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DE60037370D1 - Sinusförmiges Zellkulturmodul zur Kultivierung von Hepatozyten - Google Patents

Sinusförmiges Zellkulturmodul zur Kultivierung von Hepatozyten

Info

Publication number
DE60037370D1
DE60037370D1 DE60037370T DE60037370T DE60037370D1 DE 60037370 D1 DE60037370 D1 DE 60037370D1 DE 60037370 T DE60037370 T DE 60037370T DE 60037370 T DE60037370 T DE 60037370T DE 60037370 D1 DE60037370 D1 DE 60037370D1
Authority
DE
Germany
Prior art keywords
hepatocytes
cultivation
cell culture
culture module
sinusoidal cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60037370T
Other languages
English (en)
Other versions
DE60037370T2 (de
Inventor
Kazumori Funatsu
Hiroyuki Ijima
Kouji Nakazawa
Hiroshi Mizumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyobo Co Ltd
Original Assignee
Toyobo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyobo Co Ltd filed Critical Toyobo Co Ltd
Publication of DE60037370D1 publication Critical patent/DE60037370D1/de
Application granted granted Critical
Publication of DE60037370T2 publication Critical patent/DE60037370T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/033—Specific distribution of fibres within one potting or tube-sheet
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/14—Specific spacers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
DE60037370T 1999-08-25 2000-08-24 Sinusförmiges Zellkulturmodul zur Kultivierung von Hepatozyten Expired - Lifetime DE60037370T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP23881899 1999-08-25
JP23881899 1999-08-25
JP2000188275 2000-06-22
JP2000188275A JP3553858B2 (ja) 1999-08-25 2000-06-22 血管網類似構造体を有する細胞培養用モジュール

Publications (2)

Publication Number Publication Date
DE60037370D1 true DE60037370D1 (de) 2008-01-24
DE60037370T2 DE60037370T2 (de) 2008-11-27

Family

ID=26533908

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60037370T Expired - Lifetime DE60037370T2 (de) 1999-08-25 2000-08-24 Sinusförmiges Zellkulturmodul zur Kultivierung von Hepatozyten

Country Status (4)

Country Link
US (1) US6284451B1 (de)
EP (1) EP1078982B1 (de)
JP (1) JP3553858B2 (de)
DE (1) DE60037370T2 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002315566A (ja) * 2001-04-24 2002-10-29 Takagi Ind Co Ltd 細胞・組織培養装置
USH2168H1 (en) * 2001-06-13 2006-09-05 The United States Of America As Represented By The Secretary Of The Navy Arrangement and construction of an element bundling module
US20040058309A1 (en) * 2001-10-12 2004-03-25 Junji Washizu Plasma supplement and use in liver assist systems
FR2834466A1 (fr) * 2002-01-10 2003-07-11 Centre Nat Rech Scient Nouveaux moyens pour l'hebergement de cellules et leurs applications
EP1490520A4 (de) * 2002-03-12 2006-06-07 Surface Logix Inc Testvorrichtung, die die absorption, den stoffwechsel, die permeabiltät und/oder toxizität einer kandidatenverbindung analysiert
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
DE60323561D1 (de) * 2002-05-28 2008-10-30 Toyo Boseki Verfahren zur Kultur, zum Speichern und zur Induzierung von Differenzierung von Zellen und Gerät zur Verwendung in diesem Verfahren, und dazugehöriges Gebrauchsverfahren.
US20040029266A1 (en) * 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
WO2004020614A1 (ja) * 2002-08-28 2004-03-11 Asahi Medical Co., Ltd. 異形断面中空糸膜型細胞含有デバイス
AU2002354097A1 (en) * 2002-12-05 2004-06-23 Amcite Research, Ltd. Tissue culture apparatus
JP2005034069A (ja) * 2003-07-16 2005-02-10 Fuji Photo Film Co Ltd バイオリアクター及びそれを用いた細胞培養方法
JP5038149B2 (ja) * 2004-12-27 2012-10-03 フレゼニウス メディカル ケアー ドイチュラント ゲゼルシャフト ミット ベシュレンクテル ハフツング リアクタユニット及びそのリアクタユニットを備えたリアクタ
US7514256B2 (en) * 2005-02-11 2009-04-07 Emilio Barbera-Guillem Bioreactor for selectively controlling the molecular diffusion between fluids
GB0512214D0 (en) 2005-06-15 2005-07-27 Capsant Neurotechnologies Ltd Method
GB0512216D0 (en) 2005-06-15 2005-07-27 Capsant Neurotechnologies Ltd Device
CN101096639B (zh) * 2007-05-16 2011-08-10 宁波 多组纤维管均匀分布的多功能中空纤维膜管生物反应器
AT506826B1 (de) * 2008-05-23 2010-03-15 Greiner Bio One Gmbh Bioreaktor und verfahren zum kultivieren von zellen und geweben
WO2010042478A2 (en) * 2008-10-07 2010-04-15 Arizona Board Of Regents For And On Behalf Of Arizona State University Modular experimental platform for microorganism physiology and scale-up studies
US8563307B2 (en) 2009-02-24 2013-10-22 James Wang Treatment of immunosuppression-related disorders
CN101549179B (zh) * 2009-04-30 2011-09-14 浙江大学 人工肝用多孔砖式填充支架型反应器
ES2435618T3 (es) * 2009-06-25 2013-12-20 Optonol Ltd. Matriz de fibra para mantener un espacio en tejidos blandos
JP2011103882A (ja) * 2009-11-16 2011-06-02 Shuhei Nakaji 細胞培養装置、細胞培養方法および細胞培養用プログラム
CN101711898B (zh) * 2009-12-14 2012-05-23 浙江大学 人工肝用微囊悬浮型搅拌池式生物反应器
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
TWI614340B (zh) * 2011-09-28 2018-02-11 幹細胞生物科技股份有限公司 體幹細胞及其製備方法
US9500642B2 (en) 2012-04-18 2016-11-22 Hemoshear, Llc In vitro model for pathological or physiologic conditions
US9664671B2 (en) 2012-07-24 2017-05-30 Nissan Chemical Industries, Ltd. Culture medium composition and method of culturing cell or tissue using thereof
JP5629893B2 (ja) 2012-07-24 2014-11-26 日産化学工業株式会社 培地組成物及び当該組成物を用いた細胞又は組織の培養方法
US10017805B2 (en) 2012-08-23 2018-07-10 Nissan Chemical Industries, Ltd. Enhancing ingredients for protein production from various cells
TWI687519B (zh) 2012-12-06 2020-03-11 美商幹細胞生物科技股份有限公司 Ｌｇｒ５＋體幹細胞
EP2746769A1 (de) 2012-12-21 2014-06-25 Stembios Technologies, Inc. Verfahren zur Beurteilung der Wirkung einer Aktion basierend auf Stammzelldynamik auf eine Person
PL3009506T3 (pl) 2013-06-10 2020-06-29 Corning Incorporated Struktura tkankowa i sposób jej wytwarzania
KR102539240B1 (ko) 2014-01-23 2023-06-01 닛산 가가쿠 가부시키가이샤 배양 배지 조성물
CN106414707A (zh) 2014-01-23 2017-02-15 日产化学工业株式会社 培养基组合物的制造方法
WO2015182159A1 (ja) 2014-05-30 2015-12-03 株式会社クラレ 培養方法及び細胞塊
US20160136203A1 (en) * 2014-11-19 2016-05-19 StemBios Technologies, Inc. Somatic stem cells for treating bone defects
JP6205507B1 (ja) * 2016-05-19 2017-09-27 光次 斉藤 培養装置および培養方法、並びにこの培養方法により製造された培養臓器
CN106139285B (zh) * 2016-07-29 2018-07-06 武汉仝干医疗科技股份有限公司 四合一毛绒线式生物人工肝在线监测与恒温加热一体系统
CN106139289B (zh) * 2016-07-29 2018-06-19 武汉仝干医疗科技股份有限公司 半透膜分层一体式生物反应器
US11746316B2 (en) 2016-08-10 2023-09-05 Cyberdyne Inc. Three-dimensional structuring method and three-dimensional structuring system of cells
JP6952297B2 (ja) * 2016-09-27 2021-10-20 ユニチカ株式会社 細胞培養用中空糸膜及び細胞培養方法
CN207760352U (zh) * 2017-12-18 2018-08-24 上海白泽医疗器械有限公司 细胞培养模块、培养液模块、细胞培养芯片及细胞培养机箱
CN110205245B (zh) * 2019-06-14 2022-07-08 科先医疗科技(苏州)有限公司 一种用于生物型人工肝支持系统的细胞反应器
JPWO2023120710A1 (de) * 2021-12-23 2023-06-29

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367139A (en) * 1978-11-16 1983-01-04 Monsanto Company Hollow fiber permeator
IL69664A0 (en) * 1982-09-15 1983-12-30 Collaborative Res Inc Medium supplement and method for growing cells in vitro
SE8505921D0 (sv) 1985-12-13 1985-12-13 Kabigen Ab A method to export gene products to the growth medium of gram negative bacteria
US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
CA2092474A1 (en) 1992-05-12 1993-11-13 Edwin R. Evans Flame retardant system for polyorganosiloxane compositions
JPH0669364A (ja) 1992-08-21 1994-03-11 Kyocera Corp 半導体素子収納用パッケージ
DE4230194C2 (de) * 1992-09-09 1995-07-27 Joerg Dr Med Gerlach Reaktor zur Züchtung und zur Nutzung von Stoffwechselleistungen und/oder zum Erhalt von Mikroorganismen
US5525144A (en) * 1995-04-20 1996-06-11 A/G Technology Corporation Tangential flow filtering and separating
JP3452161B2 (ja) 1995-08-24 2003-09-29 株式会社ジェイ・エム・エス 中空糸型人工肝臓
ATE274052T1 (de) * 1995-10-06 2004-09-15 Az Univ Amsterdam Fester träger für die zellkultur insbesondere für leberzellenkultur, biologischer reaktor und diese träger enthaltendes biologischer reaktor und ihre verwendung in einem künstliche leber vorrichtung
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
JP3887435B2 (ja) 1996-07-12 2007-02-28 第一製薬株式会社 スフェロイド形成促進剤
JPH1033671A (ja) * 1996-07-24 1998-02-10 Jms Co Ltd 中空糸型人工肝臓とその灌流及び培養システム
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug

Also Published As

Publication number Publication date
EP1078982B1 (de) 2007-12-12
US6284451B1 (en) 2001-09-04
JP3553858B2 (ja) 2004-08-11
EP1078982A2 (de) 2001-02-28
EP1078982A3 (de) 2004-03-31
DE60037370T2 (de) 2008-11-27
JP2001128660A (ja) 2001-05-15

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