DK0777498T3 - Konjugater fremstillet af metalkomplekser og oligonucleotider - Google Patents

Konjugater fremstillet af metalkomplekser og oligonucleotider

Info

Publication number: DK0777498T3
Authority: DK; Denmark
Prior art keywords: oligonucleotides; metal complexes; complex; bound; complexing agent
Prior art date: 1994-07-14

Application number

DK95925792T

Other languages

English (en)

Inventor

Ulrich Niedballa

Ulrich Speck

Johannes Platzek

Bernd Raduechel

Ludger Dinkelborg

Larry Gold

Wolfgang Pieken

Christoph-Stephan Hilger

Original Assignee

Schering Ag

Nexstar Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-14

Filing date

1995-06-30

Publication date

2004-08-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25938359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0777498(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-07-14 Priority claimed from DE4424922A external-priority patent/DE4424922A1/de

1994-12-05 Priority claimed from DE19944445078 external-priority patent/DE4445078A1/de

1995-06-30 Application filed by Schering Ag, Nexstar Pharmaceuticals Inc filed Critical Schering Ag

2004-08-16 Application granted granted Critical

2004-08-16 Publication of DK0777498T3 publication Critical patent/DK0777498T3/da

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 5
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 3
239000002184 metal Substances 0.000 title 1
239000008139 complexing agent Substances 0.000 abstract 2
101710163270 Nuclease Proteins 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

DK95925792T 1994-07-14 1995-06-30 Konjugater fremstillet af metalkomplekser og oligonucleotider DK0777498T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4424922A DE4424922A1 (de)	1994-07-14	1994-07-14	Konjugate aus Metallkomplexen und Oligonucleotiden, die spezifisch an bestimmte Zielstrukturen binden
DE19944445078 DE4445078A1 (de)	1994-12-05	1994-12-05	Konjugate aus Metallkomplexen und Oligonucleotiden, diese enthaltende Mittel, deren Verwendung in der Radiodiagnostik sowie Verfahren zu deren Herstellung

Publications (1)

Publication Number	Publication Date
DK0777498T3 true DK0777498T3 (da)	2004-08-16

Family

ID=25938359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95925792T DK0777498T3 (da)	1994-07-14	1995-06-30	Konjugater fremstillet af metalkomplekser og oligonucleotider

Country Status (23)

Country	Link
EP (1)	EP0777498B1 (da)
JP (2)	JPH10503182A (da)
KR (1)	KR100366525B1 (da)
CN (1)	CN1219551C (da)
AT (1)	ATE265229T1 (da)
AU (1)	AU2979195A (da)
CA (1)	CA2194558A1 (da)
CZ (1)	CZ295930B6 (da)
DE (1)	DE69532958T2 (da)
DK (1)	DK0777498T3 (da)
ES (1)	ES2220933T3 (da)
HU (1)	HU220859B1 (da)
IL (1)	IL114237A (da)
MX (1)	MX9606443A (da)
NO (1)	NO318585B1 (da)
NZ (1)	NZ289831A (da)
PL (1)	PL318147A1 (da)
PT (1)	PT777498E (da)
RU (1)	RU2165771C2 (da)
SK (1)	SK284598B6 (da)
TW (1)	TW502040B (da)
UA (1)	UA48140C2 (da)
WO (1)	WO1996002274A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2259493A1 (en) *	1996-07-03	1998-01-08	President And Fellows Of Harvard College	Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US6335437B1 (en) *	1998-09-07	2002-01-01	Isis Pharmaceuticals, Inc.	Methods for the preparation of conjugated oligomers
BRPI0711182A2 (pt) *	2006-05-03	2011-08-23	Baltic Technology Dev	agentes anti-sentido combinando base fortemente ligada-oligonucleotìdeo modificado e nuclease artificial
GB201012418D0 (en) *	2010-07-23	2010-09-08	Santaris Pharma As	Process
US10357578B2 (en)	2014-05-13	2019-07-23	Paul Scherrer Institut	Production of 43SC radionuclide and radiopharmaceuticals thereof for use in positron emission tomography

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5013831A (en) *	1984-01-30	1991-05-07	Enzo Biochem, Inc.	Detectable molecules, method of preparation and use
WO1988009152A1 (en) *	1985-03-19	1988-12-01	Mills Randell L	Apparatus providing diagnosis and selective tissue necrosis
US5057302A (en) *	1987-02-13	1991-10-15	Abbott Laboratories	Bifunctional chelating agents
WO1989000062A1 (en) *	1987-07-07	1989-01-12	The Cancer Institute Board	Radiotherapy
US5457183A (en) *	1989-03-06	1995-10-10	Board Of Regents, The University Of Texas System	Hydroxylated texaphyrins
US5270163A (en) *	1990-06-11	1993-12-14	University Research Corporation	Methods for identifying nucleic acid ligands
DK0533838T3 (da) *	1990-06-11	1998-02-23	Nexstar Pharmaceuticals Inc	Nukleinsyreligander
IE914220A1 (en) *	1990-12-10	1992-06-17	Akzo Nv	Labelled, modified oligonucleotides
EP0588229A3 (en) *	1992-09-12	1994-06-15	Hoechst Ag	Macrocyclic chelating agents for the preparation of technetium or rhenium complexes

1995
- 1995-06-20 IL IL11423795A patent/IL114237A/xx not_active IP Right Cessation
- 1995-06-30 CN CNB951940007A patent/CN1219551C/zh not_active Expired - Fee Related
- 1995-06-30 UA UA97020642A patent/UA48140C2/uk unknown
- 1995-06-30 JP JP8504630A patent/JPH10503182A/ja not_active Withdrawn
- 1995-06-30 HU HU9700100A patent/HU220859B1/hu not_active IP Right Cessation
- 1995-06-30 SK SK28-97A patent/SK284598B6/sk not_active IP Right Cessation
- 1995-06-30 WO PCT/EP1995/002539 patent/WO1996002274A1/en active IP Right Grant
- 1995-06-30 AU AU29791/95A patent/AU2979195A/en not_active Abandoned
- 1995-06-30 PT PT95925792T patent/PT777498E/pt unknown
- 1995-06-30 NZ NZ289831A patent/NZ289831A/xx not_active IP Right Cessation
- 1995-06-30 CA CA002194558A patent/CA2194558A1/en not_active Abandoned
- 1995-06-30 MX MX9606443A patent/MX9606443A/es not_active IP Right Cessation
- 1995-06-30 AT AT95925792T patent/ATE265229T1/de not_active IP Right Cessation
- 1995-06-30 KR KR1019970700223A patent/KR100366525B1/ko not_active IP Right Cessation
- 1995-06-30 PL PL95318147A patent/PL318147A1/xx unknown
- 1995-06-30 EP EP95925792A patent/EP0777498B1/en not_active Expired - Lifetime
- 1995-06-30 CZ CZ1997114A patent/CZ295930B6/cs not_active IP Right Cessation
- 1995-06-30 RU RU97102039/14A patent/RU2165771C2/ru not_active IP Right Cessation
- 1995-06-30 ES ES95925792T patent/ES2220933T3/es not_active Expired - Lifetime
- 1995-06-30 DK DK95925792T patent/DK0777498T3/da active
- 1995-06-30 DE DE69532958T patent/DE69532958T2/de not_active Expired - Fee Related
- 1995-10-14 TW TW084110812A patent/TW502040B/zh not_active IP Right Cessation
1997
- 1997-01-13 NO NO19970141A patent/NO318585B1/no not_active IP Right Cessation
2009
- 2009-06-04 JP JP2009134684A patent/JP2009197024A/ja active Pending

Also Published As

Publication number	Publication date
EP0777498B1 (en)	2004-04-28
NO970141L (no)	1997-03-14
CA2194558A1 (en)	1996-02-01
NO970141D0 (no)	1997-01-13
JPH10503182A (ja)	1998-03-24
SK2897A3 (en)	1997-09-10
HU220859B1 (en)	2002-06-29
AU2979195A (en)	1996-02-16
CN1152879A (zh)	1997-06-25
TW502040B (en)	2002-09-11
WO1996002274A1 (en)	1996-02-01
NZ289831A (en)	1999-01-28
RU2165771C2 (ru)	2001-04-27
NO318585B1 (no)	2005-04-11
CZ295930B6 (cs)	2005-12-14
PL318147A1 (en)	1997-05-12
PT777498E (pt)	2004-09-30
MX9606443A (es)	1997-12-31
JP2009197024A (ja)	2009-09-03
CZ11497A3 (cs)	1998-08-12
CN1219551C (zh)	2005-09-21
UA48140C2 (uk)	2002-08-15
EP0777498A1 (en)	1997-06-11
KR100366525B1 (ko)	2003-03-15
ATE265229T1 (de)	2004-05-15
HU9700100D0 (en)	1997-02-28
SK284598B6 (sk)	2005-07-01
DE69532958T2 (de)	2009-04-09
DE69532958D1 (de)	2004-06-03
IL114237A0 (en)	1995-10-31
KR970704471A (ko)	1997-09-06
HUT76329A (en)	1997-08-28
IL114237A (en)	2000-08-31
ES2220933T3 (es)	2004-12-16

Publication	Publication Date	Title
ATE228361T1 (de)	2002-12-15	Reduzierung der kardiotoxizität von antitumormitteln mit manganverbindungen
DK0871649T3 (da)	2003-03-24	Konjugater af et polypeptid og en biokompatibel polymer
MXPA02010801A (es)	2004-09-06	Agentes diagnosticos, de representacion y terapeuticos cationicos asociados con sitios vasculares activados.
NO166267C (no)	1991-06-26	Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet.
ATE120457T1 (de)	1995-04-15	Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikörper.
DK0841949T3 (da)	2006-08-21	Anvendelse af saccharid-konjugater
DK1242115T3 (da)	2009-10-05	Kemisk programmerbar immunitet
ES2109495T3 (es)	1998-01-16	Tioureas sustituidas utilizadas como agentes quelantes bifuncionales.
EP2112165A3 (en)	2011-03-23	Methods and compositions for the treatment of glomerulonephritis and other inflammatory diseases
TR200003161T2 (tr)	2001-01-22	Poliol-IFN-Beta konjugatları
WO2001076645A3 (en)	2002-09-19	Targeted agents useful for diagnostic and therapeutic applications
CA2001765A1 (en)	1990-04-30	Chelants possessing ortho ligating functionality and complexes thereof
WO2000013712A3 (en)	2000-09-28	Methods and compositions for the prevention or treatment of cancer
EP1071443A4 (en)	2004-10-27	ISOLATED PEPTIDES CORRESPOND THE NY-ESO-1 AMINO ACID SEQUENCES AND BIND TO MHC CLASS I AND MHC CLASS II MOLECULES AND THEIR USE
DK0777498T3 (da)	2004-08-16	Konjugater fremstillet af metalkomplekser og oligonucleotider
WO1996040273A3 (en)	1997-03-27	Conjugates of ferrites and oligonucleotides, which bond specifically to certain target structures
EP1234585A3 (en)	2004-01-21	Methods and compositions for the prevention or treatment of cancer
TR200000728T2 (tr)	2000-09-21	Kronik hepatit C' nin tedavisinde IFN-alfa ve amantadin kullanımı.
ES1035180U (es)	1997-03-16	Armadura para refuerzo de terrenos.