DE60020260D1 - Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent - Google Patents

Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent

Info

Publication number: DE60020260D1
Authority: DE; Germany
Prior art keywords: alkyl; alkynyl; alkenyl; alpha; hydrocarbyl substituent
Prior art date: 1999-09-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60020260T

Other languages

English (en)

Other versions

DE60020260T2 (de

Inventor

Jan Loozen

Herman Veeneman

Gerardus Schoonen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Organon NV

Original Assignee

Akzo Nobel NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-06

Filing date

2000-08-28

Publication date

2005-06-23

2000-08-28 Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV

2005-06-23 Publication of DE60020260D1 publication Critical patent/DE60020260D1/de

2006-01-19 Application granted granted Critical

2006-01-19 Publication of DE60020260T2 publication Critical patent/DE60020260T2/de

2020-08-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE60020260T 1999-09-06 2000-08-28 Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent Expired - Lifetime DE60020260T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP99202900		1999-09-06
EP99202900		1999-09-06
PCT/EP2000/008406 WO2001018027A1 (en)	1999-09-06	2000-08-28	Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11

Publications (2)

Publication Number	Publication Date
DE60020260D1 true DE60020260D1 (de)	2005-06-23
DE60020260T2 DE60020260T2 (de)	2006-01-19

Family

ID=8240610

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60020260T Expired - Lifetime DE60020260T2 (de)	1999-09-06	2000-08-28	Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent

Country Status (24)

Country	Link
US (1)	US6677329B1 (de)
EP (1)	EP1224204B1 (de)
JP (1)	JP2003508541A (de)
KR (1)	KR20020092907A (de)
CN (2)	CN100354299C (de)
AT (1)	ATE295851T1 (de)
AU (1)	AU770331B2 (de)
BR (1)	BR0013769A (de)
CA (1)	CA2382489C (de)
CZ (1)	CZ2002831A3 (de)
DE (1)	DE60020260T2 (de)
EC (1)	ECSP013947A (de)
ES (1)	ES2241657T3 (de)
HU (1)	HUP0202595A3 (de)
IL (2)	IL148116A0 (de)
MX (1)	MXPA02001831A (de)
NO (1)	NO20021079L (de)
NZ (1)	NZ517281A (de)
PL (1)	PL353826A1 (de)
RU (1)	RU2245886C2 (de)
SK (1)	SK3282002A3 (de)
TR (1)	TR200200575T2 (de)
WO (1)	WO2001018027A1 (de)
ZA (1)	ZA200201250B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE246703T1 (de) *	1999-04-06	2003-08-15	Akzo Nobel Nv	Oral wirksame 7-alpha-alkyl androgene
CZ2002831A3 (cs) *	1999-09-06	2002-05-15	Akzo Nobel N. V.	Nearomatické estrogenní steroidy
US8173628B2 (en) *	2000-06-22	2012-05-08	Northeastern University	Steroidal antiestrogens and antiandrogens and uses thereof
US7041839B2 (en) *	2000-06-22	2006-05-09	Northeastern University	Steroidal antiestrogens and antiandrogens and uses thereof
HRP20030060A2 (en) *	2000-07-28	2004-06-30	Akzo Nobel Nv	16alpha-methyl or ethyl substituted estrogens
UA89964C2 (ru)	2004-09-08	2010-03-25	Н.В. Органон	15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
JP7264569B2 (ja) *	2016-03-03	2023-04-25	クリスタルファルマ、エセ、ア、ウ	１１－メチレンステロイドの製造のための方法および新規な中間体
CN114249789B (zh) *	2020-09-23	2023-06-02	湖南普尔生物医药有限公司	一种7α-甲基-3,3-二甲氧基-5(10)-雄烯-17-酮的制备方法
CN114409717B (zh) *	2021-12-17	2023-03-17	湖南科益新生物医药有限公司	替勃龙中间体醚化物和替勃龙的制备方法
CN114230627B (zh) *	2021-12-31	2023-09-15	湖南新合新生物医药有限公司	一种倍他米松环氧水解物中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3092645A (en) *	1961-12-28	1963-06-04	Searle & Co	Esters of 17alpha-alkynylester-5(10)-ene-3beta, 17beta-diols
GB1110792A (en) *	1964-04-07	1968-04-24	Res Inst Medicine Chem	Novel 5(10)-dehydro-steroids
US3465010A (en) *	1966-11-22	1969-09-02	Searle & Co	17 - (unsaturated hydrocarbon - substituted) 11,13beta - dialkylgon -4 - ene - 3,17beta-diols and esters thereof
US3377366A (en) *	1966-12-02	1968-04-09	Searle & Co	17alpha-alkynyl/alkenyl-11, 13beta-dialkylgon-5(10)-en-3-ones and esters thereof
US3652606A (en) *	1970-08-07	1972-03-28	Searle & Co	3-oxygenated 11beta-methylestr-4-en-17beta-ol and esters thereof
AU572589B2 (en) *	1983-12-14	1988-05-12	Upjohn Company, The	11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
ZA94715B (en) *	1993-02-08	1994-10-24	Akzo Nv	Steroids for treating menopausal complaints
ZA941464B (en)	1993-03-05	1994-09-27	Akzo Nv	Use of pregnane derivative
ID25621A (id)	1998-03-09	2000-10-19	Akzo Nobel Nv	Perlengkapan kontrasepsi baru
CZ2002831A3 (cs) *	1999-09-06	2002-05-15	Akzo Nobel N. V.	Nearomatické estrogenní steroidy

2000
- 2000-08-28 CZ CZ2002831A patent/CZ2002831A3/cs unknown
- 2000-08-28 AU AU75117/00A patent/AU770331B2/en not_active Ceased
- 2000-08-28 CN CNB2004100946128A patent/CN100354299C/zh not_active Expired - Fee Related
- 2000-08-28 US US10/070,262 patent/US6677329B1/en not_active Expired - Fee Related
- 2000-08-28 HU HU0202595A patent/HUP0202595A3/hu unknown
- 2000-08-28 ES ES00964053T patent/ES2241657T3/es not_active Expired - Lifetime
- 2000-08-28 EP EP00964053A patent/EP1224204B1/de not_active Expired - Lifetime
- 2000-08-28 DE DE60020260T patent/DE60020260T2/de not_active Expired - Lifetime
- 2000-08-28 CA CA002382489A patent/CA2382489C/en not_active Expired - Fee Related
- 2000-08-28 TR TR2002/00575T patent/TR200200575T2/xx unknown
- 2000-08-28 NZ NZ517281A patent/NZ517281A/en unknown
- 2000-08-28 AT AT00964053T patent/ATE295851T1/de not_active IP Right Cessation
- 2000-08-28 SK SK328-2002A patent/SK3282002A3/sk unknown
- 2000-08-28 CN CNB008125155A patent/CN1185249C/zh not_active Expired - Fee Related
- 2000-08-28 IL IL14811600A patent/IL148116A0/xx active IP Right Grant
- 2000-08-28 PL PL00353826A patent/PL353826A1/xx not_active Application Discontinuation
- 2000-08-28 KR KR1020027002929A patent/KR20020092907A/ko not_active Withdrawn
- 2000-08-28 WO PCT/EP2000/008406 patent/WO2001018027A1/en active Search and Examination
- 2000-08-28 RU RU2002108723/04A patent/RU2245886C2/ru not_active IP Right Cessation
- 2000-08-28 BR BR0013769-3A patent/BR0013769A/pt not_active IP Right Cessation
- 2000-08-28 JP JP2001522250A patent/JP2003508541A/ja not_active Withdrawn
- 2000-08-28 MX MXPA02001831A patent/MXPA02001831A/es active IP Right Grant
2001
- 2001-02-22 EC EC2001003947A patent/ECSP013947A/es unknown
2002
- 2002-02-12 IL IL148116A patent/IL148116A/en not_active IP Right Cessation
- 2002-02-13 ZA ZA200201250A patent/ZA200201250B/xx unknown
- 2002-03-05 NO NO20021079A patent/NO20021079L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1372565A (zh)	2002-10-02
HUP0202595A3 (en)	2004-06-28
NO20021079L (no)	2002-04-29
ES2241657T3 (es)	2005-11-01
KR20020092907A (ko)	2002-12-12
RU2245886C2 (ru)	2005-02-10
ATE295851T1 (de)	2005-06-15
AU7511700A (en)	2001-04-10
CN100354299C (zh)	2007-12-12
US6677329B1 (en)	2004-01-13
IL148116A0 (en)	2002-09-12
HUP0202595A2 (hu)	2002-12-28
CA2382489A1 (en)	2001-03-15
NO20021079D0 (no)	2002-03-05
MXPA02001831A (es)	2002-10-23
IL148116A (en)	2006-10-31
WO2001018027A1 (en)	2001-03-15
ZA200201250B (en)	2003-07-30
CA2382489C (en)	2008-03-11
TR200200575T2 (tr)	2002-06-21
JP2003508541A (ja)	2003-03-04
DE60020260T2 (de)	2006-01-19
AU770331B2 (en)	2004-02-19
SK3282002A3 (en)	2002-06-04
CZ2002831A3 (cs)	2002-05-15
CN1185249C (zh)	2005-01-19
EP1224204B1 (de)	2005-05-18
EP1224204A1 (de)	2002-07-24
BR0013769A (pt)	2002-04-30
PL353826A1 (en)	2003-12-01
CN1637016A (zh)	2005-07-13
ECSP013947A (es)	2002-09-27
NZ517281A (en)	2003-09-26

Publication	Publication Date	Title
ATE295851T1 (de)	2005-06-15	Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent
DE69634039D1 (de)	2005-01-20	Neuroaktive steroide der androstan- und pregnanreihe
ES2121570T3 (es)	1998-12-01	Derivados de androgenos para uso en la inhibicion de la actividad de los esteroides sexuales.
ES550822A0 (es)	1988-01-16	Procedimiento para preparar esteroides sustituidos en posi- cion 10
ATE410171T1 (de)	2008-10-15	Graduierte östrogen-kontrazeptiva
RS20070075A (en)	2008-09-29	15beta-substituted steroids having selective estrogenic activity
FI961792L (fi)	1996-04-26	Steroidi-C17-20-lyaasiestäjinä käyttökelpoiset delta16-tyydyttymättömät heterosykliset C17-steroidit
NO20013632D0 (no)	2001-07-24	Steroide sulfataseinhibitorer og fremgangsmåter for å fremstille og anvende disse
AU1967300A (en)	2000-06-13	Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11
RU2002108723A (ru)	2003-11-20	Неароматические эстрогенные стероиды с углеводородным заместителем в положении 11
DK165987C (da)	1993-07-26	14-azido-steroider, der er anvendelige som mellemprodukter
ATE154606T1 (de)	1997-07-15	2beta,19-methylenamin überbrückte steroide als aromatasehemmer
GR3023294T3 (en)	1997-07-30	New 16-methyl substituted steroid derivatives of pregna-1,4-dien-3,20-dione, their preparation, their use in the preparation of 16-methylene substituted steroids and new intermediates therefor
NO20020260D0 (no)	2002-01-17	11<beta>-aryl-17,17-spirotiolansubstituerte steroider
DK352086D0 (da)	1986-07-24	Steroide aromatase-inhibitorer
GB1051580A (de)
CO5261633A1 (es)	2003-03-31	Compuestos estrogenicos
CO5251432A1 (es)	2003-02-28	Derivados de 3-metileno esteroides
MXPA03005224A (es)	2004-03-26	Esteroides de metileno como androgenos novedosos.
JPS5777698A (en)	1982-05-15	18-substituted pregn-4-ene-3,20-dione
RU2000116237A (ru)	2002-05-10	Ингибиторы стероидсульфатазы

Legal Events

Date	Code	Title	Description
2006-06-14	8364	No opposition during term of opposition
2007-06-14	8327	Change in the person/name/address of the patent owner	Owner name: N.V. ORGANON, OSS, NL