DK0555276T3 - Immunogene komplekser, især iscomer - Google Patents

Immunogene komplekser, især iscomer

Info

Publication number: DK0555276T3
Authority: DK; Denmark
Prior art keywords: pct; iscoms; immunogenic; quil; fractions
Prior art date: 1990-10-23

Application number

DK91918619.7T

Other languages

English (en)

Inventor

Gideon Frank Anne Kersten

Arjen Spiekstra

Gerrit Van De Werken

Eduard Coen Beuvery

Original Assignee

Nederlanden Staat

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-23

Filing date

1991-10-23

Publication date

1995-09-18

1991-10-23 Application filed by Nederlanden Staat filed Critical Nederlanden Staat

1995-09-18 Application granted granted Critical

1995-09-18 Publication of DK0555276T3 publication Critical patent/DK0555276T3/da

Links

230000002163 immunogen Effects 0.000 title abstract 6
UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 abstract 3
239000001397 quillaja saponaria molina bark Substances 0.000 abstract 3
229930182490 saponin Natural products 0.000 abstract 3
150000007949 saponins Chemical class 0.000 abstract 3
229930182558 Sterol Natural products 0.000 abstract 1
239000000427 antigen Substances 0.000 abstract 1
230000000890 antigenic effect Effects 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
230000008105 immune reaction Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
150000003432 sterols Chemical class 0.000 abstract 1
235000003702 sterols Nutrition 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Mycology (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK91918619.7T 1990-10-23 1991-10-23 Immunogene komplekser, især iscomer DK0555276T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL9002314A NL9002314A (nl)	1990-10-23	1990-10-23	Immunogene complexen, in het bijzonder iscoms.

Publications (1)

Publication Number	Publication Date
DK0555276T3 true DK0555276T3 (da)	1995-09-18

Family

ID=19857870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91918619.7T DK0555276T3 (da)	1990-10-23	1991-10-23	Immunogene komplekser, især iscomer

Country Status (10)

Country	Link
US (1)	US5620690A (da)
EP (1)	EP0555276B1 (da)
AT (1)	ATE127024T1 (da)
CA (1)	CA2094600C (da)
DE (1)	DE69112634T2 (da)
DK (1)	DK0555276T3 (da)
ES (1)	ES2075964T3 (da)
GR (1)	GR3017778T3 (da)
NL (1)	NL9002314A (da)
WO (1)	WO1992006710A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08502416A (ja) *	1992-10-30	1996-03-19	シード・キャピタル・インベストメント・（エス・シー・アイ）・ベスローテン・フェンノートシャップ	キラヤ種の培養細胞
NL9301690A (nl) *	1993-08-12	1995-04-18	Seed Capital Investments	Verbindingen met adjuvans-activiteit.
AU1077795A (en) *	1993-09-30	1995-04-18	Seed Capital Investments (Sci) B.V.	Compounds with adjuvant activity
AUPM500494A0 (en) *	1994-04-12	1994-05-05	Minister For Agriculture & Rural Affairs For The State Of New South Wales, The	Composition for use in increasing mucosal immunity
AUPM873294A0 (en) *	1994-10-12	1994-11-03	Csl Limited	Saponin preparations and use thereof in iscoms
UA56132C2 (uk) *	1995-04-25	2003-05-15	Смітклайн Бічем Байолоджікалс С.А.	Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
GB9620795D0 (en) *	1996-10-05	1996-11-20	Smithkline Beecham Plc	Vaccines
SE9600648D0 (sv) *	1996-02-21	1996-02-21	Bror Morein	Receptorbimdande enhet
AUPO517897A0 (en) *	1997-02-19	1997-04-11	Csl Limited	Chelating immunostimulating complexes
ATE435661T1 (de) *	1997-08-29	2009-07-15	Antigenics Inc	Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittel
GB9817052D0 (en) *	1998-08-05	1998-09-30	Smithkline Beecham Biolog	Vaccine
NZ529347A (en)	2001-04-04	2008-01-31	Nordic Vaccine Technology As	Use of at least one sterol capable of interacting with a nucleic acid and at least saponin to form immunostimulating complexes ( IMSCO )
US7713942B2 (en)	2001-04-04	2010-05-11	Nordic Vaccine Technology A/S	Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
SE0202110D0 (sv) *	2002-07-05	2002-07-05	Isconova Ab	Iscom preparation and use thereof
CA2500911A1 (en) *	2002-10-02	2004-04-15	Nordic Vaccine Technology A/S	Composition for vaccination
SE0300795D0 (sv)	2003-03-24	2003-03-24	Isconova Ab	Composition comprising iscom particles and live micro-organisms
SE0301998D0 (sv) *	2003-07-07	2003-07-07	Isconova Ab	Quil A fraction with low toxicity and use thereof
US8007806B2 (en) *	2005-01-20	2011-08-30	Isconova Ab	Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide
KR20070116103A (ko) *	2005-04-14	2007-12-06	마츠시타 덴끼 산교 가부시키가이샤	헤모글로빈 유도체의 측정 방법, 그것에 이용되는 시약조성물, 측정 키트, 분석 디바이스, 및 분석 시스템
AU2010205717A1 (en)	2009-01-13	2010-07-22	Transgene Sa	Use of a Saccharomyces cerevisiae mitochondrial nucleic acids fraction for immune stimulation
DK3311827T3 (da)	2011-10-03	2023-04-03	Canqura Oncology Ab	Nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf som bærere for amfipatiske eller hydrofobe molekyler inden for det medicinske område, inklusiv cancerbehandling, samt fødevarerelaterede forbindelser
EP3344291B1 (en)	2015-09-03	2024-11-27	Novavax, Inc.	Vaccine compositions having improved stability and immunogenicity
EP3658118A4 (en)	2017-07-24	2021-03-31	Novavax, Inc.	METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISEASE
MX2020009682A (es)	2018-03-19	2020-10-12	Novavax Inc	Vacunas de nanoparticulas multivalentes contra la influenza.
US10953089B1 (en)	2020-01-27	2021-03-23	Novavax, Inc.	Coronavirus vaccine formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8205892D0 (sv) *	1982-10-18	1982-10-18	Bror Morein	Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE8405493D0 (sv) *	1984-11-01	1984-11-01	Bror Morein	Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
DK166762B1 (da) *	1986-01-14	1993-07-12	Nederlanden Staat	Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser
CA1331443C (en) *	1987-05-29	1994-08-16	Charlotte A. Kensil	Saponin adjuvant
US5057540A (en) *	1987-05-29	1991-10-15	Cambridge Biotech Corporation	Saponin adjuvant
NZ230747A (en) *	1988-09-30	1992-05-26	Bror Morein	Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
US4981684A (en) *	1989-10-24	1991-01-01	Coopers Animal Health Limited	Formation of adjuvant complexes
US5273965A (en) *	1992-07-02	1993-12-28	Cambridge Biotech Corporation	Methods for enhancing drug delivery with modified saponins

1990
- 1990-10-23 NL NL9002314A patent/NL9002314A/nl not_active Application Discontinuation
1991
- 1991-10-23 US US08/039,294 patent/US5620690A/en not_active Expired - Lifetime
- 1991-10-23 CA CA002094600A patent/CA2094600C/en not_active Expired - Lifetime
- 1991-10-23 AT AT91918619T patent/ATE127024T1/de not_active IP Right Cessation
- 1991-10-23 WO PCT/NL1991/000211 patent/WO1992006710A1/en active IP Right Grant
- 1991-10-23 DK DK91918619.7T patent/DK0555276T3/da active
- 1991-10-23 DE DE69112634T patent/DE69112634T2/de not_active Expired - Lifetime
- 1991-10-23 EP EP91918619A patent/EP0555276B1/en not_active Expired - Lifetime
- 1991-10-23 ES ES91918619T patent/ES2075964T3/es not_active Expired - Lifetime
1995
- 1995-10-18 GR GR950402880T patent/GR3017778T3/el unknown

Also Published As

Publication number	Publication date
DE69112634D1 (de)	1995-10-05
CA2094600A1 (en)	1992-04-24
CA2094600C (en)	1998-12-08
EP0555276B1 (en)	1995-08-30
GR3017778T3 (en)	1996-01-31
ES2075964T3 (es)	1995-10-16
EP0555276A1 (en)	1993-08-18
DE69112634T2 (de)	1996-02-08
NL9002314A (nl)	1992-05-18
ATE127024T1 (de)	1995-09-15
WO1992006710A1 (en)	1992-04-30
US5620690A (en)	1997-04-15

Publication	Publication Date	Title
DK0555276T3 (da)	1995-09-18	Immunogene komplekser, især iscomer
HU9500571D0 (en)	1995-04-28	Retro-, inverso-, and retro-inverso synthetic peptide analogues
DK602989D0 (da)	1989-11-29	Saponinadjuvans
MY103182A (en)	1993-05-29	Vaccines against acquired immune deficiency syndrome.
ES500567A0 (es)	1982-04-16	Procedimiento de preparar complejos vacunantes por reaccion de arn ribonosales y de antigenos especificos.
EP0109942A3 (en)	1985-08-14	Immunogenic protein or peptide complex, method of producing said complex and the use thereof as an immune stimulant and as a vaccine
GB2303855B (en)	1998-10-28	Helicobacter pylori antigenic protein preparation and immunoassays
PT584348E (pt)	2005-10-31	Vacina genetica para virus da imunodeficiencia
NZ219113A (en)	1991-02-26	Hiv peptide containing epitope of the env protein
NZ331651A (en)	2000-01-28	BSW17 peptide immunogens for vaccination against and treatment of allergy
PT98156A (pt)	1992-04-30	Um processo de preparacao de uma composicao de vacina
HUP9903770A2 (hu)	2000-03-28	Eljárások és készítmények többepitópos antigének konformációjának megváltoztatására immunválasz kiváltása céljából
GR3029774T3 (en)	1999-06-30	Method of preparing a radioactive rhenium complex solution.
DK1267924T3 (da)	2012-05-29	Immunterapeutiske metoder og sammensætninger
DE69716240D1 (de)	2002-11-14	Neue methode zur impfung sowie impfstoffe dafür, die eine epitopkodierende nukleinsäure und ein epitopenthaltende peptid beinhalten
ATE162550T1 (de)	1998-02-15	Ospc-antigen-impfstoffe immunogene zusammensetzung zur vorbeugung und behandlung von lyme-krankheit und rekombinante verfahren zur herstellung von derartige antigene
ATE188484T1 (de)	2000-01-15	Immunologisch mit hla homologe hiv protein epitope
IL76271A0 (en)	1986-01-31	Cross-reactive and protective epitopes of circumsporozoite proteins
IL106407A (en)	1997-09-30	Antigens, vaccines containing them and their preparation
EP1020516A3 (en)	2000-10-11	Leptospira vaccine antigens for the prevention of leptospirosis
DE69615537D1 (en)	2001-10-31	Helicobacter pylori antigen
MX9708226A (es)	1998-06-30	Vacunas que contienen una saponina y un esterol.