DE60230869D1 - 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen - Google Patents

4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen

Info

Publication number: DE60230869D1
Authority: DE; Germany
Prior art keywords: phenylpiperazinylmethyl; fear; pain; treatment; gastrointestinal disorder
Prior art date: 2001-05-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60230869T

Other languages

English (en)

Inventor

William Brown

Christopher Walpole

Niklas Plobeck

Hudzik Wilmington Thomas

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

AstraZeneca AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-16

Publication date

2009-03-05

2001-05-18 Priority claimed from SE0101772A external-priority patent/SE0101772D0/xx

2001-11-15 Priority claimed from SE0103820A external-priority patent/SE0103820D0/xx

2002-05-16 Application filed by AstraZeneca AB filed Critical AstraZeneca AB

2009-03-05 Application granted granted Critical

2009-03-05 Publication of DE60230869D1 publication Critical patent/DE60230869D1/de

2022-05-17 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Immunology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

DE60230869T 2001-05-18 2002-05-16 4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen Expired - Lifetime DE60230869D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE0101772A SE0101772D0 (sv)	2001-05-18	2001-05-18	Novel compounds
SE0103820A SE0103820D0 (sv)	2001-11-15	2001-11-15	Novel compounds
PCT/SE2002/000956 WO2002094794A1 (en)	2001-05-18	2002-05-16	4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders

Publications (1)

Publication Number	Publication Date
DE60230869D1 true DE60230869D1 (de)	2009-03-05

Family

ID=26655470

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60230869T Expired - Lifetime DE60230869D1 (de)	2001-05-18	2002-05-16	4-(phenylpiperazinylmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen

Country Status (32)

Country	Link
US (3)	US7229994B2 (de)
EP (2)	EP2042495A1 (de)
JP (2)	JP4549024B2 (de)
KR (2)	KR100915263B1 (de)
CN (1)	CN1269805C (de)
AR (1)	AR035974A1 (de)
AT (1)	ATE420866T1 (de)
AU (1)	AU2002305994B2 (de)
BG (1)	BG108333A (de)
BR (1)	BR0209678A (de)
CA (1)	CA2446326C (de)
CO (1)	CO5540309A2 (de)
CY (1)	CY1108913T1 (de)
CZ (1)	CZ20033092A3 (de)
DE (1)	DE60230869D1 (de)
DK (1)	DK1395567T3 (de)
EE (1)	EE05243B1 (de)
ES (1)	ES2319876T3 (de)
HK (1)	HK1061237A1 (de)
HU (1)	HUP0401086A3 (de)
IL (2)	IL158631A0 (de)
IS (1)	IS2625B (de)
MX (1)	MXPA03010445A (de)
MY (1)	MY140070A (de)
NO (1)	NO326632B1 (de)
NZ (2)	NZ539828A (de)
PL (1)	PL367142A1 (de)
PT (1)	PT1395567E (de)
RU (1)	RU2297412C2 (de)
SI (1)	SI1395567T1 (de)
SK (1)	SK287555B6 (de)
WO (1)	WO2002094794A1 (de)

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WO2014202999A1 (en)	2013-06-21	2014-12-24	Takeda Cambridge Limited	1-sulfonyl piperidine derivatives as modulators of prokineticin receptors
GB201314286D0 (en)	2013-08-08	2013-09-25	Takeda Pharmaceutical	Therapeutic Compounds
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TW201613864A (en)	2014-02-20	2016-04-16	Takeda Pharmaceutical	Novel compounds
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- 2002-05-16 AT AT02733712T patent/ATE420866T1/de active
- 2002-05-16 EP EP08171062A patent/EP2042495A1/de not_active Withdrawn
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Also Published As

Publication number	Publication date
CA2446326C (en)	2010-12-07
US20110039858A1 (en)	2011-02-17
NO20035120D0 (no)	2003-11-17
HUP0401086A3 (en)	2011-07-28
MXPA03010445A (es)	2004-03-09
US7915413B2 (en)	2011-03-29
NO326632B1 (no)	2009-01-26
CA2446326A1 (en)	2002-11-28
MY140070A (en)	2009-11-30
NZ529401A (en)	2005-09-30
US8022074B2 (en)	2011-09-20
IS7032A (is)	2003-11-13
SI1395567T1 (sl)	2009-04-30
KR100915263B1 (ko)	2009-09-03
WO2002094794A1 (en)	2002-11-28
RU2003131964A (ru)	2005-05-10
IL158631A (en)	2010-12-30
EE05243B1 (et)	2009-12-15
ATE420866T1 (de)	2009-01-15
CO5540309A2 (es)	2005-07-29
RU2297412C2 (ru)	2007-04-20
PT1395567E (pt)	2009-03-26
US20070270435A1 (en)	2007-11-22
CY1108913T1 (el)	2014-07-02
JP5028500B2 (ja)	2012-09-19
BR0209678A (pt)	2004-09-14
EP1395567A1 (de)	2004-03-10
PL367142A1 (en)	2005-02-21
US20040147526A1 (en)	2004-07-29
US7229994B2 (en)	2007-06-12
AU2002305994B2 (en)	2008-06-26
AR035974A1 (es)	2004-07-28
JP2005508293A (ja)	2005-03-31
KR20080106586A (ko)	2008-12-08
KR100885100B1 (ko)	2009-02-20
JP2010132670A (ja)	2010-06-17
DK1395567T3 (da)	2009-04-06
CN1269805C (zh)	2006-08-16
IL158631A0 (en)	2004-05-12
NZ539828A (en)	2007-01-26
BG108333A (bg)	2004-12-30
EP2042495A1 (de)	2009-04-01
HK1061237A1 (en)	2004-09-10
HUP0401086A2 (hu)	2004-08-30
JP4549024B2 (ja)	2010-09-22
ES2319876T3 (es)	2009-05-14
CZ20033092A3 (cs)	2004-08-18
EP1395567B1 (de)	2009-01-14
IS2625B (is)	2010-05-15
SK287555B6 (sk)	2011-01-04
CN1527820A (zh)	2004-09-08
SK13982003A3 (sk)	2004-04-06
WO2002094794A8 (en)	2004-04-22
EE200300545A (et)	2004-02-16
KR20040000471A (ko)	2004-01-03

Publication	Publication Date	Title
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EE200300527A (et)	2004-02-16	4-(fenüülpiperidiin-4-ülideenmetüül)bensamiidi derivaadid ja nende kasutamine valu, ärevuse või seedetrakti häirete raviks
DE60027429D1 (de)	2006-05-24	Dihydrobenzodiazepinen und deren verwendung zur behandlung von dyslipidämien
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DE60224004D1 (de)	2008-01-24	Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten
DE60202679D1 (de)	2005-02-24	4-(phenylpiperidin-4-ylidenmethyl) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
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DE60208193D1 (de)	2006-01-26	4-(phenyl(piperidin-4-yl)amino) benzamidderivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
DE50308460D1 (de)	2007-12-06	Verwendung von ambroxol zur behandlung von chronischen schmerzen
DE60233740D1 (de)	2009-10-29	Benzoägüchinolinderivate zur behandlung von glaucom und kurzsichtigkeit
EE200300535A (et)	2004-02-16	4-(fenüül(piperidiin-4-üül)amino)bensamiidi derivaadid ja nende kasutamine valu, ärevuse või seedetrakti häirete raviks
ATE359270T1 (de)	2007-05-15	Phenyl-piperidin-4-yliden-methyl-benzamidderiva e zur behandlung von schmerz oder magen-darm- erkrankungen
DE60217493D1 (de)	2007-02-22	Verwendung von carbamat-verbindungen zur prävention oder behandlung von neuropathischen schmerzen und migräneartigen kopfschmerzen

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