[go: up one dir, main page]

DK0770077T3 - Fremgangsmåde til fremstilling af 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1h-benz[de]isoquinolin-1-on og mellemprodukter - Google Patents

Fremgangsmåde til fremstilling af 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1h-benz[de]isoquinolin-1-on og mellemprodukter

Info

Publication number
DK0770077T3
DK0770077T3 DK95925803T DK95925803T DK0770077T3 DK 0770077 T3 DK0770077 T3 DK 0770077T3 DK 95925803 T DK95925803 T DK 95925803T DK 95925803 T DK95925803 T DK 95925803T DK 0770077 T3 DK0770077 T3 DK 0770077T3
Authority
DK
Denmark
Prior art keywords
isoquinolin
benz
azabicyclo
tetrahydro
oct
Prior art date
Application number
DK95925803T
Other languages
English (en)
Inventor
Alois Dvorak Charles
Andrew Kowalczyk Bruce
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23040964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0770077(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0770077T3 publication Critical patent/DK0770077T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95925803T 1994-07-08 1995-07-01 Fremgangsmåde til fremstilling af 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1h-benz[de]isoquinolin-1-on og mellemprodukter DK0770077T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/272,715 US5567818A (en) 1994-07-08 1994-07-08 Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein
PCT/EP1995/002556 WO1996001824A1 (en) 1994-07-08 1995-07-01 Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1h-benz(de)isoquinolin-1-one and intermediate product

Publications (1)

Publication Number Publication Date
DK0770077T3 true DK0770077T3 (da) 2002-01-14

Family

ID=23040964

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95925803T DK0770077T3 (da) 1994-07-08 1995-07-01 Fremgangsmåde til fremstilling af 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1h-benz[de]isoquinolin-1-on og mellemprodukter

Country Status (16)

Country Link
US (1) US5567818A (da)
EP (1) EP0770077B1 (da)
JP (1) JP2898758B2 (da)
CN (1) CN1048727C (da)
AT (1) ATE205845T1 (da)
AU (1) AU2979995A (da)
BR (1) BR9508249A (da)
CL (2) CL2004001244A1 (da)
CY (1) CY2342B1 (da)
DE (1) DE69522808T2 (da)
DK (1) DK0770077T3 (da)
ES (1) ES2162929T3 (da)
FI (1) FI120198B (da)
MX (1) MX9700157A (da)
PT (1) PT770077E (da)
WO (1) WO1996001824A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO120468B1 (ro) 2000-04-20 2006-02-28 Masonite Corporation Articol compozit din material lemnos presat în relief şi metodă de obţinere a acestuia
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
US8614225B2 (en) * 2006-08-30 2013-12-24 Dr. Reddy's Laboratories Limited Process for the purification of palonosetron or its salt
WO2008051539A2 (en) * 2006-10-23 2008-05-02 Sicor Inc. Processes for preparing palonosetron salts
JP2010512333A (ja) * 2006-12-07 2010-04-22 ヘルシン ヘルスケア ソシエテ アノニム 塩酸パロノセトロンの結晶及び非晶質形
WO2008146283A2 (en) * 2007-05-29 2008-12-04 Chemagis Ltd. Novel palonosetron salts and processes for preparation and purification thereof
WO2009010987A1 (en) * 2007-07-19 2009-01-22 Natco Pharma Limited An improved process for the preparation of pure palonosetron hydrochloride
AR069625A1 (es) * 2007-12-13 2010-02-03 Glenmark Generics Ltd Base libre de palonosetron y procedimiento para su preparacion
WO2009087643A1 (en) * 2008-01-11 2009-07-16 Natco Pharma Limited Novel crystalline forms of palonosetron hydrochloride
WO2009136405A1 (en) * 2008-05-05 2009-11-12 Natco Pharma Limited High purity palonosetron base and its solid state characteristics
WO2010056656A2 (en) * 2008-11-11 2010-05-20 Dr. Reddy's Laboratories Ltd. Preparation of crystalline palonosetron hydrochloride
CN101851233B (zh) * 2009-04-03 2013-03-06 四川滇虹医药开发有限公司 盐酸帕洛诺司琼和其前体化合物及制备
WO2011001400A2 (en) 2009-06-30 2011-01-06 Ranbaxy Laboratories Limited Processes for the preparation of form i and form ii of palonosetron hydrochloride
WO2011013095A1 (en) 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Processes for the preparation of palonosetron
JP2014070036A (ja) * 2012-09-28 2014-04-21 Mitsubishi Gas Chemical Co Inc １，８−テトラリンジカルボン酸無水物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007191A (en) * 1975-10-14 1977-02-08 E. R. Squibb & Sons, Inc. 2-(Piperidinyl or tetrahydropyridinyl)-alkyl)-2,3-dihydro-3-hydroxy-1H-benz(DE)isoquinolin-1-ones
IL110622A (en) * 1989-11-28 1995-03-30 Syntex Inc Bicyclic carboxamides n-substituted by bridged bicyclic amines
US5202318A (en) * 1990-05-14 1993-04-13 Syntex (U.S.A.) Inc. Tricyclic compounds acting at serotonin receptor subtypes

Also Published As

Publication number Publication date
MX9700157A (es) 1997-04-30
FI970068A0 (fi) 1997-01-07
ATE205845T1 (de) 2001-10-15
EP0770077A1 (en) 1997-05-02
CL2007001958A1 (es) 2008-02-22
PT770077E (pt) 2002-02-28
WO1996001824A1 (en) 1996-01-25
JPH09508645A (ja) 1997-09-02
JP2898758B2 (ja) 1999-06-02
DE69522808T2 (de) 2002-04-04
FI120198B (fi) 2009-07-31
ES2162929T3 (es) 2002-01-16
DE69522808D1 (de) 2001-10-25
AU2979995A (en) 1996-02-09
CL2004001244A1 (es) 2005-04-15
US5567818A (en) 1996-10-22
BR9508249A (pt) 1998-01-06
CN1152313A (zh) 1997-06-18
CN1048727C (zh) 2000-01-26
CY2342B1 (en) 2004-02-06
EP0770077B1 (en) 2001-09-19
FI970068A (fi) 1997-01-07

Similar Documents

Publication Publication Date Title
DK0770077T3 (da) Fremgangsmåde til fremstilling af 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1h-benz[de]isoquinolin-1-on og mellemprodukter
DK0770615T3 (da) Fremgangsmåde til fremstilling af dihalogenazolopyrimidiner
DE3581512D1 (de) Verfahren zur herstellung von pyrrolo-(3,4-c)-pyrrolen und neue pyrrolo-(3,4-c)-pyrrole.
DK1032566T3 (da) Fremgangsmåde til fremstilling af citalopram
DK0787115T3 (da) Fremgangsmåde til fremstilling af 4a,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepinderivater
FI960949L (fi) Uusi lipaasi, lipaasia tuottavat mikro-organismit, menetelmä lipaasin tuottamiseksi ja lipaasin käyttö
DK0839138T3 (da) Fremgangsmåde til fremstilling af N-substituerede 3-hydroxypyrazoler
DK0417680T3 (da) Fremgangsmåde til fremstilling af 1,1,1,2-tetrafluorethan
DK0805806T3 (da) Fremgangsmåde til fremstilling af 4,10-diacetoxy-2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxotax-11-en-13alpha-
DE59105224D1 (de) Verfahren zur Herstellung von N-substituierten Pyrrolidonen.
DE69738985D1 (de) Raffinosesynthetase gen, verfahren zur herstellung von raffinose und transformierte pflanze
ATE232721T1 (de) Verfahren zur vermehrung der produktion und zur verbesserung der qualität von sperma
DK0815092T3 (da) Fremgangsmåde til fremstilling af 1,2-benzisothiazolin-3-oner
DK0648738T3 (da) Fremgangsmåde til fremstilling af acetoacetarylamider
DE59006268D1 (de) Verfahren zur Herstellung von Propylen-Ethylen-Copolymerisaten.
DE59911288D1 (de) Verfahren zur herstellung von tetrahydrofuran
ATE233323T1 (de) Verfahren zur präparation von enantiomer- angereicherten, n-derivatisierten laktamen.
DK153592A (da) Fremgangsmåde til fremstilling af 2,3,5,6-tetrachlorpyridin
FI900175A0 (fi) Menetelmä valmistaa farmaseuttisesti arvokkaita fuusioituja bentsatsepiineja
FR2719580B1 (fr) Procédé de préparation d'octadiénols.
NO303495B1 (no) FremgangsmÕte til fremstilling av N-alkyl-laktamer
DK0796256T3 (da) Fremgangsmåde til fremstilling af ranitidin
DE69112236D1 (de) Verfahren zur mikrobiologischen Herstellung von Ironen.
DK0730861T3 (da) Anvendelse af 6,7-substituerede 2-aminotetraliner til fremstilling af farmaceutiske præparater, der er nyttige til behandli
DK0377437T3 (da) Fremgangsmåde til fremstilling af 2,4-diamino-6-piperidinylpyrimidin-3-N-oxid