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CY1119539T1 - Πληρως ανθρωπινα αντισωματα ειδικα για to cadμ1 - Google Patents

Πληρως ανθρωπινα αντισωματα ειδικα για to cadμ1

Info

Publication number
CY1119539T1
CY1119539T1 CY20171100907T CY171100907T CY1119539T1 CY 1119539 T1 CY1119539 T1 CY 1119539T1 CY 20171100907 T CY20171100907 T CY 20171100907T CY 171100907 T CY171100907 T CY 171100907T CY 1119539 T1 CY1119539 T1 CY 1119539T1
Authority
CY
Cyprus
Prior art keywords
antibodies
cadmi
methods
cadm1
antibiles
Prior art date
Application number
CY20171100907T
Other languages
English (en)
Inventor
Jonathan Alexander Terrett
Heidi Leblanc
Haichun Huang
Erika Meaddough
Chin Pan
Bingliang Chen
Chetana Rao-Naik
Original Assignee
E. R. Squibb & Sons, L.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E. R. Squibb & Sons, L.L.C. filed Critical E. R. Squibb & Sons, L.L.C.
Publication of CY1119539T1 publication Critical patent/CY1119539T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Η παρούσα περιγραφή παρέχει απομονωμένα μονοκλωνικά αντισώματα, συγκεκριμένα ανθρώπινα μονοκλωνικά αντισώματα, πιο συγκεκριμένα τροποποιημένα αντισώματα με συνέπεια την αυξημένη πρόσδεση στους υποδοχείς Fc ή/και την αυξημένη ισχύ για ADCC. ή ανοσοσυζεύγματα, που δεσμεύονται ειδικά στο CADMI με υψηλή συγγένεια. Παρέχονται επίσης μόρια νουκλεϊκού οξέος που κωδικοποιούν για τα CADMI αντισώματα, φορείς έκφρασης, κύτταρα ξενιστές και μέθοδοι για την έκφραση των αντισωμάτων. Επίσης παρέχονται μόρια διπλής ειδικότητας και φαρμακευτικές συνθέσεις που περιλαμβάνουν τα CADMI αντισώματα. Περιγράφονται μέθοδοι για την ανίχνευση του CADM1, καθώς και μέθοδοι για τη θεραπεία διάφορων καρκίνων, συμπεριλαμβανομένων των καρκίνων του πνεύμονα και του παγκρέατος.
CY20171100907T 2009-03-05 2017-08-29 Πληρως ανθρωπινα αντισωματα ειδικα για to cadμ1 CY1119539T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20939009P 2009-03-05 2009-03-05
US20947109P 2009-03-05 2009-03-05
PCT/US2010/026315 WO2010102175A1 (en) 2009-03-05 2010-03-05 Fully human antibodies specific to cadm1

Publications (1)

Publication Number Publication Date
CY1119539T1 true CY1119539T1 (el) 2018-03-07

Family

ID=42144944

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100907T CY1119539T1 (el) 2009-03-05 2017-08-29 Πληρως ανθρωπινα αντισωματα ειδικα για to cadμ1

Country Status (25)

Country Link
US (2) US8420084B2 (el)
EP (1) EP2403878B1 (el)
JP (1) JP5816558B2 (el)
KR (1) KR101769160B1 (el)
CN (1) CN102341412B (el)
AU (1) AU2010221186B2 (el)
BR (1) BRPI1009232B1 (el)
CA (1) CA2753702C (el)
CY (1) CY1119539T1 (el)
DK (1) DK2403878T3 (el)
EA (1) EA028336B1 (el)
ES (1) ES2639026T3 (el)
HR (1) HRP20171274T1 (el)
HU (1) HUE034196T2 (el)
IL (1) IL214779A (el)
LT (1) LT2403878T (el)
ME (1) ME02842B (el)
MX (1) MX2011009220A (el)
NZ (1) NZ594682A (el)
PL (1) PL2403878T3 (el)
PT (1) PT2403878T (el)
SG (1) SG173742A1 (el)
UA (1) UA102891C2 (el)
WO (1) WO2010102175A1 (el)
ZA (1) ZA201105918B (el)

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JP5173838B2 (ja) 2006-02-13 2013-04-03 アレシア・バイオセラピューティクス・インコーポレーテッド 骨リモデリングのプロセスと関係があるポリヌクレオチドおよびポリペプチド配列
WO2008026010A1 (en) 2006-08-29 2008-03-06 Oxford Genome Sciences (Uk) Ltd Identification of protein associated with hepatocellular carcinoma, glioblastoma and lung cancer
EP2403878B1 (en) * 2009-03-05 2017-06-14 E. R. Squibb & Sons, L.L.C. Fully human antibodies specific to cadm1
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JP6440968B2 (ja) * 2013-05-28 2018-12-19 国立大学法人 宮崎大学 ＩｇＳＦ４／ＴＳＬＣ１／ＣＡＤＭ１を特異的に認識できる抗体
WO2017084078A1 (en) * 2015-11-19 2017-05-26 Zeling Cai Ctla-4 antibodies and uses thereof
JP7229503B2 (ja) 2018-03-16 2023-02-28 国立大学法人 東京大学 ＣＡＤＭ１ｖ９認識抗体
MX2021004588A (es) * 2018-10-22 2022-01-18 Shanghai Genbase Biotechnology Co Ltd Anticuerpo anti-cldn18.2 y sus usos.
CN111925440B (zh) * 2020-08-19 2022-09-09 重庆医科大学 新冠病毒rbd特异性单克隆抗体和应用
US20240317853A1 (en) * 2021-05-11 2024-09-26 The University Of Tokyo Anti-cadm1 antibody
TW202321296A (zh) * 2021-10-06 2023-06-01 美商鏈接免疫療法公司 抗間皮素抗原結合分子及其用途
KR20230061710A (ko) 2021-10-29 2023-05-09 주식회사 이뮤노로지컬디자이닝랩 Cadm1을 인식하는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물
KR20230062691A (ko) 2021-10-29 2023-05-09 주식회사 이뮤노로지컬디자이닝랩 Cadm1에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도
EP4483894A1 (en) * 2022-02-25 2025-01-01 NEC Corporation Pharmaceutical composition for treatment or prevention of adult t-cell leukemia
JP7270944B1 (ja) 2022-09-13 2023-05-11 学校法人近畿大学 抗ｃａｄｍ１抗体またはその抗原結合断片

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