[go: up one dir, main page]

DE68918406D1 - Xanthinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate. - Google Patents

Xanthinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.

Info

Publication number
DE68918406D1
DE68918406D1 DE68918406T DE68918406T DE68918406D1 DE 68918406 D1 DE68918406 D1 DE 68918406D1 DE 68918406 T DE68918406 T DE 68918406T DE 68918406 T DE68918406 T DE 68918406T DE 68918406 D1 DE68918406 D1 DE 68918406D1
Authority
DE
Germany
Prior art keywords
substituted
compound
processes
preparation
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918406T
Other languages
English (en)
Other versions
DE68918406T2 (de
Inventor
Harald Beecham-Wuelfi Maschler
Rolf Theodor Beecham-Wue Wilke
Johannes Beecham-Wuelfin Jukna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Pharma GmbH and Co KG
Original Assignee
SmithKline Beecham Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Pharma GmbH and Co KG filed Critical SmithKline Beecham Pharma GmbH and Co KG
Application granted granted Critical
Publication of DE68918406D1 publication Critical patent/DE68918406D1/de
Publication of DE68918406T2 publication Critical patent/DE68918406T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inductance-Capacitance Distribution Constants And Capacitance-Resistance Oscillators (AREA)
DE68918406T 1988-11-14 1989-11-14 Xanthinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate. Expired - Fee Related DE68918406T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888826595A GB8826595D0 (en) 1988-11-14 1988-11-14 Active compounds

Publications (2)

Publication Number Publication Date
DE68918406D1 true DE68918406D1 (de) 1994-10-27
DE68918406T2 DE68918406T2 (de) 1995-03-30

Family

ID=10646826

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918406T Expired - Fee Related DE68918406T2 (de) 1988-11-14 1989-11-14 Xanthinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.

Country Status (15)

Country Link
EP (1) EP0369744B1 (de)
JP (1) JPH02178283A (de)
KR (1) KR0161261B1 (de)
AT (1) ATE111912T1 (de)
AU (1) AU614680B2 (de)
CA (1) CA2002834C (de)
DE (1) DE68918406T2 (de)
DK (1) DK570689A (de)
ES (1) ES2064461T3 (de)
GB (1) GB8826595D0 (de)
HK (1) HK1004551A1 (de)
IE (1) IE65585B1 (de)
NZ (1) NZ231380A (de)
PT (1) PT92303B (de)
ZA (1) ZA898678B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8918297D0 (en) * 1989-08-10 1989-09-20 Beecham Group Plc Novel treatment
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
JPH04112889A (ja) * 1990-09-04 1992-04-14 Kyowa Hakko Kogyo Co Ltd Ｋｓ―５０５誘導体
GB9020959D0 (en) * 1990-09-26 1990-11-07 Beecham Group Plc Novel compounds
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
AU4527996A (en) 1994-12-13 1996-07-03 Euro-Celtique S.A. Trisubstituted thioxanthines
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
EP0825993A1 (de) * 1995-05-19 1998-03-04 Chiroscience Limited Xanthine und ihre therapeutische anwendung
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
DE59708533D1 (de) * 1996-06-07 2002-11-28 Hoechst Ag Verwendung von Theophyllinderivaten zur Behandlung und Propylaxe von Schockzuständen, neue Xanthinverbindungen und Verfahren zu deren Herstellung
US5965555A (en) * 1996-06-07 1999-10-12 Hoechst Aktiengesellschaft Xanthine compounds having terminally animated alkynol side chains
GB9623859D0 (en) * 1996-11-15 1997-01-08 Chiroscience Ltd Novel compounds
GB9703044D0 (en) 1997-02-14 1997-04-02 Glaxo Group Ltd Phenyl xanthine esters and amides
GB9817623D0 (en) 1998-08-13 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608236A5 (de) * 1974-01-22 1978-12-29 Wuelfing J A Fa
US4061753A (en) * 1976-02-06 1977-12-06 Interx Research Corporation Treating psoriasis with transient pro-drug forms of xanthine derivatives
CA1077932A (en) * 1976-03-31 1980-05-20 Berlex Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases
DE2714953C2 (de) * 1977-04-02 1986-09-25 Hoechst Ag, 6230 Frankfurt Arzneimittel
SE416810C (sv) * 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
SE7810947L (sv) * 1978-10-20 1980-04-21 Draco Ab 3-alkylxanthines
CH643260A5 (fr) * 1980-05-02 1984-05-30 Nestle Sa 1-allyl-3-butyl-8-methylxanthine, procede de preparation et utilisation dans un medicament.
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung

Also Published As

Publication number Publication date
AU4466789A (en) 1990-05-17
EP0369744A3 (de) 1991-04-10
EP0369744B1 (de) 1994-09-21
JPH02178283A (ja) 1990-07-11
HK1004551A1 (en) 1998-11-27
IE893653L (en) 1990-05-14
ES2064461T3 (es) 1995-02-01
PT92303A (pt) 1990-05-31
DE68918406T2 (de) 1995-03-30
NZ231380A (en) 1992-12-23
DK570689D0 (da) 1989-11-14
CA2002834C (en) 2000-02-22
ZA898678B (en) 1990-09-26
GB8826595D0 (en) 1988-12-21
EP0369744A2 (de) 1990-05-23
ATE111912T1 (de) 1994-10-15
KR900007842A (ko) 1990-06-02
CA2002834A1 (en) 1990-05-14
AU614680B2 (en) 1991-09-05
KR0161261B1 (ko) 1998-12-01
IE65585B1 (en) 1995-11-01
DK570689A (da) 1990-05-15
PT92303B (pt) 1995-07-18

Similar Documents

Publication Publication Date Title
DE68918406D1 (de) Xanthinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
DE10199003I2 (de)
DE69033915D1 (de) Xanthinderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Anwendung
HUT53368A (en) Process for producing pyrazolo-pyridine derivatives and pharmaceutical compositions containing them
AU6129890A (en) Novel compounds
AU6128590A (en) Novel compounds
DE69312984D1 (de) Substituierte Aminophosphonatderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
EP0488513A3 (de) Verwendung von Dioxabicyclo [3.3.0]octane Derivaten zur Herstellung eines Arzneimittels zur Hemmung des Cholesterinmetabolismus.
PT86232A (en) Process for preparing a pharmaceutical composition containing a9-substituted guanine
DE3789290D1 (de) Theophyllinmethyldithiolan und Theophyllinmethyldithianylderivate, ein Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
DE69315501D1 (de) Neue 17-Hydroxyiminomethyl-5beta, 14beta-Androstan-Derivate, kardioaktives Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon
ATE53209T1 (de) Piperazinverbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzung und verwendung.
DE68922053D1 (de) Pyridoindolderivate und Verfahren zu ihrer Herstellung.
ATE86993T1 (de) Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
AU8029091A (en) Disubstituted polymethyleneimines, a process for the preparation thereof, and pharmaceutical compositions containing them
WO1987004435A3 (en) Xanthine compounds
GR3001493T3 (en) D-nor-7-ergoline derivatives, process for preparing them, pharmaceutical composition and use
DE69024154D1 (de) Pyrimidoindolderivate und Verfahren zu ihrer Herstellung
ATE36154T1 (de) 4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ATE82289T1 (de) 1-hydroxyalkylxanthine, verfahren zu ihrer herstellung und sie enthaltende medikamente.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee