DK0631786T3 - Lys-plasminogen i forbindelse med forebyggelse og behandling af iskæmi og reperfusionsskade - Google Patents
Lys-plasminogen i forbindelse med forebyggelse og behandling af iskæmi og reperfusionsskadeInfo
- Publication number
- DK0631786T3 DK0631786T3 DK94110267T DK94110267T DK0631786T3 DK 0631786 T3 DK0631786 T3 DK 0631786T3 DK 94110267 T DK94110267 T DK 94110267T DK 94110267 T DK94110267 T DK 94110267T DK 0631786 T3 DK0631786 T3 DK 0631786T3
- Authority
- DK
- Denmark
- Prior art keywords
- plasminogen
- lys
- ischemia
- treatment
- reperfusion
- Prior art date
Links
- 108010087750 lysyl-plasminogen Proteins 0.000 title abstract 5
- 206010063837 Reperfusion injury Diseases 0.000 title abstract 2
- 208000028867 ischemia Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 230000010410 reperfusion Effects 0.000 abstract 2
- 108010051456 Plasminogen Proteins 0.000 abstract 1
- 102000013566 Plasminogen Human genes 0.000 abstract 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 abstract 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 229940012957 plasmin Drugs 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000006337 proteolytic cleavage Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960000187 tissue plasminogen activator Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Farming Of Fish And Shellfish (AREA)
- Electrotherapy Devices (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8803393A | 1993-07-02 | 1993-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0631786T3 true DK0631786T3 (da) | 1999-04-06 |
Family
ID=22208925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94110267T DK0631786T3 (da) | 1993-07-02 | 1994-07-01 | Lys-plasminogen i forbindelse med forebyggelse og behandling af iskæmi og reperfusionsskade |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5520912A (da) |
| EP (1) | EP0631786B1 (da) |
| JP (1) | JP2784146B2 (da) |
| AT (2) | AT407706B (da) |
| AU (1) | AU680492B2 (da) |
| CA (1) | CA2127199C (da) |
| CZ (1) | CZ283352B6 (da) |
| DE (1) | DE69411084T2 (da) |
| DK (1) | DK0631786T3 (da) |
| ES (1) | ES2119934T3 (da) |
| GR (1) | GR3027778T3 (da) |
| HR (1) | HRP940381B1 (da) |
| HU (1) | HU217961B (da) |
| NO (1) | NO942367L (da) |
| PL (1) | PL304061A1 (da) |
| RU (1) | RU2153353C2 (da) |
| SI (1) | SI0631786T1 (da) |
| SK (1) | SK281472B6 (da) |
| ZA (1) | ZA944522B (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4411143C2 (de) * | 1994-03-30 | 1996-08-01 | Immuno Ag | Thrombosemittel |
| EP1117437B1 (en) * | 1998-09-29 | 2006-12-27 | Leuven Research & Development vzw | Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke |
| EP1062953A1 (en) * | 1999-06-22 | 2000-12-27 | Leuven Research & Development vzw | Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke |
| US7184963B1 (en) | 1999-01-19 | 2007-02-27 | Bristol-Myers Squibb Company | Method for determining care and prevention pathways for clinical management of wounds |
| AU778729B2 (en) * | 1999-01-19 | 2004-12-16 | Convatec Technologies Inc. | Method for determining care and prevention pathways for clinical management of wounds |
| AU3173301A (en) * | 2000-02-11 | 2001-08-20 | European Molecular Biology Laboratory | Methods and compositions for treatment of alzheimer's disease by enhancing plasmin or plasmin-like activity |
| DE10390418D2 (de) * | 2002-02-06 | 2005-01-13 | N Zyme Biotec Gmbh | Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen |
| EP1545588A4 (en) * | 2002-07-23 | 2007-12-05 | Ludwig Inst Cancer Res | METHOD AND COMPOSITIONS FOR THE ACTIVATION OR INHIBITION OF VEGF-D AND VEGF-C |
| PE20050438A1 (es) * | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
| WO2011004011A1 (en) | 2009-07-10 | 2011-01-13 | Thrombogenics Nv | Variants of plasminogen and plasmin |
| WO2011023805A1 (en) | 2009-08-28 | 2011-03-03 | Thrombogenics N.V. | Use of plasmin for the treatment of filtration failure after trabeculectomy |
| MX337248B (es) | 2011-01-05 | 2016-02-19 | Thrombogenics Nv | Variantes de plasminogeno y plasmina. |
| CA2844644A1 (en) | 2011-08-12 | 2013-02-21 | Thrombogenics N.V. | Plasminogen and plasmin variants |
| WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| US11478535B2 (en) | 2016-12-15 | 2022-10-25 | Talengen International Limited | Method for preventing and treating fatty liver |
| WO2018107707A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种改善心脏病变的方法 |
| TW201829448A (zh) | 2016-12-15 | 2018-08-16 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備預防或治療肥胖症及疾病倂發的肥胖的藥物中的用途 |
| CN110831668B (zh) * | 2017-06-23 | 2024-04-12 | 普罗米蒂克生物治疗公司 | 与pai-1过表达相关的病状的血纤维蛋白溶酶原治疗 |
| RU2729788C2 (ru) * | 2018-09-04 | 2020-08-12 | Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр "Пущинский научный центр биологических исследований Российской академии наук" | Средство, его применение и способ повышения устойчивости организма млекопитающих к ишемически-реперфузионному поражению тонкого кишечника |
| EP3914288A1 (en) | 2019-01-24 | 2021-12-01 | PreviPharma Consulting GmbH | Plasminogen for treating and preventing microthrombosis |
| CN113677200B (zh) | 2019-04-12 | 2023-09-26 | 乌格勒希研究有限公司 | 用于修复器官的方法和装置 |
| CA3134900A1 (en) * | 2019-04-12 | 2020-10-15 | Uglk Science Ab | Method and apparatus for reconditioning kidneys |
| CN114642722A (zh) * | 2020-12-18 | 2022-06-21 | 四川大学华西医院 | 纤溶酶原用于制备促进血管新生的药物中的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3065190D1 (en) * | 1979-11-05 | 1983-11-10 | Beecham Group Plc | Enzyme derivatives, and their preparation |
| JP2764264B2 (ja) * | 1987-10-01 | 1998-06-11 | 株式会社ミドリ十字 | 線溶活性増強剤 |
| US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
| US5256642A (en) * | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
| AT390801B (de) * | 1988-07-28 | 1990-07-10 | Immuno Ag | Verfahren zur herstellung von lys-plasminogen |
| US5358936A (en) * | 1990-08-03 | 1994-10-25 | Paul Gordon | Anionic furanose derivatives, methods of making and using the same |
| AT402367B (de) * | 1990-10-11 | 1997-04-25 | Immuno Ag | Pharmazeutische zubereitung auf basis von lys-plasminogen |
-
1994
- 1994-06-08 US US08/257,626 patent/US5520912A/en not_active Expired - Fee Related
- 1994-06-21 NO NO942367A patent/NO942367L/no not_active Application Discontinuation
- 1994-06-22 AU AU64854/94A patent/AU680492B2/en not_active Ceased
- 1994-06-23 ZA ZA944522A patent/ZA944522B/xx unknown
- 1994-06-30 CA CA002127199A patent/CA2127199C/en not_active Expired - Fee Related
- 1994-06-30 PL PL94304061A patent/PL304061A1/xx unknown
- 1994-07-01 RU RU94022754/14A patent/RU2153353C2/ru active
- 1994-07-01 HU HU9401983A patent/HU217961B/hu not_active IP Right Cessation
- 1994-07-01 JP JP6150797A patent/JP2784146B2/ja not_active Expired - Fee Related
- 1994-07-01 AT AT0131094A patent/AT407706B/de not_active IP Right Cessation
- 1994-07-01 DE DE69411084T patent/DE69411084T2/de not_active Expired - Fee Related
- 1994-07-01 AT AT94110267T patent/ATE167400T1/de not_active IP Right Cessation
- 1994-07-01 EP EP94110267A patent/EP0631786B1/en not_active Expired - Lifetime
- 1994-07-01 ES ES94110267T patent/ES2119934T3/es not_active Expired - Lifetime
- 1994-07-01 SI SI9430143T patent/SI0631786T1/xx unknown
- 1994-07-01 CZ CZ941613A patent/CZ283352B6/cs not_active IP Right Cessation
- 1994-07-01 DK DK94110267T patent/DK0631786T3/da active
- 1994-07-01 HR HR08/088,033A patent/HRP940381B1/xx not_active IP Right Cessation
- 1994-07-01 SK SK798-94A patent/SK281472B6/sk unknown
- 1994-11-21 US US08/345,468 patent/US5597800A/en not_active Expired - Fee Related
-
1998
- 1998-08-31 GR GR980401956T patent/GR3027778T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL304061A1 (en) | 1995-01-09 |
| EP0631786B1 (en) | 1998-06-17 |
| SK281472B6 (sk) | 2001-04-09 |
| CA2127199C (en) | 2000-11-28 |
| CA2127199A1 (en) | 1995-01-03 |
| ATA131094A (de) | 2000-10-15 |
| GR3027778T3 (en) | 1998-11-30 |
| SI0631786T1 (en) | 1998-10-31 |
| DE69411084D1 (de) | 1998-07-23 |
| US5597800A (en) | 1997-01-28 |
| AU680492B2 (en) | 1997-07-31 |
| US5520912A (en) | 1996-05-28 |
| ZA944522B (en) | 1995-02-23 |
| ES2119934T3 (es) | 1998-10-16 |
| HRP940381A2 (en) | 1997-04-30 |
| HU9401983D0 (en) | 1994-09-28 |
| CZ283352B6 (cs) | 1998-03-18 |
| JP2784146B2 (ja) | 1998-08-06 |
| NO942367L (no) | 1995-01-03 |
| NO942367D0 (da) | 1994-06-21 |
| SK79894A3 (en) | 1995-05-10 |
| RU2153353C2 (ru) | 2000-07-27 |
| DE69411084T2 (de) | 1998-12-03 |
| RU94022754A (ru) | 1996-08-10 |
| JPH07145076A (ja) | 1995-06-06 |
| EP0631786A1 (en) | 1995-01-04 |
| HRP940381B1 (en) | 1999-06-30 |
| AU6485494A (en) | 1995-01-12 |
| HU217961B (hu) | 2000-05-28 |
| AT407706B (de) | 2001-05-25 |
| ATE167400T1 (de) | 1998-07-15 |
| HUT67225A (en) | 1995-03-28 |
| CZ161394A3 (en) | 1995-01-18 |
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