DE60019628D1 - Bicyclische aminosäuren als pharmazeutische mittel - Google Patents

Bicyclische aminosäuren als pharmazeutische mittel

Info

Publication number: DE60019628D1
Authority: DE; Germany
Prior art keywords: amino acids; pharmaceutical agents; bicyclic amino; bicyclic; pharmaceutical
Prior art date: 1999-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60019628T

Other languages

English (en)

Other versions

DE60019628T2 (de

Inventor

Justin Stephen Bryans

Clive Blakemore

Simon Osborne

Jean-Marie Receveur

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-20

Filing date

2000-10-17

Publication date

2005-05-25

2000-10-17 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2005-05-25 Publication of DE60019628D1 publication Critical patent/DE60019628D1/de

2006-01-19 Application granted granted Critical

2006-01-19 Publication of DE60019628T2 publication Critical patent/DE60019628T2/de

2020-10-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/22—All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)

DE60019628T 1999-10-20 2000-10-17 Bicyclische aminosäuren als pharmazeutische mittel Expired - Lifetime DE60019628T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US16072599P	1999-10-20	1999-10-20
US160725P		1999-10-20
PCT/US2000/028687 WO2001028978A1 (en)	1999-10-20	2000-10-17	Bicyclic amino acids as pharmaceutical agents

Publications (2)

Publication Number	Publication Date
DE60019628D1 true DE60019628D1 (de)	2005-05-25
DE60019628T2 DE60019628T2 (de)	2006-01-19

Family

ID=22578159

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60034157T Expired - Lifetime DE60034157T2 (de)	1999-10-20	2000-10-17	Bicyclische Aminosäuren als pharmazeutische Mittel
DE60019628T Expired - Lifetime DE60019628T2 (de)	1999-10-20	2000-10-17	Bicyclische aminosäuren als pharmazeutische mittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60034157T Expired - Lifetime DE60034157T2 (de)	1999-10-20	2000-10-17	Bicyclische Aminosäuren als pharmazeutische Mittel

Country Status (50)

Country	Link
US (2)	US6689906B1 (de)
EP (2)	EP1226110B1 (de)
JP (2)	JP3632191B2 (de)
KR (2)	KR100566462B1 (de)
CN (1)	CN1165518C (de)
AP (2)	AP2002002517A0 (de)
AR (2)	AR026087A1 (de)
AT (2)	ATE293590T1 (de)
AU (2)	AU778871B2 (de)
BG (2)	BG106719A (de)
BR (1)	BR0014972B1 (de)
CA (1)	CA2386297C (de)
CO (1)	CO5280060A1 (de)
CR (1)	CR6620A (de)
CU (1)	CU23112A3 (de)
CZ (1)	CZ295960B6 (de)
DE (2)	DE60034157T2 (de)
DO (1)	DOP2000000083A (de)
DZ (1)	DZ3197A1 (de)
EA (1)	EA005206B1 (de)
EC (1)	ECSP045393A (de)
EE (1)	EE200200211A (de)
ES (2)	ES2237464T3 (de)
GE (1)	GEP20043297B (de)
GT (2)	GT200000183A (de)
HK (1)	HK1049826B (de)
HN (1)	HN2000000224A (de)
HR (2)	HRP20020428B1 (de)
HU (1)	HUP0203325A3 (de)
IL (3)	IL164060A0 (de)
IS (2)	IS6348A (de)
MA (1)	MA26842A1 (de)
MX (1)	MXPA02003229A (de)
MY (1)	MY127678A (de)
NO (2)	NO20021780L (de)
NZ (1)	NZ517961A (de)
OA (1)	OA12070A (de)
PA (1)	PA8505201A1 (de)
PE (1)	PE20010740A1 (de)
PL (1)	PL354607A1 (de)
PT (1)	PT1226110E (de)
SI (1)	SI1226110T1 (de)
SK (1)	SK5232002A3 (de)
SV (1)	SV2001000188A (de)
TR (2)	TR200201094T2 (de)
TW (2)	TW200505824A (de)
UA (1)	UA72931C2 (de)
WO (1)	WO2001028978A1 (de)
YU (2)	YU73004A (de)
ZA (1)	ZA200202543B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7164034B2 (en)	1999-06-10	2007-01-16	Pfizer Inc.	Alpha2delta ligands for fibromyalgia and other disorders
SK17922002A3 (sk) *	2000-06-26	2003-11-04	Warner-Lambert Company	Obdoby gabapentínu na liečenie porúch spánku
US6620829B2 (en)	2000-10-17	2003-09-16	Warner-Lambert Company	Method of treating noninflammatory cartilage damage
EP1226820A1 (de) *	2001-01-26	2002-07-31	Warner-Lambert Company	Verwendung von bicyclische Aminosäuren zur Prophylaxe und Behandlung von Eingeweideschmerzen und gastrointestinalen Erkrankungen
SK12822003A3 (sk) *	2001-04-19	2004-04-06	Warner - Lambert Company Llc	Fúzne bicyklické alebo tricyklické aminokyseliny
GB2375109A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Process for preparing bicyclic amino acid
GB2375108A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Production of a bicycloheptanone
US7186855B2 (en)	2001-06-11	2007-03-06	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
AU2002345664C1 (en) *	2001-06-11	2008-03-06	Xenoport, Inc.	Prodrugs of gaba analogs, compositions and uses thereof
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en)	2001-06-11	2007-06-19	Xenoport, Inc.	Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en)	2001-06-11	2004-11-16	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
EP1469841A1 (de)	2002-01-31	2004-10-27	Warner-Lambert Company	Alpha 2 delta ligands zur behandlung von ohrensausen
CN1635887A (zh) *	2002-02-22	2005-07-06	沃纳-兰伯特公司	α－2－δ配体与选择性环加氧酶－2抑制剂的组合
CA2488566A1 (en) *	2002-06-27	2004-01-08	Warner-Lambert Company Llc	Use of an alpha2delta ligand such as gabapentin or pregabalin for treating attention deficit hyperactivity disorder
GB0219024D0 (en) *	2002-08-15	2002-09-25	Pfizer Ltd	Synergistic combinations
CA2494811A1 (en) *	2002-08-15	2004-02-26	Pfizer Inc.	Therapeutic use of fused bicyclic or tricyclic amino acids
US7419981B2 (en)	2002-08-15	2008-09-02	Pfizer Inc.	Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
GB0223072D0 (en)	2002-10-04	2002-11-13	Pfizer Ltd	Cyclic nitromethyl acetic acid derivatives
US7018818B2 (en)	2002-10-04	2006-03-28	Pfizer Inc.	Intermediates in the preparation of therapeutic fused bicyclic amino acids
AU2003297927A1 (en)	2002-12-11	2004-06-30	Xenoport, Inc.	Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
CA2451267A1 (en)	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
JP2006513257A (ja)	2002-12-13	2006-04-20	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	線維筋痛症および他の障害を処置するためのプレガバリン誘導体
DK1572173T3 (da)	2002-12-13	2010-06-14	Warner Lambert Co	Alpha-2-delta-ligand til behandling af symptomer i den nedre urinvej
AU2004271800A1 (en)	2003-09-12	2005-03-24	Pfizer Inc.	Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
AR061728A1 (es) *	2006-06-30	2008-09-17	Pfizer Prod Inc	Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
ES2367881T3 (es)	2006-12-22	2011-11-10	Recordati Ireland Limited	Politerapia para trastornos de las vías urinarias inferiores con ligandos a2d y los aine.
EP2192109B1 (de)	2007-09-28	2013-09-04	Daiichi Sankyo Company, Limited	Bicyclisches aminosäurederivat
HUE031770T2 (en) *	2009-03-26	2017-08-28	Daiichi Sankyo Co Ltd	A method for producing a bicyclic gamma-amino acid derivative
CA2838650C (en)	2011-06-08	2016-07-12	Daiichi Sankyo Company, Limited	Method for producing bicyclic compound via iminium salt
EP2719677B1 (de)	2011-06-08	2017-09-06	Daiichi Sankyo Company, Limited	Verfahren zur herstellung einer bicyclischen verbindung durch claisen-umlagerung
KR101944575B1 (ko)	2011-12-15	2019-04-17	다이이찌 산쿄 가부시키가이샤	부제 촉매를 사용하는 2고리형 화합물의 광학 분할 방법
ES2624314T3 (es)	2012-04-10	2017-07-13	Daiichi Sankyo Company, Limited	Procedimiento de resolución óptica para compuestos bicíclicos usando enzima
US9066853B2 (en)	2013-01-15	2015-06-30	Warsaw Orthopedic, Inc.	Clonidine compounds in a biodegradable fiber
TWI635071B (zh)	2013-07-08	2018-09-11	第一三共股份有限公司	光學活性二環γ－胺基酸衍生物及其製造方法
WO2018166855A1 (en)	2017-03-16	2018-09-20	Basf Se	Heterobicyclic substituted dihydroisoxazoles
CN113045410A (zh) *	2021-03-29	2021-06-29	华东理工大学	一种双环降二萜类化合物及其合成基因及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3641129A (en) *	1969-06-17	1972-02-08	Merck & Co Inc	Antifibrinolytic compounds
US4087544A (en) *	1974-12-21	1978-05-02	Warner-Lambert Company	Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) *	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
CA2303244C (en)	1997-10-27	2005-12-06	Warner-Lambert Company	Cyclic amino acids and derivatives thereof useful as pharmaceutical agents

2000
- 2000-10-05 HN HN2000000224A patent/HN2000000224A/es unknown
- 2000-10-06 SV SV2000000188A patent/SV2001000188A/es not_active Application Discontinuation
- 2000-10-17 CA CA2386297A patent/CA2386297C/en not_active Expired - Fee Related
- 2000-10-17 IL IL16406000A patent/IL164060A0/xx unknown
- 2000-10-17 AU AU10920/01A patent/AU778871B2/en not_active Ceased
- 2000-10-17 BR BRPI0014972-1A patent/BR0014972B1/pt not_active IP Right Cessation
- 2000-10-17 TR TR2002/01094T patent/TR200201094T2/xx unknown
- 2000-10-17 MX MXPA02003229A patent/MXPA02003229A/es active IP Right Grant
- 2000-10-17 CZ CZ20021310A patent/CZ295960B6/cs not_active IP Right Cessation
- 2000-10-17 GE GE4783A patent/GEP20043297B/en unknown
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2002
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Also Published As

Publication number	Publication date
NZ517961A (en)	2002-12-20
TR200201094T2 (tr)	2002-09-23
EP1226110A1 (de)	2002-07-31
KR100593349B1 (ko)	2006-06-26
YU73004A (sh)	2005-11-28
CN1382118A (zh)	2002-11-27
US6689906B1 (en)	2004-02-10
SV2001000188A (es)	2001-09-07
AP2004003186A0 (en)	2004-12-31
AU778871B2 (en)	2004-12-23
JP3632191B2 (ja)	2005-03-23
BG108860A (en)	2006-03-31
CA2386297C (en)	2010-02-09
MY127678A (en)	2006-12-29
OA12070A (en)	2003-11-10
CA2386297A1 (en)	2001-04-26
EA200200293A1 (ru)	2002-10-31
AU1092001A (en)	2001-04-30
SK5232002A3 (en)	2003-07-01
HN2000000224A (es)	2001-04-11
IL164060A0 (en)	2005-12-18
JP2003512348A (ja)	2003-04-02
HK1049826A1 (en)	2003-05-30
PE20010740A1 (es)	2001-07-27
YU29302A (sh)	2005-06-10
DE60034157D1 (de)	2007-05-10
HUP0203325A3 (en)	2003-12-29
SI1226110T1 (en)	2005-08-31
HRP20040709A2 (en)	2004-12-31
ZA200202543B (en)	2003-09-23
CO5280060A1 (es)	2003-05-30
BR0014972A (pt)	2002-07-16
PA8505201A1 (es)	2002-08-29
HUP0203325A2 (hu)	2003-02-28
PL354607A1 (en)	2004-01-26
IS7497A (is)	2004-10-08
US20040152779A1 (en)	2004-08-05
ATE293590T1 (de)	2005-05-15
AR026087A1 (es)	2002-12-26
NO20021780D0 (no)	2002-04-16
CZ20021310A3 (cs)	2003-05-14
US6835751B2 (en)	2004-12-28
AP2002002517A0 (en)	2002-06-30
CZ295960B6 (cs)	2005-12-14
CU23112A3 (es)	2006-02-27
TWI225855B (en)	2005-01-01
CN1165518C (zh)	2004-09-08
ECSP045393A (es)	2004-10-23
GT200000183AA (es)	2005-06-17
EE200200211A (et)	2003-06-16
UA72931C2 (uk)	2005-05-16
AR045456A2 (es)	2005-10-26
TR200500221T2 (tr)	2005-03-21
ES2282785T3 (es)	2007-10-16
HK1049826B (zh)	2005-02-25
WO2001028978A1 (en)	2001-04-26
KR20060013701A (ko)	2006-02-13
HRP20020428A2 (en)	2005-02-28
JP2005036009A (ja)	2005-02-10
MXPA02003229A (es)	2002-09-30
ES2237464T3 (es)	2005-08-01
EP1506955A1 (de)	2005-02-16
EP1506955B1 (de)	2007-03-28
DZ3197A1 (fr)	2001-04-26
KR100566462B1 (ko)	2006-03-31
CR6620A (es)	2004-02-02
IS6348A (is)	2002-04-17
JP3744928B2 (ja)	2006-02-15
IL149143A (en)	2007-02-11
EA005206B1 (ru)	2004-12-30
NO20021780L (no)	2002-04-16
BG106719A (bg)	2003-02-28
IL149143A0 (en)	2002-11-10
HRP20020428B1 (en)	2006-02-28
DOP2000000083A (es)	2002-03-30
NO20043663L (no)	2002-04-16
MA26842A1 (fr)	2004-12-20
PT1226110E (pt)	2005-07-29
DE60034157T2 (de)	2007-12-13
GEP20043297B (en)	2004-01-12
GT200000183A (es)	2000-10-19
KR20020040900A (ko)	2002-05-30
DE60019628T2 (de)	2006-01-19
TW200505824A (en)	2005-02-16
AU2005201268A1 (en)	2005-04-21
EP1226110B1 (de)	2005-04-20
BR0014972B1 (pt)	2011-09-06
ATE358116T1 (de)	2007-04-15

Publication	Publication Date	Title
ATE358116T1 (de)	2007-04-15	Bicyclische aminosäuren als pharmazeutische mittel
ATE368041T1 (de)	2007-08-15	Neue pyrrolderivate als pharmazeutische mittel
PT1032555E (pt)	2006-07-31	Aminoacidos ciclicos e derivados uteis como agentes farmaceuticos
ID24654A (id)	2000-07-27	Formulasi farmasi omeprazola
DE69810612D1 (de)	2003-02-13	Pharmazeutische Zusammensetzungen mit Plasmaproteinen
NO20033556D0 (no)	2003-08-11	Farmasöytiske preparater
DE59910858D1 (de)	2004-11-18	Pharmazeutische zubereitung von moxifloxacin
FIU20000164U0 (fi)	2000-04-11	Uusi farmaseuttinen formulaatio
EE200200038A (et)	2003-04-15	Konservitud farmatseutilised preparaadid
NO20020086D0 (no)	2002-01-08	Smaksmaskerte farmasöytiske flytende formuleringer
NO980546D0 (no)	1998-02-09	Farmasöytiske midler
PT1200092E (pt)	2004-07-30	Farmacos de beta-carbolina
PT1210085E (pt)	2006-05-31	Solucoes farmaceuticas de levosimendano
NO20022606L (no)	2002-07-11	Farmasöytiske kombinasjoner
DE69925882D1 (de)	2005-07-28	Aminosäurederivate als Entzündungshemmende Mittel
DE60040903D1 (de)	2009-01-08	Aminosäuren enthaltende albuminpräparationen
DE69926012D1 (de)	2005-08-04	Arzneizubereitungen
AR025867A1 (es)	2002-12-18	Formulacion portasdora farmaceutica
EE200100697A (et)	2003-02-17	Farmatseutiline kompleks
DE69906934D1 (de)	2003-05-22	Arzneizubereitungen
NO20004816D0 (no)	2000-09-26	Ny farmasøytisk formulering
EP1095026A4 (de)	2001-10-31	Pharmazeutische mittel
FI3862U1 (fi)	1999-03-18	Geelimuotoinen farmaseuttinen valmiste

Legal Events

Date	Code	Title	Description
2006-05-24	8364	No opposition during term of opposition
2006-06-01	8381	Inventor (new situation)	Inventor name: BLAKEMORE, CLIVE, DAVID, CAMBRIDGE CB1 8TH, GB Inventor name: RECEVEUR, JEAN-MARIE, CAMBRIDGE CB1 2LG, GB

Date

Code

Title

Description

2006-05-24

8364

No opposition during term of opposition

2006-06-01

8381

Inventor (new situation)

Inventor name: BLAKEMORE, CLIVE, DAVID, CAMBRIDGE CB1 8TH, GB

Inventor name: RECEVEUR, JEAN-MARIE, CAMBRIDGE CB1 2LG, GB