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DE60117157D1 - N-acylsulfonamid-apoptosis-förderer - Google Patents

N-acylsulfonamid-apoptosis-förderer

Info

Publication number
DE60117157D1
DE60117157D1 DE60117157T DE60117157T DE60117157D1 DE 60117157 D1 DE60117157 D1 DE 60117157D1 DE 60117157 T DE60117157 T DE 60117157T DE 60117157 T DE60117157 T DE 60117157T DE 60117157 D1 DE60117157 D1 DE 60117157D1
Authority
DE
Germany
Prior art keywords
apoptosis promoters
acylsulfonamide
acylsulfonamide apoptosis
promoters
apoptosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60117157T
Other languages
English (en)
Other versions
DE60117157T2 (de
Inventor
William Mcclellan
Thorsten Oost
Milan Bruncko
Xilu Wang
J Augeri
A Baumeister
A Dickman
Hong Ding
Jurgen Dinges
W Fesik
J Hajduk
R Kunzer
G Nettesheim
M Petros
H Rosenberg
Wang Shen
A Thomas
D Wendt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/935,581 external-priority patent/US20020055631A1/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE60117157D1 publication Critical patent/DE60117157D1/de
Application granted granted Critical
Publication of DE60117157T2 publication Critical patent/DE60117157T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C323/30—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/37—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to a carbon atom of a six-membered aromatic ring
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AU2001291151A1 (en) 2002-04-02
WO2002024636A2 (en) 2002-03-28
EP1318978A2 (de) 2003-06-18
DE60117157T2 (de) 2006-09-21
CA2423103A1 (en) 2002-03-28
WO2002024636A3 (en) 2002-09-26
BRPI0110101B1 (pt) 2016-08-23
CA2423103C (en) 2010-08-24
ATE317382T1 (de) 2006-02-15
JP5086513B2 (ja) 2012-11-28
JP2004529852A (ja) 2004-09-30
PT1318978E (pt) 2006-06-30
HK1058031A1 (en) 2004-04-30
BR0110101A (pt) 2005-06-07
ES2258102T3 (es) 2006-08-16
MXPA03002477A (es) 2004-09-10
UY26942A1 (es) 2002-04-26
CY1105016T1 (el) 2009-11-04

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