DK0724432T3 - Fremgangsmåder og præparater til mikroindkapsling af antigener til brug som vacciner - Google Patents
Fremgangsmåder og præparater til mikroindkapsling af antigener til brug som vaccinerInfo
- Publication number
- DK0724432T3 DK0724432T3 DK94930794T DK94930794T DK0724432T3 DK 0724432 T3 DK0724432 T3 DK 0724432T3 DK 94930794 T DK94930794 T DK 94930794T DK 94930794 T DK94930794 T DK 94930794T DK 0724432 T3 DK0724432 T3 DK 0724432T3
- Authority
- DK
- Denmark
- Prior art keywords
- vaccines
- compositions
- methods
- antigens
- microspheres
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 4
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 239000004005 microsphere Substances 0.000 abstract 3
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14179693A | 1993-10-22 | 1993-10-22 | |
| US14355593A | 1993-10-25 | 1993-10-25 | |
| PCT/US1994/011753 WO1995011010A1 (en) | 1993-10-22 | 1994-10-13 | Methods and compositions for microencapsulation of antigens for use as vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0724432T3 true DK0724432T3 (da) | 2003-01-27 |
Family
ID=26839455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94930794T DK0724432T3 (da) | 1993-10-22 | 1994-10-13 | Fremgangsmåder og præparater til mikroindkapsling af antigener til brug som vacciner |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0724432B1 (da) |
| JP (1) | JPH09504027A (da) |
| AT (1) | ATE224184T1 (da) |
| AU (1) | AU7980794A (da) |
| CA (1) | CA2172509C (da) |
| DE (1) | DE69431404T2 (da) |
| DK (1) | DK0724432T3 (da) |
| ES (1) | ES2184769T3 (da) |
| WO (1) | WO1995011010A1 (da) |
Families Citing this family (81)
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|---|---|---|---|---|
| USRE40786E1 (en) * | 1984-03-16 | 2009-06-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres |
| US5912015A (en) | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
| US6514533B1 (en) | 1992-06-11 | 2003-02-04 | Alkermas Controlled Therapeutics, Inc. | Device for the sustained release of aggregation-stabilized, biologically active agent |
| EP0686045B1 (en) * | 1993-02-23 | 2000-11-15 | Genentech, Inc. | Excipient stabilization of polypeptides treated with organic solvents |
| AU8017494A (en) * | 1993-10-22 | 1995-05-08 | Genentech Inc. | Method for preparing microspheres comprising a fluidized bed drying step |
| GB9514285D0 (en) * | 1995-07-13 | 1995-09-13 | Univ Nottingham | Polymeric lamellar substrate particles for drug delivery |
| GB2317340B (en) * | 1995-07-13 | 1998-12-23 | Danbiosyst Uk | Polymeric lamellar substrate particles for drug delivery |
| US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
| US5916597A (en) * | 1995-08-31 | 1999-06-29 | Alkermes Controlled Therapeutics, Inc. | Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent |
| GB9709900D0 (en) * | 1997-05-15 | 1997-07-09 | Microbiological Res Authority | Microencapsulated DNA for vaccination and gene therapy |
| EP1579851A3 (en) * | 1997-08-29 | 2009-09-02 | Corixa Corporation | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of use thereof |
| AU760034B2 (en) * | 1997-08-29 | 2003-05-08 | Corixa Corporation | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof |
| JP4918188B2 (ja) * | 1997-12-16 | 2012-04-18 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
| US7393630B2 (en) | 1997-12-16 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Use of microparticles combined with submicron oil-in-water emulsions |
| SE9801288D0 (sv) | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
| US7087236B1 (en) | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
| AU2841100A (en) * | 2000-02-08 | 2001-08-20 | Institute Of Materials Research And Engineering | Biodegradable and biocompatible polymeric microspheres encapsulating (I)salmonella enteritidis(I)bacteria |
| ES2160089B1 (es) * | 2000-03-15 | 2002-05-16 | Inst Cientifico Tecnol Navarra | Procedimiento y aparato para la produccion de microparticulas para la liberacion controlada de farmacos hidrosolubles y vectores virales. aplicacion a la adiministracion de adn plasmidico y de adenovirus recombinantes defectivos. |
| US6565888B1 (en) | 2000-08-23 | 2003-05-20 | Alkermes Controlled Therapeutics, Inc. | Methods and compositions for the targeted delivery of biologically active agents |
| US20030108565A1 (en) * | 2001-07-10 | 2003-06-12 | Johnson Mark E. | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
| CN100339070C (zh) | 2002-10-24 | 2007-09-26 | 莫茨药物股份两合公司 | 包含1－氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物 |
| CN1794981A (zh) | 2003-05-27 | 2006-06-28 | 森林实验室公司 | 治疗抑郁症和其它情绪障碍的nmda受体拮抗剂和选择性5－羟色胺重摄取抑制剂的组合 |
| US20050260217A1 (en) * | 2004-03-04 | 2005-11-24 | Corixa Corporation | Co-encapsulated WT1 polypeptide and immunostimulant microsphere formulations and methods thereof |
| CN100342916C (zh) * | 2004-12-08 | 2007-10-17 | 上海第二医科大学附属第九人民医院 | 一种可生物降解医用材料标记物及其制备 |
| CN101437539B (zh) | 2005-07-05 | 2013-10-02 | 康奈尔研究基金会（有限公司） | 通过干扰cd99l2阻断白细胞迁出和炎症 |
| JPWO2007024026A1 (ja) | 2005-08-25 | 2009-03-05 | 明石 満 | Ｔ細胞認識エピトープペプチドを固定化又は内包化した生分解性ナノ粒子 |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| ES2377253T3 (es) | 2007-09-12 | 2012-03-23 | Merz Pharma Gmbh & Co. Kgaa | Neramexano para uso en el tratamiento de tinitus subagudo |
| ES2358703B1 (es) * | 2007-11-14 | 2012-03-21 | Universidad Del Pais Vasco | Empleo de micropart�?culas para su uso como vacunas y la liberación de moléculas biológicamente activas. |
| ES2327375B1 (es) | 2007-11-14 | 2010-08-05 | Universidad Del Pais Vasco | Empleo de microparticulas para su uso como vacunas y la liberacion de moleculas biologicamente activas. |
| EP2085120A1 (en) | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | The use of substances for the treatment of central or peripheral insulin receptor impairment and insulin resistance |
| WO2010009271A2 (en) | 2008-07-15 | 2010-01-21 | Academia Sinica | Glycan arrays on ptfe-like aluminum coated glass slides and related methods |
| BRPI0923377A2 (pt) | 2008-12-19 | 2015-07-21 | Merz Pharma Gmbh & Co Kgaa | Derivados de 1-amino-alquilciclohexano para o tratamento de doenças mediadas por mastócitos |
| TWI432188B (zh) | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之１－胺基－烷基環己烷衍生物類 |
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| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
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| US9109007B2 (en) | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
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| JP6302909B2 (ja) | 2012-08-18 | 2018-03-28 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | シアリダーゼの同定および画像化のための細胞透過性プローブ |
| WO2014074114A1 (en) * | 2012-11-09 | 2014-05-15 | Evonik Corporation | Drying methods for tuning microparticle properties |
| WO2014210397A1 (en) | 2013-06-26 | 2014-12-31 | Academia Sinica | Rm2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| JP6486368B2 (ja) | 2013-09-06 | 2019-03-20 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化 |
| NZ714555A (en) | 2013-09-17 | 2020-03-27 | Obi Pharma Inc | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
| WO2015095230A1 (en) * | 2013-12-16 | 2015-06-25 | Massachusetts Institute Of Technology | Micromolded or 3-d printed pulsatile release vaccine formulations |
| WO2015095185A1 (en) | 2013-12-16 | 2015-06-25 | Massachusetts Institute Of Technology | Fortified micronutrient salt formulations |
| WO2015109180A2 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| JP6562942B2 (ja) | 2014-03-27 | 2019-08-28 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 反応性標識化合物およびその使用 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| TWI670078B (zh) | 2014-05-27 | 2019-09-01 | 中央研究院 | 抗ｃｄ２０醣抗體及其用途 |
| WO2015184002A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| CN106661562A (zh) | 2014-05-27 | 2017-05-10 | 中央研究院 | 得自类杆菌属的岩藻糖苷酶及其用途 |
| US11332523B2 (en) | 2014-05-28 | 2022-05-17 | Academia Sinica | Anti-TNF-alpha glycoantibodies and uses thereof |
| US9439864B2 (en) * | 2014-07-07 | 2016-09-13 | Antriabio, Inc. | Solvent extraction from biodegradable microparticles |
| EP3191500A4 (en) | 2014-09-08 | 2018-04-11 | Academia Sinica | HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| TWI736523B (zh) | 2015-01-24 | 2021-08-21 | 中央研究院 | 新穎聚醣結合物及其使用方法 |
| US10935544B2 (en) | 2015-09-04 | 2021-03-02 | Obi Pharma, Inc. | Glycan arrays and method of use |
| AU2017231749A1 (en) | 2016-03-08 | 2018-09-20 | Academia Sinica | Methods for modular synthesis of N-glycans and arrays thereof |
| TWI780045B (zh) | 2016-03-29 | 2022-10-11 | 台灣浩鼎生技股份有限公司 | 抗體、醫藥組合物及方法 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| IL262296B2 (en) | 2016-04-22 | 2024-09-01 | Obi Pharma Inc | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
| MA45738A (fr) | 2016-07-13 | 2019-05-22 | Harvard College | Échafaudages mimétiques de cellules présentant l'antigène et procédés pour les préparer et les utiliser |
| BR112019001656A2 (pt) | 2016-07-27 | 2019-05-28 | Obi Pharma Inc | composição, composição farmacêutica, vacina, método para induzir anticorpos em um indivíduo, método para tratar câncer em um paciente necessitando do mesmo e método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo |
| CN110062767B (zh) | 2016-07-29 | 2023-07-11 | 台湾浩鼎生技股份有限公司 | 人抗体、药物组合物和方法 |
| CN109963868B (zh) | 2016-08-22 | 2023-11-14 | 醣基生医股份有限公司 | 抗体、结合片段及使用方法 |
| AU2017361549B2 (en) | 2016-11-21 | 2023-12-21 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| TWI853822B (zh) | 2018-06-27 | 2024-09-01 | 台灣浩鼎生技股份有限公司 | 用於糖蛋白工程的糖苷合成酶變體及其使用方法 |
| EP3791873A1 (en) | 2019-09-16 | 2021-03-17 | Universite De Bordeaux | Methods of treatment and/or prevention of disorders and symptoms related to bkca and/or sk channelophathies |
| CA3210098A1 (en) | 2021-02-24 | 2022-09-01 | Oakwood Laboratories, Llc | Microsphere formulations comprising lurasidone and methods for making and using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| ATE151638T1 (de) * | 1987-02-20 | 1997-05-15 | Genentech Inc | Verfahren und zubereitungen für die verwendung von hiv-env-polypeptiden und antikörpern |
| US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
| JP2653255B2 (ja) * | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
-
1994
- 1994-10-13 DK DK94930794T patent/DK0724432T3/da active
- 1994-10-13 DE DE69431404T patent/DE69431404T2/de not_active Expired - Lifetime
- 1994-10-13 AT AT94930794T patent/ATE224184T1/de active
- 1994-10-13 JP JP7512118A patent/JPH09504027A/ja not_active Withdrawn
- 1994-10-13 CA CA2172509A patent/CA2172509C/en not_active Expired - Lifetime
- 1994-10-13 EP EP94930794A patent/EP0724432B1/en not_active Expired - Lifetime
- 1994-10-13 AU AU79807/94A patent/AU7980794A/en not_active Abandoned
- 1994-10-13 ES ES94930794T patent/ES2184769T3/es not_active Expired - Lifetime
- 1994-10-13 WO PCT/US1994/011753 patent/WO1995011010A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ES2184769T3 (es) | 2003-04-16 |
| JPH09504027A (ja) | 1997-04-22 |
| DE69431404D1 (de) | 2002-10-24 |
| CA2172509C (en) | 2010-08-24 |
| WO1995011010A1 (en) | 1995-04-27 |
| CA2172509A1 (en) | 1995-04-27 |
| EP0724432A1 (en) | 1996-08-07 |
| AU7980794A (en) | 1995-05-08 |
| ATE224184T1 (de) | 2002-10-15 |
| DE69431404T2 (de) | 2003-04-30 |
| EP0724432B1 (en) | 2002-09-18 |
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