[go: up one dir, main page]

MX2010002419A - (ciclopropilfenil) feniloxamidas, metodo para su produccion y uso como un medicamento. - Google Patents

(ciclopropilfenil) feniloxamidas, metodo para su produccion y uso como un medicamento.

Info

Publication number
MX2010002419A
MX2010002419A MX2010002419A MX2010002419A MX2010002419A MX 2010002419 A MX2010002419 A MX 2010002419A MX 2010002419 A MX2010002419 A MX 2010002419A MX 2010002419 A MX2010002419 A MX 2010002419A MX 2010002419 A MX2010002419 A MX 2010002419A
Authority
MX
Mexico
Prior art keywords
phenyl
oxalamides
cyclopropyl
medicament
production
Prior art date
Application number
MX2010002419A
Other languages
English (en)
Inventor
Elisabeth Defossa
Siegfried Stengelin
Andreas Herling
Thomas Klabunde
Guido Haschke
Stefan Bartoschek
Viktoria Dietrich
Johanna Kuhlmann
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2010002419A publication Critical patent/MX2010002419A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La invención se refiere a (ciclopropilfenil)feniloxamidas y sus sales fisiológicamente toleradas. La invención se refiere a compuestos de la fórmula I (Ver fórmula I) en donde R1, R2, R3, R4, R5, R6, R7, R8 y m tienen los significados indicados, y a sus sales fisiológicamente toleradas. Los compuestos son adecuados, por ejemplo, para el tratamiento de la diabetes.
MX2010002419A 2007-09-21 2008-09-04 (ciclopropilfenil) feniloxamidas, metodo para su produccion y uso como un medicamento. MX2010002419A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291131 2007-09-21
PCT/EP2008/007217 WO2009039942A1 (de) 2007-09-21 2008-09-04 (cyclopropyl-phenyl)-phenyl-oxalamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
MX2010002419A true MX2010002419A (es) 2010-03-30

Family

ID=39111440

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002419A MX2010002419A (es) 2007-09-21 2008-09-04 (ciclopropilfenil) feniloxamidas, metodo para su produccion y uso como un medicamento.

Country Status (20)

Country Link
US (1) US8148375B2 (es)
EP (1) EP2203415B1 (es)
JP (1) JP2011509239A (es)
KR (1) KR20100075444A (es)
CN (1) CN101796018A (es)
AR (1) AR070753A1 (es)
AU (1) AU2008303975B2 (es)
BR (1) BRPI0817198A2 (es)
CA (1) CA2700025A1 (es)
CL (1) CL2008002768A1 (es)
CO (1) CO6260061A2 (es)
IL (1) IL204556A (es)
MA (1) MA31979B1 (es)
MX (1) MX2010002419A (es)
NZ (1) NZ584050A (es)
RU (1) RU2010115747A (es)
TW (1) TW200934751A (es)
UY (1) UY31351A1 (es)
WO (1) WO2009039942A1 (es)
ZA (1) ZA201001014B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
BR112013004882A2 (pt) 2010-08-31 2016-05-03 Snu R&Db Foundation utilização de reprogramação fetal de agonista ppar delta
TWI516484B (zh) * 2010-09-22 2016-01-11 衛材Ｒ＆Ｄ企管股份有限公司 環丙烷化合物
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
IN2015DN03795A (es) 2012-10-24 2015-10-02 Inserm Inst Nat De La Santé Et De La Rech Médicale
EP3076959B1 (en) 2013-12-04 2018-07-04 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
EP3102198B1 (en) 2014-02-06 2020-08-26 Merck Sharp & Dohme Corp. Antidiabetic compounds
RU2703297C2 (ru) 2014-10-23 2019-10-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Композиции и способы для лечения бессонницы
WO2016151018A1 (en) 2015-03-24 2016-09-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and pharmaceutical composition for use in the treatment of diabetes
SI3752501T1 (sl) 2018-02-13 2023-08-31 Gilead Sciences, Inc. Inhibitorji pd-1/pd-l1
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
SI3820572T1 (sl) 2018-07-13 2023-12-29 Gilead Sciences, Inc. Inhibitorji pd-1/pd-l1
EP3870566A1 (en) 2018-10-24 2021-09-01 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN109574920B (zh) * 2018-12-25 2022-03-04 药大制药有限公司 3-腈基-6环丙基吡啶类ido1抑制剂及其用途
WO2020149129A1 (ja) * 2019-01-15 2020-07-23 株式会社カネカ 非対称化合物の製造方法
EP3976053A4 (en) * 2019-05-31 2022-11-23 Avolynt COMPOSITIONS AND METHODS OF TREATING A METABOLIC DISEASE
CN114945560B (zh) 2019-10-07 2024-08-13 卡尔优普公司 Gpr119激动剂
KR20230012597A (ko) 2020-05-19 2023-01-26 칼리오페, 인크. Ampk 활성화제
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890568B2 (en) * 1999-05-24 2005-05-10 Grant Pierce Method for management of blood glucose levels
MXPA03010724A (es) * 2001-05-25 2004-03-02 Boehringer Ingelheim Pharma Compuestos de carbamato y oxamida como inhibidores de la produccion de citocina.
US20050124667A1 (en) * 2003-10-30 2005-06-09 Eric Sartori Oxamide inhibitors of plasminogen activator inhibitor-1

Also Published As

Publication number Publication date
ZA201001014B (en) 2010-10-27
CA2700025A1 (en) 2009-04-02
EP2203415B1 (de) 2016-10-26
CO6260061A2 (es) 2011-03-22
WO2009039942A1 (de) 2009-04-02
IL204556A (en) 2013-06-27
AU2008303975B2 (en) 2013-05-16
JP2011509239A (ja) 2011-03-24
NZ584050A (en) 2011-09-30
EP2203415A1 (de) 2010-07-07
MA31979B1 (fr) 2011-01-03
UY31351A1 (es) 2009-04-30
US20100261644A1 (en) 2010-10-14
RU2010115747A (ru) 2011-10-27
IL204556A0 (en) 2010-11-30
CN101796018A (zh) 2010-08-04
BRPI0817198A2 (pt) 2015-03-17
AR070753A1 (es) 2010-05-05
KR20100075444A (ko) 2010-07-02
CL2008002768A1 (es) 2009-03-06
TW200934751A (en) 2009-08-16
US8148375B2 (en) 2012-04-03
AU2008303975A1 (en) 2009-04-02

Similar Documents

Publication Publication Date Title
MX2010002419A (es) (ciclopropilfenil) feniloxamidas, metodo para su produccion y uso como un medicamento.
MX2010002461A (es) (carboxilalquilenfenil)feniloxamidas, metodo para su produccion y uso de las mismas como medicamento.
MX2011011661A (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750.
TN2012000152A1 (en) Spiropiperidine compounds and pharmaceutical use thereof for treating diabetes
SG178952A1 (en) Chemical compounds
TN2012000248A1 (en) Novel spiropiperidine compounds
NZ609309A (en) Redox drug derivatives
IN2012DN01233A (es)
TW200745067A (en) Novel compounds
TN2012000369A1 (en) 5-alkynyl-pyrimidines
NZ608116A (en) Triazine-oxadiazoles
IN2012DN02139A (es)
MX2010009736A (es) Compuesto heterociclico.
MX2011005934A (es) Compuestos organicos.
MX2010008051A (es) Nuevos derivados de fluoroglicosidos aromaticos, productos farmaceuticos que comprenden dichos compuestos y uso de los mismos.
MX2011011854A (es) Dihidropirimidinonas para uso como inhibidores de la bace2.
MX2010009022A (es) Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
MX2011012643A (es) 2,4-diaminopiridinas para el tratamiento de enfermedades caracterizadas por la proliferacion celular excesiva o anormal.
TW200745084A (en) Novel compounds
JO2673B1 (en) Diosmetin compounds, method of preparation and pharmaceutical compositions
JO2682B1 (en) Derivatives of alkynil-8.1-naphthayridone, preparations thereof and therapeutic use thereof
GEP20135959B (en) Aryl piperazine and their usage as alpha2c antagonists
IN2012DN01292A (es)
MX2010009837A (es) Tiazolil-dihidro-indazoles.
TN2011000531A1 (en) 5- alkynyl - pyridines

Legal Events

Date Code Title Description
FA Abandonment or withdrawal