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DE69434032D1 - Zwischenprodukt zur Herstellung von kondensierten benzazepinderivate - Google Patents

Zwischenprodukt zur Herstellung von kondensierten benzazepinderivate

Info

Publication number
DE69434032D1
DE69434032D1 DE69434032T DE69434032T DE69434032D1 DE 69434032 D1 DE69434032 D1 DE 69434032D1 DE 69434032 T DE69434032 T DE 69434032T DE 69434032 T DE69434032 T DE 69434032T DE 69434032 D1 DE69434032 D1 DE 69434032D1
Authority
DE
Germany
Prior art keywords
production
intermediate product
benzazepine derivatives
condensed benzazepine
condensed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434032T
Other languages
English (en)
Other versions
DE69434032T2 (de
Inventor
Akihiro Tanaka
Hiroyuki Koshio
Nobuaki Taniguchi
Akira Matsuhisa
Ken-Ichiro Sakamoto
Atsuki Yamazaki
Takeyuki Yatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of DE69434032D1 publication Critical patent/DE69434032D1/de
Application granted granted Critical
Publication of DE69434032T2 publication Critical patent/DE69434032T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Output Control And Ontrol Of Special Type Engine (AREA)
DE69434032T 1993-07-21 1994-07-19 Zwischenprodukt zur Herstellung von kondensierten Benzazepinderivate Expired - Lifetime DE69434032T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18043593 1993-07-21
JP18043593 1993-07-21

Publications (2)

Publication Number Publication Date
DE69434032D1 true DE69434032D1 (de) 2004-10-28
DE69434032T2 DE69434032T2 (de) 2005-09-22

Family

ID=16083198

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69432632T Expired - Lifetime DE69432632T2 (de) 1993-07-21 1994-07-19 Verschmolzene benzazepinderivate und diese enthaltende pharmazeutische zubereitungen
DE69434032T Expired - Lifetime DE69434032T2 (de) 1993-07-21 1994-07-19 Zwischenprodukt zur Herstellung von kondensierten Benzazepinderivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69432632T Expired - Lifetime DE69432632T2 (de) 1993-07-21 1994-07-19 Verschmolzene benzazepinderivate und diese enthaltende pharmazeutische zubereitungen

Country Status (18)

Country Link
US (2) US5723606A (de)
EP (2) EP1097920B1 (de)
KR (1) KR100304331B1 (de)
CN (1) CN1040210C (de)
AT (2) ATE277003T1 (de)
AU (2) AU683483B2 (de)
CA (1) CA2167673C (de)
DE (2) DE69432632T2 (de)
ES (2) ES2228405T3 (de)
FI (1) FI113178B (de)
HU (1) HUT74582A (de)
NO (1) NO306303B1 (de)
NZ (1) NZ268671A (de)
PL (1) PL177738B1 (de)
RU (1) RU2129123C1 (de)
TW (1) TW279163B (de)
UA (1) UA64690C2 (de)
WO (1) WO1995003305A1 (de)

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US5693635A (en) * 1993-07-29 1997-12-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5760031A (en) * 1993-07-29 1998-06-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
AR002459A1 (es) * 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
US6268359B1 (en) 1998-01-28 2001-07-31 Senju Pharmaceutical Co., Ltd. Preventives or remedies for vision disorders
AR018818A1 (es) * 1998-04-03 2001-12-12 Yamano Masaki Una composicion farmaceutica para la terapia de un edema.
AU4168999A (en) * 1998-06-19 2000-01-05 Wakamoto Pharmaceutical Co., Ltd. Ocular tension lowering agents and phosphoric ester derivatives
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
US6765004B1 (en) 1999-06-17 2004-07-20 Ortho-Mcneil Pharmaceutical, Inc. Indoloazepines as vasopressin receptor antagonists
US6437006B1 (en) 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
MXPA02006352A (es) * 2000-01-26 2002-11-29 Warner Lambert Co Combinaciones del inhibidor ace con el antagonista vasopresina.
US20030103983A1 (en) * 2002-05-09 2003-06-05 Pressler Milton Lethan Ace inhibitor-vasopressin antagonist combinations
WO2001054698A1 (en) * 2000-01-26 2001-08-02 Warner-Lambert Company Method for preventing or treating postoperative ileus
US20030008860A1 (en) * 2002-05-09 2003-01-09 Bakker-Arkema Rebecca Guggemos Treatment of congestive heart failure
AU779929B2 (en) * 2000-10-04 2005-02-17 Warner-Lambert Company Treatment of pulmonary hypertension
DE60129518T2 (de) * 2000-10-04 2008-03-20 Astellas Pharma Inc. Verwendung von einem Vasopressin-Antagonisten wie Conivaptan zur Herstellung eines Medikaments für die Behandlung der pulmonalen Hypertension
EP1338597A4 (de) * 2000-11-28 2008-06-18 Astellas Pharma Inc 1,4,5,6-tetrahydroimidazo 4,5-d diazepinderivate und deren salze
CN101395147B (zh) * 2005-12-28 2013-05-29 弗特克斯药品有限公司 作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US20080221084A1 (en) * 2006-10-30 2008-09-11 Otsuka Pharmaceutical Co., Ltd. Method for reducing infarction using vasopressin antagonist compounds, and compositions and combinations therefor
US20090069295A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched conivaptan
JP2011509261A (ja) * 2008-01-07 2011-03-24 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途向けの化合物
WO2009102761A1 (en) * 2008-02-12 2009-08-20 Bristol-Myers Squibb Company 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type i inhibitors
WO2009158011A1 (en) * 2008-06-26 2009-12-30 Amgen Inc. Alkynyl alcohols as kinase inhibitors
US8940727B2 (en) 2009-10-26 2015-01-27 Otsuka Pharmaceutical Co., Ltd. Benzazepine compound
US20150238502A1 (en) 2012-10-18 2015-08-27 University Of South Florida Compositions and Methods for Treating Stroke
CN103497195B (zh) * 2013-10-21 2016-01-27 北京科莱博医药开发有限责任公司 盐酸考尼伐坦新晶型及其制备方法
CN105310978A (zh) * 2014-08-04 2016-02-10 李峰 一种含有活性成分盐酸考尼伐坦的药物组合物及其制剂
CN105884778A (zh) * 2014-09-24 2016-08-24 李峰 一种化合物和制备方法
CN105153168A (zh) * 2015-09-29 2015-12-16 上海天慈国际药业有限公司 N-[4-(2-甲基-4,5-二氢-3H-咪唑并[4,5-d][1]苯并氮杂卓-6-甲酰基)苯基]-2-苯基苯甲酰胺盐酸盐的制备方法
CN106317060B (zh) * 2016-08-22 2019-02-15 山东罗欣药业集团恒欣药业有限公司 一种盐酸考尼伐坦的制备方法
US11498903B2 (en) 2017-08-17 2022-11-15 Bristol-Myers Squibb Company 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
JP7627343B2 (ja) * 2020-11-26 2025-02-05 シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド 新規ベンズアゼピンスピロ環式誘導体
TW202246273A (zh) * 2021-03-05 2022-12-01 大陸商上海濟煜醫藥科技有限公司 新型苯并氮雜卓并環衍生物
KR20250017381A (ko) 2023-07-27 2025-02-04 김주형 논슬립 기능을 구비한 자외선 차단 안면 보호커버

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EP0346713B1 (de) * 1988-06-15 1992-09-16 L. GIVAUDAN & CIE Société Anonyme Benzamidine, verwendbar als UV-Licht-Absorptionsmittel
US5011628A (en) * 1988-06-15 1991-04-30 Givaudan Corporation N,N'-diarylbenzamidines useful as ultraviolet light absorbers
US5225402A (en) * 1989-02-10 1993-07-06 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
DE69026708T2 (de) * 1989-10-20 1997-04-03 Otsuka Pharma Co Ltd Benzoheterozyklische verbindungen
JP2905909B2 (ja) * 1991-04-19 1999-06-14 大塚製薬株式会社 バソプレシン拮抗剤
JPH03255077A (ja) * 1990-03-01 1991-11-13 Taiji Nakayama ピリミジン誘導体およびそれを有効成分とする血小板凝集阻止剤
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
JP3255077B2 (ja) * 1997-04-23 2002-02-12 日本電気株式会社 電話機

Also Published As

Publication number Publication date
EP1097920A1 (de) 2001-05-09
UA64690C2 (en) 2004-03-15
FI960260A (fi) 1996-01-19
NZ268671A (en) 1997-09-22
CN1040210C (zh) 1998-10-14
EP0709386A4 (de) 1997-06-25
US5723606A (en) 1998-03-03
NO960231L (no) 1996-03-21
US5856564A (en) 1999-01-05
ATE277003T1 (de) 2004-10-15
WO1995003305A1 (fr) 1995-02-02
CA2167673A1 (en) 1995-02-02
EP1097920B1 (de) 2004-09-22
FI113178B (fi) 2004-03-15
CN1127508A (zh) 1996-07-24
TW279163B (de) 1996-06-21
ES2228405T3 (es) 2005-04-16
HUT74582A (en) 1997-01-28
ES2198418T3 (es) 2004-02-01
DE69432632D1 (de) 2003-06-12
DE69432632T2 (de) 2004-02-19
HU9600102D0 (en) 1996-03-28
PL177738B1 (pl) 2000-01-31
FI960260A0 (fi) 1996-01-19
NO306303B1 (no) 1999-10-18
AU7195794A (en) 1995-02-20
DE69434032T2 (de) 2005-09-22
PL312654A1 (en) 1996-04-29
KR960703917A (ko) 1996-08-31
ATE239726T1 (de) 2003-05-15
NO960231D0 (no) 1996-01-19
AU3990697A (en) 1997-12-18
EP0709386B1 (de) 2003-05-07
RU2129123C1 (ru) 1999-04-20
EP0709386A1 (de) 1996-05-01
KR100304331B1 (ko) 2001-11-22
AU683483B2 (en) 1997-11-13
CA2167673C (en) 2004-09-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP