DE226469C - - Google Patents
Info
- Publication number
- DE226469C DE226469C DENDAT226469D DE226469DA DE226469C DE 226469 C DE226469 C DE 226469C DE NDAT226469 D DENDAT226469 D DE NDAT226469D DE 226469D A DE226469D A DE 226469DA DE 226469 C DE226469 C DE 226469C
- Authority
- DE
- Germany
- Prior art keywords
- ether
- drug
- ergot
- alcohol
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- 241000221751 Claviceps purpurea Species 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drugs Drugs 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000006286 aqueous extract Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001476 alcoholic Effects 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000006011 modification reaction Methods 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 description 6
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 241000031711 Cytophagaceae Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003472 neutralizing Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
- M 226469 ' — KLASSE 30 h. GRUPPE- M 226469 '- CLASS 30 h. GROUP
KNOLL & CO. in LUDWIGSHAFEN a. Rh. Verfahren zur Herstellung eines Präparates aus Mutterkorn.KNOLL & CO. in LUDWIGSHAFEN a. Rh. Process for the production of a preparation from ergot.
Zusatz zum Patente 226468 vom 24. Dezember 1907.Addendum to patent 226468 of December 24, 1907.
Patentiert im Deutschen Reiche vom 12. März 1909 ab. Längste Dauer: 23. Dezember 1922.Patented in the German Empire on March 12, 1909. Longest duration: December 23, 1922.
In dem Patent 226468 ist ein Verfahren beschrieben, wonach ein gut haltbares Produkt aus dem Mutterkorn von der vollen Wirksamkeit der Droge erhalten werden kann, wenn der wässerige Auszug des entfetteten Mutterkorns nach dem Neutralisieren und Einengen mit hochprozentigem Alkohol und Äther behandelt wird. Bei dieser Behandlung werden unwirksame Ballaststoffe neben sehr geringen Mengen wirksamer Substanz ausgeschieden, während der Hauptteil der wirksamen Stoffe in die alkoholisch-ätherische Lösung übergeht.In the patent 226468 a process is described, after which a well-preserved product from the ergot of the full effectiveness of the drug can be obtained if the aqueous extract of the defatted Ergot after neutralizing and concentrating with high percentage alcohol and Ether is treated. In this treatment, fiber is ineffective alongside very ineffective small amounts of active substance excreted, while the main part of the active substance Substances pass into the alcoholic-ethereal solution.
Es wurde nun bei weiterer Ausbildung dieses Verfahrens gefunden, daß es vorteilhaft ist, die Droge unmittelbar mit Alkohol zu extrahieren und diesen Auszug sofort oder nach dem Einengen im Vakuum mit Äther zu behandeln; denn durch die Verwendung von Alkohol als Lösungsmittel werden ebenfalls sämtliche wirksamen Stoffe, aber geringere Mengen an unwirksamen oder schädlichen Stoffen ausgezogen, die durch die Behandlung mit Äther noch weitgehender entfernt werden können.It has now been found in further development of this process that it is advantageous is to extract the drug with alcohol and extract this immediately or immediately to treat with ether after concentration in a vacuum; because by using Alcohol as a solvent also removes all active substances, but to a lesser extent Amounts of ineffective or harmful substances removed by treatment can be removed even further with ether.
Außerdem kann sowohl die Extraktion als namentlich das spätere Einengen bei so niedriger Temperatur vorgenommen werden, daß eine Zersetzung der wirksamen Bestandteile ausgeschlossen ist.In addition, both the extraction and the later concentration can be so lower Temperature can be made that decomposition of the active ingredients is excluded.
Aus der alkoholisch-ätherischen Lösung wird durch Einengen und Trocknen, vorteilhaft bei Luftleere und nach Einmischen von Milchzucker oder anderen geeigneten Stoffen, ein handliches Präparat gewonnen, das auf eine bestimmte Wirkungsstärke eingestellt werden kann. Geringe Mengen Fett können durch Ausziehen mit geeigneten Lösungsmitteln wie Petroläther entfernt werden.The alcoholic-ethereal solution becomes advantageous by concentrating and drying Empty the air and after mixing in lactose or other suitable substances handy preparation obtained, which can be adjusted to a certain potency can. Small amounts of fat can be extracted with suitable solvents such as Petroleum ether must be removed.
10 kg gepulvertes und entfettetes Mutterkorn werden einige Male mit je 20 1 Alkohol warm ausgezogen und die Auszüge entweder unmittelbar oder nach dem Einengen in der Luftleere mit etwa gleichen Mengen Äther behandelt. Es wird dann das Ausgeschiedene abfiltriert, und aus dem Filtrat werden bei Luftleere die Lösungsmittel entfernt; der Rückstand wird nach Zugabe von Milckzucker zur Trockne und in Pulverform gebracht. Der Milchzucker oder ähnliche Mittel können auch vor dem Entfernen der Lösungsmittel zugegeben werden..10 kg of powdered and defatted ergot are mixed with 20 liters of alcohol a few times Stripped warm and the excerpts either immediately or after narrowing in the Treat the vacuum with approximately equal amounts of ether. It then becomes what has been eliminated filtered off, and the solvents are removed from the filtrate in the absence of air; the residue After adding milk sugar, it is brought to dryness and in powder form. The milk sugar or similar means can also be added before removing the solvents.
Das so erhaltene Präparat bildet ein grauweißes Pulver, das mit weiteren Mengen Milchzucker auf bestimmte Wirkungsgrade eingestellt werden kann.The preparation obtained in this way forms a gray-white powder that is mixed with additional amounts of lactose can be adjusted to certain efficiencies.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE226469C true DE226469C (en) |
Family
ID=487017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT226469D Active DE226469C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE226469C (en) |
-
0
- DE DENDAT226469D patent/DE226469C/de active Active
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