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DK0582810T3 - Nye 7-(substitueret)-8-(substitueret)-9-(substitueret amino)-6-demethyl-6-deoxytetracycliner som antibiotiske midler - Google Patents

Nye 7-(substitueret)-8-(substitueret)-9-(substitueret amino)-6-demethyl-6-deoxytetracycliner som antibiotiske midler

Info

Publication number
DK0582810T3
DK0582810T3 DK93109850T DK93109850T DK0582810T3 DK 0582810 T3 DK0582810 T3 DK 0582810T3 DK 93109850 T DK93109850 T DK 93109850T DK 93109850 T DK93109850 T DK 93109850T DK 0582810 T3 DK0582810 T3 DK 0582810T3
Authority
DK
Denmark
Prior art keywords
substituted
deoxytetracyclines
demethyl
antibiotics
new
Prior art date
Application number
DK93109850T
Other languages
English (en)
Inventor
Ving J Lee
Joseph J Hlavka
Phaik-Eng Sum
Raymond T Testa
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DK0582810T3 publication Critical patent/DK0582810T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK93109850T 1992-08-13 1993-06-21 Nye 7-(substitueret)-8-(substitueret)-9-(substitueret amino)-6-demethyl-6-deoxytetracycliner som antibiotiske midler DK0582810T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13

Publications (1)

Publication Number Publication Date
DK0582810T3 true DK0582810T3 (da) 2002-06-03

Family

ID=25456505

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93109850T DK0582810T3 (da) 1992-08-13 1993-06-21 Nye 7-(substitueret)-8-(substitueret)-9-(substitueret amino)-6-demethyl-6-deoxytetracycliner som antibiotiske midler

Country Status (24)

Country Link
US (4) US5430162A (da)
EP (1) EP0582810B1 (da)
JP (1) JP3639313B2 (da)
KR (1) KR100309540B1 (da)
CN (1) CN1048719C (da)
AT (1) ATE215530T1 (da)
AU (1) AU674524B2 (da)
CA (1) CA2103861C (da)
CZ (1) CZ289195B6 (da)
DE (1) DE69331774T2 (da)
DK (1) DK0582810T3 (da)
ES (1) ES2173876T3 (da)
FI (1) FI933567L (da)
HU (2) HU213269B (da)
IL (4) IL119750A (da)
NO (1) NO302568B1 (da)
NZ (1) NZ248359A (da)
PH (1) PH31210A (da)
PL (4) PL175487B1 (da)
PT (1) PT582810E (da)
RU (1) RU2127255C1 (da)
SG (1) SG47520A1 (da)
SK (1) SK281871B6 (da)
ZA (1) ZA935892B (da)

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US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
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EP1666454B1 (en) * 1999-09-14 2011-09-07 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
KR20030007489A (ko) * 2000-03-31 2003-01-23 트러스티즈 오브 터프츠 칼리지 7- 및 9-카르바메이트, 우레아, 티오우레아,티오카르바메이트 및 헤테로아릴-아미노 치환된테트라사이클린 화합물
ATE288779T1 (de) * 2000-06-02 2005-02-15 Yu Liu Nicht-antibakterielle tetrazykline als anti-pilz medikamente
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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002004404A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
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US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
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EP1501490A2 (en) * 2002-05-06 2005-02-02 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating mucositis and fungal infection
WO2004000223A2 (en) * 2002-06-20 2003-12-31 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
JP4416652B2 (ja) 2002-07-12 2010-02-17 パラテック ファーマシューティカルズ インコーポレイテッド ３、１０、および１２ａ置換されたテトラサイクリン化合物
JP2006503898A (ja) * 2002-10-24 2006-02-02 パラテック ファーマシューティカルズ， インク． マラリア治療のための置換テトラサイクリン化合物
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
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EP2332904A3 (en) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
PT1753713T (pt) 2004-05-21 2016-11-08 Harvard College Síntese de tetraciclinas e seus análogos
AU2005299569B2 (en) 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2301912A3 (en) 2004-10-25 2012-07-11 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US7534766B2 (en) 2004-11-05 2009-05-19 Wyeth Glucuronide metabolites and epimers thereof of tigecycline
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Also Published As

Publication number Publication date
DE69331774D1 (de) 2002-05-08
JP3639313B2 (ja) 2005-04-20
PL174230B1 (pl) 1998-07-31
NO302568B1 (no) 1998-03-23
SK281871B6 (sk) 2001-08-06
HU213269B (en) 1997-04-28
JPH06228072A (ja) 1994-08-16
US5512553A (en) 1996-04-30
SK85793A3 (en) 1994-04-06
CZ157593A3 (en) 1994-02-16
US5430162A (en) 1995-07-04
IL119751A (en) 1998-09-24
FI933567A0 (fi) 1993-08-12
EP0582810A1 (en) 1994-02-16
CZ289195B6 (cs) 2001-11-14
CA2103861C (en) 2004-07-27
SG47520A1 (en) 1998-04-17
DE69331774T2 (de) 2002-11-14
KR940003925A (ko) 1994-03-14
US5495018A (en) 1996-02-27
PL175487B1 (pl) 1999-01-29
PL300066A1 (en) 1994-02-21
KR100309540B1 (ko) 2002-04-24
US5886175A (en) 1999-03-23
PL174022B1 (pl) 1998-06-30
RU2127255C1 (ru) 1999-03-10
NZ248359A (en) 1996-03-26
HU9302333D0 (en) 1993-10-28
ES2173876T3 (es) 2002-11-01
PT582810E (pt) 2002-08-30
IL106677A0 (en) 1993-12-08
AU4460193A (en) 1994-02-17
NO932872D0 (no) 1993-08-12
CA2103861A1 (en) 1994-02-14
FI933567L (fi) 1994-02-14
HU211303A9 (en) 1995-11-28
IL119750A0 (en) 1997-03-18
NO932872L (no) 1994-02-14
PH31210A (en) 1998-05-05
IL106677A (en) 1998-06-15
ATE215530T1 (de) 2002-04-15
ZA935892B (en) 1994-03-10
IL119750A (en) 1998-09-24
AU674524B2 (en) 1997-01-02
HUT64945A (en) 1994-03-28
CN1090267A (zh) 1994-08-03
EP0582810B1 (en) 2002-04-03
CN1048719C (zh) 2000-01-26
PL174127B1 (pl) 1998-06-30

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