av en cellulosaeter, sätt för dess framställning samt komposition
CN1110557C (zh) *	1994-05-06	2003-06-04	古斯达威罗斯研究所	Lag－3蛋白的可溶性多肽组分;生产方法、治疗组合物、抗独特型抗体
CA2194488A1 (en) *	1994-08-05	1996-02-15	Tod Paul Holler	Method of using transdominant negative retroviral integrase in the treatment of retroviral infection
JP2001506122A (ja) *	1994-12-07	2001-05-15	エフ．ホフマン−ラロシュアーゲー	免疫抑制作用を有するモノクローナル抗体断片
EP0800534A2 (en) *	1994-12-23	1997-10-15	Laboratoires Om S.A.	Use of mhc-ii binding and/or mhc-ii mimicking molecules for the prevention and/or treatment of inflammatory diseases
EP0869803B1 (en) *	1995-12-28	2003-04-16	The Johns Hopkins University School Of Medicine	Allogeneic paracrine cytokine tumor vaccines

1997
- 1997-07-25 EP EP97401800A patent/EP0893507A1/en not_active Withdrawn
1998
- 1998-07-23 BR BR9811037-3A patent/BR9811037A/pt not_active IP Right Cessation
- 1998-07-23 DE DE69834330T patent/DE69834330T2/de not_active Expired - Lifetime
- 1998-07-23 WO PCT/EP1998/004621 patent/WO1999004810A2/en active IP Right Grant
- 1998-07-23 AU AU92547/98A patent/AU753738B2/en not_active Expired
- 1998-07-23 EE EEP200000039A patent/EE200000039A/xx unknown
- 1998-07-23 CN CNB988075474A patent/CN1184320C/zh not_active Expired - Lifetime
- 1998-07-23 EA EA200200565A patent/EA005405B1/ru not_active IP Right Cessation
- 1998-07-23 JP JP2000503862A patent/JP4723722B2/ja not_active Expired - Lifetime
- 1998-07-23 ES ES98945090T patent/ES2262242T3/es not_active Expired - Lifetime
- 1998-07-23 EP EP06008545A patent/EP1698701B1/en not_active Expired - Lifetime
- 1998-07-23 CA CA2732570A patent/CA2732570C/en not_active Expired - Lifetime
- 1998-07-23 DE DE69841866T patent/DE69841866D1/de not_active Expired - Lifetime
- 1998-07-23 DK DK98945090T patent/DK1002108T3/da active
- 1998-07-23 UA UA2000020976A patent/UA75322C2/uk unknown
- 1998-07-23 CA CA2293805A patent/CA2293805C/en not_active Expired - Lifetime
- 1998-07-23 EA EA200000161A patent/EA003740B1/ru not_active IP Right Cessation
- 1998-07-23 EP EP98945090A patent/EP1002108B1/en not_active Expired - Lifetime
- 1998-07-23 IL IL13421298A patent/IL134212A0/xx unknown
- 1998-07-23 AT AT98945090T patent/ATE324455T1/de active
- 1998-07-23 AT AT06008545T patent/ATE478956T1/de not_active IP Right Cessation
- 1998-07-23 KR KR1020007000265A patent/KR100603075B1/ko not_active IP Right Cessation
- 1998-07-23 EA EA200300092A patent/EA200300092A1/ru unknown
- 1998-07-23 PT PT98945090T patent/PT1002108E/pt unknown
2000
- 2000-01-24 IL IL134212A patent/IL134212A/en not_active IP Right Cessation
- 2000-01-25 NO NO20000378A patent/NO20000378D0/no not_active Application Discontinuation
- 2000-01-27 US US09/492,113 patent/US6410509B1/en not_active Expired - Lifetime
2001
- 2001-01-30 HK HK01100662A patent/HK1030014A1/xx not_active IP Right Cessation
2002
- 2002-01-10 US US10/041,600 patent/US7109026B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7109026B2 (en)	2006-09-19
WO1999004810A3 (en)	1999-07-08
EP1698701B1 (en)	2010-08-25
ATE324455T1 (de)	2006-05-15
AU753738B2 (en)	2002-10-24
DE69841866D1 (de)	2010-10-07
CA2732570C (en)	2014-11-18
NO20000378L (no)	2000-01-25
EA200200565A1 (ru)	2002-10-31
CN1184320C (zh)	2005-01-12
EA003740B1 (ru)	2003-08-28
KR100603075B1 (ko)	2006-07-20
BR9811037A (pt)	2000-08-01
US6410509B1 (en)	2002-06-25
EP1002108A2 (en)	2000-05-24
WO1999004810A2 (en)	1999-02-04
KR20010021706A (ko)	2001-03-15
HK1030014A1 (en)	2001-04-20
EE200000039A (et)	2000-10-16
NO20000378D0 (no)	2000-01-25
US20020192195A1 (en)	2002-12-19
JP4723722B2 (ja)	2011-07-13
DE69834330D1 (de)	2006-06-01
EA005405B1 (ru)	2005-02-24
PT1002108E (pt)	2006-09-29
AU9254798A (en)	1999-02-16
DE69834330T2 (de)	2007-03-29
EA200000161A1 (ru)	2000-10-30
EP0893507A1 (en)	1999-01-27
EP1698701A1 (en)	2006-09-06
IL134212A0 (en)	2001-04-30
EA200300092A1 (ru)	2003-06-26
CA2293805A1 (en)	1999-02-04
CA2732570A1 (en)	1999-02-04
ATE478956T1 (de)	2010-09-15
CA2293805C (en)	2011-05-03
IL134212A (en)	2012-03-29
EP1002108B1 (en)	2006-04-26
JP2001510806A (ja)	2001-08-07
CN1265149A (zh)	2000-08-30
UA75322C2 (en)	2006-04-17
ES2262242T3 (es)	2006-11-16

Publication	Publication Date	Title
DK1002108T3 (da)	2006-08-21	Anvendelse af MHC klasse II-ligander som adjuvans til vaccination af LAG-3 ved cancerbehandling
BR0116169A (pt)	2003-12-23	Composto, composição farmacêutica que compreende esse composto, processo para a preparação de uma composição farmacêutica, utilização dos compostos, processo para o tratamento profilático ou terapêutico de diabetes do tipo ii e processo para a preparação do composto.
BR8300475A (pt)	1983-11-01	Composto, composicao farmaceutica, processo para tratamento de infeccao virotica em um animal de sangue quente ou de sangue frio, e processo para a preparacao de tal composto
ID21529A (id)	1999-06-24	Metode dan komposisi untuk pengobatan dan pencegahan tumor, gangguan yang berhubungan dengan tumor dan kakeksia
EP1005368A4 (en)	2004-09-29	USE OF NON-METHYLATED CpG DINUCLEOTIDE AS ADJUVANS
DK1409006T3 (da)	2011-06-14	Monodispergerede blandinger og fremgangsmåder til behandling af diabetes
PT1187629E (pt)	2005-02-28	Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador
DK16487A (da)	1987-03-16	Vacciner til oral indgift
BG95935A (bg)	1993-12-24	Метод и средство за приемане на дексмедетомидин директно през кожата
DK0955995T3 (da)	2006-08-28	Anvendelse af komplekser til fremstilling af præparater til behandling af sensibel hud, fremgangsmåde til fremstilling af hypoallergene præparater
BR9814923A (pt)	2000-10-17	Método para tratamento de doença de alzheimer
DK0751781T3 (da)	2004-08-09	Anvendelse af monoklonale antistoffer eller oplöselige oligomere ligander til fremstillingen af et medikament til forebyggelse eller behandling af neoplastiske sygdomme
BR0213540A (pt)	2004-10-19	Compostos, método para o tratamento de enfermidades ou distúrbios em um paciente e composição farmacêutica que compreende os mesmos
EP0722324A4 (en)	1999-06-16	PHARMACEUTICAL COMPOSITION FOR IMMUNITIMULATING THERAPY
DE69130071D1 (de)	1998-10-01	Zusammensetzung verwendbar als therapeutisches mittel gegen chronische virale leberkrankheiten
CA2034484A1 (en)	1990-12-20	Radioimmunotherapy using .alpha.-particles emission
DE60015084D1 (de)	2004-11-25	Verbesserung der bakterizidaktivität von neisseria antigenen mit cg enthaltende oligonukleotiden
BR9610679A (pt)	1999-03-30	Antígenos de leishmania para uso na terapia e disgnose da leishmaniose
PT845998E (pt)	2002-04-29	Medicamentos para imunoterapia contendo anticorpos que reconhecem de forma especifica o antigenio mhcii de um paciente a ser tratado
EP1037918A4 (en)	2004-11-03	METHOD AND COMPOSITIONS FOR INCREASING THE EFFICIENCY OF VACCINALS USING CHEMOKINES
WO1998035045A3 (en)	1998-10-29	Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
WO2002072013A3 (en)	2003-12-11	Method of treating malignancies through induction of blood immune responses
BR0212446A (pt)	2004-08-17	Uso de 4-piridilmetilftalazinas para tratamento de câncer
DK0835309T3 (da)	2002-12-02	Vaccine imod infektiøse agenser, præparat til behandling og forebyggelse af HIV infektioner
ATE345838T1 (de)	2006-12-15	Verfahren und mittel zur prävention, hemmung und therapie von krebserkrankungen