DK0748800T3 - Pyrimidindion-, pyrimidintrion- og triazindionderivater som alfa-1-adrenergiske receptorantagonister - Google Patents

Pyrimidindion-, pyrimidintrion- og triazindionderivater som alfa-1-adrenergiske receptorantagonister

Info

Publication number: DK0748800T3
Authority: DK; Denmark
Prior art keywords: intrion; pyrimidinedione; pyrimidine; alpha; receptor antagonists
Prior art date: 1995-06-09

Application number

DK96108493T

Other languages

English (en)

Inventor

Francisco J Lopez-Tapia

David J Morgans Jr

Arturo Perez-Medrano

Juerg R Pfister

Eric B Sjogren

Francisco X Talamas

Gary W Bantle

Todd R Elworthy

Angel Guzman

Saul Jaime-Figueroa

J Jr Morgans David

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-09

Filing date

1996-05-28

Publication date

2001-08-27

1996-05-28 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2001-08-27 Application granted granted Critical

2001-08-27 Publication of DK0748800T3 publication Critical patent/DK0748800T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK96108493T 1995-06-09 1996-05-28 Pyrimidindion-, pyrimidintrion- og triazindionderivater som alfa-1-adrenergiske receptorantagonister DK0748800T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48918395A	1995-06-09	1995-06-09

Publications (1)

Publication Number	Publication Date
DK0748800T3 true DK0748800T3 (da)	2001-08-27

Family

ID=23942748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96108493T DK0748800T3 (da)	1995-06-09	1996-05-28	Pyrimidindion-, pyrimidintrion- og triazindionderivater som alfa-1-adrenergiske receptorantagonister

Country Status (32)

Country	Link
EP (1)	EP0748800B1 (da)
JP (1)	JP2721147B2 (da)
KR (1)	KR100446877B1 (da)
CN (1)	CN1118459C (da)
AR (1)	AR003428A1 (da)
AT (1)	ATE201016T1 (da)
AU (1)	AU710754B2 (da)
BR (1)	BR9602705A (da)
CA (1)	CA2178548A1 (da)
CO (1)	CO4700472A1 (da)
CZ (1)	CZ290004B6 (da)
DE (1)	DE69612698T2 (da)
DK (1)	DK0748800T3 (da)
ES (1)	ES2157366T3 (da)
GR (1)	GR3036307T3 (da)
HK (1)	HK1013065A1 (da)
HU (1)	HU223594B1 (da)
IL (1)	IL118519A (da)
MA (1)	MA23899A1 (da)
MY (1)	MY113499A (da)
NO (1)	NO309424B1 (da)
NZ (1)	NZ286720A (da)
PE (1)	PE46497A1 (da)
PL (1)	PL188061B1 (da)
PT (1)	PT748800E (da)
RU (1)	RU2175322C2 (da)
SA (1)	SA96170263B1 (da)
SG (1)	SG45486A1 (da)
TR (1)	TR970073A2 (da)
TW (1)	TW340846B (da)
UY (1)	UY24257A1 (da)
ZA (1)	ZA964561B (da)

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WO2000029386A1 (en)	1998-11-12	2000-05-25	Merck & Co., Inc.	Pyrimidinedione derivatives useful as alpha 1a adrenoceptor antagonists
US6358959B1 (en)	1999-01-26	2002-03-19	Merck & Co., Inc.	Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists
US6387909B1 (en)	1999-07-30	2002-05-14	Recordati S.A. Chemical And Pharmaceutical Company	Thienopyranecarboxamide derivatives
US6306861B1 (en)	1999-07-30	2001-10-23	Recordati S.A. Chemical And Pharmaceutical Company	Thienopyrancecarboxamide derivatives
GB2355263A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
GB2355456A (en)	1999-09-30	2001-04-25	Merck & Co Inc	Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en)	1999-09-30	2001-04-25	Merck & Co Inc	Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
US6403594B1 (en)	1999-10-18	2002-06-11	Recordati, S.A. Chemical And Pharmaceutical Company	Benzopyran derivatives
US6365591B1 (en)	1999-10-18	2002-04-02	Recordati, S.A., Chemical And Pharmacueticals Company	Isoxazolecarboxamide derivatives
KR100814269B1 (ko)	2000-01-25	2008-03-18	뉴로크린 바이오사이언시즈 인코퍼레이티드	고나도트로핀-분비 호르몬 수용체 길항제 및 이를 포함하는 약제학적 조성물
SK8052003A3 (en) *	2000-11-30	2003-12-02	Ranbaxy Lab Ltd	1,4-Disubstituted piperazine derivatives useful as uro-selective alpha1-adrenoceptor blockers
US6673796B2 (en)	2001-08-02	2004-01-06	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
DE10311065A1 (de)	2003-03-13	2004-09-23	Abbott Gmbh & Co. Kg	Pyrimidin-2-on-Verbindungen und ihre therapeutische Verwendung
KR20050122220A (ko)	2003-03-25	2005-12-28	다케다 샌디에고, 인코포레이티드	디펩티딜 펩티다제 억제제
US20050065148A1 (en)	2003-08-13	2005-03-24	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
EP1699777B1 (en)	2003-09-08	2012-12-12	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
MY140489A (en) *	2003-12-26	2009-12-31	Eisai R&D Man Co Ltd	1,2-di (cyclic) substituted benzene compounds
GB0400290D0 (en)	2004-01-08	2004-02-11	Medivir Ab	dUTPase inhibitors
CN102079743B (zh)	2004-03-15	2020-08-25	武田药品工业株式会社	二肽基肽酶抑制剂
EP1655288A1 (en) *	2004-11-05	2006-05-10	Institut Pasteur	Aryl pyrimidyl compounds, pharmaceutical compositions comprising them, their use as antimicrobial agents
AU2005320217B2 (en)	2004-12-20	2011-11-10	Eisai R & D Management Co., Ltd.	Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5)-tetramethylcyclohexyl)phenyl]piperazine
US7872124B2 (en)	2004-12-21	2011-01-18	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
CA2609255A1 (en) *	2005-05-25	2006-11-30	Eisai R&D Management Co., Ltd.	Intermediate in production of [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound
PT1942898E (pt)	2005-09-14	2011-12-20	Takeda Pharmaceutical	Inibidores da dipeptidilpeptidase para o tratamento da diabetes
EP1924567B1 (en) *	2005-09-16	2012-08-22	Takeda Pharmaceutical Company Limited	Process for the preparation of pyrimidinedione derivatives
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
DE102008030091B4 (de) *	2008-06-25	2011-03-03	Resprotect Gmbh	Uracilderivate und deren Verwendung
US9452980B2 (en) *	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
RU2449994C1 (ru) *	2011-03-10	2012-05-10	Светлана Алексеевна Мещерякова	6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность
PE20141378A1 (es) *	2011-03-18	2014-10-12	Corcept Therapeutics Inc	Moduladores de receptores de glucocorticoides de pirimidina ciclohexilo
GB201318886D0 (en) *	2013-10-25	2013-12-11	Givaudan Sa	Improvements i or relating to organic compounds
WO2017157873A1 (en)	2016-03-17	2017-09-21	F. Hoffmann-La Roche Ag	5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
AU2020376386A1 (en) *	2019-10-28	2022-03-24	Nippon Soda Co., Ltd.	2,6-dioxo-3,6-dihydropyrimidine compound, agricultural and horticultural bactericide, nematicide, and medical and veterinary antifungal agent
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DE2727469A1 (de) *	1977-06-18	1978-12-21	Hoechst Ag	Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JPH02184667A (ja) *	1989-01-11	1990-07-19	Meiji Seika Kaisha Ltd	Ｎ，ｎ’―ジ置換ピペラジル誘導体及びそれを有効成分とする排尿障害改善剤
JPH0344379A (ja) *	1989-07-13	1991-02-26	Yamasa Shoyu Co Ltd	Ｎ↑３―ピペラジノウラシル誘導体
JP2814600B2 (ja) *	1989-08-31	1998-10-22	正幸石川	排尿障害治療剤
HRP930210A2 (en) *	1992-02-25	1995-06-30	Recordati Chem Pharm	Heterobicyclic compounds and pharmaceutical preparations containing them
FR2727682A1 (fr) *	1994-12-02	1996-06-07	Pf Medicament	Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament

1996
- 1996-05-28 AT AT96108493T patent/ATE201016T1/de not_active IP Right Cessation
- 1996-05-28 ES ES96108493T patent/ES2157366T3/es not_active Expired - Lifetime
- 1996-05-28 DE DE69612698T patent/DE69612698T2/de not_active Expired - Fee Related
- 1996-05-28 EP EP96108493A patent/EP0748800B1/en not_active Expired - Lifetime
- 1996-05-28 PT PT96108493T patent/PT748800E/pt unknown
- 1996-05-28 DK DK96108493T patent/DK0748800T3/da active
- 1996-05-31 IL IL11851996A patent/IL118519A/xx not_active IP Right Cessation
- 1996-06-03 AU AU54690/96A patent/AU710754B2/en not_active Ceased
- 1996-06-03 ZA ZA964561A patent/ZA964561B/xx unknown
- 1996-06-04 NZ NZ286720A patent/NZ286720A/en unknown
- 1996-06-05 HU HU9601529A patent/HU223594B1/hu not_active IP Right Cessation
- 1996-06-05 PL PL96314635A patent/PL188061B1/pl not_active IP Right Cessation
- 1996-06-06 MA MA24270A patent/MA23899A1/fr unknown
- 1996-06-06 AR ARP960103000A patent/AR003428A1/es active IP Right Grant
- 1996-06-06 PE PE1996000428A patent/PE46497A1/es not_active Application Discontinuation
- 1996-06-06 TR TR96/00475A patent/TR970073A2/xx unknown
- 1996-06-07 NO NO962412A patent/NO309424B1/no unknown
- 1996-06-07 SG SG1996010018A patent/SG45486A1/en unknown
- 1996-06-07 JP JP8145236A patent/JP2721147B2/ja not_active Expired - Fee Related
- 1996-06-07 MY MYPI96002314A patent/MY113499A/en unknown
- 1996-06-07 RU RU96111418/04A patent/RU2175322C2/ru not_active IP Right Cessation
- 1996-06-07 CN CN96110490A patent/CN1118459C/zh not_active Expired - Fee Related
- 1996-06-07 UY UY24257A patent/UY24257A1/es not_active IP Right Cessation
- 1996-06-07 CA CA002178548A patent/CA2178548A1/en not_active Abandoned
- 1996-06-07 CO CO96029677A patent/CO4700472A1/es unknown
- 1996-06-07 BR BR9602705A patent/BR9602705A/pt not_active IP Right Cessation
- 1996-06-08 KR KR1019960020447A patent/KR100446877B1/ko not_active IP Right Cessation
- 1996-06-10 CZ CZ19961696A patent/CZ290004B6/cs not_active IP Right Cessation
- 1996-07-11 TW TW085108416A patent/TW340846B/zh active
- 1996-08-26 SA SA96170263A patent/SA96170263B1/ar unknown
1998
- 1998-12-21 HK HK98114167A patent/HK1013065A1/xx not_active IP Right Cessation
2001
- 2001-07-31 GR GR20010401157T patent/GR3036307T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUP9601529A3 (en)	2000-02-28
IL118519A0 (en)	1996-09-12
HU9601529D0 (en)	1996-07-29
JPH09100269A (ja)	1997-04-15
EP0748800A2 (en)	1996-12-18
KR100446877B1 (ko)	2004-11-06
AR003428A1 (es)	1998-08-05
HUP9601529A2 (hu)	1998-09-28
CZ290004B6 (cs)	2002-05-15
AU710754B2 (en)	1999-09-30
EP0748800B1 (en)	2001-05-09
PT748800E (pt)	2001-10-30
IL118519A (en)	1999-12-22
EP0748800A3 (en)	1996-12-27
TW340846B (en)	1998-09-21
ES2157366T3 (es)	2001-08-16
RU2175322C2 (ru)	2001-10-27
NO962412L (no)	1996-12-10
PE46497A1 (es)	1997-12-04
SA96170263B1 (ar)	2006-05-23
BR9602705A (pt)	1998-09-08
NZ286720A (en)	1998-08-26
CN1118459C (zh)	2003-08-20
GR3036307T3 (en)	2001-10-31
PL188061B1 (pl)	2004-12-31
DE69612698T2 (de)	2001-12-06
HU223594B1 (hu)	2004-09-28
UY24257A1 (es)	2000-12-29
JP2721147B2 (ja)	1998-03-04
ZA964561B (en)	1996-12-09
DE69612698D1 (de)	2001-06-13
HK1013065A1 (en)	1999-08-13
ATE201016T1 (de)	2001-05-15
CN1149051A (zh)	1997-05-07
NO962412D0 (no)	1996-06-07
SG45486A1 (en)	1998-01-16
KR970001344A (ko)	1997-01-24
TR970073A2 (tr)	1997-02-21
CA2178548A1 (en)	1996-12-10
AU5469096A (en)	1996-12-19
CO4700472A1 (es)	1998-12-29
CZ169696A3 (en)	1997-01-15
PL314635A1 (en)	1996-12-23
NO309424B1 (no)	2001-01-29
MY113499A (en)	2002-03-30
MA23899A1 (fr)	1996-12-31

Publication	Publication Date	Title
DK0748800T3 (da)	2001-08-27	Pyrimidindion-, pyrimidintrion- og triazindionderivater som alfa-1-adrenergiske receptorantagonister
NO996178D0 (no)	1999-12-14	4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonister
NO981477L (no)	1998-06-02	Pyrimidinderivater som 5HT2C-reseptor antagonister
NO985225L (no)	1998-11-09	Indolderivater nyttige som endotelinreseptorantagonister
TR199600212A2 (tr)	1997-01-21	Endotelin-reseptörü-antagonistleri.
MA26520A1 (fr)	2004-12-20	Derives de la 5h-thiazolo (3,2-a) pyrimidine.
ATE242232T1 (de)	2003-06-15	2,3,6-trisubstituierte 4(3h)-chinazolinone
DZ2320A1 (fr)	2002-12-28	Antagonistes de récepteurs de vitronectine.
AU5640299A (en)	2000-03-27	4-quinolinemethanol derivatives as purine receptor antagonists.(ii)
DE60025385D1 (de)	2006-03-30	2,4-diaminopyrimidinderivate als immunosuppressiva
ZA969775B (en)	1998-05-21	Endothelin receptor antagonists.
TR199600359A2 (tr)	1996-11-21	Adezyon reseptörü antagonistleri.
DE19653645A1 (de)	1998-06-25	Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE69716901D1 (de)	2002-12-12	2,4-diaminopyrimidin-derivate
FI952682A0 (fi)	1995-06-01	Insektisidisiä 5-substituoituja 2,4-diamiinipyrimidiinijohdannaisia
TR199600065A2 (tr)	1996-08-21	Herbisidal, 2,6-konumunda iki ornatmali piridinler ve 2,4-konumunda iki ornatmali pirimidinler.
DZ2322A1 (fr)	2002-12-28	Antagonistes de récepteurs de vitronectine.
NO972612D0 (no)	1997-06-06	Pyridazoner som endotelinreseptorantagonister
DK1185525T3 (da)	2007-06-04	4-heterocyclylsulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidinderivater, fremstilling deraf samt anvendelse deraf som endothelinreceptorantagonister
DK1070078T3 (da)	2003-05-19	Form VI 5,6-dichlor-2-(isopropylamino-)-1-beta-L-ribofuranosyl)-1H-benzimidazol
NZ315846A (en)	1999-01-28	Endothelin receptor antagonists, in particular, substituted pyrazol-4-yl-substituted-prop-2-enoic acid derivatives
ATE310732T1 (de)	2005-12-15	7-phenyl-1,4-diazepanderivate als neurokininrezeptorantagonisten
FI941117A0 (fi)	1994-03-09	Bentsyyli-imidatsopyridiinijohdannaiset angiotensiini II reseptoriantagonisteina