SE0000538D0 - Methods and kits for proximity probing - Google Patents
Methods and kits for proximity probingInfo
- Publication number
- SE0000538D0 SE0000538D0 SE0000538A SE0000538A SE0000538D0 SE 0000538 D0 SE0000538 D0 SE 0000538D0 SE 0000538 A SE0000538 A SE 0000538A SE 0000538 A SE0000538 A SE 0000538A SE 0000538 D0 SE0000538 D0 SE 0000538D0
- Authority
- SE
- Sweden
- Prior art keywords
- proximity
- kits
- methods
- nucleic acid
- solution
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000523 sample Substances 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 239000012491 analyte Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0000538A SE516272C2 (sv) | 2000-02-18 | 2000-02-18 | Metoder och kit för analytdetektion mha proximitets-probning |
| EP01906476A EP1255861B1 (en) | 2000-02-18 | 2001-02-16 | Methods and kits for proximity probing |
| PCT/SE2001/000341 WO2001061037A1 (en) | 2000-02-18 | 2001-02-16 | Methods and kits for proximity probing |
| CA002400384A CA2400384A1 (en) | 2000-02-18 | 2001-02-16 | Methods and kits for proximity probing |
| AT01906476T ATE402269T1 (de) | 2000-02-18 | 2001-02-16 | Methoden und testsätze für annäherungstest |
| AU34300/01A AU783644B2 (en) | 2000-02-18 | 2001-02-16 | Methods and kits for proximity probing |
| DE60134957T DE60134957D1 (de) | 2000-02-18 | 2001-02-16 | Methoden und testsätze für annäherungstest |
| JP2001559873A JP4804691B2 (ja) | 2000-02-18 | 2001-02-16 | 近接プロービング方法およびキット |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0000538A SE516272C2 (sv) | 2000-02-18 | 2000-02-18 | Metoder och kit för analytdetektion mha proximitets-probning |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE0000538D0 true SE0000538D0 (sv) | 2000-02-18 |
| SE0000538L SE0000538L (sv) | 2001-08-19 |
| SE516272C2 SE516272C2 (sv) | 2001-12-10 |
Family
ID=20278505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0000538A SE516272C2 (sv) | 2000-02-18 | 2000-02-18 | Metoder och kit för analytdetektion mha proximitets-probning |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1255861B1 (sv) |
| JP (1) | JP4804691B2 (sv) |
| AT (1) | ATE402269T1 (sv) |
| AU (1) | AU783644B2 (sv) |
| CA (1) | CA2400384A1 (sv) |
| DE (1) | DE60134957D1 (sv) |
| SE (1) | SE516272C2 (sv) |
| WO (1) | WO2001061037A1 (sv) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| US7595202B2 (en) | 2001-04-23 | 2009-09-29 | Teruyuki Nagamune | Analysis method using reporter (label) intermolecular interaction |
| US20030096275A1 (en) * | 2001-08-20 | 2003-05-22 | Laing Lance G. | Biosensor for small molecule analytes |
| EP1436419A1 (en) * | 2001-10-03 | 2004-07-14 | ISEAO Technologies Limited | Methods for detection of target molecules and molecular interactions |
| GB0212544D0 (en) * | 2002-05-30 | 2002-07-10 | Microsens Biophage Ltd | Methods for detection of target molecules and molecular interactions |
| EP1451356A1 (en) | 2001-11-23 | 2004-09-01 | Simon Fredriksson | Method and kit for proximity probing with multivalent proximity probes |
| US7553619B2 (en) | 2002-02-08 | 2009-06-30 | Qiagen Gmbh | Detection method using dissociated rolling circle amplification |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| WO2005067692A2 (en) | 2004-01-13 | 2005-07-28 | U.S. Genomics, Inc. | Detection and quantification of analytes in solution using polymers |
| US7595160B2 (en) | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
| CA2552858A1 (en) * | 2004-01-23 | 2005-08-04 | Lingvitae As | Improving polynucleotide ligation reactions |
| US7914987B2 (en) | 2004-06-14 | 2011-03-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in analyte detection using proximity probes |
| DE602005023529D1 (de) † | 2004-11-03 | 2010-10-21 | Iris Molecular Diagnostics Inc | Homogener nachweis von analyten |
| EP1904648A4 (en) * | 2005-07-06 | 2010-03-10 | Uppsala Uni Projekt Ab | PROCESS FOR LOCALIZING NUCLEIC ACID ASSOCIATED MOLECULES AND MODIFICATIONS |
| EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
| WO2007044903A2 (en) * | 2005-10-11 | 2007-04-19 | Stratagene California | Binary signal detection assays |
| EP1957664A1 (en) * | 2005-11-14 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Method for detecting microorganisms |
| WO2007084886A2 (en) * | 2006-01-17 | 2007-07-26 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| GB0605584D0 (en) | 2006-03-20 | 2006-04-26 | Olink Ab | Method for analyte detection using proximity probes |
| WO2007117444A2 (en) * | 2006-03-31 | 2007-10-18 | Yinghe Hu | Protein detection by aptamers |
| US8012685B2 (en) * | 2006-08-01 | 2011-09-06 | Applied Biosystems, Llc | Detection of analytes and nucleic acids |
| US8778846B2 (en) * | 2006-12-04 | 2014-07-15 | General Electric Company | Composition, device and associated method |
| US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US20110136099A1 (en) | 2007-01-16 | 2011-06-09 | Somalogic, Inc. | Multiplexed Analyses of Test Samples |
| GB0918712D0 (en) * | 2009-10-26 | 2009-12-09 | Axis Shield Diagnostics Ltd | An assay |
| GB201004292D0 (en) | 2010-03-15 | 2010-04-28 | Olink Ab | Assay for localised detection of analytes |
| US20120004132A1 (en) * | 2010-07-02 | 2012-01-05 | Affymetrix, Inc. | Detection of Nucleic Acids and Proteins |
| GB201011971D0 (en) | 2010-07-15 | 2010-09-01 | Olink Ab | Methods and product |
| EP2627781B1 (en) | 2010-10-15 | 2017-02-22 | Olink Bioscience AB | Dynamic range methods |
| US20130323729A1 (en) * | 2010-10-29 | 2013-12-05 | Olink Ab | Proximity Ligation Technology for Western Blot Applications |
| EP2466310A1 (en) | 2010-12-17 | 2012-06-20 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Means and methods for detecting double-strand breaks |
| ES2645953T3 (es) | 2011-01-17 | 2017-12-11 | Life Technologies Corporation | Ligamiento enzimático de ácidos nucleicos |
| EP3216878B1 (en) * | 2011-01-17 | 2019-04-03 | Life Technologies Corporation | Workflow for detection of ligands using nucleic acids |
| US11560585B2 (en) | 2011-01-31 | 2023-01-24 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| JP6069224B2 (ja) | 2011-01-31 | 2017-02-01 | アプライズ バイオ， インコーポレイテッド | 細胞において複数のエピトープを同定する方法 |
| GB201101621D0 (en) | 2011-01-31 | 2011-03-16 | Olink Ab | Method and product |
| US10597701B2 (en) | 2011-05-11 | 2020-03-24 | Navinci Diagnostics Ab | Unfolding proximity probes and methods for the use thereof |
| GB201107863D0 (en) | 2011-05-11 | 2011-06-22 | Olink Ab | Method and product |
| GB201108678D0 (en) | 2011-05-24 | 2011-07-06 | Olink Ab | Multiplexed proximity ligation assay |
| US9029086B2 (en) * | 2012-01-26 | 2015-05-12 | Masood Kamali Moghaddam | Detection of single and multimodal analytes |
| GB201201547D0 (en) | 2012-01-30 | 2012-03-14 | Olink Ab | Method and product |
| EP2920324B1 (en) | 2012-11-14 | 2017-12-27 | Olink Bioscience AB | Localised rca-based amplification method |
| CN104955963A (zh) | 2012-11-14 | 2015-09-30 | 欧凌科公司 | Rca报告探针及其用于检测核酸分子的用途 |
| GB201320145D0 (en) | 2013-11-14 | 2014-01-01 | Olink Ab | Localised RCA-based amplification method using a padlock-probe |
| GB201321123D0 (en) | 2013-11-29 | 2014-01-15 | Linea Ab Q | Amplification of circular molecules |
| GB201401885D0 (en) | 2014-02-04 | 2014-03-19 | Olink Ab | Proximity assay with detection based on hybridisation chain reaction (HCR) |
| CN107110849B (zh) * | 2014-12-19 | 2019-07-26 | 豪夫迈·罗氏有限公司 | 在选定的细胞亚群中鉴别多个表位的方法 |
| US20180179576A1 (en) * | 2015-03-02 | 2018-06-28 | The Regents Of The University Of California | Homogeneous entropy-driven biomolecular assay (heba) |
| US11149296B2 (en) | 2015-04-17 | 2021-10-19 | The Regents Of The University Of California | Methods for detecting agglutination and compositions for use in practicing the same |
| WO2017070309A1 (en) | 2015-10-20 | 2017-04-27 | Quateris Llc | Multiplex dna immuno-sandwich assay (mdisa) |
| GB201518655D0 (en) * | 2015-10-21 | 2015-12-02 | Olink Ab | Method for generating proximity probes |
| US11008608B2 (en) | 2016-02-26 | 2021-05-18 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplexed single molecule RNA visualization with a two-probe proximity ligation system |
| CA3037855A1 (en) * | 2016-06-17 | 2017-12-21 | Proximity Biosciences, Llc | Method for aptamer pair selection |
| GB201614023D0 (en) | 2016-08-16 | 2016-09-28 | Olink Bioscience Ab | Double-stranded circle probes |
| CA3009990A1 (en) | 2016-10-21 | 2018-04-26 | Zelda Therapeutics Operations Pty Ltd | Method for determining levels of her2/cb2 heteromer expression and uses in the treatment of a subject |
| GB201621514D0 (en) | 2016-12-16 | 2017-02-01 | Q-Linea Ab | Padlock probe detection method |
| CN111139285A (zh) * | 2018-11-02 | 2020-05-12 | 深圳华大生命科学研究院 | 一种高通量检测多个待测样本中不同目的蛋白含量的方法及其专用试剂盒 |
| WO2021034971A1 (en) * | 2019-08-19 | 2021-02-25 | Brickbio, Inc. | Methods and compositions for analyte detection and quantification |
| CN115066434A (zh) | 2019-12-03 | 2022-09-16 | 阿拉玛生物科学公司 | 核酸连接的免疫-夹心测定(nulisa) |
| GB201919032D0 (en) | 2019-12-20 | 2020-02-05 | Cartana Ab | Method of detecting an analyte |
| GB201919029D0 (en) | 2019-12-20 | 2020-02-05 | Cartana Ab | Method of detecting an analyte |
| WO2021191449A1 (en) | 2020-03-27 | 2021-09-30 | Olink Proteomics Ab | Method for detecting analytes |
| GB202004469D0 (en) | 2020-03-27 | 2020-05-13 | Olink Proteomics Ab | Controls for proximity detection assays |
| GB202004472D0 (en) | 2020-03-27 | 2020-05-13 | Olink Proteomics Ab | Method for detecting analytes of varying abundance |
| GB202017873D0 (en) | 2020-11-12 | 2020-12-30 | Olso Unversitetssykehus Hf | Method of determining DLBCL prognosis |
| GB202018503D0 (en) | 2020-11-25 | 2021-01-06 | Olink Proteomics Ab | Analyte detection method employing concatamers |
| CN113945720B (zh) * | 2021-09-26 | 2024-08-16 | 瑞博奥(广州)生物科技股份有限公司 | 基于核酸适配体探针的pdgf-bb识别方法及检测pdgf-bb的试剂盒 |
| US20250059592A1 (en) * | 2021-12-23 | 2025-02-20 | California Institute Of Technology | Suppression of non-specific signals by exonucleases in fish experiment |
| GB202213930D0 (en) | 2022-09-23 | 2022-11-09 | Xu Bo | Padlock blocking oligonucleotide |
| WO2024100258A1 (en) | 2022-11-11 | 2024-05-16 | Olink Proteomics Ab | Library of proximity probes and method of use |
| EP4382534A1 (en) | 2022-12-06 | 2024-06-12 | Biomérieux | Synthetic peptide for use in an immunomolecular assay |
| WO2025012398A1 (en) | 2023-07-11 | 2025-01-16 | Olink Proteomics Ab | Dried reagents |
| WO2025012226A1 (en) | 2023-07-12 | 2025-01-16 | Olink Proteomics Ab | Method, components and software for detecting a systematic error in a protein detection system |
| WO2025031642A1 (en) | 2023-08-07 | 2025-02-13 | Olink Proteomics Ab | A method for determining run errors for an analysis-method for quantifying a plurality of analytes in a plurality of biological samples |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4883750A (en) * | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| CA1323293C (en) * | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| DK0666927T3 (da) * | 1991-09-13 | 1997-09-15 | Cytocell Ltd | Fremgangsmåde til påvisning af en nukleinsyresekvens. |
| US5846709A (en) * | 1993-06-15 | 1998-12-08 | Imclone Systems Incorporated | Chemical process for amplifying and detecting nucleic acid sequences |
| SE504798C2 (sv) * | 1995-06-16 | 1997-04-28 | Ulf Landegren | Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten |
| WO2001023894A1 (de) * | 1999-09-28 | 2001-04-05 | Evotec Oai Ag | Quantitative analyse und typisierung subzellulärer partikel |
-
2000
- 2000-02-18 SE SE0000538A patent/SE516272C2/sv not_active IP Right Cessation
-
2001
- 2001-02-16 DE DE60134957T patent/DE60134957D1/de not_active Expired - Lifetime
- 2001-02-16 AU AU34300/01A patent/AU783644B2/en not_active Expired
- 2001-02-16 EP EP01906476A patent/EP1255861B1/en not_active Expired - Lifetime
- 2001-02-16 WO PCT/SE2001/000341 patent/WO2001061037A1/en active IP Right Grant
- 2001-02-16 JP JP2001559873A patent/JP4804691B2/ja not_active Expired - Lifetime
- 2001-02-16 AT AT01906476T patent/ATE402269T1/de not_active IP Right Cessation
- 2001-02-16 CA CA002400384A patent/CA2400384A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001061037A1 (en) | 2001-08-23 |
| EP1255861B1 (en) | 2008-07-23 |
| AU3430001A (en) | 2001-08-27 |
| DE60134957D1 (de) | 2008-09-04 |
| SE0000538L (sv) | 2001-08-19 |
| AU783644B2 (en) | 2005-11-17 |
| CA2400384A1 (en) | 2001-08-23 |
| JP4804691B2 (ja) | 2011-11-02 |
| JP2003524419A (ja) | 2003-08-19 |
| ATE402269T1 (de) | 2008-08-15 |
| EP1255861A1 (en) | 2002-11-13 |
| SE516272C2 (sv) | 2001-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |