FI963050L - Menetelmä klavulaanihapposuolan valmistamiseksi - Google Patents

Menetelmä klavulaanihapposuolan valmistamiseksi Download PDF

Info

Publication number: FI963050L
Authority: FI; Finland
Prior art keywords: preparing; acid salt; clavulanic acid; clavulanic; salt
Prior art date: 1994-02-02

Application number

FI963050A

Other languages

English (en)

Swedish (sv)

Other versions

FI963050A0 (fi

FI111949B (fi

Inventor

Michael Alan Cook

Geoffrey Clive Webb

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-02

Filing date

1996-08-01

Publication date

1996-10-01

1996-08-01 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1996-08-01 Publication of FI963050A0 publication Critical patent/FI963050A0/fi

1996-10-01 Publication of FI963050L publication Critical patent/FI963050L/fi

2003-10-15 Application granted granted Critical

2003-10-15 Publication of FI111949B publication Critical patent/FI111949B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)

FI963050A 1994-02-02 1996-08-01 Menetelmä kaliumklavulanaatin valmistamiseksi FI111949B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9401969		1994-02-02
GB9401969A GB9401969D0 (en)	1994-02-02	1994-02-02	Process
PCT/GB1995/000191 WO1995021173A1 (en)	1994-02-02	1995-01-31	Process for the preparation of a salt of clavulanic acid
GB9500191		1995-01-31

Publications (3)

Publication Number	Publication Date
FI963050A0 FI963050A0 (fi)	1996-08-01
FI963050L true FI963050L (fi)	1996-10-01
FI111949B FI111949B (fi)	2003-10-15

Family

ID=10749727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI963050A FI111949B (fi)	1994-02-02	1996-08-01	Menetelmä kaliumklavulanaatin valmistamiseksi

Country Status (32)

Country	Link
US (1)	US5965728A (fi)
EP (1)	EP0741732B1 (fi)
JP (1)	JP4074336B2 (fi)
KR (1)	KR100388769B1 (fi)
CN (1)	CN1065246C (fi)
AP (1)	AP610A (fi)
AT (1)	ATE202358T1 (fi)
AU (1)	AU688849B2 (fi)
BG (1)	BG63307B1 (fi)
BR (1)	BR9506919A (fi)
CA (1)	CA2182504C (fi)
CZ (1)	CZ294005B6 (fi)
DE (1)	DE69521415T2 (fi)
DK (1)	DK0741732T3 (fi)
ES (1)	ES2159626T3 (fi)
FI (1)	FI111949B (fi)
GB (1)	GB9401969D0 (fi)
GR (1)	GR3036602T3 (fi)
HK (1)	HK1012373A1 (fi)
HU (1)	HU226597B1 (fi)
MX (1)	MX9603204A (fi)
NO (1)	NO314505B1 (fi)
NZ (1)	NZ278927A (fi)
OA (1)	OA10587A (fi)
PL (1)	PL181451B1 (fi)
PT (1)	PT741732E (fi)
RO (1)	RO115730B1 (fi)
RU (1)	RU2140418C1 (fi)
SI (1)	SI0741732T1 (fi)
SK (1)	SK282544B6 (fi)
UA (1)	UA48944C2 (fi)
WO (1)	WO1995021173A1 (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT400033B (de)	1992-03-10	1995-09-25	Biochemie Gmbh	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en)	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) *	1995-01-19	1995-03-08	Smithkline Beecham Plc	Novel process
SI9500134B (sl) *	1995-04-20	2004-04-30	Lek,	Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) *	1995-08-02	1995-10-04	Smithkline Beecham Plc	Process
AT403375B (de) *	1995-11-15	1998-01-26	Biochemie Gmbh	Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) *	1996-06-13	1997-12-15	Smithkline Beecham Corp	Improved process for preparing potassium clavulanate.
PT867515E (pt)	1997-03-24	2000-05-31	Cipan Companhia Ind P De Antib	Processo para isolar um sal de acido clavulanico e de um metal alcalino farmaceuticamente aceitavel
WO1998042858A1 (en) *	1997-03-24	1998-10-01	Cipan-Companhia Industrial Produtora De Antibióticos, S.A.	Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) *	1997-04-04	2003-01-18	Smithkline Beecham Plc	Procédé de préparation de sels de l'acide clavulanique.
DE60229255D1 (de)	2001-08-02	2008-11-20	Lg Life Sciences Ltd	Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze
US10624899B2 (en)	2016-07-14	2020-04-21	Achaogen, Inc.	Combination products for the treatment of bacterial infections and methods of producing or dosing of same
CN108822134B (zh) *	2018-04-25	2021-06-25	国药集团威奇达药业有限公司	克拉维酸叔丁胺盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1508977A (en) *	1974-04-20	1978-04-26	Beecham Group Ltd	Beta-lactam antibiotic from streptomyces clavuligerus
GB1563103A (en) *	1975-10-13	1980-03-19	Beecham Group Ltd	Process for the preparation of clavulanic acid
DE3063683D1 (en) *	1979-08-24	1983-07-14	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) *	1984-02-23	1984-03-28	Atomic Energy Authority Uk	Fluidic contactor

1994
- 1994-02-02 GB GB9401969A patent/GB9401969D0/en active Pending
1995
- 1995-01-31 BR BR9506919A patent/BR9506919A/pt not_active Application Discontinuation
- 1995-01-31 AU AU15412/95A patent/AU688849B2/en not_active Ceased
- 1995-01-31 CN CN95192179A patent/CN1065246C/zh not_active Expired - Fee Related
- 1995-01-31 JP JP52044595A patent/JP4074336B2/ja not_active Expired - Fee Related
- 1995-01-31 DE DE69521415T patent/DE69521415T2/de not_active Expired - Lifetime
- 1995-01-31 CA CA002182504A patent/CA2182504C/en not_active Expired - Fee Related
- 1995-01-31 PL PL95315782A patent/PL181451B1/pl not_active IP Right Cessation
- 1995-01-31 DK DK95907075T patent/DK0741732T3/da active
- 1995-01-31 WO PCT/GB1995/000191 patent/WO1995021173A1/en active IP Right Grant
- 1995-01-31 MX MX9603204A patent/MX9603204A/es not_active IP Right Cessation
- 1995-01-31 ES ES95907075T patent/ES2159626T3/es not_active Expired - Lifetime
- 1995-01-31 CZ CZ19962294A patent/CZ294005B6/cs not_active IP Right Cessation
- 1995-01-31 SK SK1003-96A patent/SK282544B6/sk not_active IP Right Cessation
- 1995-01-31 HU HU9602128A patent/HU226597B1/hu not_active IP Right Cessation
- 1995-01-31 RU RU96117347A patent/RU2140418C1/ru not_active IP Right Cessation
- 1995-01-31 RO RO96-01582A patent/RO115730B1/ro unknown
- 1995-01-31 KR KR1019960704202A patent/KR100388769B1/ko not_active Expired - Fee Related
- 1995-01-31 EP EP95907075A patent/EP0741732B1/en not_active Expired - Lifetime
- 1995-01-31 US US08/663,158 patent/US5965728A/en not_active Expired - Lifetime
- 1995-01-31 SI SI9530525T patent/SI0741732T1/xx unknown
- 1995-01-31 UA UA96083392A patent/UA48944C2/uk unknown
- 1995-01-31 AT AT95907075T patent/ATE202358T1/de not_active IP Right Cessation
- 1995-01-31 NZ NZ278927A patent/NZ278927A/en not_active IP Right Cessation
- 1995-01-31 PT PT95907075T patent/PT741732E/pt unknown
- 1995-01-31 AP APAP/P/1996/000838A patent/AP610A/en active
1996
- 1996-08-01 NO NO19963217A patent/NO314505B1/no not_active IP Right Cessation
- 1996-08-01 FI FI963050A patent/FI111949B/fi active
- 1996-08-01 BG BG100765A patent/BG63307B1/bg unknown
- 1996-08-02 OA OA60872A patent/OA10587A/en unknown
1998
- 1998-12-16 HK HK98113569A patent/HK1012373A1/xx not_active IP Right Cessation
2001
- 2001-09-12 GR GR20010401463T patent/GR3036602T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2182504A1 (en)	1995-08-10
PL315782A1 (en)	1996-12-09
BG100765A (en)	1997-09-30
DE69521415D1 (de)	2001-07-26
CN1065246C (zh)	2001-05-02
SK100396A3 (en)	1996-12-04
HU226597B1 (en)	2009-04-28
BG63307B1 (bg)	2001-09-28
DE69521415T2 (de)	2002-05-29
BR9506919A (pt)	1997-09-30
EP0741732B1 (en)	2001-06-20
CN1144528A (zh)	1997-03-05
UA48944C2 (uk)	2002-09-16
ES2159626T3 (es)	2001-10-16
RO115730B1 (ro)	2000-05-30
FI963050A0 (fi)	1996-08-01
CZ229496A3 (en)	1997-01-15
CA2182504C (en)	2008-04-08
DK0741732T3 (da)	2001-10-15
AU1541295A (en)	1995-08-21
CZ294005B6 (cs)	2004-09-15
GB9401969D0 (en)	1994-03-30
RU2140418C1 (ru)	1999-10-27
PT741732E (pt)	2001-11-30
SI0741732T1 (fi)	2001-10-31
GR3036602T3 (en)	2001-12-31
KR100388769B1 (ko)	2003-09-02
AP9600838A0 (en)	1996-07-31
JPH09508411A (ja)	1997-08-26
HUT74885A (en)	1997-02-28
NO963217L (no)	1996-10-01
HU9602128D0 (en)	1996-09-30
ATE202358T1 (de)	2001-07-15
EP0741732A1 (en)	1996-11-13
NZ278927A (en)	1998-02-26
AP610A (en)	1997-09-04
WO1995021173A1 (en)	1995-08-10
NO963217D0 (no)	1996-08-01
AU688849B2 (en)	1998-03-19
NO314505B1 (no)	2003-03-31
SK282544B6 (sk)	2002-10-08
HK1012373A1 (en)	1999-07-30
FI111949B (fi)	2003-10-15
US5965728A (en)	1999-10-12
OA10587A (en)	2002-07-10
JP4074336B2 (ja)	2008-04-09
PL181451B1 (en)	2001-07-31
MX9603204A (es)	1997-03-29

Publication	Publication Date	Title
FI980631L (fi)	1998-03-20	Menetelmä klavulaanihapon valmistamiseksi
FI964106L (fi)	1996-10-14	Makeutusaineena käyttökelpoisen aspartaamista johdetun yhdisteen parannettu valmistusmenetelmä
FI954739L (fi)	1995-12-05	Menetelmä etikkahapon valmistamiseksi
FI971812A0 (fi)	1997-04-28	Menetelmä yhdistekokoelman valmistamiseksi
FI962069L (fi)	1996-05-15	Menetelmä karpolaktaamin valmistamiseksi
FI945441L (fi)	1994-11-18	Uusi menetelmä 7beta-substituoitu-4-atsa-5alfa-androstan-3-onien valmistamiseksi
PT96411A (pt)	1991-10-15	Processo para a preparacao de derivados de azaoxindole
KR970001365A (ko)	1997-01-24	알킬하이드로겐클로로실란의 제조방법
FI963050L (fi)	1996-10-01	Menetelmä klavulaanihapposuolan valmistamiseksi
FI955800L (fi)	1995-12-01	Menetelmä aminoalkyyliganidiinien valmistamiseksi
FI964001L (fi)	1996-10-04	Menetelmä 7-trialkyylisilyylibakkatiini III:n valmistamiseksi
IL115919A0 (en)	1996-01-31	Process for manufacturing clavulanic acid salt
FI935019L (fi)	1995-05-13	Menetelmä klodronaattivalmisteen valmistamiseksi
FI973287L (fi)	1997-08-22	Klavulaanihapposuoloja
FI963018L (fi)	1996-07-30	Menetelmä gammapyronien valmistamiseksi
FI954786L (fi)	1995-10-06	Menetelmä aminometaanifosfonihapon valmistamiseksi
GB9426261D0 (en)	1995-02-22	Clavulanic acid salts
AU2566895A (en)	1995-12-18	A method for preparing an organic acid or its salt
FI954749L (fi)	1995-10-05	Uusi menetelmä klonidiinijohdannaisten valmistamiseksi
FI972694L (fi)	1997-06-23	Uusi menetelmä sameridiinin valmistamiseksi
FI971038L (fi)	1997-03-12	Menetelmä selegiliinin valmistamiseksi
FI950307L (fi)	1995-07-27	Menetelmä bisyklopentadienyyliyhdisteiden valmistamiseksi
FI890309L (fi)	1989-07-22	Parannettu menetelmä tiotepan valmistamiseksi
IL134912A0 (en)	2001-05-20	Method for preparing 1-phenylpyrrazolin-3-carboxylic acid derivatives
GB2298201B (en)	1997-05-28	Clavulanic acid salts