DK0741732T3 - Fremgangsmåde til dannelse af et clavulansyresalt - Google Patents

Fremgangsmåde til dannelse af et clavulansyresalt

Info

Publication number: DK0741732T3
Authority: DK; Denmark
Prior art keywords: forming; acid salt; clavulanic acid; clavulanic; salt
Prior art date: 1994-02-02

Application number

DK95907075T

Other languages

Danish (da)

English (en)

Inventor

Michael Alan Cook

Geoffrey Clive Webb

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-02

Filing date

1995-01-31

Publication date

2001-10-15

1995-01-31 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2001-10-15 Application granted granted Critical

2001-10-15 Publication of DK0741732T3 publication Critical patent/DK0741732T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)

DK95907075T 1994-02-02 1995-01-31 Fremgangsmåde til dannelse af et clavulansyresalt DK0741732T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9401969A GB9401969D0 (en)	1994-02-02	1994-02-02	Process
PCT/GB1995/000191 WO1995021173A1 (en)	1994-02-02	1995-01-31	Process for the preparation of a salt of clavulanic acid

Publications (1)

Publication Number	Publication Date
DK0741732T3 true DK0741732T3 (da)	2001-10-15

Family

ID=10749727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95907075T DK0741732T3 (da)	1994-02-02	1995-01-31	Fremgangsmåde til dannelse af et clavulansyresalt

Country Status (31)

Country	Link
US (1)	US5965728A (fi)
EP (1)	EP0741732B1 (fi)
JP (1)	JP4074336B2 (fi)
KR (1)	KR100388769B1 (fi)
CN (1)	CN1065246C (fi)
AP (1)	AP610A (fi)
AT (1)	ATE202358T1 (fi)
AU (1)	AU688849B2 (fi)
BG (1)	BG63307B1 (fi)
BR (1)	BR9506919A (fi)
CA (1)	CA2182504C (fi)
CZ (1)	CZ294005B6 (fi)
DE (1)	DE69521415T2 (fi)
DK (1)	DK0741732T3 (fi)
ES (1)	ES2159626T3 (fi)
FI (1)	FI111949B (fi)
GB (1)	GB9401969D0 (fi)
GR (1)	GR3036602T3 (fi)
HU (1)	HU226597B1 (fi)
MX (1)	MX9603204A (fi)
NO (1)	NO314505B1 (fi)
NZ (1)	NZ278927A (fi)
OA (1)	OA10587A (fi)
PL (1)	PL181451B1 (fi)
PT (1)	PT741732E (fi)
RO (1)	RO115730B1 (fi)
RU (1)	RU2140418C1 (fi)
SI (1)	SI0741732T1 (fi)
SK (1)	SK282544B6 (fi)
UA (1)	UA48944C2 (fi)
WO (1)	WO1995021173A1 (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT400033B (de)	1992-03-10	1995-09-25	Biochemie Gmbh	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en)	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) *	1995-01-19	1995-03-08	Smithkline Beecham Plc	Novel process
SI9500134B (sl) *	1995-04-20	2004-04-30	Lek,	Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) *	1995-08-02	1995-10-04	Smithkline Beecham Plc	Process
AT403375B (de) *	1995-11-15	1998-01-26	Biochemie Gmbh	Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) *	1996-06-13	1997-12-15	Smithkline Beecham Corp	Improved process for preparing potassium clavulanate.
WO1998042858A1 (en) *	1997-03-24	1998-10-01	Cipan-Companhia Industrial Produtora De Antibióticos, S.A.	Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
EP0867515B1 (en) *	1997-03-24	1999-12-08	CIPAN-Companhia Industrial Produtora De Antibioticos, S.A.	Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr)	1997-04-04	2003-01-18	Smithkline Beecham Plc	Procédé de préparation de sels de l'acide clavulanique.
ATE410225T1 (de)	2001-08-02	2008-10-15	Lg Life Sciences Ltd	Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze
CN109715156A (zh)	2016-07-14	2019-05-03	尔察祯有限公司	用于治疗细菌感染的头孢布烯和克拉维酸的组合
CN108822134B (zh) *	2018-04-25	2021-06-25	国药集团威奇达药业有限公司	克拉维酸叔丁胺盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1508977A (en) *	1974-04-20	1978-04-26	Beecham Group Ltd	Beta-lactam antibiotic from streptomyces clavuligerus
ES444195A1 (es) *	1974-10-09	1977-08-01	Beecham Group Ltd	Un procedimiento para la preparacion de acido clavulanico.
GB1543563A (en) *	1975-02-07	1979-04-04	Glaxo Lab Ltd	Beta-lactam antibiotic in purified form
GB1563103A (en) *	1975-10-13	1980-03-19	Beecham Group Ltd	Process for the preparation of clavulanic acid
GB1578739A (en) *	1976-07-23	1980-11-05	Beecham Group Ltd	Amine salts of clavulanic acid methods for their preparation and compositions containing them
EP0026044B1 (en) *	1979-08-24	1983-06-08	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) *	1984-02-23	1984-03-28	Atomic Energy Authority Uk	Fluidic contactor
ES2010143A6 (es) *	1989-03-01	1989-10-16	Pharma Mar S A Pharmar	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

1994
- 1994-02-02 GB GB9401969A patent/GB9401969D0/en active Pending
1995
- 1995-01-31 HU HU9602128A patent/HU226597B1/hu not_active IP Right Cessation
- 1995-01-31 SI SI9530525T patent/SI0741732T1/xx unknown
- 1995-01-31 CA CA002182504A patent/CA2182504C/en not_active Expired - Fee Related
- 1995-01-31 MX MX9603204A patent/MX9603204A/es not_active IP Right Cessation
- 1995-01-31 SK SK1003-96A patent/SK282544B6/sk not_active IP Right Cessation
- 1995-01-31 AT AT95907075T patent/ATE202358T1/de not_active IP Right Cessation
- 1995-01-31 ES ES95907075T patent/ES2159626T3/es not_active Expired - Lifetime
- 1995-01-31 NZ NZ278927A patent/NZ278927A/en not_active IP Right Cessation
- 1995-01-31 JP JP52044595A patent/JP4074336B2/ja not_active Expired - Fee Related
- 1995-01-31 AU AU15412/95A patent/AU688849B2/en not_active Ceased
- 1995-01-31 RO RO96-01582A patent/RO115730B1/ro unknown
- 1995-01-31 UA UA96083392A patent/UA48944C2/uk unknown
- 1995-01-31 RU RU96117347A patent/RU2140418C1/ru not_active IP Right Cessation
- 1995-01-31 PT PT95907075T patent/PT741732E/pt unknown
- 1995-01-31 PL PL95315782A patent/PL181451B1/pl not_active IP Right Cessation
- 1995-01-31 EP EP95907075A patent/EP0741732B1/en not_active Expired - Lifetime
- 1995-01-31 BR BR9506919A patent/BR9506919A/pt not_active Application Discontinuation
- 1995-01-31 CN CN95192179A patent/CN1065246C/zh not_active Expired - Fee Related
- 1995-01-31 KR KR1019960704202A patent/KR100388769B1/ko not_active Expired - Fee Related
- 1995-01-31 DE DE69521415T patent/DE69521415T2/de not_active Expired - Lifetime
- 1995-01-31 DK DK95907075T patent/DK0741732T3/da active
- 1995-01-31 AP APAP/P/1996/000838A patent/AP610A/en active
- 1995-01-31 CZ CZ19962294A patent/CZ294005B6/cs not_active IP Right Cessation
- 1995-01-31 US US08/663,158 patent/US5965728A/en not_active Expired - Lifetime
- 1995-01-31 WO PCT/GB1995/000191 patent/WO1995021173A1/en active IP Right Grant
1996
- 1996-08-01 NO NO19963217A patent/NO314505B1/no not_active IP Right Cessation
- 1996-08-01 BG BG100765A patent/BG63307B1/bg unknown
- 1996-08-01 FI FI963050A patent/FI111949B/fi active
- 1996-08-02 OA OA60872A patent/OA10587A/en unknown
2001
- 2001-09-12 GR GR20010401463T patent/GR3036602T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL315782A1 (en)	1996-12-09
ATE202358T1 (de)	2001-07-15
RU2140418C1 (ru)	1999-10-27
AU688849B2 (en)	1998-03-19
AU1541295A (en)	1995-08-21
CZ229496A3 (en)	1997-01-15
EP0741732A1 (en)	1996-11-13
WO1995021173A1 (en)	1995-08-10
HUT74885A (en)	1997-02-28
HU9602128D0 (en)	1996-09-30
JP4074336B2 (ja)	2008-04-09
NO963217L (no)	1996-10-01
FI963050A0 (fi)	1996-08-01
BG100765A (en)	1997-09-30
HK1012373A1 (en)	1999-07-30
CA2182504A1 (en)	1995-08-10
EP0741732B1 (en)	2001-06-20
NO314505B1 (no)	2003-03-31
SK282544B6 (sk)	2002-10-08
FI963050L (fi)	1996-10-01
PT741732E (pt)	2001-11-30
ES2159626T3 (es)	2001-10-16
CN1065246C (zh)	2001-05-02
RO115730B1 (ro)	2000-05-30
AP9600838A0 (en)	1996-07-31
BR9506919A (pt)	1997-09-30
OA10587A (en)	2002-07-10
CZ294005B6 (cs)	2004-09-15
NO963217D0 (no)	1996-08-01
SK100396A3 (en)	1996-12-04
AP610A (en)	1997-09-04
NZ278927A (en)	1998-02-26
UA48944C2 (uk)	2002-09-16
JPH09508411A (ja)	1997-08-26
HU226597B1 (en)	2009-04-28
FI111949B (fi)	2003-10-15
MX9603204A (es)	1997-03-29
CN1144528A (zh)	1997-03-05
SI0741732T1 (fi)	2001-10-31
CA2182504C (en)	2008-04-08
PL181451B1 (en)	2001-07-31
KR100388769B1 (ko)	2003-09-02
DE69521415D1 (de)	2001-07-26
BG63307B1 (bg)	2001-09-28
GB9401969D0 (en)	1994-03-30
US5965728A (en)	1999-10-12
GR3036602T3 (en)	2001-12-31
DE69521415T2 (de)	2002-05-29

Publication	Publication Date	Title
DK0845956T4 (da)	2008-06-16	Fremgangsmåde til fremstilling af en tandbörste
FI941866L (fi)	1995-10-22	Menetelmä liuoksen fraktioimiseksi
FI942842L (fi)	1995-12-16	Menetelmä yhteyden muodostamiseksi
DK0650006T3 (da)	1999-02-22	Fremgangsmåde til foring af et siderør
FI922938A0 (fi)	1992-06-24	Menetelmä kanavanvaihdon tehostamiseksi
FI945441L (fi)	1994-11-18	Uusi menetelmä 7beta-substituoitu-4-atsa-5alfa-androstan-3-onien valmistamiseksi
FI982790A7 (fi)	1998-12-23	Menetelmä klavulaanihapon valmistamiseksi
FI940487A7 (fi)	1994-02-02	Vianmääritysmenetelmä kehitysprosessia varten
FI972764A7 (fi)	1997-09-10	Menetelmä liuosten muodostamiseksi
FI943938A0 (fi)	1994-08-26	Menetelmä suodatinpanoksen valmistamiseksi
DK0506973T3 (da)	1996-01-29	Fremgangsmåde til fremstilling af et aminocarboxylsyresalt
DK0741732T3 (da)	2001-10-15	Fremgangsmåde til dannelse af et clavulansyresalt
FI953993L (fi)	1995-08-24	Menetelmä betonin valmistamiseksi
DK0721743T3 (da)	2001-04-02	Forbedret fremgangsmåde til fremstilling af et skaldyrprodukt
ZA959443B (en)	1996-05-29	Process for manufacturing clavulanic acid salt
FI973287A7 (fi)	1997-08-22	Klavulaanihapposuoloja
FI970564L (fi)	1997-02-10	Uusi menetelmä di-isopinokamfeyyliklooriboraanin valmistamiseksi
FI935019L (fi)	1995-05-13	Menetelmä klodronaattivalmisteen valmistamiseksi
DK0692511T3 (da)	2000-09-18	Fremgangsmåde til fremstilling af et farvehjælpemiddel
FI954786A7 (fi)	1995-10-06	Menetelmä aminometaanifosfonihapon valmistamiseksi
DK0789700T3 (da)	2002-04-29	Forbedret fremgangsmåde til fremstilling af et D-(+)-biotin-mellemprodukt
FI972694A0 (fi)	1997-06-23	Uusi menetelmä sameridiinin valmistamiseksi
ATE261976T1 (de)	2004-04-15	Clavulansäure extraktionsverfahren
DK0802901T3 (da)	2001-02-05	Hidtil ukendte carbamatforbindelser indeholdende en thiocarbamoylgruppe samt fremgangsmåde til fremstilling af samme
PT1071674E (pt)	2004-10-29	Metodo para a producao de clorobenzoxazoles