DE60224004D1 - Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten - Google Patents

Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten

Info

Publication number: DE60224004D1
Authority: DE; Germany
Prior art keywords: inhibitors; prevention; treatment; heart diseases; heart
Prior art date: 2001-01-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60224004T

Other languages

English (en)

Other versions

DE60224004T2 (de

Inventor

Charles Dinarello

Benjamin Pomerantz

Leonid Reznikov

Alden Harken

Yolande Chvatchko

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Serono SA

Serono Laboratories UK Ltd

Original Assignee

Laboratoires Serono SA

Serono Laboratories UK Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-29

Filing date

2002-01-28

Publication date

2008-01-24

2002-01-28 Application filed by Laboratoires Serono SA, Serono Laboratories UK Ltd filed Critical Laboratoires Serono SA

2008-01-24 Publication of DE60224004D1 publication Critical patent/DE60224004D1/de

2009-07-23 Application granted granted Critical

2009-07-23 Publication of DE60224004T2 publication Critical patent/DE60224004T2/de

2022-01-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DE60224004T 2001-01-29 2002-01-28 Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten Expired - Lifetime DE60224004T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01101959		2001-01-29
EP01101959		2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en)	2001-01-29	2002-01-28	Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (2)

Publication Number	Publication Date
DE60224004D1 true DE60224004D1 (de)	2008-01-24
DE60224004T2 DE60224004T2 (de)	2009-07-23

Family

ID=8176323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60224004T Expired - Lifetime DE60224004T2 (de)	2001-01-29	2002-01-28	Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten

Country Status (32)

Country	Link
US (1)	US20040234523A1 (de)
EP (1)	EP1355668B1 (de)
JP (2)	JP4860897B2 (de)
KR (1)	KR100857376B1 (de)
CN (1)	CN1326562C (de)
AR (1)	AR032422A1 (de)
AT (1)	ATE380558T1 (de)
BG (1)	BG66483B1 (de)
BR (1)	BR0206819A (de)
CA (1)	CA2435466C (de)
CY (1)	CY1107203T1 (de)
CZ (1)	CZ305653B6 (de)
DE (1)	DE60224004T2 (de)
DK (1)	DK1355668T3 (de)
EA (2)	EA006767B1 (de)
EE (1)	EE05534B1 (de)
ES (1)	ES2295332T3 (de)
HK (1)	HK1062810A1 (de)
HR (1)	HRP20030609A2 (de)
HU (1)	HU229164B1 (de)
IL (2)	IL157024A0 (de)
ME (1)	ME00549B (de)
MX (1)	MXPA03006776A (de)
NO (1)	NO331083B1 (de)
PL (1)	PL213568B1 (de)
PT (1)	PT1355668E (de)
RS (1)	RS51125B (de)
SI (1)	SI1355668T1 (de)
SK (1)	SK287620B6 (de)
UA (1)	UA80676C2 (de)
WO (1)	WO2002060479A1 (de)
ZA (1)	ZA200305439B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK12942002A3 (sk)	2000-02-10	2003-05-02	Abbott Laboratories	Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia
AU2002211744B8 (en)	2000-10-11	2008-03-20	Viron Therapeutics, Inc.	Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en)	2000-12-04	2010-05-18	Viron Therapeutics Inc.	Immunomodulatory protein and useful embodiments thereof
ES2384241T3 (es)	2003-05-13	2012-07-02	Merck Serono Sa	Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas
US7968684B2 (en) *	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
JP4961559B2 (ja) *	2004-03-11	2012-06-27	友昭星野	インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
ES2370417T3 (es)	2005-06-03	2011-12-15	Ares Trading S.A.	Producción de una proteína de unión a il-18 recombinante.
PL1891088T3 (pl)	2005-06-10	2012-03-30	Ares Trading Sa	Sposób oczyszczania białka wiążącego IL-18
JP5968590B2 (ja)	2007-11-05	2016-08-10	ケーシーアイライセンシングインコーポレイテッド	創面切除のための組織の同定
JOP20200308A1 (ar)	2012-09-07	2017-06-16	Novartis Ag	جزيئات إرتباط il-18
ES2892923T3 (es)	2013-09-05	2022-02-07	Ab2 Bio Sa	Proteína de unión a IL-18 (IL-18BP) en enfermedades inflamatorias
AU2016227644B2 (en) *	2015-03-05	2022-06-16	Ab2 Bio Sa	IL-18 Binding Protein (IL-18BP) and antibodies in inflammatory diseases
US11091795B2 (en)	2016-07-11	2021-08-17	Arizona Board Of Regents On Behalf Of The University Of Arizona	Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) *	1989-09-05	1997-02-25	Immunex Corporation	Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) *	1995-11-21	1999-02-25	Yamanouchi Pharma Co Ltd	Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
EP0929311B8 (de) *	1996-09-12	2006-02-01	Idun Pharmaceuticals, Inc.	Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie
AU7624798A (en) *	1996-12-06	1998-06-29	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1 beta converting enzyme
CN1269722A (zh) *	1997-03-18	2000-10-11	Basf公司	调节对皮质类固醇反应的方法及组合物
IL121860A0 (en) *	1997-08-14	1998-02-22	Yeda Res & Dev	Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) *	1997-10-06	1998-11-26	Henkel Kgaa	Detergensgemische und deren Verwendung
WO2000000490A2 (en) *	1998-06-26	2000-01-06	Eli Lilly And Company	5-ht1f agonists
CA2340579A1 (en) *	1998-09-01	2000-03-09	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	Interleukin 18-binding protein
EP1022027A1 (de) *	1999-01-22	2000-07-26	Applied Research Systems ARS Holding N.V.	Antagonisten von Tumornecrosefaktor und ihre Verwendungen gegen Endometriose
AU3876600A (en) *	1999-03-16	2000-10-04	Cytovia, Inc.	Substituted 2-aminobenzamide caspase inhibitors and the use thereof
AU4213500A (en) *	1999-04-09	2000-11-14	Cytovia, Inc.	Caspase inhibitors and the use thereof
WO2001003719A2 (en) *	1999-07-09	2001-01-18	Amgen Inc.	Combination therapy for conditions leading to bone loss
SK12942002A3 (sk) *	2000-02-10	2003-05-02	Abbott Laboratories	Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia
EA007014B1 (ru) *	2000-05-05	2006-06-30	Апплайд Резеч Системз Арс Холдинг Н.В.	Применение il-18 в качестве диагностического маркера
AU2002224417A1 (en) *	2000-10-18	2002-04-29	Immunex Corporation	Methods for treating il-18 mediated disorders

2002
- 2002-01-28 IL IL15702402A patent/IL157024A0/xx unknown
- 2002-01-28 CA CA2435466A patent/CA2435466C/en not_active Expired - Lifetime
- 2002-01-28 EA EA200300844A patent/EA006767B1/ru not_active IP Right Cessation
- 2002-01-28 KR KR1020037009941A patent/KR100857376B1/ko active IP Right Grant
- 2002-01-28 DE DE60224004T patent/DE60224004T2/de not_active Expired - Lifetime
- 2002-01-28 US US10/470,303 patent/US20040234523A1/en not_active Abandoned
- 2002-01-28 SI SI200230667T patent/SI1355668T1/sl unknown
- 2002-01-28 CN CNB02807503XA patent/CN1326562C/zh not_active Expired - Lifetime
- 2002-01-28 ME MEP-2008-681A patent/ME00549B/me unknown
- 2002-01-28 ES ES02718052T patent/ES2295332T3/es not_active Expired - Lifetime
- 2002-01-28 RS YUP-578/03A patent/RS51125B/sr unknown
- 2002-01-28 ZA ZA200305439A patent/ZA200305439B/en unknown
- 2002-01-28 AT AT02718052T patent/ATE380558T1/de active
- 2002-01-28 PL PL366802A patent/PL213568B1/pl unknown
- 2002-01-28 DK DK02718052T patent/DK1355668T3/da active
- 2002-01-28 UA UA2003088056A patent/UA80676C2/uk unknown
- 2002-01-28 BR BR0206819-2A patent/BR0206819A/pt not_active Application Discontinuation
- 2002-01-28 HU HU0303306A patent/HU229164B1/hu unknown
- 2002-01-28 CZ CZ2003-2335A patent/CZ305653B6/cs not_active IP Right Cessation
- 2002-01-28 SK SK1089-2003A patent/SK287620B6/sk not_active IP Right Cessation
- 2002-01-28 MX MXPA03006776A patent/MXPA03006776A/es active IP Right Grant
- 2002-01-28 EA EA200501549A patent/EA010180B1/ru not_active IP Right Cessation
- 2002-01-28 JP JP2002560670A patent/JP4860897B2/ja not_active Expired - Lifetime
- 2002-01-28 WO PCT/EP2002/000844 patent/WO2002060479A1/en active IP Right Grant
- 2002-01-28 PT PT02718052T patent/PT1355668E/pt unknown
- 2002-01-28 EE EEP200300328A patent/EE05534B1/xx unknown
- 2002-01-28 EP EP02718052A patent/EP1355668B1/de not_active Expired - Lifetime
- 2002-01-29 AR ARP020100315A patent/AR032422A1/es unknown
2003
- 2003-07-16 NO NO20033228A patent/NO331083B1/no not_active IP Right Cessation
- 2003-07-20 IL IL157024A patent/IL157024A/en active IP Right Grant
- 2003-07-28 HR HR20030609A patent/HRP20030609A2/xx not_active Application Discontinuation
- 2003-08-25 BG BG108128A patent/BG66483B1/bg unknown
2004
- 2004-08-02 HK HK04105655A patent/HK1062810A1/xx not_active IP Right Cessation
2008
- 2008-02-18 CY CY20081100195T patent/CY1107203T1/el unknown
- 2008-12-16 JP JP2008319532A patent/JP2009102354A/ja active Pending

Also Published As

Publication number	Publication date
JP4860897B2 (ja)	2012-01-25
EA006767B1 (ru)	2006-04-28
HU229164B1 (en)	2013-09-30
US20040234523A1 (en)	2004-11-25
PT1355668E (pt)	2008-01-04
HUP0303306A2 (hu)	2004-01-28
CZ305653B6 (cs)	2016-01-27
EE200300328A (et)	2003-10-15
CN1326562C (zh)	2007-07-18
CA2435466A1 (en)	2002-08-08
HUP0303306A3 (en)	2005-12-28
BR0206819A (pt)	2004-02-03
KR20030070143A (ko)	2003-08-27
ZA200305439B (en)	2004-07-15
SK10892003A3 (sk)	2004-02-03
AR032422A1 (es)	2003-11-05
HRP20030609A2 (en)	2005-06-30
CZ20032335A3 (en)	2004-07-14
MXPA03006776A (es)	2003-10-24
BG66483B1 (bg)	2015-03-31
EE05534B1 (et)	2012-04-16
ME00549B (me)	2011-10-10
EA200300844A1 (ru)	2003-12-25
EA200501549A1 (ru)	2006-04-28
EA010180B1 (ru)	2008-06-30
RS51125B (sr)	2010-10-31
HK1062810A1 (en)	2004-11-26
KR100857376B1 (ko)	2008-09-05
JP2004522748A (ja)	2004-07-29
BG108128A (bg)	2004-11-30
NO20033228D0 (no)	2003-07-16
ES2295332T3 (es)	2008-04-16
EP1355668B1 (de)	2007-12-12
SI1355668T1 (sl)	2008-06-30
CY1107203T1 (el)	2012-11-21
ATE380558T1 (de)	2007-12-15
CN1499982A (zh)	2004-05-26
DK1355668T3 (da)	2008-05-05
WO2002060479A1 (en)	2002-08-08
DE60224004T2 (de)	2009-07-23
SK287620B6 (sk)	2011-04-05
IL157024A0 (en)	2004-02-08
EP1355668A1 (de)	2003-10-29
NO20033228L (no)	2003-09-26
CA2435466C (en)	2012-04-03
YU57803A (sh)	2006-05-25
NO331083B1 (no)	2011-10-03
UA80676C2 (en)	2007-10-25
PL213568B1 (pl)	2013-03-29
JP2009102354A (ja)	2009-05-14
IL157024A (en)	2014-02-27
PL366802A1 (en)	2005-02-07

Publication	Publication Date	Title
DE60324777D1 (de)	2009-01-02	Verwendung von il-18-inhibitoren zur behandlung und/oder prävention von peripheren gefässkrankheiten
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EP1534074A4 (de)	2008-01-09	Kombinationstherapie zur behandlung von fettleibigkeit
DE60327622D1 (de)	2009-06-25	Kombinierte antitachykardie - schrittmacher und hochspannungstherapie zur behandlung von ventrikulären arrhythmien
DE60114580D1 (de)	2005-12-08	Verwendung von cyanochinolinen zur behandlung oder inhibierung von dickdarmpolypen
DE60023128D1 (de)	2006-02-23	Pyrazolecarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen
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DE60335293D1 (de)	2011-01-20	Pyrrolopyridazin-verbindungen und verwendungsverfahren dafür zur behandlung von proliferativen erkrankungen
DE60221627D1 (de)	2007-09-20	Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren
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DE60214542D1 (de)	2006-10-19	Verwendung von cox2 inhibitoren zur behandlung von schizophrenia und des ticks
DE60134009D1 (de)	2008-06-26	Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose
EP1191941A4 (de)	2006-12-13	Methode der prophylaxe und/oder behandlung von erkrankungen
ATE296628T1 (de)	2005-06-15	Integrinhemmer zur behandlung von augenkrankheiten
DE60224004D1 (de)	2008-01-24	Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten
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DE60314003D1 (de)	2007-07-05	4-(phenylpiperazinylmethyl)benzamidderivate und deren verwendung zur behandlung von schmerzen oder gastrointestinalen erkrankungen
EP1494696A4 (de)	2006-01-25	Behandlung von lungenerkrankungen
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DE50313329D1 (de)	2011-01-27	1-phenyl-2-dimethylaminomethylcyclohexanverbindungen zur therapie von depressiven symptomatiken, schmerz und inkontinenz
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Legal Events

Date	Code	Title	Description
2009-01-02	8364	No opposition during term of opposition