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DE69614535D1 - Vorrichtung und verfahren zum aufbewahren und zur züchtung biologischer zellen - Google Patents

Vorrichtung und verfahren zum aufbewahren und zur züchtung biologischer zellen

Info

Publication number
DE69614535D1
DE69614535D1 DE69614535T DE69614535T DE69614535D1 DE 69614535 D1 DE69614535 D1 DE 69614535D1 DE 69614535 T DE69614535 T DE 69614535T DE 69614535 T DE69614535 T DE 69614535T DE 69614535 D1 DE69614535 D1 DE 69614535D1
Authority
DE
Germany
Prior art keywords
cassette
cells
cell growth
instrument
portable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69614535T
Other languages
English (en)
Other versions
DE69614535T2 (de
Inventor
Douglas Armstrong
James Maluta
W Roecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vericel Corp
Original Assignee
Aastrom Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aastrom Biosciences Inc filed Critical Aastrom Biosciences Inc
Publication of DE69614535D1 publication Critical patent/DE69614535D1/de
Application granted granted Critical
Publication of DE69614535T2 publication Critical patent/DE69614535T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/54—Constructional details, e.g. recesses, hinges hand portable
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69614535T 1995-06-07 1996-06-07 Vorrichtung und verfahren zum aufbewahren und zur züchtung biologischer zellen Expired - Lifetime DE69614535T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US48351695A 1995-06-07 1995-06-07
US48352095A 1995-06-07 1995-06-07
US48351995A 1995-06-07 1995-06-07
US48351795A 1995-06-07 1995-06-07
US48351895A 1995-06-07 1995-06-07
PCT/US1996/009770 WO1996040858A1 (en) 1995-06-07 1996-06-07 Apparatus and method for maintaining and growing biological cells

Publications (2)

Publication Number Publication Date
DE69614535D1 true DE69614535D1 (de) 2001-09-20
DE69614535T2 DE69614535T2 (de) 2002-06-06

Family

ID=27541734

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69614535T Expired - Lifetime DE69614535T2 (de) 1995-06-07 1996-06-07 Vorrichtung und verfahren zum aufbewahren und zur züchtung biologischer zellen

Country Status (7)

Country Link
EP (1) EP0832182B1 (de)
JP (1) JP3880622B2 (de)
AT (1) ATE204322T1 (de)
CA (1) CA2223525C (de)
DE (1) DE69614535T2 (de)
ES (1) ES2162081T3 (de)
WO (1) WO1996040858A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
DE69837393T2 (de) 1997-09-29 2007-12-06 Point Therapeutics, Inc., Boston Stimulierung von hämatopoietischen zellen im vitro
US6300314B1 (en) 1998-05-04 2001-10-09 Point Therapeutics, Inc. Hematopoietic stimulation
US6355614B1 (en) 1998-06-05 2002-03-12 Point Therapeutics Cyclic boroproline compounds
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
FR2794130B1 (fr) * 1999-05-26 2003-01-03 Bertin Technologies Sa Procede et dispositif de culture de cellules a applications multiples
DE60043640D1 (de) * 1999-10-11 2010-02-25 Dsm Ip Assets Bv Kontinuierliche Fermentation
ES2713559T3 (es) * 2002-04-08 2019-05-22 Octane Biotech Inc Sistema automatizado de ingeniería de tejidos
JP4751566B2 (ja) * 2002-04-09 2011-08-17 オリンパス株式会社 細胞培養システム、培養細胞照合装置および細胞培養装置
JP2004073187A (ja) * 2002-06-18 2004-03-11 Olympus Corp 培養関連容器管理方法および培養関連容器
CA2553374A1 (en) * 2004-01-14 2005-07-28 Daikin Industries, Ltd. Temperature control device
GB0603965D0 (en) 2006-02-28 2006-04-05 Centeo Biosciences Ltd Incubator apparatus and method
KR100946643B1 (ko) * 2007-11-30 2010-03-09 코아스템(주) 세포배양장치 및 이를 구비한 대용량 자동화 세포배양기
KR100932861B1 (ko) * 2007-11-30 2009-12-21 코아스템(주) 세포배양플라스크
EP2392640A1 (de) 2009-01-30 2011-12-07 Emilio Mateu Sentamans Verfahren und modulare ausrüstung zur verarbeitung und lagerung von zellkulturen
DE102009029305A1 (de) 2009-09-09 2011-03-10 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Analysegerät zur automatisierten Bestimmung einer Messgröße einer Flüssigkeitsprobe
US9783768B2 (en) * 2010-04-21 2017-10-10 Octane Biotech, Inc. Automated cell culture system
JP5351823B2 (ja) * 2010-04-28 2013-11-27 株式会社日立ハイテクノロジーズ 自動分析装置
DE102012013267A1 (de) 2012-07-04 2014-01-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Substrateinrichtung, Konservierungsgerät und Verfahren zur Kryokonservierung einer biologischen Probe
JP6051730B2 (ja) 2012-09-24 2016-12-27 東洋製罐グループホールディングス株式会社 気泡除去方法、及び気泡除去装置
WO2016005971A1 (en) * 2014-07-06 2016-01-14 Fertilesafe Ltd Devices for culturing a biological sample in a culturing liquid
JP6339432B2 (ja) * 2014-07-16 2018-06-06 オリンパス株式会社 細胞観察情報処理システム、細胞観察情報処理方法、細胞観察情報処理プログラム
FR3053051B1 (fr) * 2016-06-24 2022-11-11 Cellprothera Cassette et automate de culture cellulaire
JP6863382B2 (ja) * 2016-08-26 2021-04-21 株式会社Ihi 細胞培養システム
US10406252B2 (en) 2017-01-19 2019-09-10 Curium Us Llc Systems and methods for autoclave cart loading and unloading system
JP2020528284A (ja) 2017-09-01 2020-09-24 ロンザ ウォーカーズヴィル，インコーポレーテッド エンドツーエンド細胞療法の自動化
DE202018000370U1 (de) 2018-01-24 2018-04-12 Zellwerk Gmbh Mäander-Bioreaktor für die Isolierung und Vermehrung von Zellen aus Gewebeteilen von Tumoren, Metastasen und anderen Geweben
DE102018000561B4 (de) 2018-01-24 2019-11-07 Zellwerk Gmbh Mäander-Bioreaktor und Verfahren für die Isolierung und Vermehrung von Zellen aus Gewebeteilen von Tumoren, Metastasen und anderen Geweben
EP3556841A1 (de) * 2018-04-19 2019-10-23 Aglaris Ltd Wegwerfkartusche mit einer plattform in einem flexiblen system zum handhaben und/oder manipulieren von flüssigkeiten
DE202018004857U1 (de) 2018-10-20 2019-01-14 Zellwerk Gmbh Mäander-Perfusions-Bioreaktor für die Differenzierung, Aktivierung, Stimulierung und Abtrennung von Zellen
JP7598864B2 (ja) 2018-12-21 2024-12-12 ロンザ ウォーカーズヴィル，インコーポレーテッド ウイルスベクターの自動産生方法
SG11202106384YA (en) 2018-12-21 2021-07-29 Octane Biotech Inc Carousel for modular biologic production units
KR20210110322A (ko) 2018-12-28 2021-09-07 옥테인 바이오테크 인코포레이티드 제어된 환경 존을 포함하는 세포 배양 및 조직 공학 시스템
EP3914690A4 (de) 2019-02-08 2022-11-09 Lonza Walkersville, Inc. Verfahren und vorrichtungen zur bestimmung der zellkonzentration in automatisierten bioreaktoren
EP3999623A4 (de) * 2019-07-15 2024-02-07 Lonza Walkersville, Inc. Verfahrenssteuerungssysteme für automatisierte zellengineering-systeme
IL292409A (en) 2019-10-24 2022-06-01 Octane Biotech Inc Cell culture chamber with improved cell-contacting surfaces
CN114667341A (zh) 2019-11-11 2022-06-24 隆萨沃克斯维尔股份有限公司 用于自动化细胞处理的质量控制方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0182926B1 (de) * 1984-11-22 1989-03-01 Personal Diagnostics, Inc. Autarker Brutschrank
DE69033032T2 (de) * 1989-08-04 1999-11-11 Peter Grandics Integriertes zellkultur-proteinreinigungssystem zur automatisierten herstellung und reinigung von zellkulturprodukten
WO1993011498A1 (en) * 1991-11-25 1993-06-10 Cornell Research Foundation, Inc. Automated multicompartmental cell culture system
US5612188A (en) * 1991-11-25 1997-03-18 Cornell Research Foundation, Inc. Automated, multicompartmental cell culture system
US5352414A (en) * 1992-12-30 1994-10-04 Rothenberg Barry E Incubator unit and filter system
US5424209A (en) * 1993-03-19 1995-06-13 Kearney; George P. Automated cell culture and testing system

Also Published As

Publication number Publication date
JP3880622B2 (ja) 2007-02-14
ES2162081T3 (es) 2001-12-16
CA2223525C (en) 2008-12-23
EP0832182B1 (de) 2001-08-16
WO1996040858A1 (en) 1996-12-19
JPH11507229A (ja) 1999-06-29
CA2223525A1 (en) 1996-12-19
EP0832182A1 (de) 1998-04-01
ATE204322T1 (de) 2001-09-15
DE69614535T2 (de) 2002-06-06

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