[go: up one dir, main page]

DK0746398T3 - Antistofrensning - Google Patents

Antistofrensning

Info

Publication number
DK0746398T3
DK0746398T3 DK95910250T DK95910250T DK0746398T3 DK 0746398 T3 DK0746398 T3 DK 0746398T3 DK 95910250 T DK95910250 T DK 95910250T DK 95910250 T DK95910250 T DK 95910250T DK 0746398 T3 DK0746398 T3 DK 0746398T3
Authority
DK
Denmark
Prior art keywords
antibody purification
purification
chromatography
application
relates
Prior art date
Application number
DK95910250T
Other languages
English (en)
Inventor
Thomas M Smith
Paula J Shadle
John C Erickson
Robert G Scott
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22740445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0746398(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of DK0746398T3 publication Critical patent/DK0746398T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK95910250T 1994-02-22 1995-02-21 Antistofrensning DK0746398T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/200,126 US5429746A (en) 1994-02-22 1994-02-22 Antibody purification
PCT/US1995/001823 WO1995022389A1 (en) 1994-02-22 1995-02-21 Antibody purification

Publications (1)

Publication Number Publication Date
DK0746398T3 true DK0746398T3 (da) 2002-09-16

Family

ID=22740445

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95910250T DK0746398T3 (da) 1994-02-22 1995-02-21 Antistofrensning

Country Status (22)

Country Link
US (4) US5429746A (da)
EP (1) EP0746398B1 (da)
JP (1) JP4198751B2 (da)
KR (1) KR100372209B1 (da)
CN (1) CN1146730A (da)
AT (1) ATE218387T1 (da)
AU (1) AU689552B2 (da)
BR (1) BR9507100A (da)
CA (1) CA2183888C (da)
CZ (1) CZ292001B6 (da)
DE (1) DE69526929T2 (da)
DK (1) DK0746398T3 (da)
ES (1) ES2177632T3 (da)
HK (1) HK1013806A1 (da)
HU (1) HU217850B (da)
MX (1) MX9603637A (da)
NO (1) NO319182B1 (da)
NZ (1) NZ281480A (da)
PT (1) PT746398E (da)
SI (1) SI0746398T1 (da)
WO (1) WO1995022389A1 (da)
ZA (1) ZA951372B (da)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5935800A (en) * 1994-10-31 1999-08-10 Beth Israel Deaconess Medical Center Assays and kits for determining male fertility
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
DK1900751T3 (da) * 1996-11-27 2010-04-19 Genentech Inc Affinitetsoprensning af et polypeptid på Protein A-matrix
AU735883C (en) * 1997-06-13 2002-02-07 Genentech Inc. Protein recovery by chromatography followed by filtration upon a charged layer
US5993653C1 (en) * 1997-08-11 2001-11-06 Phenomenex Composition and column used in hplc
CN1088605C (zh) * 1997-09-30 2002-08-07 中国科学院新疆化学研究所 生产石油磺酸钠的质量控制方法
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
KR100960211B1 (ko) * 1998-05-06 2010-05-27 제넨테크, 인크. 이온 교환 크로마토그래피에 의한 단백질 정제 방법
EP1308456B1 (en) * 1998-05-06 2007-08-22 Genentech, Inc. Antibody purification by ion exchange chromatography
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
GB9907553D0 (en) * 1999-04-01 1999-05-26 Cantab Pharma Res Purification of biological preparations
DE19932782A1 (de) * 1999-07-14 2001-01-18 Biotest Pharma Gmbh Verfahren zur chromatographischen Fraktionierung von Plasma oder Serum, so erhaltene Präparate und deren Verwendung
ES2338687T3 (es) * 2000-03-27 2010-05-11 Genetics Institute, Llc Procedimientos para purificar proteinas altamente anionicas.
SE0001128D0 (sv) * 2000-03-30 2000-03-30 Amersham Pharm Biotech Ab A method of producing IgG
US7064191B2 (en) * 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
WO2002072615A1 (fr) 2001-03-09 2002-09-19 Chugai Seiyaku Kabushiki Kaisha Methode de purification de proteines
CA2444680A1 (en) * 2001-04-18 2002-10-31 Dyax Corp. Binding molecules for fc-region polypeptides
ES2321539T3 (es) * 2001-06-05 2009-06-08 Genetics Institute, Llc Procedimientos relativos a la purificacion de proteinas altamente anionicas.
WO2003062375A2 (en) * 2001-12-19 2003-07-31 Genentech, Inc. Stabilizing polypeptides which have been exposed to urea
DE60325334D1 (de) * 2002-02-05 2009-01-29 Genentech Inc Proteinaufreinigung
CA2477569C (en) † 2002-02-28 2013-09-24 Microsens Biophage Limited Selective binding of pathological forms of prion proteins using polyionic polymers
US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
GB0220894D0 (en) * 2002-09-09 2002-10-16 Millipore Uk Ltd Method of separation
SI2261230T1 (sl) * 2002-09-11 2017-08-31 Chugai Seiyaku Kabushiki Kaisha Postopek čiščenja proteinov
WO2004026427A2 (en) * 2002-09-17 2004-04-01 Gtc Biotherapeutics, Inc. Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds
DK1601697T3 (da) * 2003-02-28 2007-10-01 Lonza Biologics Plc Oprensning af antistof ved protein A- og ionbytningskromatografi
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
US20060257972A1 (en) * 2003-03-31 2006-11-16 Takashi Ishihara Purification of human monoclonal antibody and human polyclonal antibody
US20050163782A1 (en) 2003-06-27 2005-07-28 Biogen Idec Ma Inc. Modified binding molecules comprising connecting peptides
US6913695B2 (en) * 2003-07-08 2005-07-05 Bayer Healthcare Llc Sanitization of chromatographic media
MEP31408A (en) * 2003-07-18 2010-10-10 Abgenix Inc Specific binding agents to hepatocyte growth factor
SI1648940T1 (sl) 2003-07-28 2016-08-31 Genentech, Inc. Zmanjševanje izluževanja proteina A med afinitetno kromatografijo proteina A
US20070017870A1 (en) * 2003-09-30 2007-01-25 Belov Yuri P Multicapillary device for sample preparation
WO2005032688A1 (en) * 2003-09-30 2005-04-14 Chromba, Inc. Multicapillary column for chromatography and sample preparation
ES2342539T3 (es) * 2003-10-24 2010-07-08 Amgen, Inc. Proceso para la purificacion de proteinas en una fraccion de flujo-directo de cromatografia de interaccion hidrofobica.
NZ548126A (en) * 2004-02-27 2009-10-30 Ge Healthcare Bio Sciences Ab A process for the purification of antibodies involving addition of a second resin
SE0400501D0 (sv) * 2004-02-27 2004-02-27 Amersham Biosciences Ab Antibody purification
EP1730191B1 (en) 2004-03-30 2011-07-06 Glaxo Group Limited Immunoglobulin binding hosm
SE0400886D0 (sv) * 2004-04-02 2004-04-02 Amersham Biosciences Ab Process of purification
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
JP5064225B2 (ja) 2004-10-21 2012-10-31 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 抗体精製法
ATE461211T1 (de) * 2004-12-23 2010-04-15 Novo Nordisk As Liganden mit antikörperbindender affinität
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
JP2008529495A (ja) * 2005-02-04 2008-08-07 グラクソ グループ リミテッド 異種ポリペプチド発現の最適化
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
BRPI0608584B8 (pt) * 2005-03-11 2021-05-25 Wyeth Corp métodos de recuperar um produto purificado
DE102005012594A1 (de) * 2005-03-18 2006-09-21 Bayer Technology Services Gmbh Elektrofiltrationsverfahren
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
US20070049732A1 (en) * 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
WO2007035283A1 (en) * 2005-09-15 2007-03-29 Wyeth Protein floculation using salts
GB0525662D0 (en) 2005-12-16 2006-01-25 Glaxo Group Ltd Immunoglobulins
DK2253644T3 (da) 2005-12-20 2014-01-13 Bristol Myers Squibb Co Sammensætninger og fremgangsmåder til fremstilling af en sammensætning
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
US20070269863A1 (en) * 2005-12-22 2007-11-22 Bridon Dominique P Process for the production of preformed conjugates of albumin and a therapeutic agent
CN101935665B (zh) * 2006-03-17 2013-08-28 上海抗体药物国家工程研究中心有限公司 一种重组蛋白a基因及其表达产物的制备方法和用途
DE102006014579A1 (de) * 2006-03-29 2007-10-04 Epcos Ag Verfahren zur Reinigung einer Monomer-Lösung und Herstellungsverfahren für ein elektrisches Bauelement umfassend das Reinigungsverfahren
TW201333030A (zh) * 2006-04-05 2013-08-16 Abbott Biotech Ltd 抗體之純化
WO2009017491A1 (en) * 2006-06-14 2009-02-05 Smithkline Beecham Corporation Methods for purifying antibodies using ceramic hydroxyapatite
MX345141B (es) 2006-09-13 2017-01-18 Abbvie Inc * Mejoras de cultivos celulares.
JP5732196B2 (ja) * 2006-11-01 2015-06-10 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． 低ｐＨおよび二価カチオンを用いる生物高分子を単離する方法
US7589183B2 (en) * 2006-11-28 2009-09-15 Bio-Rad Laboratories, Inc. Prevention of leaching of ligands from affinity-based purification systems
WO2009007993A2 (en) * 2007-04-23 2009-01-15 Arvind Mallinath Lali A process for purification of immunoglobulins using a pseudobioaffinity adsorbent
RU2009148891A (ru) 2007-06-01 2011-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Очистка иммуноглобулина
US20090149638A1 (en) * 2007-10-03 2009-06-11 Ley Arthur C Systems and methods for purifying proteins
WO2009058769A1 (en) * 2007-10-30 2009-05-07 Schering Corporation Purification of antibodies containing hydrophobic variants
CN101889025B (zh) 2007-10-30 2013-11-13 健泰科生物技术公司 通过阳离子交换层析进行的抗体纯化
SI2220107T1 (sl) * 2007-11-12 2017-02-28 Chreto Aps Polipeptidi z dvojno afiniteto za čiščenje
US20110092686A1 (en) * 2008-03-28 2011-04-21 Pelican Group Holdings, Inc. Multicapillary sample preparation devices and methods for processing analytes
EP2274099B1 (en) * 2008-03-28 2019-07-17 Biotix Inc Sample preparation devices and methods for processing analytes
CA2720048A1 (en) * 2008-04-16 2009-10-22 Biogen Idec Ma Inc. Method of isolating biomacromolecules using polyalkylene glycol and transition metals
EP2321338A1 (en) * 2008-08-14 2011-05-18 Merck Sharp & Dohme Corp. Methods for purifying antibodies using protein a affinity chromatography
WO2010048190A2 (en) * 2008-10-20 2010-04-29 Abbott Laboratories Antibodies that bind to il-12 and methods of purifying the same
JP2012506239A (ja) * 2008-10-20 2012-03-15 アボット・ラボラトリーズ Ｉｌ−１８に結合する抗体およびそれを精製する方法
CN102257005A (zh) * 2008-10-20 2011-11-23 雅培制药有限公司 在抗体纯化过程中的病毒灭活
WO2010141039A1 (en) * 2008-10-20 2010-12-09 Abbott Laboratories Isolation and purification of antibodies using protein a affinity chromatography
TW201029662A (en) 2008-12-19 2010-08-16 Glaxo Group Ltd Novel antigen binding proteins
AU2009331897A1 (en) 2008-12-22 2010-07-01 F. Hoffmann-La Roche Ag Immunoglobulin purification
WO2010080062A1 (en) * 2009-01-08 2010-07-15 Ge Healthcare Bio-Sciences Ab Separation method using single polymer phase systems
EP2414321B1 (en) 2009-03-31 2020-02-12 3M Innovative Properties Company Hydrophobic monomers, hydrophobically-derivatized supports, and methods of making and using the same
MX341136B (es) * 2009-10-20 2016-08-09 Abbvie Inc Aislamiento y purificacion de los anticuerpos anti-il-13 al usar la cromatografia de afinidad con proteina a.
WO2011080050A2 (en) 2009-12-11 2011-07-07 Novartis Ag Binding molecules
DK2513134T3 (da) 2009-12-18 2017-12-18 Novartis Ag Vaskeopløsning og fremgangsmåde til affinitetschromatografi
UY33202A (es) 2010-01-28 2011-08-31 Glaxo Group Ltd Proteínas de unión a cd127
UA108227C2 (xx) 2010-03-03 2015-04-10 Антигензв'язуючий білок
US20130052209A1 (en) * 2010-04-23 2013-02-28 Purdue Research Foundation Protein drug formulations and packages
KR101152036B1 (ko) 2010-04-27 2012-06-08 (주)셀트리온 컬럼 순환 및 시료 연속주입법을 이용한 단백질 ａ 크로마토그래피 정제 방법
UY33421A (es) 2010-06-03 2011-12-30 Glaxo Wellcome House Proteinas de union al antígeno humanizados
JP5873016B2 (ja) * 2010-06-21 2016-03-01 協和発酵キリン株式会社 アミノ酸を利用したタンパク質の精製方法
BR112013001637A2 (pt) 2010-07-22 2016-05-24 Glaxosmithkline Biolog Sa proteína ligadora de antígeno, molécula de ácido nucleico, vetor de expressão, célula hospedeira recombinante, métodos para produção de proteína ligadora de antígeno, e para detectar mage-a3 e/ou mage-a6 em tecido de humano fixado com formalina e infiltrado em parafina.
JP2013544524A (ja) * 2010-12-06 2013-12-19 ターポン バイオシステムズ，インコーポレイテッド 生物学的生成物の連続プロセス法
RU2586515C2 (ru) 2010-12-21 2016-06-10 Ф.Хоффманн-Ля Рош Аг Препарат антитела, обогащенного изоформами и способ его получения
SI3318571T1 (sl) 2011-03-16 2021-08-31 F. Hoffmann-La Roche Ag Ionska izmenjevalna kromatografija z izboljšano selektivnostjo za ločevanje polipeptidnih monomerov, agregatov in fragmentov s spremembo mobilne faze
CN107915769A (zh) 2011-03-29 2018-04-17 葛兰素史密斯克莱有限责任公司 用于蛋白纯化的缓冲液体系
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CA2831572C (en) * 2011-05-02 2019-11-26 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
KR20140058532A (ko) 2011-06-30 2014-05-14 겐자임 코포레이션 Ｔ-세포 활성화 억제제
WO2013004587A1 (en) * 2011-07-01 2013-01-10 F. Hoffmann-La Roche Ag Method for separation of monomeric polypeptides from aggregated polypeptides
WO2013010749A1 (en) 2011-07-19 2013-01-24 Philogen S.P.A Sequential anti - ctla4 and targeted il-2 therapy
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
US8685241B1 (en) 2011-12-21 2014-04-01 Sepragen Corporation Axial and radial flow columns with inflatable seals to facilitate packing and unpacking
EP2647709B1 (en) * 2012-04-05 2016-02-24 F. Hoffmann-La Roche AG Amine compounds for the selective preparation of biological samples
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
KR20150027060A (ko) * 2012-05-31 2015-03-11 에이전시 포 사이언스, 테크놀로지 앤드 리서치 다중 모드의 기능성들을 갖는 입자들로 면역글로불린 g 조제물들의 크로마토그래피 정제
JP6253584B2 (ja) * 2012-08-27 2017-12-27 旭化成メディカル株式会社 温度応答性クロマトグラフィーによる抗体の精製方法
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
CA2883272A1 (en) 2012-09-02 2014-03-06 Abbvie Inc. Methods to control protein heterogeneity
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
KR102196230B1 (ko) 2012-09-17 2020-12-29 더블유.알. 그레이스 앤드 캄파니-콘. 크로마토그래피 매질 및 장치
CN103073616A (zh) * 2013-01-06 2013-05-01 西北大学 使用混合模式层析技术去除抗体聚集体的方法
RU2768003C2 (ru) 2013-03-08 2022-03-22 Джензим Корпорейшн Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
CN105188872B (zh) * 2013-03-15 2019-01-15 葛兰素史克知识产权第二有限公司 用于纯化抗体的方法
WO2014145744A1 (en) * 2013-03-15 2014-09-18 Alder Biopharmaceuticals, Inc. Antibody purification and purity monitoring
CA2909969A1 (en) * 2013-05-13 2014-12-31 Medimmune, Llc Separation of recombinant polyclonal antibody multimers with minimal separation of monomers
ES2531459B1 (es) * 2013-06-10 2015-12-28 Antonio VILA SANJURJO Método para la separación física de "traductomas" convolucionados
TWI596107B (zh) * 2013-06-25 2017-08-21 卡地拉保健有限公司 單株抗體之新穎純化方法
WO2015038884A2 (en) 2013-09-13 2015-03-19 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
MY176026A (en) 2013-09-13 2020-07-22 Genentech Inc Methods and composions comprising purified recombinant polypeptides
EP3903599A1 (en) * 2013-09-25 2021-11-03 Bioverativ Therapeutics Inc. On-column viral inactivation methods
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015069459A1 (en) 2013-11-05 2015-05-14 Novartis Ag Organic compounds
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
JP6853670B2 (ja) 2014-01-16 2021-04-07 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 親和性クロマトグラフィー媒体及びクロマトグラフィーデバイス
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
CN106061992A (zh) * 2014-02-27 2016-10-26 新加坡科技研究局 通过用烷基阳离子处理来降低蛋白质制剂中的染色质含量的方法
EP3116891B1 (en) 2014-03-10 2020-02-12 Richter Gedeon Nyrt. Immunoglobulin purification using pre-cleaning steps
DK3131589T3 (da) 2014-04-15 2023-08-07 Boehringer Ingelheim Int Fremgangsmåde og anvendelse til fortløbende inaktivering af en virus under tilvejebringelse af et biologisk produkt
US11389783B2 (en) 2014-05-02 2022-07-19 W.R. Grace & Co.-Conn. Functionalized support material and methods of making and using functionalized support material
CN106795215A (zh) 2014-06-24 2017-05-31 通用电气医疗集团生物工艺研发股份公司 层析方法
AR102198A1 (es) 2014-10-09 2017-02-08 Regeneron Pharma Proceso para reducir partículas subvisibles en una formulación farmacéutica
WO2016059602A2 (en) 2014-10-16 2016-04-21 Glaxo Group Limited Methods of treating cancer and related compositions
EP3611188B1 (en) 2014-11-06 2022-05-04 F. Hoffmann-La Roche AG Fc-region variants with modified fcrn-binding and methods of use
GB201506868D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method for protein purification
ES2896897T3 (es) 2015-06-05 2022-02-28 Grace W R & Co Agentes de clarificación para el bioprocesamiento de adsorbentes y métodos para producir y usar los mismos
ES3008383T3 (en) 2015-10-09 2025-03-24 Genzyme Corp Improved flare (flow cytometry attenuated reporter expression) technology for rapid bulk sorting
EP3426683A1 (en) 2016-03-11 2019-01-16 Boehringer Ingelheim International GmbH Methods for continuously inactivating a virus during manufacture of a protein
EP3487868B1 (en) 2016-07-25 2024-08-28 Cephalon, Inc. Affinity chromatography wash buffer
CN119119244A (zh) 2016-08-16 2024-12-13 里珍纳龙药品有限公司 用于对混合物中的个体抗体进行量化的方法
KR102489451B1 (ko) 2016-09-07 2023-01-16 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 항체를 정제하는 방법
SG11201903018WA (en) 2016-10-07 2019-05-30 Genzyme Corp Early post-transfection isolation of cells (epic) for biologics production
CN114858957B (zh) 2016-10-25 2024-11-22 里珍纳龙药品有限公司 用于色谱数据分析的方法和系统
GB201622343D0 (en) * 2016-12-29 2017-02-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
US10799597B2 (en) 2017-04-03 2020-10-13 Immunomedics, Inc. Subcutaneous administration of antibody-drug conjugates for cancer therapy
DK3668985T3 (da) 2017-08-17 2021-09-20 Just Evotec Biologics Inc Fremgangsmåde til rensning af glycosyleret protein fra værtscellegalectiner og andre urenheder
JP7301043B2 (ja) 2017-09-19 2023-06-30 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 粒子の形成を低減する方法及びそれにより形成される組成物
US20200406232A1 (en) * 2018-03-08 2020-12-31 Bio-Rad Laboratories, Inc. Anionic exchange-hydrophobic mixed mode chromatography resin
EP3769083A1 (en) 2018-03-21 2021-01-27 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
TW202448568A (zh) 2018-07-02 2024-12-16 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
MX2021002314A (es) 2018-08-31 2021-04-28 Genzyme Corp Resina de cromatografia esteril y uso de la misma en procedimientos de produccion.
US20220153840A1 (en) 2019-04-03 2022-05-19 Genzyme Corporation Anti-alpha beta tcr binding polypeptides with reduced fragmentation
HU231498B1 (hu) 2019-04-04 2024-05-28 Richter Gedeon Nyrt Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelőző flokkulálás alkalmazásával
AR119270A1 (es) * 2019-06-10 2021-12-09 Millennium Pharm Inc MÉTODOS PARA PRODUCIR UN ANTICUERPO ANTI-a4b7
CN114907430B (zh) * 2022-06-21 2023-12-01 中国科学院过程工程研究所 一种mRNA的分离纯化方法
WO2024062074A1 (en) 2022-09-21 2024-03-28 Sanofi Biotechnology Humanized anti-il-1r3 antibody and methods of use
CN117327189B (zh) * 2023-09-21 2024-06-11 南京京达生物技术有限公司 一种交联型异嗜性抗体阻断剂的生产工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
DK166763B1 (da) * 1983-03-16 1993-07-12 Immuno Ag Immunoglobulin-g-holdig fraktion
US5268306A (en) * 1988-02-29 1993-12-07 Boehringer Mannheim Gmbh Preparation of a solid phase matrix containing a bound specific binding pair
US4983722A (en) * 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
US5115101A (en) * 1988-06-08 1992-05-19 Miles Inc. Removal of protein A from antibody preparations
DE3825429C2 (de) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt
WO1991002049A1 (en) * 1989-08-04 1991-02-21 Peter Grandics An integrated cell culture-protein purification system for the automated production and purification of cell culture products
JPH0778025B2 (ja) * 1990-03-20 1995-08-23 日本赤十字社 免疫グロブリンｇの製造方法
DK0447585T4 (da) * 1990-03-22 2003-09-01 Biotest Pharma Gmbh Fremgangsmåde til fremstilling af et intravenøst tolerant immunglobulin-G-præparat
JPH0480959A (ja) * 1990-07-24 1992-03-13 Seiko Epson Corp 半導体装置
GB9019812D0 (en) 1990-09-11 1990-10-24 Scotgen Ltd Novel antibodies for treatment and prevention of infection in animals and man
DK0605442T3 (da) 1991-07-25 2003-08-04 Idec Pharma Corp Rekombinante antistoffer til human terapi
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
KR0160900B1 (ko) * 1995-07-31 1998-12-15 배순훈 브이.씨.알의 드럼모터 장치

Also Published As

Publication number Publication date
HUT74845A (en) 1997-02-28
USRE40070E1 (en) 2008-02-19
CZ292001B6 (cs) 2003-07-16
ES2177632T3 (es) 2002-12-16
EP0746398A1 (en) 1996-12-11
CA2183888C (en) 2008-06-17
ZA951372B (en) 1995-10-24
HK1013806A1 (en) 1999-09-10
AU1843395A (en) 1995-09-04
NO319182B1 (no) 2005-06-27
MX9603637A (es) 1997-04-30
HU9602313D0 (en) 1996-10-28
HU217850B (hu) 2000-04-28
CA2183888A1 (en) 1995-08-24
USRE41555E1 (en) 2010-08-24
CN1146730A (zh) 1997-04-02
NO963475L (no) 1996-10-21
DE69526929D1 (de) 2002-07-11
NZ281480A (en) 1998-06-26
DE69526929T2 (de) 2003-01-02
WO1995022389A1 (en) 1995-08-24
USRE41595E1 (en) 2010-08-31
EP0746398B1 (en) 2002-06-05
EP0746398A4 (en) 1997-10-08
US5429746A (en) 1995-07-04
JPH09509658A (ja) 1997-09-30
PT746398E (pt) 2002-10-31
SI0746398T1 (en) 2002-10-31
AU689552B2 (en) 1998-04-02
ATE218387T1 (de) 2002-06-15
CZ248196A3 (en) 1997-04-16
JP4198751B2 (ja) 2008-12-17
BR9507100A (pt) 1997-09-16
NO963475D0 (no) 1996-08-21
KR100372209B1 (ko) 2003-04-10

Similar Documents

Publication Publication Date Title
DK0746398T3 (da) Antistofrensning
DK0643608T3 (da) Proteinrensning
ATE425989T1 (de) Proteinreinigungsverfahren
DK0971946T3 (da) Selektion af proteiner ved anvendelse af RNA-protein-fusioner
DK0821695T3 (da) Oprensning af antistof ved hydrofob interaktionschromatografi ved lav pH-værdi
HUT77049A (hu) Katepszin-02-fehérjék, -nukleinsavak és -ellenanyagok
DE69430016D1 (de) Proteinreinigung
DK0538754T3 (da) Anvendelse af antistofholdige præparater til immunundertrykkelse
ES2076999T3 (es) Peptidos anticoagulantes radiomarcados.
ITRM920658A0 (it) Procedimento per la purificazione della proteina endotelina
FI930265A0 (fi) Antikoagulantpeptider
KR970001106U (ko) 자동차용 헤드램프의 결합구조
ES2191785T3 (es) Proteina de accion antitumoral.
KR960027420U (ko) 자동차 부품 조립용 클립
KR970001108U (ko) 자동차용 헤드램프의 결합구조
KR970006421U (ko) 자동차의 헤드 램프 어셈블리
KR970017111U (ko) 자동차용 헤드램프의 구조
ATE269871T1 (de) Reinigung von faktor viii-komplex durch immunaffinitätschromatographie