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MXPA03010724A - Compuestos de carbamato y oxamida como inhibidores de la produccion de citocina. - Google Patents

Compuestos de carbamato y oxamida como inhibidores de la produccion de citocina.

Info

Publication number
MXPA03010724A
MXPA03010724A MXPA03010724A MXPA03010724A MXPA03010724A MX PA03010724 A MXPA03010724 A MX PA03010724A MX PA03010724 A MXPA03010724 A MX PA03010724A MX PA03010724 A MXPA03010724 A MX PA03010724A MX PA03010724 A MXPA03010724 A MX PA03010724A
Authority
MX
Mexico
Prior art keywords
compounds
carbamate
inhibitors
cytokine production
disclosed
Prior art date
Application number
MXPA03010724A
Other languages
English (en)
Inventor
F Cirillo Pier
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA03010724A publication Critical patent/MXPA03010724A/es

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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Abstract

Se describen compuestos aromaticos novedosos de la formula (I) descrita aqui, donde G, E, W, Ar, X, Y y Z son descritos aqui. Los compuestos son utiles para tratar enfermedades o condiciones medidas por citosina como las enfermedades inflamatorias cronicas. Tambien se describen composiciones farmaceuticas que contienen y procesos para producir esos compuestos. Un ejemplo representativo de los compuestos de formula (I) es (a) (ver formula).
MXPA03010724A 2001-05-25 2002-05-08 Compuestos de carbamato y oxamida como inhibidores de la produccion de citocina. MXPA03010724A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29360001P 2001-05-25 2001-05-25
PCT/US2002/014400 WO2002096876A1 (en) 2001-05-25 2002-05-08 Carbamate and oxamide compounds as inhibitors of cytokine production

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MXPA03010724A true MXPA03010724A (es) 2004-03-02

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MXPA03010724A MXPA03010724A (es) 2001-05-25 2002-05-08 Compuestos de carbamato y oxamida como inhibidores de la produccion de citocina.

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US (1) US6743788B2 (es)
EP (1) EP1395561A1 (es)
JP (1) JP2004531571A (es)
CA (1) CA2448626A1 (es)
MX (1) MXPA03010724A (es)
WO (1) WO2002096876A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072569A1 (en) * 2002-02-25 2003-09-04 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases
PL377821A1 (pl) * 2002-11-21 2006-02-20 Chiron Corporation 2,4,6-tripodstawione pirymidyny jako inhibitory kinazy fosfatydyloinozytolu (PI) 3 i ich zastosowanie w leczeniu nowotworu
AU2004270733B2 (en) 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
WO2005105757A1 (en) * 2004-04-22 2005-11-10 The Procter & Gamble Company Tri-substituted ureas as cytokine inhibitors
RS53600B1 (en) 2004-06-17 2015-02-27 Cytokinetics, Inc. UNITS, PREPARATIONS AND METHODS
JP2008523072A (ja) 2004-12-07 2008-07-03 ルーカス ファーマシューティカルズ， インコーポレイテッド タンパク質キナーゼの阻害剤
US7741479B2 (en) 2004-12-07 2010-06-22 Locus Pharmaceuticals, Inc. Urea inhibitors of MAP kinases
US20100016319A1 (en) * 2005-11-29 2010-01-21 Toray Industries, Inc. A Corporation Of Japan Arylmethylene urea derivative and use thereof
EP1959960B1 (en) 2005-12-15 2013-04-10 Cytokinetics, Inc. Certain chemical entities, compositions and methods
EP1962852B1 (en) * 2005-12-19 2017-01-25 Cytokinetics, Inc. Compounds, compositions and methods
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US20080064717A1 (en) * 2006-05-19 2008-03-13 Rajesh Iyengar Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
US20080015227A1 (en) * 2006-05-19 2008-01-17 Kym Philip R Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
ES2381895T3 (es) * 2007-02-06 2012-06-01 Novartis Ag Inhibidores de PI 3-quinasa y métodos para su uso
RU2010115747A (ru) * 2007-09-21 2011-10-27 Санофи-Авентис (Fr) (циклопропилфенил)фенилоксаламиды, способ их получения и их применения в качестве лекарственного средства
MX2010002461A (es) * 2007-09-21 2010-03-26 Sanofi Aventis (carboxilalquilenfenil)feniloxamidas, metodo para su produccion y uso de las mismas como medicamento.
BR112014007310A2 (pt) 2011-09-27 2017-04-04 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
ES2665619T3 (es) 2013-03-14 2018-04-26 Novartis Ag 3-Pirimidin-4-il-oxazolidin-2-onas como inhibidores de IDH mutante
MX363949B (es) 2013-04-02 2019-04-08 Topivert Pharma Ltd Inhibidor de quinasa.
AU2014369449B2 (en) 2013-12-20 2018-07-05 Oxular Acquisitions Limited Urea derivatives useful as kinase inhibitors
MA40775A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38
US10072034B2 (en) 2016-04-06 2018-09-11 Respivert Limited Kinase inhibitors
CN106748991B (zh) * 2016-11-14 2020-03-17 西安交通大学 一种具有抗肿瘤活性的双芳基脲化合物及其制备方法和应用
CN106748990A (zh) * 2016-11-14 2017-05-31 西安交通大学 一种具有抗肿瘤活性的双芳基脲类化合物及其制备方法和应用
CN106748989B (zh) * 2016-11-14 2020-03-17 西安交通大学 一种具有抗肿瘤活性的二芳基脲类化合物及其制备方法和应用
EP3728228A1 (en) 2017-12-22 2020-10-28 Ravenna Pharmaceuticals, Inc. Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU185294B (en) 1980-12-29 1984-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted urea derivatives
GB8908869D0 (en) 1989-04-19 1989-06-07 Shell Int Research A process for the preparation of aromatic ureas
WO1991004027A1 (en) 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
RU94046149A (ru) 1992-05-28 1996-11-27 Пфайзер Инк. (US) Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат)
GB9302275D0 (en) 1993-02-05 1993-03-24 Smithkline Beecham Plc Novel compounds
JPH11514651A (ja) 1995-10-31 1999-12-14 メルク エンド カンパニー インコーポレーテッド 置換ピリジルピロール、前記化合物を含む組成物及び使用方法
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
EP0986382B1 (en) 1997-05-23 2008-06-25 Bayer Pharmaceuticals Corporation Raf kinase inhibitors
ES2151467T3 (es) 1997-05-23 2005-03-01 Bayer Corporation Arilureas para el tratamiento de enfermedades inflamatorias o inmunomoduladoras.
WO1999032111A1 (en) 1997-12-22 1999-07-01 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS
TR200100917T2 (tr) 1997-12-22 2001-07-23 Bayer Corporation Aril ve heteroaril sübstitüentli heteroksiklik üreler kullanılarak RAF kinazın inhibe edilmesi
AU1939999A (en) 1997-12-22 1999-07-12 Bayer Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
ATE346600T1 (de) 1997-12-22 2006-12-15 Bayer Pharmaceuticals Corp Inhibierung der p38 kinase-aktivität durch die verwendung von aryl- und heteroarylsubstituierten harnstoffen
RU2232015C2 (ru) 1997-12-22 2004-07-10 Байер Копэрейшн Способ подавления роста опухолевых клеток, опосредованного киназой raf, гетероциклические производные мочевины (варианты), фармацевтическая композиция (варианты)
TR200100840T2 (tr) * 1998-09-25 2001-10-22 Astrazeneca Ab Benzamid türevleri ve bunların sitokin inhibe edicileri olarak kullanımı
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
SK12832001A3 (sk) * 1999-03-12 2002-01-07 Boehringer Ingelheim Pharmaceuticals, Inc. Protizápalové látky, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
EP1163236B1 (en) 1999-03-12 2005-11-09 Boehringer Ingelheim Pharmaceuticals Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
MXPA02004879A (es) * 1999-11-16 2002-08-30 Boehringer Ingelheim Pharma Derivados de urea como agentes antiinflamatorios.

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