[go: up one dir, main page]

ES2131863T3 - Derivados de colchicina y su uso terapeutico. - Google Patents

Derivados de colchicina y su uso terapeutico.

Info

Publication number
ES2131863T3
ES2131863T3 ES95935393T ES95935393T ES2131863T3 ES 2131863 T3 ES2131863 T3 ES 2131863T3 ES 95935393 T ES95935393 T ES 95935393T ES 95935393 T ES95935393 T ES 95935393T ES 2131863 T3 ES2131863 T3 ES 2131863T3
Authority
ES
Spain
Prior art keywords
sub
colquicina
group
derivatives
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95935393T
Other languages
English (en)
Inventor
Ezio Bombardelli
Bruno Gabetta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of ES2131863T3 publication Critical patent/ES2131863T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE COLQUICINA DE FORMULA (1), DONDE Y ES UN GRUPO -CH{SUB,2}-CH-NHR{SUB,3} O UN GRUPO -CH-CH{SUB,2}-OR{SUB,3} Y LAS OTRAS VARIABLES SON COMO SE DEFINIAN EN LA REIVINDICACION 1, QUE TIENEN ACTIVIDADES ANTIPROLIFERATIVAS, ANTITUMORALES Y ANTIINFLAMATORIAS. LOS NUEVOS COMPUESTOS TIENEN UNA CITOTOXICIDAD EN LINEAS CELULARES TUMORALES HUMANAS COMPARABLE CON COLQUICINA, PERO, EN COMPARACION CON LA ULTIMA, SON MENOS TOXICOS Y MAS SELECTIVOS, EN PARTICULAR EN CELULAS RESISTENTES A LOS MEDICAMENTOS USUALES. ALGUNOS COMPUESTOS TIENEN UNA ACTIVIDAD MARCADA EN TFN E INTERLEUCINA 2, Y POR TANTO SON AGENTES ANTIINFLAMATORIOS MUY POTENTES. PUEDEN SER INCLUIDOS EN FORMULACIONES FARMACEUTICAS UTILES PARA LAS ADMINISTRACIONES PARENTERALES, ORALES Y TOPICAS.
ES95935393T 1994-10-05 1995-09-27 Derivados de colchicina y su uso terapeutico. Expired - Lifetime ES2131863T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942026A IT1270124B (it) 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico

Publications (1)

Publication Number Publication Date
ES2131863T3 true ES2131863T3 (es) 1999-08-01

Family

ID=11369650

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95935393T Expired - Lifetime ES2131863T3 (es) 1994-10-05 1995-09-27 Derivados de colchicina y su uso terapeutico.
ES98121484T Expired - Lifetime ES2224322T3 (es) 1994-10-05 1995-09-27 Derivados de colchicina y su uso terapeutico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98121484T Expired - Lifetime ES2224322T3 (es) 1994-10-05 1995-09-27 Derivados de colchicina y su uso terapeutico.

Country Status (22)

Country Link
US (1) US5843910A (es)
EP (2) EP0909763B1 (es)
JP (1) JP2921990B2 (es)
KR (1) KR100255074B1 (es)
CN (2) CN1075059C (es)
AT (2) ATE181060T1 (es)
AU (1) AU692624B2 (es)
CA (1) CA2201723C (es)
CZ (1) CZ290309B6 (es)
DE (2) DE69510212T2 (es)
DK (2) DK0909763T3 (es)
ES (2) ES2131863T3 (es)
FI (1) FI120452B (es)
GR (1) GR3030449T3 (es)
HU (1) HU223779B1 (es)
IT (1) IT1270124B (es)
NO (1) NO308030B1 (es)
PL (1) PL182204B1 (es)
PT (1) PT909763E (es)
RU (1) RU2145598C1 (es)
SK (1) SK281831B6 (es)
WO (1) WO1996011184A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
FR2779147B1 (fr) * 1998-05-27 2000-06-30 Synthelabo Derive de thiocolchicoside sa preparation et son application en therapeutique
WO2000035865A2 (en) * 1998-12-17 2000-06-22 Tularik Inc. Tubulin-binding agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
KR20030014425A (ko) * 2000-07-07 2003-02-17 앤지오젠 파마슈티칼스 리미티드 혈관 손상제인 콜치놀 유도체
US6720323B2 (en) * 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
DK1646608T3 (da) * 2003-06-25 2011-06-14 Je Il Pharmaceutical Co Ltd Tricykliske derivater eller farmaceutisk acceptable salte deraf, deres fremstillinger og farmaceutiske sammensætninger indeholdende dem
ES2356494T3 (es) * 2008-05-28 2011-04-08 Indena S.P.A. Procedimiento para la glucosidación de colchicina y tiocolchicina.
PL2470499T3 (pl) 2009-08-26 2019-11-29 Alberta Health Services Nowe pochodne kolchicyny, sposoby i ich zastosowania
WO2016059650A1 (en) 2014-10-14 2016-04-21 Council Of Scientific & Industrial Research 10-substituted colchicinoids as potent anticancer agents
CA3136489A1 (en) 2018-06-29 2020-01-02 Alberta Health Services Methods and uses of colchicine derivatives
WO2023077977A1 (zh) * 2021-11-08 2023-05-11 天津市昕晨投资发展有限公司 秋水仙碱衍生物的制备方法及其用途
CN120136821A (zh) * 2021-11-18 2025-06-13 杭州新元素药业有限公司 一类抗炎镇痛化合物及其用途
CN114907228B (zh) * 2022-06-27 2023-11-28 深圳市锦泰医药科技合伙企业(有限合伙) 一种秋水仙碱和厚朴酚复合物及其合成方法以及在抗新冠病毒方面的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH513119A (de) * 1968-02-23 1971-09-30 Merck Patent Gmbh Verfahren zur Herstellung neuer Halogencolchicinderivate
GB1345991A (en) * 1972-05-05 1974-02-06 Roussel Uclaf Thiocolchicine derivatives
ES2062014T3 (es) * 1988-08-24 1994-12-16 Advance Biofactures Corp Carbonatos de 3-desmetiltiocolchicina y analogos n-acilados.

Also Published As

Publication number Publication date
ATE271061T1 (de) 2004-07-15
FI120452B (fi) 2009-10-30
CZ101597A3 (en) 1997-10-15
CN1308059A (zh) 2001-08-15
HK1017361A1 (en) 1999-11-19
WO1996011184A1 (en) 1996-04-18
JP2921990B2 (ja) 1999-07-19
SK281831B6 (sk) 2001-08-06
PL182204B1 (en) 2001-11-30
DK0784613T3 (da) 1999-11-15
ATE181060T1 (de) 1999-06-15
CA2201723C (en) 2003-03-25
FI971364A0 (fi) 1997-04-03
IT1270124B (it) 1997-04-28
JPH10507169A (ja) 1998-07-14
NO308030B1 (no) 2000-07-10
CZ290309B6 (cs) 2002-07-17
GR3030449T3 (en) 1999-09-30
CN1075059C (zh) 2001-11-21
FI971364L (fi) 1997-05-30
AU3743295A (en) 1996-05-02
CA2201723A1 (en) 1996-04-18
CN1127480C (zh) 2003-11-12
NO971503D0 (no) 1997-04-03
HK1001394A1 (en) 1998-06-19
US5843910A (en) 1998-12-01
DE69533267D1 (de) 2004-08-19
EP0784613B1 (en) 1999-06-09
PT909763E (pt) 2004-10-29
EP0909763A2 (en) 1999-04-21
DE69510212D1 (de) 1999-07-15
CN1159801A (zh) 1997-09-17
HU223779B1 (hu) 2005-01-28
PL319455A1 (en) 1997-08-04
ES2224322T3 (es) 2005-03-01
ITMI942026A1 (it) 1996-04-05
EP0909763B1 (en) 2004-07-14
DE69510212T2 (de) 1999-11-11
KR100255074B1 (ko) 2000-05-01
RU2145598C1 (ru) 2000-02-20
EP0784613A1 (en) 1997-07-23
DE69533267T2 (de) 2005-08-04
DK0909763T3 (da) 2004-11-22
HUT77223A (hu) 1998-03-02
ITMI942026A0 (it) 1994-10-05
AU692624B2 (en) 1998-06-11
EP0909763A3 (en) 2003-01-22
SK42497A3 (en) 1997-11-05
NO971503L (no) 1997-05-14

Similar Documents

Publication Publication Date Title
ES2131863T3 (es) Derivados de colchicina y su uso terapeutico.
ES2171691T3 (es) Derivados de la colchicina, uso de los mismos y formulaciones que los contienen.
ATE269089T1 (de) Verwendung von vitamin d derivaten zur verstärkung der wirkung von zytotoxischen stoffen
ES2091737T1 (es) Formulados farmaceuticos de fluoxetina.
ES2167377T3 (es) Derivados de piridina farmacologicamente activos y procedimientos para la preparacion de los mismos.
AR003220A1 (es) Derivados acilados de melatonina; composicion farmaceutica y cosmetica y el uso de los mismos para la preparacion de un medicamento.
ECSP941104A (es) Derivados de 2,6 diaminopurina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ATE323473T1 (de) Pharmazeutische zusammensetzungen enthaltend resveratrol und verwendungen davon
CO5720000A2 (es) Derivados de macrolidos con actividad antiinflamatoria, su procedimiento de sintesis y composiciones farmaceuticas que los contienen
ES2171933T3 (es) Derivados de androsteno.
CY1105849T1 (el) Χρηση αντισηπτικων στην εμπορικη κατασκευη φαρμακευτικου παρασκευασματος προς αποτροπη ή θepαπεια εναντι φλεγμονων εντος του ανθρωπινου σωματος
CO5160321A1 (es) Novedosas composiciones de tipranavir y ritonavir
DE3586935D1 (de) Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.
ES2130152T3 (es) Medicamentos para tratar dolencias inflamatorias o para analgesia que contienen un nsaid y ranitidina/citrato de bismuto.
HUP0200152A2 (hu) KQT1 csatornák gátlóinak alkalmazása parazita férgek és ektoparaziták által okozott betegségek kezelésére alkalmas gyógyszerkészítmények előállítására
AR021086A1 (es) Omega-amidas de n-arilsulfonil-aminoacidos, un procedimiento para su preparacion, medicamento, uso de dichos compuestos para la preparacion de un medicamento y procedimiento para la preparacion de un medicamento.
ES2077559T3 (es) Estabilizacion de proteinas terapeuticamente activas en preparados farmaceuticos.
PA8525801A1 (es) Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2
ES2159054T3 (es) Compuestos di-terc-butil-fenolicos que contienen azufre utiles como agentes antiinflamatorios.
ES2145234T3 (es) Derivados de la diosmetina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DK0773782T3 (da) Terpenderivater (sarcodictyiner) anvendelse som antitumormidler
DK0700897T3 (da) L-carnitinsalt og kosmetiske og farmaceutiske præparater indeholdende samme til behandling af hudsygdomme
IT8021550A0 (it) Derivati adenosinici ad attivita'antinfiammatoria ed analgesica e composizioni terapeutiche che licontengono come principio attivo.
ITMI922742A0 (it) Composti ad attivita' terapeutica utili per il trattamento di malattieconnesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
ES2138668T3 (es) Nuevos derivados de peptidos terapeuticamente activos en la cadena de coagulacion sanguinea, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 784613

Country of ref document: ES