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DE69225169D1 - Gegen menschliches stromelysin gerichteter monoklonaler antikörper und diagnose rheumatischer arthritis mittels enzym-immuntest - Google Patents

Gegen menschliches stromelysin gerichteter monoklonaler antikörper und diagnose rheumatischer arthritis mittels enzym-immuntest

Info

Publication number
DE69225169D1
DE69225169D1 DE69225169T DE69225169T DE69225169D1 DE 69225169 D1 DE69225169 D1 DE 69225169D1 DE 69225169 T DE69225169 T DE 69225169T DE 69225169 T DE69225169 T DE 69225169T DE 69225169 D1 DE69225169 D1 DE 69225169D1
Authority
DE
Germany
Prior art keywords
diagnosis
monoclonal antibody
against human
rheumatic arthritis
immunity test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69225169T
Other languages
English (en)
Other versions
DE69225169T2 (de
Inventor
Yasunori Okada
Masayoshi Shinmei
Taro Hayakawa
Kazushi Iwata
Yumi Korin
Shuji Kodama
Shinichi Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Pharma Chemical Co Ltd
Original Assignee
Fuji Yakuhin Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Yakuhin Kogyo KK filed Critical Fuji Yakuhin Kogyo KK
Publication of DE69225169D1 publication Critical patent/DE69225169D1/de
Application granted granted Critical
Publication of DE69225169T2 publication Critical patent/DE69225169T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69225169T 1991-01-21 1992-01-21 Gegen menschliches stromelysin gerichteter monoklonaler antikörper und diagnose rheumatischer arthritis mittels enzym-immuntest Expired - Lifetime DE69225169T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3078155A JPH085920B2 (ja) 1991-01-21 1991-01-21 抗ヒトストロムライシンモノクローナル抗体及び酵素免疫測定法
PCT/JP1992/000041 WO1992013096A1 (en) 1991-01-21 1992-01-21 Antihuman stromelysin monoclonal antibody and diagnosis of rheumatoid arthritis by enzyme immunoassay

Publications (2)

Publication Number Publication Date
DE69225169D1 true DE69225169D1 (de) 1998-05-28
DE69225169T2 DE69225169T2 (de) 1998-12-17

Family

ID=13654029

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69225169T Expired - Lifetime DE69225169T2 (de) 1991-01-21 1992-01-21 Gegen menschliches stromelysin gerichteter monoklonaler antikörper und diagnose rheumatischer arthritis mittels enzym-immuntest

Country Status (5)

Country Link
US (1) US5834212A (de)
EP (1) EP0522169B1 (de)
JP (1) JPH085920B2 (de)
DE (1) DE69225169T2 (de)
WO (1) WO1992013096A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19543265A1 (de) * 1995-11-20 1997-06-05 Univ Konstanz Autoantigene und Verfahren zur Diagnose von Autoimmunkrankheiten
WO1998040475A1 (en) * 1997-03-11 1998-09-17 Abbott Laboratories Human matrix metalloprotease gene, proteins encoded therefrom and methods of using same
WO2002036165A1 (fr) * 2000-10-27 2002-05-10 Chugai Seiyaku Kabushiki Kaisha Agent à base d'antagoniste d'il-6, faisant baisser le niveau des mmp-3 dans le sang
US6600057B2 (en) 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
US7041787B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
EP1721163B1 (de) * 2004-02-27 2015-04-29 Roche Diagnostics GmbH Methode zur detektion von rheumatischer arthritis beinhaltend die messung von rheumatoidem faktor und interleukin-6
EP2021792B1 (de) * 2006-05-09 2013-02-27 The University Of British Columbia Gelöste arthritis-proteinmarker
WO2010090079A1 (ja) * 2009-02-03 2010-08-12 第一ファインケミカル株式会社 ストロムライシン１と特異的に反応するモノクローナル抗体
WO2011129382A1 (en) * 2010-04-16 2011-10-20 Abbott Japan Co. Ltd. Methods and reagents for diagnosing rheumatoid arthritis
JP4987117B2 (ja) * 2010-12-27 2012-07-25 中外製薬株式会社 Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4859595A (en) * 1985-05-03 1989-08-22 Strosberg Arthur D Method for preparing rabbit monoclonal antibodies, the cell lines used therein and the antibodies produced thereby

Also Published As

Publication number Publication date
JPH085920B2 (ja) 1996-01-24
JPH04237499A (ja) 1992-08-25
EP0522169B1 (de) 1998-04-22
WO1992013096A1 (en) 1992-08-06
EP0522169A4 (en) 1993-06-30
DE69225169T2 (de) 1998-12-17
EP0522169A1 (de) 1993-01-13
US5834212A (en) 1998-11-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAIICHI FINE CHEMICAL CO., LTD., TAKAOKA, TOYAMA,