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DE69323759D1 - Verwendung von toremifene für die behandlung von sle - Google Patents

Verwendung von toremifene für die behandlung von sle

Info

Publication number
DE69323759D1
DE69323759D1 DE69323759T DE69323759T DE69323759D1 DE 69323759 D1 DE69323759 D1 DE 69323759D1 DE 69323759 T DE69323759 T DE 69323759T DE 69323759 T DE69323759 T DE 69323759T DE 69323759 D1 DE69323759 D1 DE 69323759D1
Authority
DE
Germany
Prior art keywords
treatment
toremifene
sle
glucocorticoid
estrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69323759T
Other languages
English (en)
Other versions
DE69323759T2 (de
Inventor
Junpei Itoh
Osamu Miyazaki
Hisao Ekimoto
Michinori Koyama
Tetsushi Saino
Lauri Kangas
Anni Warri
Christer Granberg Chr Granberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Nippon Kayaku Co Ltd
Original Assignee
Orion Yhtyma Oy
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy, Nippon Kayaku Co Ltd filed Critical Orion Yhtyma Oy
Application granted granted Critical
Publication of DE69323759D1 publication Critical patent/DE69323759D1/de
Publication of DE69323759T2 publication Critical patent/DE69323759T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
DE69323759T 1992-10-27 1993-10-26 Verwendung von toremifene für die behandlung von sle Expired - Fee Related DE69323759T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31077292 1992-10-27
PCT/JP1993/001543 WO1994009764A1 (en) 1992-10-27 1993-10-26 Use of non steroidal anti estrogens for autoimmune diseases

Publications (2)

Publication Number Publication Date
DE69323759D1 true DE69323759D1 (de) 1999-04-08
DE69323759T2 DE69323759T2 (de) 1999-07-22

Family

ID=18009292

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69323759T Expired - Fee Related DE69323759T2 (de) 1992-10-27 1993-10-26 Verwendung von toremifene für die behandlung von sle

Country Status (12)

Country Link
US (3) US6355688B1 (de)
EP (2) EP0776661A1 (de)
KR (1) KR100303634B1 (de)
CN (1) CN1053337C (de)
AT (1) ATE177008T1 (de)
AU (1) AU5286693A (de)
DE (1) DE69323759T2 (de)
DK (1) DK0667768T3 (de)
ES (1) ES2128441T3 (de)
GR (1) GR3029682T3 (de)
NO (2) NO314533B1 (de)
WO (1) WO1994009764A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
WO1994026303A1 (en) * 1993-05-13 1994-11-24 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US5521198A (en) * 1993-12-21 1996-05-28 Eli Lilly And Company Methods of inhibiting autoimmune diseases
CA2280181A1 (en) * 1997-02-09 1998-08-13 Pharmos Corporation Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
US6433846B1 (en) 1997-03-06 2002-08-13 Nashua Corporation Apparatus for maintaining and converting a localized polarization shift into a localized intensity variation in a LCD display assembly
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
MXPA02001547A (es) 1999-08-13 2002-07-02 Wieland Heinrich Extractos de glicinas de soya e inhibidores de aromatasa para afectar positivamente colageno.
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US7069444B2 (en) * 2002-01-25 2006-06-27 Brent A. Lowensohn Portable wireless access to computer-based systems
US9040507B2 (en) * 2008-06-02 2015-05-26 Novelmed Therapeutics, Inc. Method for treating inflammatory conditions
WO2010091418A1 (en) 2009-02-09 2010-08-12 Valspar Sourcing, Inc. In-store tintable non-infrared-absorptive paint and stain system
CN102307795B (zh) 2009-02-09 2015-04-15 威士伯采购公司 在店内可调色的不吸收红外线的漆料和色料系统
US20130102216A1 (en) 2010-07-01 2013-04-25 Valspar Sourcing, Inc. Infrared-reflective two-part coating composition
WO2012074617A2 (en) 2010-10-20 2012-06-07 Valspar Sourcing, Inc. Water-based coating system with improved moisture and heat resistance
RU2572504C1 (ru) * 2013-12-26 2016-01-10 Андрей Константинович Иорданишвили Способ лечения лучевой сиалоаденопатии
EP3420024A4 (de) 2016-02-23 2020-02-19 Advanced Environmental Recycling Technologies, Inc Zusammensetzungen und verfahren zur verringerung der oberflächentemperatur von verbundartikeln
WO2018126276A1 (en) 2017-01-01 2018-07-05 Advanced Environmental Recycling Technologies, Inc. Methods for coating composite articles

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU172948B (hu) 1976-02-05 1979-01-28 Gyogyszerkutato Intezet Sposob poluchenija osnovnykh proizvodnykh trifenil-alkenov
EP0002097B1 (de) 1977-08-22 1981-08-05 Imperial Chemical Industries Plc Triphenylalken-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
DE3046719C2 (de) 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
GB2126576B (en) * 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
FI67538C (fi) 1982-05-27 1985-04-10 Farmos Oy Foerfarande foer framstaellning av (z)-1,2-difenyl-1-(4-(2-(n n-dimetylamino)etoxi)fenyl)-1-buten
US5348729A (en) * 1988-11-30 1994-09-20 The United States Of America As Represented By The Department Of Health And Human Services Evaluative means for detecting inflammatory reactivity
US4990538A (en) 1989-08-23 1991-02-05 Harris Adrian L Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs
JPH04312526A (ja) * 1991-04-09 1992-11-04 Fujisawa Pharmaceut Co Ltd 骨疾患治療剤

Also Published As

Publication number Publication date
ES2128441T3 (es) 1999-05-16
DE69323759T2 (de) 1999-07-22
WO1994009764A1 (en) 1994-05-11
US20020107231A1 (en) 2002-08-08
NO951596L (no) 1995-04-26
ATE177008T1 (de) 1999-03-15
NO20025179D0 (no) 2002-10-28
NO317544B1 (no) 2004-11-08
AU5286693A (en) 1994-05-24
KR940008677A (ko) 1994-05-16
US6387958B1 (en) 2002-05-14
DK0667768T3 (da) 1999-09-27
GR3029682T3 (en) 1999-06-30
US6355688B1 (en) 2002-03-12
CN1053337C (zh) 2000-06-14
US6458848B1 (en) 2002-10-01
NO20025179L (no) 1995-04-26
KR100303634B1 (ko) 2001-11-22
NO951596D0 (no) 1995-04-26
EP0776661A1 (de) 1997-06-04
NO314533B1 (no) 2003-04-07
CN1100930A (zh) 1995-04-05
EP0667768B1 (de) 1999-03-03
EP0667768A1 (de) 1995-08-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee