[go: up one dir, main page]

DK0555276T3 - Immunogene komplekser, især iscomer - Google Patents

Immunogene komplekser, især iscomer

Info

Publication number
DK0555276T3
DK0555276T3 DK91918619.7T DK91918619T DK0555276T3 DK 0555276 T3 DK0555276 T3 DK 0555276T3 DK 91918619 T DK91918619 T DK 91918619T DK 0555276 T3 DK0555276 T3 DK 0555276T3
Authority
DK
Denmark
Prior art keywords
pct
iscoms
immunogenic
quil
fractions
Prior art date
Application number
DK91918619.7T
Other languages
Danish (da)
English (en)
Inventor
Gideon Frank Anne Kersten
Arjen Spiekstra
Gerrit Van De Werken
Eduard Coen Beuvery
Original Assignee
Nederlanden Staat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlanden Staat filed Critical Nederlanden Staat
Application granted granted Critical
Publication of DK0555276T3 publication Critical patent/DK0555276T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK91918619.7T 1990-10-23 1991-10-23 Immunogene komplekser, især iscomer DK0555276T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL9002314A NL9002314A (nl) 1990-10-23 1990-10-23 Immunogene complexen, in het bijzonder iscoms.

Publications (1)

Publication Number Publication Date
DK0555276T3 true DK0555276T3 (da) 1995-09-18

Family

ID=19857870

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91918619.7T DK0555276T3 (da) 1990-10-23 1991-10-23 Immunogene komplekser, især iscomer

Country Status (10)

Country Link
US (1) US5620690A (el)
EP (1) EP0555276B1 (el)
AT (1) ATE127024T1 (el)
CA (1) CA2094600C (el)
DE (1) DE69112634T2 (el)
DK (1) DK0555276T3 (el)
ES (1) ES2075964T3 (el)
GR (1) GR3017778T3 (el)
NL (1) NL9002314A (el)
WO (1) WO1992006710A1 (el)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08502416A (ja) * 1992-10-30 1996-03-19 シード・キャピタル・インベストメント・（エス・シー・アイ）・ベスローテン・フェンノートシャップ キラヤ種の培養細胞
NL9301690A (nl) * 1993-08-12 1995-04-18 Seed Capital Investments Verbindingen met adjuvans-activiteit.
WO1995009179A1 (en) * 1993-09-30 1995-04-06 Seed Capital Investments (Sci) B.V. Compounds with adjuvant activity
AUPM500494A0 (en) * 1994-04-12 1994-05-05 Minister For Agriculture & Rural Affairs For The State Of New South Wales, The Composition for use in increasing mucosal immunity
AUPM873294A0 (en) * 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
GB9620795D0 (en) * 1996-10-05 1996-11-20 Smithkline Beecham Plc Vaccines
UA56132C2 (uk) * 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
SE9600648D0 (sv) * 1996-02-21 1996-02-21 Bror Morein Receptorbimdande enhet
AUPO517897A0 (en) * 1997-02-19 1997-04-11 Csl Limited Chelating immunostimulating complexes
DE69840962D1 (de) * 1997-08-29 2009-08-20 Antigenics Inc Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittel
GB9817052D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Biolog Vaccine
US7713942B2 (en) 2001-04-04 2010-05-11 Nordic Vaccine Technology A/S Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
DE60229118D1 (de) 2001-04-04 2008-11-13 Nordic Vaccine Technology As Polynukleotide-bindende komplexe die sterolen und saponine enthalten
SE0202110D0 (sv) * 2002-07-05 2002-07-05 Isconova Ab Iscom preparation and use thereof
EP1545605B8 (en) * 2002-10-02 2010-05-26 Nordic Vaccine A/S Composition for vaccination
SE0300795D0 (sv) 2003-03-24 2003-03-24 Isconova Ab Composition comprising iscom particles and live micro-organisms
SE0301998D0 (sv) * 2003-07-07 2003-07-07 Isconova Ab Quil A fraction with low toxicity and use thereof
EP1838341B1 (en) * 2005-01-20 2013-08-14 Isconova AB Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide
EP1873522B1 (en) * 2005-04-14 2014-08-13 Panasonic Healthcare Co., Ltd. Method for determination of hemoglobin derivative, and reagent composition, assay kit, analysis device and analysis system for use in the method
US20110287089A1 (en) 2009-01-13 2011-11-24 Karola Rittner Use of a saccharomyces cerevisiae mitochondrial nucleic acids fraction for immune stimulation
EP4176871A1 (en) * 2011-10-03 2023-05-10 Canqura Oncology Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
EP4494650A3 (en) 2015-09-03 2025-03-26 Novavax, Inc. Vaccine compositions having improved stability and immunogenicity
WO2019023196A1 (en) 2017-07-24 2019-01-31 Novavax, Inc. METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISEASE
BR112020019108A2 (pt) 2018-03-19 2020-12-29 Novavax, Inc. Vacinas polivalentes de nanopartículas de influenza
US10953089B1 (en) 2020-01-27 2021-03-23 Novavax, Inc. Coronavirus vaccine formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8205892D0 (sv) * 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE8405493D0 (sv) * 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
ATE71303T1 (de) * 1986-01-14 1992-01-15 Nederlanden Staat Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung.
US5057540A (en) * 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
CA1331443C (en) * 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
NZ230747A (en) * 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
US4981684A (en) * 1989-10-24 1991-01-01 Coopers Animal Health Limited Formation of adjuvant complexes
US5273965A (en) * 1992-07-02 1993-12-28 Cambridge Biotech Corporation Methods for enhancing drug delivery with modified saponins

Also Published As

Publication number Publication date
ATE127024T1 (de) 1995-09-15
DE69112634T2 (de) 1996-02-08
NL9002314A (nl) 1992-05-18
ES2075964T3 (es) 1995-10-16
DE69112634D1 (de) 1995-10-05
GR3017778T3 (en) 1996-01-31
US5620690A (en) 1997-04-15
EP0555276A1 (en) 1993-08-18
CA2094600A1 (en) 1992-04-24
CA2094600C (en) 1998-12-08
EP0555276B1 (en) 1995-08-30
WO1992006710A1 (en) 1992-04-30

Similar Documents

Publication Publication Date Title
DK0555276T3 (da) Immunogene komplekser, især iscomer
HU9500571D0 (en) Retro-, inverso-, and retro-inverso synthetic peptide analogues
DK602989D0 (da) Saponinadjuvans
MY103182A (en) Vaccines against acquired immune deficiency syndrome.
EA199700272A1 (ru) Вакцины, содержащие сапонин и стерин
ES8203226A1 (es) Procedimiento de preparar complejos vacunantes por reaccion de arn ribonosales y de antigenos especificos.
NZ219113A (en) Hiv peptide containing epitope of the env protein
NO924780L (no) Ekspresjon av spesifikke immunogener ved bruk av virusantigener
PT98156A (pt) Um processo de preparacao de uma composicao de vacina
HUP9903770A2 (hu) Eljárások és készítmények többepitópos antigének konformációjának megváltoztatására immunválasz kiváltása céljából
GR3029774T3 (en) Method of preparing a radioactive rhenium complex solution.
AU1800597A (en) Novel methods of vaccination and vaccines therefore comprising a nucleic acid encoding a first epitope and a peptide containing a second epitope
IT8248474A0 (it) Antigene anti-malarico, procedimento per la sua preparazione e vaccino che lo contiene
ATE544470T1 (de) Immuntherapeutische methoden und zusammensetzungen
ES2114064T3 (es) Inmunoanalisis para la deteccion de colageno o fragmentos de colageno.
DK0701612T3 (da) Immunogent præparat af OspC-antigenvacciner til forebyggelse og behandling af Lyme sygdom og rekombinantmetode til fremsti
ATE188484T1 (de) Immunologisch mit hla homologe hiv protein epitope
ZA856655B (en) Cross-reactive and protective epitopes of circumsporozoite proteins
IL106407A (en) Antigens, vaccines containing them and their preparation
DE69229043D1 (de) Das durch den monoklonalen menschlichen antikörper 81av78 erkannte antigen ctaa 81av78
EP1020516A3 (en) Leptospira vaccine antigens for the prevention of leptospirosis
NZ301334A (en) Helicobacter pylori antigen