CY1122466T1 - Σκευασμα αντισωματος αντι il-17ra και θεραπευτικα σχηματα για την αγωγη της ψωριασης - Google Patents
Σκευασμα αντισωματος αντι il-17ra και θεραπευτικα σχηματα για την αγωγη της ψωριασηςInfo
- Publication number
- CY1122466T1 CY1122466T1 CY20191101143T CY191101143T CY1122466T1 CY 1122466 T1 CY1122466 T1 CY 1122466T1 CY 20191101143 T CY20191101143 T CY 20191101143T CY 191101143 T CY191101143 T CY 191101143T CY 1122466 T1 CY1122466 T1 CY 1122466T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- psoriasis
- antibody formulation
- therapeutic forms
- therapeutic
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 201000004681 Psoriasis Diseases 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
Abstract
Η παρούσα αποκάλυψη σχετίζεται με ΑΜ-14 φαρμακευτικά σκευάσματα και θεραπευτικά σχήματα δοσολόγησης για την αγωγή πάθησης.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29538710P | 2010-01-15 | 2010-01-15 | |
US42205910P | 2010-12-10 | 2010-12-10 | |
PCT/US2011/020985 WO2011088120A1 (en) | 2010-01-15 | 2011-01-12 | Antibody formulation and therapeutic regimens |
EP11705713.3A EP2523688B1 (en) | 2010-01-15 | 2011-01-12 | Antibody formulation and therapeutic regimens |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122466T1 true CY1122466T1 (el) | 2020-10-14 |
Family
ID=43858045
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100022T CY1119852T1 (el) | 2010-01-15 | 2018-01-09 | Σκευασμα αντισωματος και θεραπευτικα σχηματα |
CY20191101143T CY1122466T1 (el) | 2010-01-15 | 2019-11-04 | Σκευασμα αντισωματος αντι il-17ra και θεραπευτικα σχηματα για την αγωγη της ψωριασης |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100022T CY1119852T1 (el) | 2010-01-15 | 2018-01-09 | Σκευασμα αντισωματος και θεραπευτικα σχηματα |
Country Status (38)
Country | Link |
---|---|
US (5) | US8883151B2 (el) |
EP (3) | EP3295957B1 (el) |
JP (2) | JP5743234B2 (el) |
KR (1) | KR101766936B1 (el) |
CN (1) | CN102821787B (el) |
AR (1) | AR079903A1 (el) |
AU (3) | AU2011205402B2 (el) |
BR (1) | BR112012017150B1 (el) |
CA (1) | CA2787128C (el) |
CL (1) | CL2012001966A1 (el) |
CO (1) | CO6640206A2 (el) |
CR (1) | CR20120419A (el) |
CY (2) | CY1119852T1 (el) |
DK (2) | DK3295957T3 (el) |
EA (2) | EA031209B9 (el) |
ES (2) | ES2652637T3 (el) |
HR (1) | HRP20171939T1 (el) |
HU (2) | HUE046670T2 (el) |
IL (1) | IL220602B (el) |
IN (1) | IN2012DN06720A (el) |
LT (2) | LT2523688T (el) |
MA (1) | MA33989B1 (el) |
MX (1) | MX349856B (el) |
MY (1) | MY182680A (el) |
NO (1) | NO2523688T3 (el) |
NZ (1) | NZ601125A (el) |
PE (1) | PE20121691A1 (el) |
PH (1) | PH12012501364A1 (el) |
PL (2) | PL3295957T3 (el) |
PT (2) | PT3295957T (el) |
RS (2) | RS59743B1 (el) |
SG (2) | SG10201604093XA (el) |
SI (2) | SI2523688T1 (el) |
TN (1) | TN2012000335A1 (el) |
TW (1) | TWI554282B (el) |
UA (1) | UA112288C2 (el) |
WO (1) | WO2011088120A1 (el) |
ZA (1) | ZA201205167B (el) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
SG10201604093XA (en) | 2010-01-15 | 2016-07-28 | Kirin Amgen Inc | Antibody formulation and therapeutic regimens |
ES2716088T3 (es) | 2010-02-04 | 2019-06-10 | Csl Behring Ag | Preparado de inmunoglobulina |
CA2791951C (en) | 2010-05-20 | 2019-05-14 | Ablynx Nv | Biological materials related to her3 |
JP6159660B2 (ja) * | 2010-09-22 | 2017-07-05 | アムジエン・インコーポレーテツド | 担体としての免疫グロブリンおよびその使用 |
WO2012138958A1 (en) * | 2011-04-07 | 2012-10-11 | Glaxosmithkline Llc | Formulations with reduced viscosity |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
JOP20200043A1 (ar) * | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
WO2013016220A1 (en) * | 2011-07-22 | 2013-01-31 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
JP6203740B2 (ja) * | 2011-11-23 | 2017-09-27 | アムジェン インコーポレイテッド | アルファ4ベータ7ヘテロ二量体特異抗体の投与 |
KR101653082B1 (ko) * | 2012-03-07 | 2016-08-31 | 일라이 릴리 앤드 캄파니 | Il-17 항체 제제 |
MX2014013508A (es) | 2012-05-14 | 2015-02-10 | Novo Nordisk As | Soluciones proteinicas estabilizadas. |
SG10201805015TA (en) | 2013-03-15 | 2018-07-30 | Amgen Inc | Methods for treating crohn's disease using an anti-il23 antibody |
EA201591581A1 (ru) | 2013-03-15 | 2016-01-29 | Амген Инк. | Способы лечения псориаза при помощи анти-il-23 антитела |
KR102530900B1 (ko) * | 2014-03-31 | 2023-05-12 | 암젠 케이-에이, 인크. | 손발톱 및 두피 건선의 치료 방법 |
MX2016014761A (es) | 2014-05-16 | 2017-05-25 | Amgen Inc | Ensayo para detectar poblaciones celulares linfocitos t colaboradores 1 (th1) y linfocitos t colaboradores (th2). |
EP3185902B1 (en) | 2014-08-26 | 2020-07-29 | Amgen K-A, Inc. | Method for treating psoriasis patient which received anti-tnf-alpha antibody therapy |
JP6795397B2 (ja) * | 2014-09-10 | 2020-12-02 | 日油株式会社 | 蛋白質吸着抑制剤及び蛋白質吸着抑制方法 |
HUE069126T2 (hu) | 2014-12-03 | 2025-02-28 | Csl Behring Ag | Immunoglobulinokat tartalmazó megnövelt stabilitású gyógyszerészeti termék |
EP3349854A4 (en) | 2015-09-17 | 2019-04-03 | Amgen Inc. | PREDICTING THE CLINICAL RESPONSE TO IL23 ANTAGONISTS WITH IL23 PATIENT BIOMARKERS |
AU2016349113A1 (en) | 2015-11-04 | 2018-06-07 | Astrazeneca Ab | Dipeptidyl peptidase-4 and periostin as predictors of clinical response to eosinophil-targeted therapeutic agents in eosinophilic diseases |
CA3007098A1 (en) | 2015-12-22 | 2017-06-29 | Amgen Inc | Ccl20 as a predictor of clinical response to il23-antagonists |
JP6694522B2 (ja) | 2016-04-19 | 2020-05-13 | セイジ・エレクトロクロミクス,インコーポレイテッド | 透明導電性酸化物層及びバスバーを含むエレクトロクロミックデバイス、ならびにその形成プロセス |
GB201612043D0 (en) * | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
CA2974531A1 (en) * | 2017-07-26 | 2019-01-26 | Michael Giroux | Safety anchor and roof vent |
GB201719447D0 (en) | 2017-11-23 | 2018-01-10 | Ucb Biopharma Sprl | Pharmaceutical composition |
EA202190197A1 (ru) | 2018-07-13 | 2021-04-26 | Астразенека Коллаборэйшн Венчерз, Ллс | Лечение язвенного колита с помощью бразикумаба |
BR112021015034A2 (pt) | 2019-02-18 | 2021-10-05 | Eli Lilly And Company | Formulação de anticorpo terapêutico |
WO2021050563A1 (en) * | 2019-09-09 | 2021-03-18 | The Rockefeller University | Antibody treatment for lesional tissue of hidradenitis suppurativa |
CN114401993A (zh) | 2019-09-11 | 2022-04-26 | 博世健康爱尔兰有限公司 | 使用il-17ra抗体治疗非酒精性脂肪肝疾病(nafld)的方法 |
CN112891530B (zh) * | 2020-06-19 | 2021-08-24 | 北京东方百泰生物科技股份有限公司 | 一种抗il-17ra单克隆抗体的注射制剂 |
EP4337257A1 (en) * | 2021-05-12 | 2024-03-20 | AnaptysBio, Inc. | Antibody composition |
WO2023240071A1 (en) * | 2022-06-06 | 2023-12-14 | Fusion Pharmaceuticals Inc. | Methods of dosing therapeutic agents |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1000835A (en) | 1911-06-19 | 1911-08-15 | Stewart A Minnick | Calipers. |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
IL83878A (en) | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
IL98078A0 (en) | 1991-05-07 | 1992-06-21 | Yeda Res & Dev | Pharmaceutical compositions comprising an anticytokyne |
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
GB8807803D0 (en) | 1988-03-31 | 1988-05-05 | Glaxo Group Ltd | Biochemical product |
EP0362371A4 (en) | 1988-04-15 | 1990-10-24 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
IL94039A (en) | 1989-08-06 | 2006-09-05 | Yeda Res & Dev | Antibodies to tbp - 1 and their use |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
ATE289350T1 (de) | 1989-04-21 | 2005-03-15 | Amgen Inc | Tnf-rezeptor, tnf bindende proteine und dafür kodierende dnas |
DE3922089A1 (de) | 1989-05-09 | 1990-12-13 | Basf Ag | Neue proteine und ihre herstellung |
EP0398327B2 (en) | 1989-05-18 | 2013-02-20 | Yeda Research And Development Co., Ltd. | Tumor necrosis factor binding protein II, its purification and antibodies thereto |
IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | A method of producing a recombinant human necrotic factor absorber |
US5703088A (en) | 1989-08-21 | 1997-12-30 | Beth Israel Deaconess Medical Center, Inc. | Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses |
US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
CA2485553A1 (en) | 1989-09-05 | 1991-03-21 | Immunex Corporation | Tumor necrosis factor - .alpha. and - .beta. receptors |
DE59010933D1 (de) | 1989-09-12 | 2003-05-08 | Hoffmann La Roche | TFN-bindende Proteine |
JPH03127800A (ja) | 1989-10-13 | 1991-05-30 | Teijin Ltd | 腫瘍壊死因子活性抑制物質 |
AU642938B2 (en) | 1989-12-13 | 1993-11-04 | Yeda Research And Development Co. Ltd. | Expression of the recombinant tumor necrosis factor binding protein 1 (TBP-1) |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
WO1991010741A1 (en) | 1990-01-12 | 1991-07-25 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
US5136021A (en) | 1990-02-27 | 1992-08-04 | Health Research, Inc. | TNF-inhibitory protein and a method of production |
US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
GB2243569A (en) | 1990-05-02 | 1991-11-06 | Andrew Langdon | Brush with timer |
EP0835939B8 (de) | 1990-06-28 | 2006-01-11 | Sanofi-Aventis Deutschland GmbH | Fusionsproteine mit Immunglobulinanteilen, ihre Herstellung und Verwendung |
WO1992001002A1 (fr) | 1990-07-11 | 1992-01-23 | Teijin Limited | Inhibiteur de l'activite du facteur de la necrose tumorale et son procede de preparation |
KR100234520B1 (ko) | 1991-01-18 | 1999-12-15 | 그레고리 아보트 | 종양괴사인자 매개병 치료용 의약품 조성물 |
SG89295A1 (en) | 1991-03-15 | 2002-06-18 | Amgen Inc | Pegylation of polypeptides |
IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
JP3122139B2 (ja) | 1991-10-15 | 2001-01-09 | マラーキー,ミッシェル,エフ. | 後期段階炎症反応の治療用組成物 |
US5716805A (en) | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
ATE297465T1 (de) | 1991-11-25 | 2005-06-15 | Enzon Inc | Verfahren zur herstellung von multivalenten antigenbindenden proteinen |
AU671116B2 (en) | 1992-03-30 | 1996-08-15 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
EP0639079B1 (en) | 1992-04-30 | 2000-01-12 | Amgen Inc. | Methods for treating interleukin-1 and tumor necrosis factor mediated diseases |
JPH05312248A (ja) | 1992-05-08 | 1993-11-22 | Nissan Motor Co Ltd | シフトレバー装置 |
NZ256293A (en) | 1992-09-15 | 1997-06-24 | Immunex Corp | Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist |
WO1994013804A1 (en) | 1992-12-04 | 1994-06-23 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US6562333B1 (en) | 1993-06-14 | 2003-05-13 | Schering Corporation | Purified mammalian CTLA-8 antigens and related reagents |
US6680057B1 (en) | 1995-03-23 | 2004-01-20 | Immunex Corporation | Methods of treating autoimmune disease by administering interleukin-17 receptor |
JP4373495B2 (ja) | 1995-03-23 | 2009-11-25 | イミュネックス・コーポレーション | Il−17受容体 |
PT839196E (pt) | 1995-07-19 | 2005-09-30 | Inst Genetics Llc | Ctla-8 humana e utilizacoes de proteinas relacionadas com ctla-8 |
US6074849A (en) | 1995-07-19 | 2000-06-13 | Genetics Institute, Inc. | Polynucleotides encoding human CTLA-8 related proteins |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
US6406867B1 (en) | 1996-08-16 | 2002-06-18 | Human Genome Sciences, Inc. | Antibody to human endokine alpha and methods of use |
JP2001506982A (ja) | 1996-11-27 | 2001-05-29 | イミュネックス・コーポレーション | 一酸化窒素産生の制御法 |
EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
US6482923B1 (en) | 1997-09-17 | 2002-11-19 | Human Genome Sciences, Inc. | Interleukin 17-like receptor protein |
US6635443B1 (en) | 1997-09-17 | 2003-10-21 | Human Genome Sciences, Inc. | Polynucleotides encoding a novel interleukin receptor termed interleukin-17 receptor-like protein |
EP1076703B2 (en) | 1998-05-15 | 2010-12-15 | Genentech, Inc. | Therapeutic uses of il-17 homologous polypeptides |
JP2000247903A (ja) * | 1999-03-01 | 2000-09-12 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
IL149008A0 (en) | 1999-10-04 | 2002-11-10 | Chiron Corp | Stabilized liquid polypeptide-containing pharmaceutical compositions |
AR030554A1 (es) | 2000-03-16 | 2003-08-27 | Amgen Inc | Moleculas similares a receptores il-17 y usos de las mismas |
AR028256A1 (es) | 2000-03-16 | 2003-04-30 | Amgen Inc | Moleculas similares a receptores il-17 y usos de las mismas |
US20030180255A1 (en) | 2000-08-24 | 2003-09-25 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
MXPA03003407A (es) | 2000-10-18 | 2004-05-04 | Immunex Corp | Metodos para el tratamiento de artritis reumatoide usando antagonistas il-17. |
JP4583762B2 (ja) | 2002-02-27 | 2010-11-17 | イミュネックス・コーポレーション | ポリペプチド製剤 |
US20050153880A1 (en) | 2002-06-27 | 2005-07-14 | Yukio Goto | Methods of treating or preventing ibd with il-18 |
DE60305919T2 (de) | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | Dual-specifische liganden mit erhöhter halbwertszeit |
DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
US8221771B2 (en) | 2003-08-05 | 2012-07-17 | 3M Innovative Properties Company | Formulations containing an immune response modifier |
GB0321703D0 (en) * | 2003-09-16 | 2003-10-15 | Imerys Minerals Ltd | Surface modified fillers for polymer resin compositions |
US20070184050A1 (en) | 2003-12-25 | 2007-08-09 | Kirin Beer Kabushiki Kaisha | Stable water-based medicinal preparation containing antibody |
IL159670A0 (en) | 2003-12-31 | 2004-06-01 | Yeda Res & Dev | Use of il-18 binding protein in inflammations |
KR20070085199A (ko) | 2004-06-04 | 2007-08-27 | 디자이너 몰레큘스 인코퍼레이티드 | 자유-라디칼에 경화되는 폴리에스테르 및 그 사용 방법 |
GB0425569D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Biological products |
CA2596986A1 (en) | 2005-02-14 | 2006-08-24 | Wyeth | Use of il-17f in diagnosis and therapy of airway inflammation |
WO2006138181A2 (en) | 2005-06-14 | 2006-12-28 | Amgen Inc. | Self-buffering protein formulations |
AU2006278573A1 (en) | 2005-08-03 | 2007-02-15 | Immunogen, Inc. | Immunoconjugate formulations |
AU2006295340B2 (en) | 2005-08-05 | 2010-11-11 | Amgen Inc. | Stable aqueous protein or antibody pharmaceutical formulations and their preparation |
ES2333260T3 (es) | 2005-09-01 | 2010-02-18 | Schering Corporation | Uso de antagonistas de il-23 e il-17 para tratar la enfermedad inflamatoria ocular autoinmunologica. |
CA2624763A1 (en) | 2005-10-18 | 2007-04-26 | Zymogenetics, Inc. | Il-17c antagonists and methods of using the same |
PE20070714A1 (es) | 2005-11-01 | 2007-07-20 | Wyeth Corp | Solucion de cloruro de sodio para reconstitucion o dilucion de farmaco |
JP5231810B2 (ja) * | 2005-12-28 | 2013-07-10 | 中外製薬株式会社 | 抗体含有安定化製剤 |
US20080071063A1 (en) * | 2006-02-03 | 2008-03-20 | Medimmune, Inc. | Protein Formulations |
UA99716C2 (ru) * | 2006-10-02 | 2012-09-25 | Кирин-Амген Инк. | Антитело, которое специфично связывает человеческий il-17 рецептор а (il-17ra) |
US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
CA2666842A1 (en) | 2006-10-18 | 2008-04-24 | Zymogenetics, Inc. | Il-17c antagonists and methods of using the same |
FR2910324B1 (fr) | 2006-12-21 | 2009-03-06 | Biomerieux Sa | Nouveau medicament pour le traitement d'un cancer gastrique |
CA2790018C (en) * | 2006-12-21 | 2015-02-03 | Amgen Inc. | Formulations |
GB0700523D0 (en) | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
WO2008118930A1 (en) | 2007-03-26 | 2008-10-02 | Zymogenetics, Inc. | Soluble il-17ra/rc fusion proteins and related methods |
EP2170958A1 (en) | 2007-06-13 | 2010-04-07 | Amgen Inc. | Il-17 heteromeric receptor complex |
WO2009006301A2 (en) | 2007-06-29 | 2009-01-08 | Battelle Memorial Institute | Protein stabilization |
WO2009026122A1 (en) | 2007-08-17 | 2009-02-26 | Amgen Inc. | Formulations of antibodies and fc-fusion molecules using polycations |
WO2009136976A2 (en) | 2008-02-21 | 2009-11-12 | Amgen Inc | Il-17ra-il-17rb antagonists and uses thereof |
TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
SG10201604093XA (en) | 2010-01-15 | 2016-07-28 | Kirin Amgen Inc | Antibody formulation and therapeutic regimens |
RU2591083C2 (ru) | 2010-10-08 | 2016-07-10 | Новартис Аг | Способы лечения псориаза с использованием антагонистов il-17 |
EP2633317A1 (en) | 2010-10-25 | 2013-09-04 | Genentech, Inc. | Treatment of gastrointestinal inflammation and psoriasis a |
JP2014510152A (ja) * | 2011-04-07 | 2014-04-24 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 粘度が低減された処方物 |
WO2012138958A1 (en) * | 2011-04-07 | 2012-10-11 | Glaxosmithkline Llc | Formulations with reduced viscosity |
WO2013016220A1 (en) | 2011-07-22 | 2013-01-31 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
KR102530900B1 (ko) | 2014-03-31 | 2023-05-12 | 암젠 케이-에이, 인크. | 손발톱 및 두피 건선의 치료 방법 |
EP3185902B1 (en) | 2014-08-26 | 2020-07-29 | Amgen K-A, Inc. | Method for treating psoriasis patient which received anti-tnf-alpha antibody therapy |
-
2011
- 2011-01-12 SG SG10201604093XA patent/SG10201604093XA/en unknown
- 2011-01-12 SG SG2012051108A patent/SG182468A1/en unknown
- 2011-01-12 LT LTEP11705713.3T patent/LT2523688T/lt unknown
- 2011-01-12 NO NO11705713A patent/NO2523688T3/no unknown
- 2011-01-12 BR BR112012017150-0A patent/BR112012017150B1/pt active IP Right Grant
- 2011-01-12 PT PT171955305T patent/PT3295957T/pt unknown
- 2011-01-12 IN IN6720DEN2012 patent/IN2012DN06720A/en unknown
- 2011-01-12 ES ES11705713.3T patent/ES2652637T3/es active Active
- 2011-01-12 DK DK17195530.5T patent/DK3295957T3/da active
- 2011-01-12 CN CN201180012846.1A patent/CN102821787B/zh active Active
- 2011-01-12 UA UAA201209849A patent/UA112288C2/uk unknown
- 2011-01-12 RS RS20191335A patent/RS59743B1/sr unknown
- 2011-01-12 PH PH1/2012/501364A patent/PH12012501364A1/en unknown
- 2011-01-12 SI SI201131350T patent/SI2523688T1/en unknown
- 2011-01-12 ES ES17195530T patent/ES2753216T3/es active Active
- 2011-01-12 MY MYPI2016001562A patent/MY182680A/en unknown
- 2011-01-12 WO PCT/US2011/020985 patent/WO2011088120A1/en active Application Filing
- 2011-01-12 EP EP17195530.5A patent/EP3295957B1/en active Active
- 2011-01-12 SI SI201131792T patent/SI3295957T1/sl unknown
- 2011-01-12 PT PT117057133T patent/PT2523688T/pt unknown
- 2011-01-12 PL PL17195530T patent/PL3295957T3/pl unknown
- 2011-01-12 EA EA201290653A patent/EA031209B9/ru not_active IP Right Cessation
- 2011-01-12 HU HUE17195530A patent/HUE046670T2/hu unknown
- 2011-01-12 US US13/521,999 patent/US8883151B2/en active Active
- 2011-01-12 NZ NZ601125A patent/NZ601125A/en unknown
- 2011-01-12 HU HUE11705713A patent/HUE035618T2/en unknown
- 2011-01-12 PL PL11705713T patent/PL2523688T3/pl unknown
- 2011-01-12 MX MX2012008213A patent/MX349856B/es active IP Right Grant
- 2011-01-12 MA MA35124A patent/MA33989B1/fr unknown
- 2011-01-12 EP EP19189613.3A patent/EP3632466A1/en not_active Withdrawn
- 2011-01-12 JP JP2012549047A patent/JP5743234B2/ja active Active
- 2011-01-12 EP EP11705713.3A patent/EP2523688B1/en active Active
- 2011-01-12 AU AU2011205402A patent/AU2011205402B2/en active Active
- 2011-01-12 EA EA201891433A patent/EA201891433A3/ru unknown
- 2011-01-12 LT LTEP17195530.5T patent/LT3295957T/lt unknown
- 2011-01-12 CA CA2787128A patent/CA2787128C/en active Active
- 2011-01-12 DK DK11705713.3T patent/DK2523688T3/en active
- 2011-01-12 RS RS20171311A patent/RS56781B1/sr unknown
- 2011-01-12 KR KR1020127021299A patent/KR101766936B1/ko active IP Right Grant
- 2011-01-12 PE PE2012001003A patent/PE20121691A1/es active IP Right Grant
- 2011-01-14 AR ARP110100123A patent/AR079903A1/es not_active Application Discontinuation
- 2011-01-14 TW TW100101536A patent/TWI554282B/zh active
-
2012
- 2012-06-24 IL IL220602A patent/IL220602B/en active IP Right Grant
- 2012-06-26 TN TNP2012000335A patent/TN2012000335A1/en unknown
- 2012-07-11 ZA ZA2012/05167A patent/ZA201205167B/en unknown
- 2012-07-13 CL CL2012001966A patent/CL2012001966A1/es unknown
- 2012-08-10 CO CO12135074A patent/CO6640206A2/es unknown
- 2012-08-10 CR CR20120419A patent/CR20120419A/es unknown
-
2014
- 2014-09-29 US US14/499,691 patent/US10072085B2/en active Active
- 2014-12-05 JP JP2014247218A patent/JP2015052017A/ja active Pending
-
2015
- 2015-04-21 AU AU2015202023A patent/AU2015202023B2/en active Active
-
2017
- 2017-08-18 AU AU2017216579A patent/AU2017216579A1/en not_active Abandoned
- 2017-12-14 HR HRP20171939TT patent/HRP20171939T1/hr unknown
-
2018
- 2018-01-09 CY CY20181100022T patent/CY1119852T1/el unknown
- 2018-08-02 US US16/053,564 patent/US10808033B2/en active Active
-
2019
- 2019-11-04 CY CY20191101143T patent/CY1122466T1/el unknown
-
2020
- 2020-09-08 US US17/015,029 patent/US11505612B2/en active Active
-
2022
- 2022-10-11 US US18/045,534 patent/US20230192873A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1122466T1 (el) | Σκευασμα αντισωματος αντι il-17ra και θεραπευτικα σχηματα για την αγωγη της ψωριασης | |
CY1124436T1 (el) | Δικυκλικες ετεροκυκλικες ενωσεις και χρησεις αυτων στη θεραπεια | |
CY1124928T1 (el) | Αναστολεις πυραζολυλο κινοξαλινο κινασης | |
CY1124000T1 (el) | Υποκατεστημενες 5-φθορο-1η-πυραζολοπυριδινες σε κρυσταλλικη μορφη | |
CY1123476T1 (el) | Τροποποιητες πυρηνικης μεταφορας και χρησεις αυτων | |
CY1120429T1 (el) | Παραγωγα κιναζολινης για τη θεραπευτικη αντιμετωπιση ιογενων λοιμωξεων και αλλων νοσων | |
CY1121150T1 (el) | Νευροδραστικα 19-αλκοξυ-17-υποκατεστημενα στεροειδη, χρησιμα σε μεθοδους θεραπειας | |
CY1117372T1 (el) | Υποκατεστημενες 5-φθορο-1η-πυραζολοπυριδινες και η χρηση τους | |
CY1119616T1 (el) | Συζευγματα ανθρωπινου αντισωματος-φαρμακου κατα του ιστικου παραγοντα | |
CY1119200T1 (el) | Νεα παραγωγα βενζιμιδαζολιου ως ερ4 ανταγωνιστες | |
CY1118813T1 (el) | Φαρμακευτικες συνθεσεις συν-κρυσταλλων τραμαδολης και κοξιμπων | |
EA201991484A1 (ru) | Лекарственные формы энзалутамида | |
CY1121538T1 (el) | Μονοκλωνικα αντισωματα εναντι του αναστολεα του μονοπατιου ιστικου παραγοντα (tfpi) | |
EA201300558A1 (ru) | Соединения и способы для купирования боли | |
CY1119410T1 (el) | Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi) | |
EA201590343A1 (ru) | Алкилпиримидиновые производные для лечения вирусных инфекций и дальнейших заболеваний | |
CY1120008T1 (el) | Βενζαμιδια | |
EA201590667A1 (ru) | Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний | |
CY1112758T1 (el) | Καινοτομοι ανταγωνιστες p2x7r και η χρηση τους | |
EA201591133A1 (ru) | СОСТАВЫ В ВИДЕ РАСТВОРА СКОНСТРУИРОВАННЫХ АНТИТЕЛ К IL-23p19 | |
CY1117785T1 (el) | Αναστολεας φωσφοϊνοσιτιδιου 3-κινασης με ενα τμημα δεσμευσης ψευδαργυρου | |
EA201291211A1 (ru) | Фармацевтические композиции, содержащие гидроморфон и налоксон | |
EA201400623A1 (ru) | Новые 2h-индазолы в качестве антагонистов рецептора ep | |
EA201201296A1 (ru) | Способы лечения диабетических язв стопы | |
CY1116234T1 (el) | Υποκατεστημενα 2-οξυ-κινολινο-3-καρβοξαμιδια σαν διαμορφωτες kcnq2/3 |