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DE69838061D1 - Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteine - Google Patents

Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteine

Info

Publication number
DE69838061D1
DE69838061D1 DE69838061T DE69838061T DE69838061D1 DE 69838061 D1 DE69838061 D1 DE 69838061D1 DE 69838061 T DE69838061 T DE 69838061T DE 69838061 T DE69838061 T DE 69838061T DE 69838061 D1 DE69838061 D1 DE 69838061D1
Authority
DE
Germany
Prior art keywords
fusion proteins
tgf
immunoglobulin constant
type
constant domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69838061T
Other languages
English (en)
Other versions
DE69838061T2 (de
Inventor
Philip Gotwals
Victor Koteliansky
Richard Cate
Michelle Sanicola-Nadel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Biogen MA Inc
Original Assignee
Biogen Idec Inc
Biogen Idec MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc, Biogen Idec MA Inc filed Critical Biogen Idec Inc
Publication of DE69838061D1 publication Critical patent/DE69838061D1/de
Application granted granted Critical
Publication of DE69838061T2 publication Critical patent/DE69838061T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
DE69838061T 1997-04-18 1998-04-16 Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteine Expired - Fee Related DE69838061T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4464197P 1997-04-18 1997-04-18
US44641P 1997-04-18
PCT/US1998/007587 WO1998048024A1 (en) 1997-04-18 1998-04-16 Type ii tgf-beta receptor/immunoglobulin constant region fusion proteins

Publications (2)

Publication Number Publication Date
DE69838061D1 true DE69838061D1 (de) 2007-08-23
DE69838061T2 DE69838061T2 (de) 2008-03-13

Family

ID=21933495

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69838061T Expired - Fee Related DE69838061T2 (de) 1997-04-18 1998-04-16 Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteine

Country Status (22)

Country Link
US (1) US20050203022A1 (de)
EP (1) EP0975771B1 (de)
JP (2) JP2001515360A (de)
KR (1) KR20010006534A (de)
CN (1) CN1257545A (de)
AT (1) ATE366816T1 (de)
AU (1) AU737106B2 (de)
BR (1) BR9808934A (de)
CA (1) CA2286933A1 (de)
DE (1) DE69838061T2 (de)
DK (1) DK0975771T3 (de)
EA (1) EA199900947A1 (de)
EE (1) EE9900492A (de)
ES (1) ES2289778T3 (de)
IL (1) IL132249A0 (de)
IS (1) IS5217A (de)
NO (1) NO994998L (de)
NZ (1) NZ500284A (de)
PL (1) PL336306A1 (de)
PT (1) PT975771E (de)
TR (1) TR199902878T2 (de)
WO (1) WO1998048024A1 (de)

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US6352842B1 (en) 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US6361974B1 (en) 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6562594B1 (en) 1999-09-29 2003-05-13 Diversa Corporation Saturation mutagenesis in directed evolution
US6492325B1 (en) 1998-05-22 2002-12-10 Boys Town National Research Hospital Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease
EP1087998A1 (de) * 1998-06-16 2001-04-04 Biogen, Inc. Variante tgf-beta rezeptor typ ii fusionsproteine und verfahren
DE1221490T1 (de) 1999-09-17 2003-05-28 Tgt Lab S A De C V Rekombinante, adenovirale vektoren und ihre verwendung zur behandlung von unterschiedlichen typen der leber-, nieren- und lungenfibrose und hypertrophischen narben
US6808902B1 (en) * 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
MXPA00011713A (es) * 2000-11-28 2002-05-31 Tgt Lab S A De C V Vectores recombinantes virales y no virales conteniendo el gen humano del activador de plasminogeno derivado de urocinasa y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar, pancreatica, cardiaca y cicatrices hipe
US20030103986A1 (en) * 2001-05-24 2003-06-05 Rixon Mark W. TACI-immunoglobulin fusion proteins
MXPA06011199A (es) 2004-03-31 2007-04-16 Genentech Inc Anticuerpos anti-tgf-beta humanizados.
JP5602365B2 (ja) 2005-10-25 2014-10-08 ザ・ジョンズ・ホプキンス・ユニバーシティ マルファン症候群及び関連疾患を治療するための方法及び組成物。
EP1998810A4 (de) 2006-03-13 2009-09-02 Univ Johns Hopkins Erhöhung der endothelialen thromboresistenz
US20100098668A1 (en) * 2006-09-29 2010-04-22 Northshore University Health System Oncolytic Adenoviruses and Uses Thereof
EP2083863B1 (de) 2006-10-03 2015-03-18 Genzyme Corporation Anti-tgf-beta antikörper zur behandlung von kleinkindern, die gefahr laufen eine bronchopulmonäre dysplasie zu entwickeln
EP2171062A1 (de) * 2007-06-15 2010-04-07 Genzyme Corporation Fusionsproteine mit zwei tgf-beta-bindungsdomänen des tgf-beta-typ-ii-rezeptors
WO2009152610A1 (en) 2008-06-20 2009-12-23 The Royal Institution For The Advancement Of Learning/Mcgill University Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof
EP2547328B1 (de) * 2010-02-11 2017-06-07 Ecole Polytechnique Fédérale de Lausanne (EPFL) Ccr7-liganden-verabreichung und co-verabreichung in einer immuntherapie
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
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EP2660314A4 (de) 2010-12-27 2014-09-03 Lsip Llc Ips-zellen und verfahren zu ihrer erzeugung
CN102175501A (zh) * 2011-01-07 2011-09-07 山东省农业科学院作物研究所 用于显微镜观察的植物样品的前处理方法
WO2013014262A1 (en) 2011-07-27 2013-01-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating myhre syndrome
CN102898508B (zh) * 2011-08-12 2014-04-30 北京大学第一医院 封闭TGF-β受体或IL-10受体的多肽、其药物组合物及其用途
AU2011379972B2 (en) 2011-10-26 2016-05-12 Seattle Children's Research Institute Cysteamine in the treatment of fibrotic disease
ES2917222T3 (es) 2011-12-28 2022-07-07 Kyoto Prefectural Public Univ Corp Normalización del cultivo de células endoteliales de la córnea
EA028087B1 (ru) 2012-02-15 2017-10-31 Эколь Политекник Федераль Де Лозан Связывающиеся с эритроцитами терапевтические средства
WO2015027082A1 (en) 2013-08-22 2015-02-26 Acceleron Pharma, Inc. Tgf-beta receptor type ii variants and uses thereof
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PE20210168A1 (es) * 2014-02-10 2021-01-28 Merck Patent Gmbh INHIBICION DIRIGIDA DEL FACTOR DE CRECIMIENTO TRANSFORMADOR ß (TGFß)
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Also Published As

Publication number Publication date
KR20010006534A (ko) 2001-01-26
IS5217A (is) 1999-10-15
PT975771E (pt) 2007-10-01
AU7120898A (en) 1998-11-13
IL132249A0 (en) 2001-03-19
EP0975771B1 (de) 2007-07-11
CA2286933A1 (en) 1998-10-29
EA199900947A1 (ru) 2000-04-24
EP0975771A1 (de) 2000-02-02
WO1998048024A1 (en) 1998-10-29
PL336306A1 (en) 2000-06-19
DK0975771T3 (da) 2007-10-22
ATE366816T1 (de) 2007-08-15
CN1257545A (zh) 2000-06-21
AU737106B2 (en) 2001-08-09
ES2289778T3 (es) 2008-02-01
JP2008106076A (ja) 2008-05-08
NO994998L (no) 1999-12-20
NZ500284A (en) 2001-09-28
US20050203022A1 (en) 2005-09-15
TR199902878T2 (xx) 2000-02-21
NO994998D0 (no) 1999-10-14
BR9808934A (pt) 2000-08-01
JP2001515360A (ja) 2001-09-18
DE69838061T2 (de) 2008-03-13
EE9900492A (et) 2000-06-15

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