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DE60329194D1 - Nachweis der rezeptoroligomerisierung - Google Patents

Nachweis der rezeptoroligomerisierung

Info

Publication number
DE60329194D1
DE60329194D1 DE60329194T DE60329194T DE60329194D1 DE 60329194 D1 DE60329194 D1 DE 60329194D1 DE 60329194 T DE60329194 T DE 60329194T DE 60329194 T DE60329194 T DE 60329194T DE 60329194 D1 DE60329194 D1 DE 60329194D1
Authority
DE
Germany
Prior art keywords
probes
binding
molecules
probe includes
cleaving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329194T
Other languages
English (en)
Inventor
Po-Ying Chan-Hui
Yining Shi
Sailaja Pidaparthi
Rajiv Dua
Sharat Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Aclara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences Inc filed Critical Aclara Biosciences Inc
Application granted granted Critical
Publication of DE60329194D1 publication Critical patent/DE60329194D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
DE60329194T 2002-07-25 2003-07-17 Nachweis der rezeptoroligomerisierung Expired - Lifetime DE60329194D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39872402P 2002-07-25 2002-07-25
PCT/US2003/022611 WO2004011900A2 (en) 2002-07-25 2003-07-17 Detecting receptor oligomerization

Publications (1)

Publication Number Publication Date
DE60329194D1 true DE60329194D1 (de) 2009-10-22

Family

ID=31188464

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60329194T Expired - Lifetime DE60329194D1 (de) 2002-07-25 2003-07-17 Nachweis der rezeptoroligomerisierung

Country Status (13)

Country Link
US (2) US7105308B2 (de)
EP (1) EP1540347B1 (de)
JP (2) JP4443407B2 (de)
KR (1) KR20050025669A (de)
CN (1) CN1672054A (de)
AT (1) ATE442589T1 (de)
AU (1) AU2003259175B2 (de)
CA (1) CA2490654C (de)
DE (1) DE60329194D1 (de)
ES (1) ES2332310T3 (de)
NO (1) NO20050916L (de)
PL (1) PL374875A1 (de)
WO (1) WO2004011900A2 (de)

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US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
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AU2003265268A1 (en) * 2002-07-26 2004-02-16 Aclara Biosciences, Inc. Methods and compositions for screening cell binding molecules
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
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US7405053B2 (en) * 2003-05-20 2008-07-29 The University Court Of The University Of Glasgow Materials and methods relating to G-protein coupled receptor oligomers
US20100291594A1 (en) * 2003-07-17 2010-11-18 Laboratory Corporation Of America Holdings ErbB Surface Receptor Complexes as Biomarkers
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
BRPI0413471A (pt) * 2003-08-11 2006-10-17 Monogram Biosciences Inc métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica
EP1681983A4 (de) * 2003-10-14 2008-12-10 Monogram Biosciences Inc Rezeptor-tyrosin-kinase-signalpfad-analyse für diagnose und therapie
US8282921B2 (en) 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
US20060204999A1 (en) * 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
JP5656406B2 (ja) 2006-11-28 2015-01-21 ユースリー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツングＵ３ Ｐｈａｒｍａ ＧｍｂＨ 治療効力を予測するためのマーカーとしての活性化ｈｅｒ３
CA2706763C (en) 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
CA2711843C (en) 2007-12-20 2018-11-13 Laboratory Corporation Of America Holdings Her-2 diagnostic methods
US8470542B2 (en) * 2008-12-01 2013-06-25 Laboratory Corporation Of America Holdings Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95
EP2387711B1 (de) 2009-01-15 2015-04-22 Laboratory Corporation of America Holdings Verfahren zur bestimmung von patientenreaktionen durch her-3-messung
ES2526519T3 (es) * 2009-01-15 2015-01-13 Laboratory Corporation Of America Holdings Métodos de determinación de la respuesta del paciente por medición de la expresión HER-2
EP2398868B1 (de) * 2009-02-20 2016-06-15 Perkinelmer Biosignal, Inc. Multiplex-assayverfahren und zusammensetzungen
WO2010132723A1 (en) * 2009-05-14 2010-11-18 Prometheus Laboratories Inc. Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy
WO2011060206A2 (en) 2009-11-13 2011-05-19 U3 Pharma Gmbh Material and methods for treating or preventing her-3 associated diseases
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
SG194609A1 (en) 2011-05-19 2013-12-30 Lab Corp America Holdings Methods for determining the likelihood of survival and for predicting likelihood of metastasis in cancer patients
US9442098B2 (en) * 2012-08-02 2016-09-13 Waters Technologies Corporation Chromatographic system quality control reference materials
CN103012193B (zh) * 2012-12-14 2015-08-19 无锡中德伯尔生物技术有限公司 隐色孔雀石绿半抗原、人工抗原及制备方法
CA2908515A1 (en) * 2013-04-05 2014-10-09 Laboratory Corporation Of America Holdings Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation
WO2015038799A1 (en) * 2013-09-11 2015-03-19 Moy Ronald L Systems and methods for the molecular quantification of skin damage in skin
CN104458708A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选乙酰胆碱酯酶抑制剂高通量筛选方法
EP3050886A1 (de) * 2015-02-02 2016-08-03 Bürkert Werke GmbH Fluoreszenzfarbstoffe und Farbstoffvorläufer
CA3016914C (en) 2016-03-15 2019-08-27 Laboratory Corporation Of America Holdings Methods of assessing protein interactions between cells
CN105891347B (zh) * 2016-03-18 2018-02-13 宁波大学 一种胶束电动毛细管电泳法测定γ‑氨基丁酸含量的方法
CN110736695A (zh) * 2016-09-30 2020-01-31 多伦多大学管理委员会 用于鉴定和靶向异质群体中的个体细胞以选择性提取细胞内容物的系统
CN111276385B (zh) * 2020-02-13 2020-12-08 清华大学 质谱仪的离子激发检测方法
CN116324410A (zh) 2020-09-28 2023-06-23 美勒斯公司 用于检测细胞表面部分的表达或聚集的方法

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Also Published As

Publication number Publication date
KR20050025669A (ko) 2005-03-14
CA2490654A1 (en) 2004-02-05
AU2003259175B2 (en) 2010-08-12
WO2004011900A2 (en) 2004-02-05
EP1540347B1 (de) 2009-09-09
ES2332310T3 (es) 2010-02-02
WO2004011900A3 (en) 2004-06-10
EP1540347A2 (de) 2005-06-15
CA2490654C (en) 2012-02-07
US20040126818A1 (en) 2004-07-01
PL374875A1 (en) 2005-11-14
US7105308B2 (en) 2006-09-12
JP4443407B2 (ja) 2010-03-31
JP2009271087A (ja) 2009-11-19
NO20050916L (no) 2005-04-14
US7135300B2 (en) 2006-11-14
JP2005534030A (ja) 2005-11-10
EP1540347A4 (de) 2006-09-20
AU2003259175A1 (en) 2004-02-16
US20040197835A1 (en) 2004-10-07
ATE442589T1 (de) 2009-09-15
CN1672054A (zh) 2005-09-21

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MONOGRAM BIOSCIENCES, INC. (N. D. GES. D. STAA, US