DE69904853D1 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number: DE69904853D1
Authority: DE; Germany
Prior art keywords: producing citalopram; citalopram; producing
Prior art date: 1998-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69904853T

Other languages

English (en)

Other versions

DE69904853T2 (de

Inventor

Asta Leone Dall

Umberto Casazza

Hans Petersen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

H Lundbeck AS

Original Assignee

H Lundbeck AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-20

Filing date

1999-10-19

Publication date

2003-02-13

1998-10-20 Priority claimed from IT002242 external-priority patent/IT1302700B1/it

1999-05-25 Priority claimed from IT1999MI001152 external-priority patent/IT1312319B1/it

1999-08-02 Priority claimed from IT99MI001724 external-priority patent/IT1313587B1/it

1999-10-19 Application filed by H Lundbeck AS filed Critical H Lundbeck AS

2003-02-13 Application granted granted Critical

2003-02-13 Publication of DE69904853D1 publication Critical patent/DE69904853D1/de

2003-09-04 Publication of DE69904853T2 publication Critical patent/DE69904853T2/de

2019-10-20 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DE69904853T 1998-10-20 1999-10-19 Verfahren zur herstellung von citalopram Expired - Lifetime DE69904853T2 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IT002242 IT1302700B1 (it)	1998-10-20	1998-10-20	Procedimento per la preparazione di un derivato dell'isobenzofurano
IT1999MI001152 IT1312319B1 (it)	1999-05-25	1999-05-25	Procedimento per la preparazione del citalopram.
IT99MI001724 IT1313587B1 (it)	1999-08-02	1999-08-02	Procedimento per la preparazione di un derivato del5-cianoisobenzofurano.
PCT/DK1999/000576 WO2000023431A1 (en)	1998-10-20	1999-10-19	Method for the preparation of citalopram

Publications (2)

Publication Number	Publication Date
DE69904853D1 true DE69904853D1 (de)	2003-02-13
DE69904853T2 DE69904853T2 (de)	2003-09-04

Family

ID=27274104

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69904853T Expired - Lifetime DE69904853T2 (de)	1998-10-20	1999-10-19	Verfahren zur herstellung von citalopram

Country Status (25)

Country	Link
US (1)	US6365747B1 (de)
EP (1)	EP1123284B1 (de)
JP (1)	JP3892667B2 (de)
KR (1)	KR100411505B1 (de)
CN (1)	CN1129592C (de)
AR (1)	AR018693A1 (de)
AT (1)	ATE230738T1 (de)
AU (1)	AU746665B2 (de)
BG (1)	BG64704B1 (de)
BR (1)	BR9915158B1 (de)
CA (1)	CA2291134C (de)
CZ (1)	CZ299920B6 (de)
DE (1)	DE69904853T2 (de)
DK (1)	DK1123284T3 (de)
EA (1)	EA002977B1 (de)
ES (1)	ES2189502T3 (de)
HK (1)	HK1042297B (de)
HU (1)	HU228576B1 (de)
IL (1)	IL142346A0 (de)
IS (1)	IS2256B (de)
NO (1)	NO327038B1 (de)
NZ (1)	NZ510858A (de)
PL (1)	PL199423B1 (de)
SK (1)	SK285719B6 (de)
WO (1)	WO2000023431A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1140886E (pt)	1998-12-23	2003-08-29	Lundbeck & Co As H	Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
DE69907037T3 (de) †	1999-04-14	2010-02-18	H. Lundbeck A/S	Verfahren zur herstellung von citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
AR021155A1 (es) *	1999-07-08	2002-06-12	Lundbeck & Co As H	Tratamiento de desordenes neuroticos
DK1228056T3 (da)	1999-10-25	2005-01-24	Lundbeck & Co As H	Fremgangsmåde til fremstilling af citalopram
CH692421A5 (de)	1999-10-25	2002-06-14	Lundbeck & Co As H	Verfahren zur Herstellung von Citalopram.
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
IL150335A0 (en)	1999-12-28	2002-12-01	Lundbeck & Co As H	Method for the preparation of citalopram
CZ20022627A3 (cs)	1999-12-30	2002-10-16	H. Lundbeck A/S	Způsob výroby citalopramu
DK1254129T3 (da)	2000-01-14	2004-03-29	Lundbeck & Co As H	Fremgangsmåde til fremstilling af 5-cyanophthalid
IT1317729B1 (it)	2000-01-18	2003-07-15	Norpharma S P A	Procedimento per la preparazione della 5-carbossiftalide.
FR2805812A1 (fr)	2000-02-24	2001-09-07	Lundbeck & Co As H	Procede de preparation du citalopram
IES20010157A2 (en)	2000-03-03	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en) *	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
IL151566A0 (en)	2000-03-13	2003-04-10	Lundbeck & Co As H	Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
HUP0300274A2 (hu)	2000-03-13	2003-06-28	H. Lundbeck A/S	Eljárás citalopram előállítására
IES20010206A2 (en)	2000-03-13	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
GB2357762B (en) *	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
SK14512002A3 (sk)	2000-03-14	2003-03-04	H. Lundbeck A/S	Spôsob výroby citalopramu, medziprodukt a citalopram výrobený týmto spôsobom
BR0109180A (pt) *	2000-03-16	2003-05-27	Lundbeck & Co As H	Método para a preparação de 5-ciano-1-(4-fluorofenil) -1,3- diidroisobenzofuranos e composição farmacêutica de antidepressivo
US6977306B2 (en) *	2000-05-02	2005-12-20	Sumitomo Chemical Company, Limited	Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622L (fi)	2000-08-18	2002-02-19	Lundbeck & Co As H	Menetelmä sitalopraamin valmistamiseksi
TR200201166T1 (tr) *	2000-12-22	2002-10-21	H.Lundbecks A/S	Saf sitalopram hazırlanması için yöntem
EP1181272B1 (de) *	2000-12-28	2002-08-28	H. Lundbeck A/S	Verfahren zur herstellung von reinem citalopram
EP1355897A1 (de)	2001-01-30	2003-10-29	Orion Corporation Fermion	Verfahren zur herstellung von 1-(3-dimethylaminopropyl)-1-(4-fluorphenyl)-1,3-dihydrobenzofuran-5-carbonitrile
HUP0400054A3 (en) *	2001-05-01	2007-03-28	Lundbeck & Co As H	The use of enantiomeric pure escitalopram
AU2002355624B2 (en)	2001-07-31	2006-02-02	H. Lundbeck A/S	Crystalline composition containing escitalopram
IS7239A (is) *	2001-12-14	2004-04-29	H. Lundbeck A/S	Aðferð til framleiðslu á essítalóprami
WO2003057132A2 (en)	2002-01-07	2003-07-17	Sun Pharmaceutical Industries Limited	Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
US7192939B2 (en) *	2002-01-30	2007-03-20	Montana State University	Pestalotiopsis microsporia isolates and compounds derived therefrom
CA2381341A1 (en) *	2002-04-09	2003-10-09	Torcan Chemical Ltd.	Process and intermediates for preparing escitalopram
AR040970A1 (es)	2002-08-12	2005-04-27	Lundbeck & Co As H	Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
US6812355B2 (en)	2002-10-22	2004-11-02	Sekhsaria Chemicals Limited	Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
EA013116B1 (ru) *	2002-12-23	2010-02-26	Х. Лундбекк А/С	Эсциталопрамгидробромид, его применение и фармкомпозиция
US7019153B2 (en)	2003-06-10	2006-03-28	Sun Pharmaceutical Industries Limited	Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CN100569765C (zh) *	2003-12-19	2009-12-16	杭州民生药业集团有限公司	西酞普兰中间体晶体碱
TWI339651B (en)	2004-02-12	2011-04-01	Lundbeck & Co As H	Method for the separation of intermediates which may be used for the preparation of escitalopram
ITMI20040717A1 (it) *	2004-04-09	2004-07-09	Adorkem Technology Spa	Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) *	2004-06-25	2006-01-12	Sumitomo Chemical Co Ltd	光学活性シタロプラムの製造方法、その中間体およびその製造方法
EP1797060A2 (de)	2004-08-23	2007-06-20	Sun Pharmaceutical Industries Limited	Verfahren zur herstellung von citalopram und enantiomeren
WO2006090409A1 (en) *	2005-02-28	2006-08-31	Kekule Pharma Ltd.,	An improved process for the preparation of 5 - carboxyphthalide
KR20080004575A (ko) *	2005-05-04	2008-01-09	팜드 메디케어 프리베이트 리미티드	염소화 반응을 위한 디(트리클로로메틸)카보네이트 유래의빌스마이어 헥크 시약의 합성
CN101157674B (zh) *	2005-07-12	2010-04-14	西陇化工股份有限公司	西酞普兰盐的提纯方法
US8258291B2 (en) *	2006-10-25	2012-09-04	Mamtek International Limited	Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
US9339500B2 (en) *	2008-03-04	2016-05-17	Intra-Cellular Therapies, Inc.	Methods of treating vasomotor symptoms
US9346777B2 (en) *	2012-09-06	2016-05-24	MediSynergics, LLC	Antiprotozoal compounds
US9284291B2 (en) *	2014-07-29	2016-03-15	MediSynergies, LLC	Kappa opioid receptor compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143702A (de)	1965-03-18
GB1526331A (en)	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
DK213290D0 (da) *	1990-09-06	1990-09-06	Lundbeck & Co As H	Treatment of cerebrovascular disorders
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
NZ501737A (en) *	1997-07-08	2001-10-26	H	Method for the preparation of citalopram using Grignard reagent 4-halogen-fluorophenyl and 3-halogen-N,N-dimethyl-propylamine
UA62985C2 (en) *	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
DE1042310T1 (de) *	1997-11-11	2001-04-19	Lundbeck & Co As H	Verfahren zur herstellung von citaloprame
PT1140886E (pt)	1998-12-23	2003-08-29	Lundbeck & Co As H	Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
DE69907037T3 (de)	1999-04-14	2010-02-18	H. Lundbeck A/S	Verfahren zur herstellung von citalopram
CH692421A5 (de)	1999-10-25	2002-06-14	Lundbeck & Co As H	Verfahren zur Herstellung von Citalopram.
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate

1999
- 1999-10-19 PL PL347189A patent/PL199423B1/pl not_active IP Right Cessation
- 1999-10-19 DE DE69904853T patent/DE69904853T2/de not_active Expired - Lifetime
- 1999-10-19 CN CN99812369A patent/CN1129592C/zh not_active Expired - Fee Related
- 1999-10-19 DK DK99950506T patent/DK1123284T3/da active
- 1999-10-19 NZ NZ510858A patent/NZ510858A/en not_active IP Right Cessation
- 1999-10-19 ES ES99950506T patent/ES2189502T3/es not_active Expired - Lifetime
- 1999-10-19 BR BRPI9915158-8A patent/BR9915158B1/pt not_active IP Right Cessation
- 1999-10-19 EA EA200100457A patent/EA002977B1/ru not_active IP Right Cessation
- 1999-10-19 AT AT99950506T patent/ATE230738T1/de active
- 1999-10-19 CA CA002291134A patent/CA2291134C/en not_active Expired - Fee Related
- 1999-10-19 US US09/830,109 patent/US6365747B1/en not_active Expired - Lifetime
- 1999-10-19 SK SK535-2001A patent/SK285719B6/sk not_active IP Right Cessation
- 1999-10-19 WO PCT/DK1999/000576 patent/WO2000023431A1/en active IP Right Grant
- 1999-10-19 JP JP2000577159A patent/JP3892667B2/ja not_active Expired - Fee Related
- 1999-10-19 HU HU0104128A patent/HU228576B1/hu unknown
- 1999-10-19 CZ CZ20011418A patent/CZ299920B6/cs not_active IP Right Cessation
- 1999-10-19 KR KR10-2001-7004889A patent/KR100411505B1/ko not_active IP Right Cessation
- 1999-10-19 AU AU63260/99A patent/AU746665B2/en not_active Ceased
- 1999-10-19 IL IL14234699A patent/IL142346A0/xx not_active IP Right Cessation
- 1999-10-19 EP EP99950506A patent/EP1123284B1/de not_active Expired - Lifetime
- 1999-10-20 AR ARP990105305A patent/AR018693A1/es active IP Right Grant
2001
- 2001-03-30 IS IS5911A patent/IS2256B/is unknown
- 2001-04-19 NO NO20011936A patent/NO327038B1/no not_active IP Right Cessation
- 2001-04-20 BG BG105457A patent/BG64704B1/bg unknown
2002
- 2002-05-16 HK HK02103712.9A patent/HK1042297B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
SK5352001A3 (en)	2002-02-05
NO327038B1 (no)	2009-04-06
NO20011936D0 (no)	2001-04-19
CZ299920B6 (cs)	2008-12-29
KR100411505B1 (ko)	2003-12-18
ATE230738T1 (de)	2003-01-15
AU6326099A (en)	2000-05-08
PL199423B1 (pl)	2008-09-30
JP2002527511A (ja)	2002-08-27
EP1123284A1 (de)	2001-08-16
HUP0104128A2 (hu)	2002-04-29
JP3892667B2 (ja)	2007-03-14
KR20010080236A (ko)	2001-08-22
IL142346A0 (en)	2002-03-10
WO2000023431A1 (en)	2000-04-27
CA2291134C (en)	2006-05-23
DK1123284T3 (da)	2003-04-28
PL347189A1 (en)	2002-03-25
AR018693A1 (es)	2001-11-28
CZ20011418A3 (cs)	2001-10-17
BG105457A (en)	2001-12-29
EA002977B1 (ru)	2002-12-26
CN1324351A (zh)	2001-11-28
HK1042297A1 (en)	2002-08-09
BR9915158A (pt)	2001-08-07
IS2256B (is)	2007-06-15
CA2291134A1 (en)	2000-04-20
BG64704B1 (bg)	2005-12-30
EP1123284B1 (de)	2003-01-08
US6365747B1 (en)	2002-04-02
CN1129592C (zh)	2003-12-03
HUP0104128A3 (en)	2003-01-28
DE69904853T2 (de)	2003-09-04
HU228576B1 (en)	2013-04-29
IS5911A (is)	2001-03-30
ES2189502T3 (es)	2003-07-01
SK285719B6 (sk)	2007-07-06
AU746665B2 (en)	2002-05-02
HK1042297B (zh)	2004-09-10
NO20011936L (no)	2001-06-01
NZ510858A (en)	2003-11-28
EA200100457A1 (ru)	2001-10-22
BR9915158B1 (pt)	2012-02-22

Publication	Publication Date	Title
ATE230738T1 (de)	2003-01-15	Verfahren zur herstellung von citalopram
ATE232524T1 (de)	2003-02-15	Verfahren zur herstellung von citalopram
DE69907037D1 (de)	2003-05-22	Verfahren zur herstellung von citalopram
ATE213237T1 (de)	2002-02-15	Verfahren zur herstellung von citalopram
ATE235478T1 (de)	2003-04-15	Verfahren zur herstellung von citalopram
ATE236145T1 (de)	2003-04-15	Verfahren zur herstellung von 5-cyanophthalid
DE69913666D1 (de)	2004-01-29	Verfahren zur herstellung von di-methyl-naphthalinen
DE60000364D1 (de)	2002-10-02	Verfahren zur herstellung von 5-cyanophthalid
DE69911398D1 (de)	2003-10-23	Verfahren zur herstellung von 4-aminodiphenylaminen
ATE281448T1 (de)	2004-11-15	Verfahren zur herstellung von citalopram
ATE339433T1 (de)	2006-10-15	Verbessertes verfahren zur herstellung von makroliden
DE59901552D1 (de)	2002-07-04	Verfahren zur herstellung von polyalkylenarylaten
ATE389645T1 (de)	2008-04-15	Verfahren zur herstellung von citalopram
DE69910995D1 (de)	2003-10-09	Verfahren zur herstellung von fluorkohlenwasserstoffen
DE69920526D1 (de)	2004-10-28	Verfahren zur herstellung von citalopram
DE59702087D1 (de)	2000-08-31	Verfahren zur herstellung von phthaliden
ATE282031T1 (de)	2004-11-15	Verfahren zur herstellung von citalopram
DE69901192D1 (de)	2002-05-08	Verfahren zur herstellung von cyclopropanmethylamin
DE69928784D1 (de)	2006-01-12	Verfahren zur herstellung von oxazolidin-2-on-derivaten
ATE225797T1 (de)	2002-10-15	Verfahren zur herstellung von oxazaphosphorin-2- aminen
DE59903764D1 (de)	2003-01-23	Verfahren zur herstellung von phytosqualan
DE59906309D1 (de)	2003-08-21	Verfahren zur herstellung von cyclohexandiaminen
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