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CY1117348T1 - Νεο παραγωγο φαινυλπυριδινης και φαρμακο που περιεχει αυτο - Google Patents

Νεο παραγωγο φαινυλπυριδινης και φαρμακο που περιεχει αυτο

Info

Publication number
CY1117348T1
CY1117348T1 CY20161100263T CY161100263T CY1117348T1 CY 1117348 T1 CY1117348 T1 CY 1117348T1 CY 20161100263 T CY20161100263 T CY 20161100263T CY 161100263 T CY161100263 T CY 161100263T CY 1117348 T1 CY1117348 T1 CY 1117348T1
Authority
CY
Cyprus
Prior art keywords
ring
group
phynylpyridine
producer
new
Prior art date
Application number
CY20161100263T
Other languages
English (en)
Inventor
Toru Miura
Seiichi Sato
Hajime Yamada
Junya Tagashira
Toshiaki Watanabe
Ryohei Sekimoto
Rie Ishida
Hitomi Aoki
Tadaaki Ohgiya
Original Assignee
Kowa Company Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Company Ltd. filed Critical Kowa Company Ltd.
Publication of CY1117348T1 publication Critical patent/CY1117348T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει: ένωση που αντιπροσωπεύεται με τον γενικό τύπο (I) παρακάτω, που έχει τόσο ανταγωνισμό υποδοχέα αγγειοτασίνης II, όσο και αποτέλεσμα ενεργοποίησης PPAR και που είναι χρήσιμη ως προληπτικός ή/και θεραπευτικός παράγων για υψηλή πίεση αίματος, καρδιακή νόσο, αρτηριοσκλήρυνση, τύπου-2 διαβήτη και τα παρόμοια και σύνθεση φαρμάκου περιέχουσα την ένωση. Γενικός τύπος (I) (στον τύπο: ο δακτύλιος Α αντιπροσωπεύει δακτύλιο πυριδίνης· ο δακτύλιος Β αντιπροσωπεύει δακτύλιο τετραζολίου ή δακτύλιο οξαδιαζολ-5(4Η)-όνης· Χ αντιπροσωπεύει C-R5 ή άτομο αζώτου· R1 αντιπροσωπεύει αλκύλ ομάδα· R2 αντιπροσωπεύει αλκύλ ομάδα ή κυκλοαλκύλ ομάδα και R3, R4 και R5 εκάστη ανεξαρτήτως αντιπροσωπεύει άτομο υδρογόνου, άτομο αλογόνου, αλκύλ ομάδα, αλκόξυ ομάδα ή παρόμοιες.
CY20161100263T 2011-03-14 2016-03-31 Νεο παραγωγο φαινυλπυριδινης και φαρμακο που περιεχει αυτο CY1117348T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011055691 2011-03-14
EP12757676.7A EP2687523B1 (en) 2011-03-14 2012-03-13 Novel phenylpyridine derivative and drug containing same

Publications (1)

Publication Number Publication Date
CY1117348T1 true CY1117348T1 (el) 2017-04-26

Family

ID=46830402

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100263T CY1117348T1 (el) 2011-03-14 2016-03-31 Νεο παραγωγο φαινυλπυριδινης και φαρμακο που περιεχει αυτο

Country Status (23)

Country Link
US (1) US9315493B2 (el)
EP (1) EP2687523B1 (el)
JP (1) JP5583841B2 (el)
KR (1) KR101559307B1 (el)
CN (1) CN103459380B (el)
AU (1) AU2012227763B2 (el)
BR (1) BR112013023038B1 (el)
CA (1) CA2830043C (el)
CY (1) CY1117348T1 (el)
DK (1) DK2687523T3 (el)
EA (1) EA026694B1 (el)
ES (1) ES2562994T3 (el)
HK (1) HK1189232A1 (el)
HU (1) HUE028252T2 (el)
MX (1) MX349697B (el)
PH (1) PH12013501857A1 (el)
PL (1) PL2687523T3 (el)
PT (1) PT2687523E (el)
RS (1) RS54666B1 (el)
SG (1) SG193477A1 (el)
TW (1) TWI525088B (el)
WO (1) WO2012124311A1 (el)
ZA (1) ZA201307333B (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103690955B (zh) * 2013-12-27 2016-04-20 福州乾正药业有限公司 含有替格瑞洛的药物组合物及其制备方法和药物应用
US20210077491A1 (en) * 2017-12-14 2021-03-18 Kowa Company, Ltd. Pharmaceutical composition
CN115138481B (zh) * 2022-07-06 2024-01-26 中南大学 一种将方铅矿、闪锌矿中的至少一种矿物与辉钼矿浮选分离的药剂和方法

Family Cites Families (19)

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JPS5331165A (en) * 1976-09-03 1978-03-24 Iseki Kaihatsu Koki Continuous specific gravity meter
JPS5779456A (en) * 1980-11-06 1982-05-18 Fujitsu Ltd Voltage readout system by electron beam
JPS6211845A (ja) * 1985-07-10 1987-01-20 Sharp Corp 複写装置
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CN1079223A (zh) * 1991-05-16 1993-12-08 格拉克索公司 苯并呋喃衍生物
JPH06211845A (ja) * 1991-05-16 1994-08-02 Glaxo Group Ltd ベンゾフラン誘導体
IL102183A (en) 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
US5212177A (en) * 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
JPH07179456A (ja) * 1993-12-21 1995-07-18 Nkk Corp アルキルベンゾフラン誘導体及びアンジオテンシンｉｉ拮抗剤
IT1273790B (it) 1994-02-18 1997-07-10 Guidotti & C Spa Labor Derivati eterociclici diazotati aventi attivita' aii antagonista
ZA200903867B (en) * 2006-11-24 2010-08-25 Takeda Pharmaceutical Heteromonocyclic compound and use thereof
CA2670404A1 (en) * 2006-11-24 2008-05-29 Takeda Pharmaceutical Company Limited Heteromonocyclic compound and use thereof
CA2671943A1 (en) 2006-12-21 2008-07-17 Pfizer Products Inc. Compounds having both angiotensin ii receptor antagonism and ppary activating activities
EP1988091B1 (en) 2007-02-07 2015-06-10 Kyowa Hakko Kirin Co., Ltd. Tricyclic compounds
WO2008096820A1 (ja) 2007-02-07 2008-08-14 Kyowa Hakko Kirin Co., Ltd. ビフェニル誘導体
EP2151440A4 (en) 2007-05-21 2010-10-20 Takeda Pharmaceutical Heterocyclic compound and use thereof
EP2399917A1 (en) 2009-02-23 2011-12-28 Kowa Company, Ltd. Novel compounds comprising a 3-(5-alkoxypyrimidin-2-yl) pyrimidin-4(3h)-one structure and drugs that comprise same
US8664226B2 (en) 2009-04-17 2014-03-04 Kowa Company, Ltd. Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same
JP5583681B2 (ja) 2009-09-29 2014-09-03 興和株式会社 新規なフェニルピリジン誘導体及びこれを含有する医薬

Also Published As

Publication number Publication date
TWI525088B (zh) 2016-03-11
HUE028252T2 (en) 2016-12-28
EP2687523A4 (en) 2014-11-12
CN103459380A (zh) 2013-12-18
PT2687523E (pt) 2016-03-31
AU2012227763B2 (en) 2016-01-14
MX349697B (es) 2017-08-09
BR112013023038B1 (pt) 2019-09-03
CN103459380B (zh) 2015-07-15
RS54666B1 (en) 2016-08-31
JP5583841B2 (ja) 2014-09-03
NZ616158A (en) 2015-07-31
CA2830043A1 (en) 2012-09-20
SG193477A1 (en) 2013-10-30
WO2012124311A8 (ja) 2013-05-10
AU2012227763A8 (en) 2013-11-21
MX2013010553A (es) 2013-10-28
DK2687523T3 (en) 2016-03-14
PH12013501857A1 (en) 2013-10-14
AU2012227763A2 (en) 2013-11-14
WO2012124311A1 (ja) 2012-09-20
HK1189232A1 (zh) 2014-05-30
ZA201307333B (en) 2015-01-28
EA026694B1 (ru) 2017-05-31
EP2687523A1 (en) 2014-01-22
US20140011823A1 (en) 2014-01-09
AU2012227763A1 (en) 2013-10-24
KR101559307B1 (ko) 2015-10-12
PL2687523T3 (pl) 2016-06-30
CA2830043C (en) 2018-06-05
EA201391314A1 (ru) 2014-02-28
US9315493B2 (en) 2016-04-19
ES2562994T3 (es) 2016-03-09
BR112013023038A2 (pt) 2016-12-13
TW201245180A (en) 2012-11-16
KR20140008431A (ko) 2014-01-21
EP2687523B1 (en) 2016-01-06
JPWO2012124311A1 (ja) 2014-07-17

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CY1117348T1 (el) Νεο παραγωγο φαινυλπυριδινης και φαρμακο που περιεχει αυτο