[go: up one dir, main page]

DE69506760D1 - Polyiodierte Verbindungen, Verfahren zu deren Herstellung und diagnostische Zusammensetzung - Google Patents

Polyiodierte Verbindungen, Verfahren zu deren Herstellung und diagnostische Zusammensetzung

Info

Publication number
DE69506760D1
DE69506760D1 DE69506760T DE69506760T DE69506760D1 DE 69506760 D1 DE69506760 D1 DE 69506760D1 DE 69506760 T DE69506760 T DE 69506760T DE 69506760 T DE69506760 T DE 69506760T DE 69506760 D1 DE69506760 D1 DE 69506760D1
Authority
DE
Germany
Prior art keywords
ch2oh
substd
formula
opt
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69506760T
Other languages
English (en)
Other versions
DE69506760T2 (de
Inventor
Myriam Petta
Dominique Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Guerbet SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet SA filed Critical Guerbet SA
Application granted granted Critical
Publication of DE69506760D1 publication Critical patent/DE69506760D1/de
Publication of DE69506760T2 publication Critical patent/DE69506760T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/12—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
DE69506760T 1994-03-22 1995-03-20 Polyiodierte Verbindungen, Verfahren zu deren Herstellung und diagnostische Zusammensetzung Expired - Fee Related DE69506760T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9403356A FR2717799B1 (fr) 1994-03-22 1994-03-22 Composés polyiodes : procédé de préparation ; composition de diagnostic.

Publications (2)

Publication Number Publication Date
DE69506760D1 true DE69506760D1 (de) 1999-02-04
DE69506760T2 DE69506760T2 (de) 1999-09-02

Family

ID=9461306

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69506760T Expired - Fee Related DE69506760T2 (de) 1994-03-22 1995-03-20 Polyiodierte Verbindungen, Verfahren zu deren Herstellung und diagnostische Zusammensetzung

Country Status (19)

Country Link
US (1) US5693311A (de)
EP (1) EP0675105B1 (de)
JP (1) JPH07316112A (de)
KR (1) KR950032116A (de)
CN (1) CN1112548A (de)
AT (1) ATE174902T1 (de)
AU (1) AU694164B2 (de)
BR (1) BR9501157A (de)
CA (1) CA2145035A1 (de)
CZ (1) CZ69595A3 (de)
DE (1) DE69506760T2 (de)
ES (1) ES2126224T3 (de)
FI (1) FI951323A (de)
FR (1) FR2717799B1 (de)
HU (1) HUT71893A (de)
IL (1) IL112985A (de)
NO (1) NO951072L (de)
NZ (1) NZ270750A (de)
ZA (1) ZA952265B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2780287B3 (fr) * 1998-06-30 2000-09-08 Guerbet Sa Derive polyhydroxyle du tetraiodoterephtalamide, son procede de preparation, son utilisation en radiologie et amino alcool intermediaire
US20060100127A1 (en) * 2004-11-11 2006-05-11 Meier Ingrid K N,N-dialkylpolyhydroxyalkylamines
CN101820923A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
CN103086915A (zh) * 2011-10-31 2013-05-08 上海海神化学生物科技有限公司 制备3,5-二取代-2,4,6-三碘代芳香胺类化合物的碘化方法
WO2017165841A1 (en) 2016-03-25 2017-09-28 Nanoprobes, Inc. Iodine-based particles
US10342232B1 (en) 2018-10-24 2019-07-09 The United States Of America As Represented By The Secretary Of The Navy Iodinated polymers for biological agent defeat
CN114262279B (zh) * 2021-12-30 2022-12-16 上海汇禾医疗科技有限公司 一种x射线可显影分子、栓塞微球及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH385423A (de) * 1958-12-03 1964-12-15 Chemie Linz Ag Verwendung polyjodierter Benzoesäureabkömmlinge als Röntgenkontrastmittel
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
IT1245853B (it) * 1990-11-16 1994-10-25 Bracco Spa 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
FR2687669B1 (fr) * 1992-02-24 1997-12-19 Guerbet Sa Composes utilisables dans des produits de contraste pour la radiographie.

Also Published As

Publication number Publication date
FI951323A (fi) 1995-09-23
FI951323A0 (fi) 1995-03-21
AU694164B2 (en) 1998-07-16
NZ270750A (en) 1996-05-28
NO951072D0 (no) 1995-03-21
JPH07316112A (ja) 1995-12-05
NO951072L (no) 1995-09-25
DE69506760T2 (de) 1999-09-02
AU1499095A (en) 1995-09-28
ATE174902T1 (de) 1999-01-15
EP0675105A1 (de) 1995-10-04
FR2717799A1 (fr) 1995-09-29
US5693311A (en) 1997-12-02
HUT71893A (en) 1996-02-28
ZA952265B (en) 1996-09-20
CN1112548A (zh) 1995-11-29
BR9501157A (pt) 1996-06-04
IL112985A (en) 1999-10-28
EP0675105B1 (de) 1998-12-23
ES2126224T3 (es) 1999-03-16
CA2145035A1 (en) 1995-09-23
HU9500823D0 (en) 1995-05-29
IL112985A0 (en) 1995-06-29
FR2717799B1 (fr) 1996-07-19
CZ69595A3 (en) 1995-11-15
KR950032116A (ko) 1995-12-20

Similar Documents

Publication Publication Date Title
KR900700494A (ko) 마크로시클릭 화합물
DE122009000040I2 (de) Naphthalin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
DE69331922D1 (de) Zyklische Peptide mit antifungischer Wirkung und Verfahren zu ihrer Herstellung
RU97106329A (ru) Иодированные рентгеноконтрастные средства
ATE123411T1 (de) Depigmentiermittel arbutosid enthaltend.
DE69103481D1 (de) Färbemittel, enthaltend 5-6-Dihydroxyindoline und Färbungsverfahren für keratinische Fasern.
DE58909022D1 (de) 5- oder 6-Ring-enthaltende makrocyclische Polyaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel.
DE69207194D1 (de) Verfahren zur Herstellung von Bacchatin III und von Desacetyl-10-Bacchatin III Derivate
ES2055368T3 (es) Procedimiento para la preparacion enantioselectiva de derivados de la fenilisoserina.
DE69506760D1 (de) Polyiodierte Verbindungen, Verfahren zu deren Herstellung und diagnostische Zusammensetzung
DE69607907D1 (de) Substituierte 2,2-Dimethyl-omega-Phenoxysäure und -ester, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
MX9200790A (es) Nuevos compuestos poliyodados, procedimientos de preparacion producto de contraste que los contiene.
NZ243695A (en) Iodinated ethers and their preparation
ES2053605T3 (es) Derivados de la tilosina y de la 10,11,12,13-tetrahidrotilosina, su metodo de preparacion y su utilizacion en composiciones farmaceuticas y en la preparacion de estas.
GR3034023T3 (en) Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
DE69318474D1 (de) Neue (Estradiol-Derivat)-Chlorambucil-Konjugate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate
HU9600517D0 (en) New tricyclic derivatives, their preparation, their use for the preparation of optically active or valemic colchicine and thiocolchine and analogues or derivatives and intermediates
ATE199706T1 (de) Vitamin d analoga und verfahren zu ihrer herstellung
AU2003206921A1 (en) Compositions for dyeing keratinous fibres comprising a levelling agent, use and method
ATE6063T1 (de) Cycloalkano-thiazolyloxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel.
DE59205849D1 (de) Verfahren zur Herstellung von 8-N,N-Dialkylaminotricyclo-(5.2.1.0 2,6)decan
TH24881A (th) สารผสมและวิธีต่อต้านแผ่นคราบฟันสำหรับช่องปาก

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee