DE69334092D1 - Nachweis von Mycobacterium tuberculosis durch Vervielfältigung von Nukleinsäuresequenzen - Google Patents
Nachweis von Mycobacterium tuberculosis durch Vervielfältigung von NukleinsäuresequenzenInfo
- Publication number
- DE69334092D1 DE69334092D1 DE69334092T DE69334092T DE69334092D1 DE 69334092 D1 DE69334092 D1 DE 69334092D1 DE 69334092 T DE69334092 T DE 69334092T DE 69334092 T DE69334092 T DE 69334092T DE 69334092 D1 DE69334092 D1 DE 69334092D1
- Authority
- DE
- Germany
- Prior art keywords
- amplification
- detection
- nucleic acid
- acid sequences
- mycobacterium tuberculosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000187479 Mycobacterium tuberculosis Species 0.000 title 1
- 230000003321 amplification Effects 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 238000003199 nucleic acid amplification method Methods 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- AIDS & HIV (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92540592A | 1992-08-04 | 1992-08-04 | |
| US925405 | 1992-08-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69334092D1 true DE69334092D1 (de) | 2007-01-11 |
| DE69334092T2 DE69334092T2 (de) | 2007-07-05 |
Family
ID=25451694
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69329636T Expired - Lifetime DE69329636T2 (de) | 1992-08-04 | 1993-08-04 | Verfahren zur Vervielfältigung von Nukleinsäuresequenzen |
| DE69334092T Expired - Lifetime DE69334092T2 (de) | 1992-08-04 | 1993-08-04 | Nachweis von Mycobacterium tuberculosis durch Vervielfältigung von Nukleinsäuresequenzen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69329636T Expired - Lifetime DE69329636T2 (de) | 1992-08-04 | 1993-08-04 | Verfahren zur Vervielfältigung von Nukleinsäuresequenzen |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0587298B1 (de) |
| JP (3) | JP4372837B2 (de) |
| KR (1) | KR100316498B1 (de) |
| AT (2) | ATE197479T1 (de) |
| AU (2) | AU670116B2 (de) |
| CA (1) | CA2141430C (de) |
| DE (2) | DE69329636T2 (de) |
| ES (1) | ES2277679T3 (de) |
| NO (1) | NO950381L (de) |
| TW (1) | TW278099B (de) |
| WO (1) | WO1994003472A1 (de) |
Families Citing this family (79)
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|---|---|---|---|---|
| US5981179A (en) * | 1991-11-14 | 1999-11-09 | Digene Diagnostics, Inc. | Continuous amplification reaction |
| EP0682121B1 (de) | 1993-12-01 | 2002-08-28 | Toyo Boseki Kabushiki Kaisha | Verfahren zur ampflifizierung und zum nachweis bestimmter nukleinsäuresequenzen mittels thermostabiler enzyme |
| FR2724934B1 (fr) * | 1994-09-26 | 1997-01-24 | Bio Merieux | Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique |
| US5514551A (en) * | 1994-10-14 | 1996-05-07 | Gen-Probe Incorporated | Compositions for the detection of Chlamydia trachomatis |
| EP0805876B1 (de) * | 1995-01-19 | 2000-07-05 | Gen-Probe Incorporated | Amplifikationsoligonukleotide und sonden für borrelia, die mit lyme kranheit assoziiert sind |
| US5622827A (en) * | 1995-02-07 | 1997-04-22 | Gen-Probe Incorporated | Amplification primers and nucleic acid probes targeted to coccidioides immitis nucleic acid |
| JP4040087B2 (ja) | 1995-05-05 | 2008-01-30 | アプレラ コーポレイション | Ｐｃｒ増幅とハイブリダイゼーションプロービングアッセイとを組み合わせた方法およびそのための試薬 |
| US5925518A (en) * | 1995-05-19 | 1999-07-20 | Akzo Nobel N.V. | Nucleic acid primers for amplification of a mycobacteria RNA template |
| US5739311A (en) * | 1995-06-07 | 1998-04-14 | Gen-Probe Incorporated | Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases |
| AU709292B2 (en) * | 1995-06-07 | 1999-08-26 | Gen-Probe Incorporated | Methods and kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| US5710029A (en) * | 1995-06-07 | 1998-01-20 | Gen-Probe Incorporated | Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| US5705365A (en) * | 1995-06-07 | 1998-01-06 | Gen-Probe Incorporated | Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| US5652126A (en) * | 1995-06-07 | 1997-07-29 | Gen-Probe Incorporated | Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides |
| US5932450A (en) * | 1995-06-07 | 1999-08-03 | Gen-Probe Incorporated | Enzymatic synthesis of oligonucleotides using digestible templates |
| US5747252A (en) | 1995-06-07 | 1998-05-05 | Gen-Probe Incorporated | Nucleic acid probes and amplification oligonucleotides for Neisseria species |
| US5882857A (en) * | 1995-06-07 | 1999-03-16 | Behringwerke Ag | Internal positive controls for nucleic acid amplification |
| CA2222305A1 (en) * | 1995-06-07 | 1996-12-19 | Gen-Probe Incorporated | Nucleic acid probes and amplification oligonucleotides for neisseria species |
| US5916777A (en) * | 1995-06-07 | 1999-06-29 | Gen-Probe Incorporated | Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers |
| DE69734576T2 (de) * | 1996-03-01 | 2006-08-03 | E.I. Dupont De Nemours And Co., Wilmington | Methode zur vervielfältigung und zum nachweis eines gewünschten nukleinsäurefragments |
| WO1997044488A2 (en) | 1996-05-22 | 1997-11-27 | Gen-Probe Incorporated | Compositions and methods for the detection of mycobacterium kansasii |
| US6013488A (en) * | 1996-07-25 | 2000-01-11 | The Institute Of Physical And Chemical Research | Method for reverse transcription |
| US6057134A (en) * | 1996-10-07 | 2000-05-02 | Ambion, Inc. | Modulating the efficiency of nucleic acid amplification reactions with 3' modified oligonucleotides |
| WO1998022625A1 (en) | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods |
| GB9626074D0 (en) | 1996-12-16 | 1997-02-05 | Cytocell Ltd | Nucleic acids amplification assay |
| US6025133A (en) * | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
| DE69836012T2 (de) | 1997-05-02 | 2007-04-05 | Gen-Probe Inc., San Diego | Zwei-schritt hybridisierung und einfang von einem polynukleotid |
| US6534273B2 (en) | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
| DE69833864T2 (de) * | 1997-08-14 | 2006-12-21 | Takara Bio Inc., Otsu | Methoden zur dns vervielfältigung und material dafür |
| AU1450699A (en) * | 1997-10-31 | 1999-05-24 | Gen-Probe Incorporated | Methods of nucleic acid detection |
| US5932451A (en) * | 1997-11-19 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Method for unbiased mRNA amplification |
| JP4438110B2 (ja) * | 1998-07-01 | 2010-03-24 | 東ソー株式会社 | 標的核酸の定量方法 |
| AU4739600A (en) * | 1999-05-17 | 2000-12-05 | Mcgill University | Method for subtracting cdnas by suppressing the synthesis of specifically targeted mrnas |
| US6294338B1 (en) | 1999-07-23 | 2001-09-25 | Gen-Probe Incorporated | Polynucleotide amplification method |
| US6489114B2 (en) | 1999-12-17 | 2002-12-03 | Bio Merieux | Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby |
| US6902891B2 (en) | 1999-12-17 | 2005-06-07 | Bio Merieux | Process for labeling a nucleic acid |
| JP2002051778A (ja) * | 2000-05-31 | 2002-02-19 | Tosoh Corp | 小型球形ウイルス（ｓｒｓｖ）ｒｎａ検出のためのオリゴヌクレオチドおよび検出法 |
| AU2001291513B2 (en) * | 2000-10-03 | 2007-06-07 | Id+Plus Ltd | Nucleotide detection method |
| AUPR050700A0 (en) | 2000-10-03 | 2000-10-26 | Id+Plus Ltd | Detection method |
| ATE386821T1 (de) | 2000-10-23 | 2008-03-15 | Gen Probe Inc | Zusammensetzungen und methoden zur detektion von humanem immundefizienz virus 2 (hiv-2) |
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| EP1921156A1 (de) * | 2006-11-10 | 2008-05-14 | bioMerieux B.V. | Verbesserte multiplexe Nukleinsäureamplifikation mittels blockierter Primer |
| GB0701253D0 (en) | 2007-01-23 | 2007-02-28 | Diagnostics For The Real World | Nucleic acid amplification and testing |
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| JP5646455B2 (ja) | 2008-04-21 | 2014-12-24 | ジェン−プロウブ インコーポレイテッド | チクングニヤウイルスを検出するための方法 |
| EP3705486B1 (de) | 2009-02-26 | 2022-11-16 | Gen-Probe Incorporated | Assay zum nachweisen menschlicher parvoviren-nukleinsäure |
| EP2593569B1 (de) | 2010-07-12 | 2018-01-03 | Gen-Probe Incorporated | Zusammensetzungen und tests für den nachweis von nukleinsäuren des saisonalen h1 influenza a virus |
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| EP4467664A3 (de) | 2018-09-27 | 2025-05-14 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von bordetella pertussis und bordetella parapertussis nukleinsäure |
| CN113195743A (zh) | 2018-10-22 | 2021-07-30 | 简·探针公司 | 扩增，检测或定量人类多瘤病毒bk病毒的组合物和方法 |
| EP4018004B1 (de) | 2019-08-23 | 2025-06-18 | Gen-Probe Incorporated | Zusammensetzungen, verfahren und kits zum nachweis von treponema pallidum |
| AU2020343334A1 (en) | 2019-09-05 | 2022-04-07 | Gen-Probe Incorporated | Detection of Chlamydia trachomatis nucleic acid variants |
| US12037638B2 (en) | 2019-12-09 | 2024-07-16 | Gen-Probe Incorporated | Quantification of polynucleotide analytes from dried samples |
| EP4582563A2 (de) | 2020-03-04 | 2025-07-09 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von sars-cov-2-nukleinsäure |
| WO2023010008A1 (en) | 2021-07-27 | 2023-02-02 | Gen-Probe Incorporated | Compositions and methods for detecting gastrointestinal pathogens |
| KR102544380B1 (ko) | 2022-01-29 | 2023-06-16 | (주)동방지퍼 | 지퍼용 슬라이더와 손잡이의 결착방법 및 이로 인해 제조된 지퍼 |
| EP4282980A1 (de) | 2022-05-23 | 2023-11-29 | Mobidiag Oy | Methoden zum verstärken einer nukleinsäure |
| WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
| WO2024233375A1 (en) | 2023-05-05 | 2024-11-14 | Gen-Probe Incorporated | Method and system for improving specificity of analyte detection using real-time nucleic acid amplification |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988003957A1 (en) * | 1986-11-24 | 1988-06-02 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| IL86724A (en) * | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Methods and kits for amplification and testing of nucleic acid sequences |
| US4994368A (en) * | 1987-07-23 | 1991-02-19 | Syntex (U.S.A.) Inc. | Amplification method for polynucleotide assays |
| EP0408295B1 (de) * | 1989-07-11 | 1996-08-28 | Gen-Probe Incorporated | Verfahren zur Vervielfältigung von Nukleinsäuresequenzen |
| CA2035010C (en) * | 1990-01-26 | 1996-12-10 | Keith C. Backman | Method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions |
| AU8920191A (en) * | 1990-10-31 | 1992-05-26 | George D. Cimino | Methods and compositions for minimizing inhibition of nucleic acid amplification |
| US5169766A (en) * | 1991-06-14 | 1992-12-08 | Life Technologies, Inc. | Amplification of nucleic acid molecules |
| US5521300A (en) * | 1991-08-13 | 1996-05-28 | Norval B. Galloway | Oligonucleotides complementary to mycobacterial nucleic acids |
| KR100249110B1 (ko) * | 1992-05-06 | 2000-04-01 | 다니엘 엘. 캐시앙 | 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트 |
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1993
- 1993-07-28 AU AU47920/93A patent/AU670116B2/en not_active Ceased
- 1993-07-28 WO PCT/US1993/007138 patent/WO1994003472A1/en active Application Filing
- 1993-07-28 JP JP50543394A patent/JP4372837B2/ja not_active Expired - Fee Related
- 1993-07-28 CA CA002141430A patent/CA2141430C/en not_active Expired - Lifetime
- 1993-07-28 KR KR1019950700406A patent/KR100316498B1/ko not_active Expired - Lifetime
- 1993-07-31 TW TW082106132A patent/TW278099B/zh active
- 1993-08-04 ES ES99121906T patent/ES2277679T3/es not_active Expired - Lifetime
- 1993-08-04 DE DE69329636T patent/DE69329636T2/de not_active Expired - Lifetime
- 1993-08-04 AT AT93306169T patent/ATE197479T1/de active
- 1993-08-04 AT AT99121906T patent/ATE346954T1/de not_active IP Right Cessation
- 1993-08-04 EP EP93306169A patent/EP0587298B1/de not_active Expired - Lifetime
- 1993-08-04 DE DE69334092T patent/DE69334092T2/de not_active Expired - Lifetime
- 1993-08-04 EP EP99121906A patent/EP0978570B1/de not_active Expired - Lifetime
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1995
- 1995-02-02 NO NO950381A patent/NO950381L/no unknown
-
1996
- 1996-10-04 AU AU68027/96A patent/AU700253B2/en not_active Ceased
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2003
- 2003-12-26 JP JP2003433721A patent/JP3860809B2/ja not_active Expired - Lifetime
-
2006
- 2006-05-10 JP JP2006131455A patent/JP2006238892A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994003472A1 (en) | 1994-02-17 |
| DE69329636T2 (de) | 2001-03-01 |
| EP0587298B1 (de) | 2000-11-08 |
| JP3860809B2 (ja) | 2006-12-20 |
| CA2141430A1 (en) | 1994-02-17 |
| AU4792093A (en) | 1994-03-03 |
| EP0978570B1 (de) | 2006-11-29 |
| ES2277679T3 (es) | 2007-07-16 |
| EP0978570A3 (de) | 2000-04-12 |
| EP0978570A2 (de) | 2000-02-09 |
| ATE197479T1 (de) | 2000-11-11 |
| DE69329636D1 (de) | 2000-12-14 |
| EP0587298A2 (de) | 1994-03-16 |
| CA2141430C (en) | 2009-05-12 |
| NO950381L (no) | 1995-04-03 |
| KR950702999A (ko) | 1995-08-23 |
| KR100316498B1 (ko) | 2002-06-20 |
| JP2004194662A (ja) | 2004-07-15 |
| ATE346954T1 (de) | 2006-12-15 |
| AU700253B2 (en) | 1998-12-24 |
| NO950381D0 (no) | 1995-02-02 |
| AU670116B2 (en) | 1996-07-04 |
| JP4372837B2 (ja) | 2009-11-25 |
| TW278099B (de) | 1996-06-11 |
| DE69334092T2 (de) | 2007-07-05 |
| AU6802796A (en) | 1996-12-19 |
| JP2006238892A (ja) | 2006-09-14 |
| JPH07509368A (ja) | 1995-10-19 |
| EP0587298A3 (en) | 1995-08-30 |
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