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UA102891C2 - Повні людські антитіла, специфічні до cadm1 - Google Patents

Повні людські антитіла, специфічні до cadm1

Info

Publication number
UA102891C2
UA102891C2 UAA201111731A UAA201111731A UA102891C2 UA 102891 C2 UA102891 C2 UA 102891C2 UA A201111731 A UAA201111731 A UA A201111731A UA A201111731 A UAA201111731 A UA A201111731A UA 102891 C2 UA102891 C2 UA 102891C2
Authority
UA
Ukraine
Prior art keywords
cadm1
antibodies
methods
human antibodies
antibodies specific
Prior art date
Application number
UAA201111731A
Other languages
English (en)
Russian (ru)
Inventor
Джонатан Алєксандр Террет
Хайді Лєблон
Хайчун Хуанг
Еріка Міддоу
Чін Пан
Бінглянг Чен
Четана Рао-Найк
Original Assignee
Медарекс, Інк.
Оксфорд Байосерапьютікс Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Медарекс, Інк., Оксфорд Байосерапьютікс Лтд filed Critical Медарекс, Інк.
Publication of UA102891C2 publication Critical patent/UA102891C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Винахід стосується ізольованого моноклонального антитіла, особливо людського моноклонального антитіла, зокрема, сконструйованого антитіла, яке приводить до одержання поліпшеного зв'язування з Fc рецепторами та/або підвищеної ефективності ADCC, або імунокон'югати, які специфічно зв'язуються з CADM1 з високою афінністю.
UAA201111731A 2009-03-05 2010-03-05 Повні людські антитіла, специфічні до cadm1 UA102891C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20939009P 2009-03-05 2009-03-05
US20947109P 2009-03-05 2009-03-05
PCT/US2010/026315 WO2010102175A1 (en) 2009-03-05 2010-03-05 Fully human antibodies specific to cadm1

Publications (1)

Publication Number Publication Date
UA102891C2 true UA102891C2 (uk) 2013-08-27

Family

ID=42144944

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201111731A UA102891C2 (uk) 2009-03-05 2010-03-05 Повні людські антитіла, специфічні до cadm1

Country Status (25)

Country Link
US (2) US8420084B2 (uk)
EP (1) EP2403878B1 (uk)
JP (1) JP5816558B2 (uk)
KR (1) KR101769160B1 (uk)
CN (1) CN102341412B (uk)
AU (1) AU2010221186B2 (uk)
BR (1) BRPI1009232B1 (uk)
CA (1) CA2753702C (uk)
CY (1) CY1119539T1 (uk)
DK (1) DK2403878T3 (uk)
EA (1) EA028336B1 (uk)
ES (1) ES2639026T3 (uk)
HR (1) HRP20171274T1 (uk)
HU (1) HUE034196T2 (uk)
IL (1) IL214779A (uk)
LT (1) LT2403878T (uk)
ME (1) ME02842B (uk)
MX (1) MX2011009220A (uk)
NZ (1) NZ594682A (uk)
PL (1) PL2403878T3 (uk)
PT (1) PT2403878T (uk)
SG (1) SG173742A1 (uk)
UA (1) UA102891C2 (uk)
WO (1) WO2010102175A1 (uk)
ZA (1) ZA201105918B (uk)

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JP5173838B2 (ja) 2006-02-13 2013-04-03 アレシア・バイオセラピューティクス・インコーポレーテッド 骨リモデリングのプロセスと関係があるポリヌクレオチドおよびポリペプチド配列
WO2008026010A1 (en) 2006-08-29 2008-03-06 Oxford Genome Sciences (Uk) Ltd Identification of protein associated with hepatocellular carcinoma, glioblastoma and lung cancer
EP2403878B1 (en) * 2009-03-05 2017-06-14 E. R. Squibb & Sons, L.L.C. Fully human antibodies specific to cadm1
WO2012119989A2 (en) 2011-03-04 2012-09-13 Oryzon Genomics, S.A. Methods and antibodies for the diagnosis and treatment of cancer
EA201590247A1 (ru) 2012-07-19 2015-10-30 Алетиа Байотерапьютикс Инк. Антитела к siglec-15
JP6440968B2 (ja) * 2013-05-28 2018-12-19 国立大学法人 宮崎大学 ＩｇＳＦ４／ＴＳＬＣ１／ＣＡＤＭ１を特異的に認識できる抗体
WO2017084078A1 (en) * 2015-11-19 2017-05-26 Zeling Cai Ctla-4 antibodies and uses thereof
JP7229503B2 (ja) 2018-03-16 2023-02-28 国立大学法人 東京大学 ＣＡＤＭ１ｖ９認識抗体
MX2021004588A (es) * 2018-10-22 2022-01-18 Shanghai Genbase Biotechnology Co Ltd Anticuerpo anti-cldn18.2 y sus usos.
CN111925440B (zh) * 2020-08-19 2022-09-09 重庆医科大学 新冠病毒rbd特异性单克隆抗体和应用
US20240317853A1 (en) * 2021-05-11 2024-09-26 The University Of Tokyo Anti-cadm1 antibody
TW202321296A (zh) * 2021-10-06 2023-06-01 美商鏈接免疫療法公司 抗間皮素抗原結合分子及其用途
KR20230061710A (ko) 2021-10-29 2023-05-09 주식회사 이뮤노로지컬디자이닝랩 Cadm1을 인식하는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물
KR20230062691A (ko) 2021-10-29 2023-05-09 주식회사 이뮤노로지컬디자이닝랩 Cadm1에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도
EP4483894A1 (en) * 2022-02-25 2025-01-01 NEC Corporation Pharmaceutical composition for treatment or prevention of adult t-cell leukemia
JP7270944B1 (ja) 2022-09-13 2023-05-11 学校法人近畿大学 抗ｃａｄｍ１抗体またはその抗原結合断片

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