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DK0699759T3 - Aspartokinasegenvarianter - Google Patents

Aspartokinasegenvarianter

Info

Publication number
DK0699759T3
DK0699759T3 DK94902116T DK94902116T DK0699759T3 DK 0699759 T3 DK0699759 T3 DK 0699759T3 DK 94902116 T DK94902116 T DK 94902116T DK 94902116 T DK94902116 T DK 94902116T DK 0699759 T3 DK0699759 T3 DK 0699759T3
Authority
DK
Denmark
Prior art keywords
corynebacterium
lysine
aspartokinase
gene variants
threonine
Prior art date
Application number
DK94902116T
Other languages
Danish (da)
English (en)
Inventor
Masakazu Central Res Sugimoto
Yuri Central Res Lab Ogawa
Tomoto Central Res Lab Suzuki
Akiko Central Res Lab Tanaka
Hiroshi Central Res Lab Matsui
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of DK0699759T3 publication Critical patent/DK0699759T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Ceramic Products (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK94902116T 1993-04-27 1993-12-14 Aspartokinasegenvarianter DK0699759T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10145093A JP3473042B2 (ja) 1992-04-28 1993-04-27 変異型アスパルトキナーゼ遺伝子
PCT/JP1993/001809 WO1994025605A1 (en) 1993-04-27 1993-12-14 Variant aspartokinase gene

Publications (1)

Publication Number Publication Date
DK0699759T3 true DK0699759T3 (da) 2003-09-15

Family

ID=14301034

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94902116T DK0699759T3 (da) 1993-04-27 1993-12-14 Aspartokinasegenvarianter

Country Status (8)

Country Link
US (1) US5688671A (ja)
EP (1) EP0699759B1 (ja)
JP (1) JP3473042B2 (ja)
AT (1) ATE235555T1 (ja)
DE (1) DE69332805T2 (ja)
DK (1) DK0699759T3 (ja)
ES (1) ES2191680T3 (ja)
WO (1) WO1994025605A1 (ja)

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JP3473042B2 (ja) * 1992-04-28 2003-12-02 味の素株式会社 変異型アスパルトキナーゼ遺伝子
US5877179A (en) * 1992-09-29 1999-03-02 The United States Of America As Represented By The Department Of Health And Human Services Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells
DK0841395T3 (da) 1995-06-07 2012-01-09 Ajinomoto Kk Fremgangsmåde til at fremstille L-lysin
JP4035855B2 (ja) 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
JP4075087B2 (ja) * 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
SK285201B6 (sk) * 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
CA2336967C (en) 1998-07-10 2010-06-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor antagonists
CN100540668C (zh) 1999-04-19 2009-09-16 协和发酵生化株式会社 新型脱敏型天冬氨酸激酶
US7270984B1 (en) 1999-06-25 2007-09-18 Basf Aktiengesellschaft Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum
WO2001000843A2 (en) 1999-06-25 2001-01-04 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding metabolic pathway proteins
US6884614B1 (en) 1999-07-01 2005-04-26 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins
DE1246922T1 (de) 1999-07-01 2003-03-20 Basf Ag Für proteine des phosphoenolpyruvat:zucker phosphotransferase systems kodierende gene aus corynebacterium glutamicum
EP1197555B1 (en) 1999-07-02 2006-04-05 Ajinomoto Co., Inc. Dna encoding sucrose pts enzyme ii
US6797509B1 (en) 1999-07-09 2004-09-28 Degussa-Huls Ag Nucleotide sequences which code for the tal gene
DE50015636D1 (de) 1999-09-15 2009-06-10 Basf Plant Science Gmbh Pflanzen mit verändertem aminosäuregehalt und verfahren zu deren herstellung
JP2001120269A (ja) * 1999-10-22 2001-05-08 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
WO2001048146A1 (fr) * 1999-12-24 2001-07-05 Ajinomoto Co., Inc. Procede de production d'acide l-amine et nouveau gene
US6927046B1 (en) * 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
AU3091301A (en) 2000-01-14 2001-07-24 Us Health Methanocarba cycloalkyl nucleoside analogues
DE10210527A1 (de) 2002-03-09 2003-09-18 Degussa Allele des aceA-Gens aus coryneformen Bakterien
WO2007086546A1 (en) * 2006-01-26 2007-08-02 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of enterobacteriaceae family with attenuated expression of the aldh gene
EP2004803A2 (en) * 2006-03-23 2008-12-24 Ajinomoto Co., Inc. A method for producing an l-amino acid using bacterium of theenterobacteriaceae family with attenuated expression of a gene coding for small rna
EP2386650B1 (en) * 2006-04-07 2013-07-03 Evonik Degussa GmbH Method for producing L-amino acids using the gap promoter
WO2007119890A1 (en) * 2006-04-18 2007-10-25 Ajinomoto Co., Inc. A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE sfmACDFH-fimZ CLUSTER OR THE fimZ GENE
JP2009165355A (ja) * 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
WO2007139219A1 (en) * 2006-06-01 2007-12-06 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the rcsa gene
RU2337961C2 (ru) * 2006-07-04 2008-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-ТРЕОНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН rspAB
EP1881076A1 (en) * 2006-07-17 2008-01-23 Evonik Degussa GmbH Method for producing L-amino acids
CN103215319A (zh) * 2006-07-19 2013-07-24 味之素株式会社 使用肠杆菌科细菌产生l-氨基酸的方法
JP2010017081A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2008072761A2 (en) * 2006-12-11 2008-06-19 Ajinomoto Co., Inc. Method for producing an l-amino acid
RU2006143864A (ru) * 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ
RU2006145712A (ru) * 2006-12-22 2008-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ получения l-аминокислот методом ферментации с использованием бактерий, обладающих повышенной способностью к утилизации глицерина
JP2010110217A (ja) * 2007-02-22 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP5217780B2 (ja) * 2008-02-08 2013-06-19 味の素株式会社 Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
EP2302066A4 (en) 2008-07-09 2012-02-08 Ajinomoto Kk METHOD FOR PRODUCING AMINOHYDROXYBENZOIC ACID
JP2012029565A (ja) 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
US8518957B2 (en) 2009-12-02 2013-08-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure
EP2374873A1 (en) 2010-04-08 2011-10-12 Technische Universität Hamburg-Harburg Modified aspartate kinase from corynebacterium and its application for amino acid production
EP2857510A4 (en) 2012-05-29 2016-02-10 Ajinomoto Kk PROCESS FOR PREPARING 3-ACETYLAMINO-4-HYDROXYBENZOIC ACID
DE102012016716A1 (de) 2012-08-22 2014-02-27 Forschungszentrum Jülich GmbH Verfahren zur Herstellung von Vektoren enthaltend ein für in seiner feedback-Inhibierung gemindertes oder ausgeschaltetes Enzym kodierendes Gen und deren Verwendung für die Herstellung von Aminosäuren und Nukleotiden
DE102014208199A1 (de) 2014-04-30 2015-11-05 Evonik Degussa Gmbh Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums
EP2940039A1 (de) 2014-04-30 2015-11-04 Evonik Degussa GmbH Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems
PL2940143T3 (pl) 2014-04-30 2020-06-29 Evonik Operations Gmbh Sposób wytwarzania L-aminokwasów z użyciem bakterii bazofilowych
JP6415845B2 (ja) * 2014-04-30 2018-10-31 日本テクニカ株式会社 展示物の展示及び収容用ケースの構造
EP2940144A1 (de) 2014-04-30 2015-11-04 Evonik Degussa GmbH Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums
KR102011994B1 (ko) * 2017-06-30 2019-08-20 씨제이제일제당 주식회사 신규한 아스파토키나제 변이체 및 이를 이용한 l-아미노산의 제조방법
EP3456833A1 (en) 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3467099A1 (en) * 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3498853A1 (en) 2017-12-14 2019-06-19 Evonik Degussa GmbH Method for the fermentative production of l-lysine
EP3594355A1 (en) 2018-07-12 2020-01-15 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3599282B1 (en) 2018-07-24 2021-03-17 Evonik Operations GmbH Method for the fermentative production of l-lysine
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3660158A1 (en) 2018-11-29 2020-06-03 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3670525A1 (en) 2018-12-18 2020-06-24 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter
US10829746B2 (en) 2019-01-23 2020-11-10 Evonik Operations Gmbh Method for the fermentative production of L-lysine
WO2021048353A1 (en) 2019-09-11 2021-03-18 Evonik Operations Gmbh Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine
WO2023041425A1 (en) 2021-09-20 2023-03-23 Evonik Operations Gmbh Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2
EP4497818A1 (en) 2023-07-25 2025-01-29 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains expressing heterologous nicotinamide nucleotide transhydrogenase pntab
CN117327677B (zh) * 2023-09-26 2024-09-20 江南大学 天冬氨酸激酶突变体及其应用

Family Cites Families (4)

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JPS5763095A (en) * 1980-09-30 1982-04-16 Ajinomoto Co Inc Production of l-lysine through fermentation process
DE3908201A1 (de) * 1989-03-14 1990-09-27 Degussa Verfahren zur fermentativen herstellung von l-lysin
JP3473042B2 (ja) * 1992-04-28 2003-12-02 味の素株式会社 変異型アスパルトキナーゼ遺伝子
JPH06261766A (ja) * 1993-03-16 1994-09-20 Mitsubishi Petrochem Co Ltd フィードバックインヒビションの解除されたアスパルトキナーゼをコードする遺伝子ｄｎａ及びその利用

Also Published As

Publication number Publication date
DE69332805D1 (de) 2003-04-30
DE69332805T2 (de) 2004-02-19
JPH0662866A (ja) 1994-03-08
US5688671A (en) 1997-11-18
ES2191680T3 (es) 2003-09-16
WO1994025605A1 (en) 1994-11-10
JP3473042B2 (ja) 2003-12-02
EP0699759A1 (en) 1996-03-06
EP0699759B1 (en) 2003-03-26
EP0699759A4 (en) 1999-09-22
ATE235555T1 (de) 2003-04-15

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