DE69533267D1 - Colchicin-derivate sowie ihre therapeutische Verwendung - Google Patents

Colchicin-derivate sowie ihre therapeutische Verwendung

Info

Publication number: DE69533267D1
Authority: DE; Germany
Prior art keywords: colchicine derivatives; therapeutic use; derivatives; colchicine; antitumoral
Prior art date: 1994-10-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69533267T

Other languages

English (en)

Other versions

DE69533267T2 (de

Inventor

Ezio Bombardelli

Bruno Gabetta

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Indena SpA

Original Assignee

Indena SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-05

Filing date

1995-09-27

Publication date

2004-08-19

1995-09-27 Application filed by Indena SpA filed Critical Indena SpA

2004-08-19 Publication of DE69533267D1 publication Critical patent/DE69533267D1/de

2005-08-04 Application granted granted Critical

2005-08-04 Publication of DE69533267T2 publication Critical patent/DE69533267T2/de

2015-09-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

DE69533267T 1994-10-05 1995-09-27 Colchicin-derivate sowie ihre therapeutische Verwendung Expired - Lifetime DE69533267T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI942026A IT1270124B (it)	1994-10-05	1994-10-05	Derivati della colchicina e loro impiego terapeutico
ITMI942026		1994-10-05

Publications (2)

Publication Number	Publication Date
DE69533267D1 true DE69533267D1 (de)	2004-08-19
DE69533267T2 DE69533267T2 (de)	2005-08-04

Family

ID=11369650

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69510212T Expired - Lifetime DE69510212T2 (de)	1994-10-05	1995-09-27	Colchicin-derivate sowie ihre therapeutische verwendung
DE69533267T Expired - Lifetime DE69533267T2 (de)	1994-10-05	1995-09-27	Colchicin-derivate sowie ihre therapeutische Verwendung

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69510212T Expired - Lifetime DE69510212T2 (de)	1994-10-05	1995-09-27	Colchicin-derivate sowie ihre therapeutische verwendung

Country Status (22)

Country	Link
US (1)	US5843910A (de)
EP (2)	EP0909763B1 (de)
JP (1)	JP2921990B2 (de)
KR (1)	KR100255074B1 (de)
CN (2)	CN1075059C (de)
AT (2)	ATE181060T1 (de)
AU (1)	AU692624B2 (de)
CA (1)	CA2201723C (de)
CZ (1)	CZ290309B6 (de)
DE (2)	DE69510212T2 (de)
DK (2)	DK0909763T3 (de)
ES (2)	ES2131863T3 (de)
FI (1)	FI120452B (de)
GR (1)	GR3030449T3 (de)
HU (1)	HU223779B1 (de)
IT (1)	IT1270124B (de)
NO (1)	NO308030B1 (de)
PL (1)	PL182204B1 (de)
PT (1)	PT909763E (de)
RU (1)	RU2145598C1 (de)
SK (1)	SK281831B6 (de)
WO (1)	WO1996011184A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9714249D0 (en)	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
FR2779147B1 (fr) *	1998-05-27	2000-06-30	Synthelabo	Derive de thiocolchicoside sa preparation et son application en therapeutique
WO2000035865A2 (en) *	1998-12-17	2000-06-22	Tularik Inc.	Tubulin-binding agents
GB9900334D0 (en)	1999-01-07	1999-02-24	Angiogene Pharm Ltd	Tricylic vascular damaging agents
US6399093B1 (en)	1999-05-19	2002-06-04	Advanced Medical Instruments	Method and composition to treat musculoskeletal disorders
KR20030014425A (ko) *	2000-07-07	2003-02-17	앤지오젠 파마슈티칼스 리미티드	혈관 손상제인 콜치놀 유도체
US6720323B2 (en) *	2000-07-07	2004-04-13	Angiogene Pharmaceuticals Limited	Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en)	2000-09-25	2003-09-23	The University Of North Carolina At Chapel Hill	Taxoid conjugates as antimitotic and antitumor agents
ITMI20031144A1 (it) *	2003-06-06	2004-12-07	Indena Spa	Analoghi del colchicoside.
DK1646608T3 (da) *	2003-06-25	2011-06-14	Je Il Pharmaceutical Co Ltd	Tricykliske derivater eller farmaceutisk acceptable salte deraf, deres fremstillinger og farmaceutiske sammensætninger indeholdende dem
ES2356494T3 (es) *	2008-05-28	2011-04-08	Indena S.P.A.	Procedimiento para la glucosidación de colchicina y tiocolchicina.
PL2470499T3 (pl)	2009-08-26	2019-11-29	Alberta Health Services	Nowe pochodne kolchicyny, sposoby i ich zastosowania
WO2016059650A1 (en)	2014-10-14	2016-04-21	Council Of Scientific & Industrial Research	10-substituted colchicinoids as potent anticancer agents
CA3136489A1 (en)	2018-06-29	2020-01-02	Alberta Health Services	Methods and uses of colchicine derivatives
WO2023077977A1 (zh) *	2021-11-08	2023-05-11	天津市昕晨投资发展有限公司	秋水仙碱衍生物的制备方法及其用途
CN120136821A (zh) *	2021-11-18	2025-06-13	杭州新元素药业有限公司	一类抗炎镇痛化合物及其用途
CN114907228B (zh) *	2022-06-27	2023-11-28	深圳市锦泰医药科技合伙企业(有限合伙)	一种秋水仙碱和厚朴酚复合物及其合成方法以及在抗新冠病毒方面的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH513119A (de) *	1968-02-23	1971-09-30	Merck Patent Gmbh	Verfahren zur Herstellung neuer Halogencolchicinderivate
GB1345991A (en) *	1972-05-05	1974-02-06	Roussel Uclaf	Thiocolchicine derivatives
ES2062014T3 (es) *	1988-08-24	1994-12-16	Advance Biofactures Corp	Carbonatos de 3-desmetiltiocolchicina y analogos n-acilados.

1994
- 1994-10-05 IT ITMI942026A patent/IT1270124B/it active IP Right Grant
1995
- 1995-09-27 PL PL95319455A patent/PL182204B1/pl not_active IP Right Cessation
- 1995-09-27 ES ES95935393T patent/ES2131863T3/es not_active Expired - Lifetime
- 1995-09-27 RU RU97107153A patent/RU2145598C1/ru not_active IP Right Cessation
- 1995-09-27 CN CN95195499A patent/CN1075059C/zh not_active Expired - Fee Related
- 1995-09-27 JP JP8512296A patent/JP2921990B2/ja not_active Expired - Lifetime
- 1995-09-27 AT AT95935393T patent/ATE181060T1/de not_active IP Right Cessation
- 1995-09-27 PT PT98121484T patent/PT909763E/pt unknown
- 1995-09-27 DK DK98121484T patent/DK0909763T3/da active
- 1995-09-27 HU HU9701700A patent/HU223779B1/hu not_active IP Right Cessation
- 1995-09-27 CA CA002201723A patent/CA2201723C/en not_active Expired - Fee Related
- 1995-09-27 US US08/817,626 patent/US5843910A/en not_active Expired - Fee Related
- 1995-09-27 SK SK424-97A patent/SK281831B6/sk not_active IP Right Cessation
- 1995-09-27 DE DE69510212T patent/DE69510212T2/de not_active Expired - Lifetime
- 1995-09-27 EP EP98121484A patent/EP0909763B1/de not_active Expired - Lifetime
- 1995-09-27 KR KR1019970702190A patent/KR100255074B1/ko not_active Expired - Fee Related
- 1995-09-27 WO PCT/EP1995/003823 patent/WO1996011184A1/en active IP Right Grant
- 1995-09-27 AT AT98121484T patent/ATE271061T1/de not_active IP Right Cessation
- 1995-09-27 DK DK95935393T patent/DK0784613T3/da active
- 1995-09-27 AU AU37432/95A patent/AU692624B2/en not_active Ceased
- 1995-09-27 CZ CZ19971015A patent/CZ290309B6/cs not_active IP Right Cessation
- 1995-09-27 ES ES98121484T patent/ES2224322T3/es not_active Expired - Lifetime
- 1995-09-27 EP EP95935393A patent/EP0784613B1/de not_active Expired - Lifetime
- 1995-09-27 DE DE69533267T patent/DE69533267T2/de not_active Expired - Lifetime
1997
- 1997-04-03 NO NO971503A patent/NO308030B1/no not_active IP Right Cessation
- 1997-04-03 FI FI971364A patent/FI120452B/fi active IP Right Grant
1999
- 1999-06-10 GR GR990401514T patent/GR3030449T3/el unknown
2000
- 2000-11-02 CN CN00131989A patent/CN1127480C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE271061T1 (de)	2004-07-15
FI120452B (fi)	2009-10-30
CZ101597A3 (en)	1997-10-15
CN1308059A (zh)	2001-08-15
HK1017361A1 (en)	1999-11-19
WO1996011184A1 (en)	1996-04-18
JP2921990B2 (ja)	1999-07-19
SK281831B6 (sk)	2001-08-06
PL182204B1 (en)	2001-11-30
DK0784613T3 (da)	1999-11-15
ATE181060T1 (de)	1999-06-15
CA2201723C (en)	2003-03-25
FI971364A0 (fi)	1997-04-03
IT1270124B (it)	1997-04-28
JPH10507169A (ja)	1998-07-14
NO308030B1 (no)	2000-07-10
CZ290309B6 (cs)	2002-07-17
ES2131863T3 (es)	1999-08-01
GR3030449T3 (en)	1999-09-30
CN1075059C (zh)	2001-11-21
FI971364L (fi)	1997-05-30
AU3743295A (en)	1996-05-02
CA2201723A1 (en)	1996-04-18
CN1127480C (zh)	2003-11-12
NO971503D0 (no)	1997-04-03
HK1001394A1 (en)	1998-06-19
US5843910A (en)	1998-12-01
EP0784613B1 (de)	1999-06-09
PT909763E (pt)	2004-10-29
EP0909763A2 (de)	1999-04-21
DE69510212D1 (de)	1999-07-15
CN1159801A (zh)	1997-09-17
HU223779B1 (hu)	2005-01-28
PL319455A1 (en)	1997-08-04
ES2224322T3 (es)	2005-03-01
ITMI942026A1 (it)	1996-04-05
EP0909763B1 (de)	2004-07-14
DE69510212T2 (de)	1999-11-11
KR100255074B1 (ko)	2000-05-01
RU2145598C1 (ru)	2000-02-20
EP0784613A1 (de)	1997-07-23
DE69533267T2 (de)	2005-08-04
DK0909763T3 (da)	2004-11-22
HUT77223A (hu)	1998-03-02
ITMI942026A0 (it)	1994-10-05
AU692624B2 (en)	1998-06-11
EP0909763A3 (de)	2003-01-22
SK42497A3 (en)	1997-11-05
NO971503L (no)	1997-05-14

Publication	Publication Date	Title
ATE271061T1 (de)	2004-07-15	Colchicin-derivate sowie ihre therapeutische verwendung
ATE249460T1 (de)	2003-09-15	1,4-diazabicyclo(3.2.2)nonanderivate, deren herstellung und deren verwendung in heilkunde
ATE172477T1 (de)	1998-11-15	Oligomere, ihre verwendungen sowie formulierungen
ATE261972T1 (de)	2004-04-15	2,5-diazabicyclo(2.2.1)heptanderivate, deren herstellung und deren verwendung in heilkunde
ATE188471T1 (de)	2000-01-15	Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzung
DE69530936D1 (de)	2003-07-03	Boronsäure-und-esterverbindungen, deren systhese und verwendungen
DE69529026D1 (de)	2003-01-16	Trehalose, ihre Herstellung und ihre Verwendung
DE60023012D1 (de)	2006-02-16	3(5)-amino-pyrazolderivate, deren herstellungsverfahren und verwendung als krebshemmende mittel
NO307092B1 (no)	2000-02-07	Sordaridin-derivater, anvendelse derav og farmasoeytisk blanding
DE59409541D1 (de)	2000-11-02	Bicyclen-derivate, ihre herstellung und verwendung
ATE268760T1 (de)	2004-06-15	Neue carbonsäurederivate, ihre herstellung und verwendung
EP0672052A1 (de)	1995-09-20	Tachyquinin antagonisten, ihre herstellung und ihre verwendung in pharmazeutischen formulierungen.
IT1286496B1 (it)	1998-07-15	Composizione farmaceutica orale ad attivita' antipiretica,analgesica ed antiinfiammatoria
DE69630391D1 (de)	2003-11-20	Prolylendopeptidase-inhibitoren, ihre herstellung und ihre pharmazeutische verwendung
DE69611303D1 (de)	2001-01-25	Benzolsulfonamidderivate, ihre herstellung und ihre therapeutische verwendung
FI930238A7 (fi)	1993-07-23	N-5-suojatut 2,5-diamino-4,6-diklooripyrimidiinit ja menetelmä niiden valmistamiseksi
DE69510331D1 (de)	1999-07-22	Halbleiterlaserdiodenverstärker und dessen herstellung
DE69703308D1 (de)	2000-11-16	Lh-rh analoge mit starrer konformation, deren verwendungen und pharmazeutische zusammensetzungen
DE59606132D1 (de)	2000-12-14	Neue carbonsäurederivate, ihre herstellung und verwendung
ATA164294A (de)	1995-09-15	Pentofuranosid-derivate, deren herstellung und verwendung
DE59308512D1 (de)	1998-06-10	Cyclohexenonoximether, ihre herstellung und ihre verwendung
DE59706478D1 (de)	2002-04-04	Chromanyl-ascorbinsäurederivate, deren Herstellung und Verwendung
ITMI913511A0 (it)	1991-12-31	Derivati dell'eserolina ad attivita' anticolinesterasica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
ITMI911444A0 (it)	1991-05-27	Derivati dell'eserolina ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
ITMI913512A0 (it)	1991-12-31	Derivati dell'eserolina ad attivita' anticolinesterasica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Legal Events

Date	Code	Title	Description
2006-10-26	8328	Change in the person/name/address of the agent	Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN
2007-06-06	8364	No opposition during term of opposition
2009-07-30	8328	Change in the person/name/address of the agent	Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC